Reactome | CFTR G551D [plasma membrane]

CFTR G551D [plasma membrane]

Stable Identifier

R-HSA-5678977

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Cystic fibrosis transmembrane conductance regulator, CFTR_HUMAN

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External Reference Information

External Reference

UniProt:P13569 CFTR

Gene Names

CFTR, ABCC7

Chain

chain:1-1480

Reference Genes

BioGPS Gene:1080 CFTR

COSMIC (genes):CFTR CFTR

CTD Gene:1080 CFTR

dbSNP Gene:1080 CFTR

ENSEMBL:ENSG00000001626.17 CFTR

HGNC:1884 CFTR

KEGG Gene (Homo sapiens):1080 CFTR

Monarch:1080 CFTR

NCBI Gene:1080 CFTR

OMIM:602421 CFTR

UCSC:P13569 CFTR

Reference Transcript

RefSeq:NM_000492.3 CFTR

Other Identifiers

1080

11722757_at

17050697

205043_PM_at

205043_at

215702_PM_s_at

215702_s_at

3020647

3020648

3020652

3020654

3020658

3020659

3020661

3020662

3020663

3020664

3020666

3020667

3020668

3020670

3020672

3020673

3020674

3020679

3020680

3020682

3020683

3020684

3020685

3020686

3020688

3020689

3020694

3020695

3020696

3020698

3020699

3020701

3020702

3020705

3020706

3020707

3020712

3020719

3020721

3020722

3020723

3020724

3020725

3020726

3020727

36816_s_at

36817_at

3902164

3902300

8135661

A_14_P104877

A_14_P114787

A_14_P129538

A_14_P132049

A_23_P215720

GE62403

GO:0000166

GO:0005215

GO:0005254

GO:0005260

GO:0005515

GO:0005524

GO:0005622

GO:0005634

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005773

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0005887

GO:0006629

GO:0006695

GO:0006811

GO:0006821

GO:0006904

GO:0009986

GO:0010008

GO:0015106

GO:0015108

GO:0015701

GO:0016020

GO:0016021

GO:0016192

GO:0016324

GO:0016787

GO:0016853

GO:0016887

GO:0017081

GO:0019869

GO:0019899

GO:0022414

GO:0023052

GO:0030154

GO:0030165

GO:0030301

GO:0030660

GO:0030669

GO:0031410

GO:0031901

GO:0032991

GO:0034707

GO:0034976

GO:0035377

GO:0035774

GO:0042626

GO:0043225

GO:0043226

GO:0045921

GO:0048240

GO:0048856

GO:0050891

GO:0051087

GO:0051454

GO:0051649

GO:0055037

GO:0055038

GO:0055085

GO:0060081

GO:0070175

GO:0071320

GO:0097186

GO:0098772

GO:0106138

GO:0140359

GO:0140657

GO:1902161

GO:1902476

GO:1902943

GO:1904322

HMNXSV003020096

Hs.663.1.A1_3p_a_at

ILMN_1705813

M55131_at

PH_hs_0024884

TC07000726.hg

g6995995_3p_at

Participates

as an input of

Ivacaftor binds CFTR G551D (Homo sapiens)

as a component of

Ivacaftor:CFTR G551D [plasma membrane] (Homo sapiens)

as a member of

CFTR mutants [plasma membrane] (Homo sapiens)

Other forms of this molecule

PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]

PolyUb-CFTR [plasma membrane]

CFTR [lysosomal membrane]

CFTR [Golgi-associated vesicle membrane]

CFTR [endosome membrane]

PolyUb-CFTR [endosome membrane]

CFTR F508del [endoplasmic reticulum membrane]

ub-CFTR F508del [cytosol]

ub-CFTR F508del [endoplasmic reticulum membrane]

CFTR G542* [plasma membrane]

CFTR W1282* [plasma membrane]

CFTR F508del [plasma membrane]

CFTR N1303K [plasma membrane]

CFTR [plasma membrane]

CFTR [endoplasmic reticulum membrane]

misfolded CFTR [endoplasmic reticulum membrane]

Modified Residues

Name

glycine 551 replaced with L-aspartic acid

Coordinate

551

PsiMod

glycine removal [MOD:01638]

A protein modification that effectively removes or replaces an glycine.

L-aspartic acid residue [MOD:00013]

A protein modification that effectively converts a source amino acid residue to an L-aspartic acid.

Disease

Name	Identifier	Synonyms
cystic fibrosis	DOID:1485	mucoviscidosis, CF

Cross References

RefSeq

NP_000483.3

ZINC - World Drugs

CFTR_HUMAN

Guide to Pharmacology - Targets

707

OpenTargets

ENSG00000001626

ZINC - FDA approved

CFTR_HUMAN

ZINC - Substances

CFTR_HUMAN

ZINC target

P13569

ZINC - Biogenic

CFTR_HUMAN

PRO

P13569

PDB

6UK1, 2PZE, 6MSM, 6HEP, 5TGK, 5D3F, 6GJQ, 2BBO, 1XMJ, 5TFD, 6GJS, 5TFF, 1XMI, 4WZ6, 7SV7, 5TFG, 6GK4, 5UAK, 6GJU, 6O2P, 5TF7, 6WBS, 5TFI, 6ZE1, 5D2D, 5TF8, 5TFJ, 2LOB, 7SVD, 3ISW, 6GKD, 3GD7, 5TFA, 6O1V, 2PZG, 2BBT, 5TFB, 5TFC, 2PZF, 7SVR, 5D3E, 2BBS

IntEnz

5.6.1.6

HPA

ENSG00000001626-CFTR

GeneCards

P13569

Ensembl

ENST00000649781, ENST00000003084, ENSP00000003084, ENSP00000497203, ENSG00000001626

Pharos - Targets

P13569

ZINC - Predictions - Purchasable

CFTR_HUMAN

Orphanet

15441

HMDB Protein

HMDBP02121

Interactors (171)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14745 NHRF1			0.905	15
UniProt:Q15599 NHRF2			0.869	14
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.813	11
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.813	14
UniProt:Q9HD26 GOPC	3	GOPC [lysosomal membrane] (R-HSA-5627281) GOPC [plasma membrane] (R-HSA-5626572) GOPC [Golgi-associated vesicle membrane] (R-HSA-5627067)	0.71	4
UniProt:Q5T2W1 NHRF3			0.702	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.702	12
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.669	5
UniProt:P02545 LMNA	3	LMNA(1-646) [nuclear envelope] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.643	13
UniProt:P31689 DNAJA1	1	DNAJA1 [cytosol] (R-HSA-3371544)	0.643	13
UniProt:P31151 S100A7	2	S100A7 [extracellular region] (R-HSA-5432925) S100A7 [azurophil granule lumen] (R-HSA-6799207)	0.643	10
UniProt:P13987 CD59	8	CD59 [specific granule membrane] (R-HSA-6799513) CD59 [tertiary granule membrane] (R-HSA-6800885) GPI-CD59 [ER to Golgi transport vesicle membrane] (R-HSA-5689801) GPI-CD59 [endoplasmic reticulum membrane] (R-HSA-5689453) GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689804) GPI-CD59 [transport vesicle] (R-HSA-6808775) GPI-CD59 [Golgi membrane] (R-HSA-6808772) CD59 [plasma membrane] (R-HSA-2530458)	0.643	9
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.643	11
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.643	11
UniProt:P06702 S100A9	3	S100A9 [secretory granule lumen] (R-HSA-6804774) S100A9 [cytosol] (R-HSA-9626869) S100A9 [extracellular region] (R-HSA-5432857)	0.643	10
UniProt:Q15370 ELOB	2	TCEB2 [nucleoplasm] (R-HSA-112423) ELOB [cytosol] (R-HSA-180551)	0.643	12
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978)	0.643	11
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.643	7
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.643	11
UniProt:O15554 KCNN4	1	KCNN4 [plasma membrane] (R-HSA-977543)	0.602	5
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.597	10
UniProt:P05787 KRT8	1	KRT8 [cytosol] (R-HSA-446043)	0.589	7
UniProt:Q9HBW0 LPAR2	1	LPAR2 [plasma membrane] (R-HSA-419393)	0.558	4
UniProt:Q9JIL4 NHRF3			0.544	7
UniProt:Q9H8Y8 GORASP2	2	GORASP2 [Golgi membrane] (R-HSA-2422385) p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965)	0.544	3
UniProt:Q9QX74	1	Shank2 [cytosol] (R-RNO-6794265)	0.544	2
UniProt:Q99942 RNF5	1	RNF5 [endoplasmic reticulum membrane] (R-HSA-975990)	0.537	3
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.527	10
UniProt:P55290 CDH13	1	CDH13 [plasma membrane] (R-HSA-419009)	0.527	7
UniProt:P13010 XRCC5	4	XRCC5 [cytosol] (R-HSA-3134849) XRCC5 [extracellular region] (R-HSA-6806530) XRCC5 [secretory granule lumen] (R-HSA-6801297) XRCC5 [nucleoplasm] (R-HSA-58274)	0.527	9
UniProt:O00299 CLIC1			0.527	9
UniProt:Q5T4S7 UBR4	5	UBR4 [specific granule membrane] (R-HSA-6801492) UBR4 [tertiary granule membrane] (R-HSA-6801489) UBR4 [plasma membrane] (R-HSA-6801583) UBR4 [ficolin-1-rich granule membrane] (R-HSA-6801503) UBR4 [cytosol] (R-HSA-976045)	0.527	9
UniProt:Q9Y608 LRRF2			0.527	7
UniProt:P14866 HNRNPL	1	HNRNPL [nucleoplasm] (R-HSA-71947)	0.527	9
UniProt:P05109 S100A8	3	S100A8 [secretory granule lumen] (R-HSA-6804772) S100A8 [cytosol] (R-HSA-9626834) S100A8 [extracellular region] (R-HSA-5432846)	0.527	7
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.527	9
UniProt:Q9UN37 VPS4A	1	VPS4A [cytosol] (R-HSA-917732)	0.527	2
UniProt:P56537 IF6			0.527	7
UniProt:Q96CS3 FAF2	3	FAF2 [cytosol] (R-HSA-6781921) FAF2 [extracellular region] (R-HSA-6806183) FAF2 [azurophil granule lumen] (R-HSA-6799138)	0.527	3
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.527	10
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.527	10
UniProt:Q08J23 NSUN2	1	NSUN2 [nucleoplasm] (R-HSA-6782382)	0.527	9
UniProt:Q6PID8 KLD10			0.527	5
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.527	5
UniProt:P00338 LDHA	1	LDHA [cytosol] (R-HSA-70502)	0.527	10
UniProt:P04899 GNAI2	1	GNAI2 [plasma membrane] (R-HSA-55435)	0.527	8
UniProt:P55060 XPO2			0.527	11
UniProt:O75340 PDCD6			0.527	2
UniProt:P30041 PRDX6	3	PRDX6 [extracellular region] (R-HSA-6806198) PRDX6 [azurophil granule lumen] (R-HSA-6798744) PRDX6 [cytosol] (R-HSA-3343670)	0.527	5
UniProt:Q9NQH7 XPP3			0.527	6
UniProt:P05121 SERPINE1	3	SERPINE1 [plasma membrane] (R-HSA-158922) SERPINE1 [platelet alpha granule lumen] (R-HSA-114649) SERPINE1 [extracellular region] (R-HSA-158797)	0.527	10
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.527	9
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.527	10
UniProt:P61160 ACTR2	4	ACTR2 [azurophil granule lumen] (R-HSA-6798740) ACTR2 [extracellular region] (R-HSA-6806232) ACTR2 [ficolin-1-rich granule lumen] (R-HSA-6800937) ACTR2 [cytosol] (R-HSA-200810)	0.527	10
UniProt:P12956 XRCC6	5	XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [nucleoplasm] (R-HSA-58272)	0.527	9
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.527	9
UniProt:P61163 ACTR1A	1	ACTR1A [cytosol] (R-HSA-380258)	0.527	3
UniProt:P0CG39 POTEJ			0.527	9
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.527	10
UniProt:P08107 HSP71			0.527	4
UniProt:Q8WWM7 ATX2L			0.527	2
UniProt:A8MQ03 CRTP1			0.527	3
UniProt:A0FGR8 ESYT2	1	ESYT2 [endoplasmic reticulum membrane] (R-HSA-8857683)	0.527	4
UniProt:P07814 EPRS1	1	EPRS [cytosol] (R-HSA-379649)	0.527	3
UniProt:P60981 DEST			0.527	9
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.527	6
UniProt:Q92747 ARPC1A	1	ARPC1A [cytosol] (R-HSA-200807)	0.527	10
UniProt:Q9NYL9 TMOD3	1	TMOD3 [cytosol] (R-HSA-217354)	0.527	10
UniProt:Q9ULV4 COR1C			0.527	10
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.527	9
UniProt:P62873 GNB1	5	GNB1 [photoreceptor disc membrane] (R-HSA-55373) Unfolded GNB1 [cytosol] (R-HSA-6814200) Partially folded GNB1 [cytosol] (R-HSA-8850526) GNB1 [plasma membrane] (R-HSA-164347) GNB1 [cytosol] (R-HSA-6814412)	0.527	10
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.527	5
UniProt:P62910 RPL32	1	RPL32 [cytosol] (R-HSA-72456)	0.527	9
UniProt:Q96N67 DOCK7	1	DOCK7 [cytosol] (R-HSA-1012970)	0.527	7
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.527	10
UniProt:P13667 PDIA4			0.527	9
UniProt:O95433 AHSA1			0.527	4
UniProt:Q06830 PRDX1	3	PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198) p-T90-PRDX1 [cytosol] (R-HSA-8868564)	0.527	10
UniProt:Q9Y678 COPG1	4	COPG1 [endoplasmic reticulum membrane] (R-HSA-6810960) COPG1 [transport vesicle] (R-HSA-6808749) COPG1 [cytosol] (R-HSA-199987) COPG1 [Golgi membrane] (R-HSA-6808747)	0.527	9
UniProt:Q9UKM9 RALY			0.527	8
UniProt:O60884 DNAJA2	1	DNAJA2 [cytosol] (R-HSA-3371555)	0.527	4
UniProt:P62879 GNB2	4	GNB2 [plasma membrane] (R-HSA-164335) Unfolded GNB2 [cytosol] (R-HSA-6814202) Partially folded GNB2 [cytosol] (R-HSA-8850536) GNB2 [cytosol] (R-HSA-6814421)	0.527	9
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.527	9
UniProt:P31040 SDHA	1	SDHA [mitochondrial inner membrane] (R-HSA-70983)	0.527	8
UniProt:P17812 CTPS1	1	CTPS1 [cytosol] (R-HSA-73536)	0.527	10
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.527	10
UniProt:P17655 CAPN2	2	CAPN2 [cytosol] (R-HSA-8848630) CAPN2 [plasma membrane] (R-HSA-8863405)	0.527	10
UniProt:O95425 SVIL			0.527	9
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.527	6
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.527	8
UniProt:Q9P035 HACD3	1	PTPLAD1 [endoplasmic reticulum membrane] (R-HSA-5676074)	0.527	4
UniProt:P26641 EEF1G	3	EEF1G(1-343)-p-6Y ALK(1106-1620) fusion [cytosol] (R-HSA-9710850) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G [cytosol] (R-HSA-156925)	0.527	10
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.527	9
UniProt:Q5EB52 MEST			0.527	9
UniProt:P06753 TPM3	3	TPM3 [cytosol] (R-HSA-390543) TPM3(2-258)-p-7Y ALK(1059-1620) fusion [cytosol] (R-HSA-9710837) TPM3(2-258)-ALK(1059-1620) fusion [cytosol] (R-HSA-9710848)	0.527	11
UniProt:Q15233 NONO			0.527	10
UniProt:P46779 RPL28	1	RPL28 [cytosol] (R-HSA-72444)	0.527	9
UniProt:Q9BUF5 TUBB6	6	TUBB6 [cytosol] (R-HSA-191698) TUBB6 [axonemal microtubule] (R-HSA-5610438) Polyglutamyl-TUBB6 [cytosol] (R-HSA-8867399) Polyglycyl-TUBB6 [cytosol] (R-HSA-8867396) TUBB6 unfolded [cytosol] (R-HSA-392780) TUBB6 folding intermediate [cytosol] (R-HSA-392787)	0.527	8
UniProt:P38646 HSPA9	6	HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964)	0.527	11
UniProt:P56192 MARS1	1	MARS [cytosol] (R-HSA-379657)	0.527	8
UniProt:P04075 ALDOA	6	ALDOA [platelet alpha granule lumen] (R-HSA-349738) ALDOA [tertiary granule lumen] (R-HSA-6801485) ALDOA [secretory granule lumen] (R-HSA-6801469) ALDOA [extracellular region] (R-HSA-349735) ALDOA [ficolin-1-rich granule lumen] (R-HSA-6801521) ALDOA [cytosol] (R-HSA-71492)	0.527	9
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.527	9
UniProt:Q9BU76 MMTAG2	3	MMTAG2 [secretory granule lumen] (R-HSA-6801073) MMTAG2 [extracellular region] (R-HSA-6806452) MMTAG2 [ficolin-1-rich granule lumen] (R-HSA-6801074)	0.527	6
UniProt:P26599 PTBP1	1	PTBP1 [nucleoplasm] (R-HSA-71923)	0.527	7
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.527	2
UniProt:P46783 RPS10	2	RPS10 [nucleoplasm] (R-HSA-6798733) RPS10 [cytosol] (R-HSA-72325)	0.527	9
UniProt:P23246 SFPQ	3	SFPQ [nucleoplasm] (R-HSA-3900138) p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [cytosol] (R-HSA-9635505)	0.527	10
UniProt:Q8WWI1 LMO7	3	LMO7(1-1073)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9713460) LMO7(1-1073)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713457) LMO7 [cytosol] (R-HSA-8862589)	0.527	9
UniProt:P47914 RPL29	1	RPL29 [cytosol] (R-HSA-72446)	0.527	10
UniProt:Q9UJW0 DCTN4	1	DCTN4 [cytosol] (R-HSA-2029070)	0.527	5
UniProt:P62841 RPS15	2	RPS15 [nucleoplasm] (R-HSA-6798706) RPS15 [cytosol] (R-HSA-72335)	0.527	9
UniProt:Q9UHB6 LIMA1			0.527	9
UniProt:P37802 TAGLN2	2	TAGLN2 [extracellular region] (R-HSA-8862999) TAGLN2 [cytosol] (R-HSA-8862962)	0.527	10
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.527	10
UniProt:P04080 CSTB	4	CSTB [tertiary granule lumen] (R-HSA-6801398) CSTB [secretory granule lumen] (R-HSA-6801394) CSTB [extracellular region] (R-HSA-6801567) CSTB [ficolin-1-rich granule lumen] (R-HSA-6801376)	0.527	9
UniProt:P31944 CASP14	2	CASP14(6-146) [cytosol] (R-HSA-8847667) CASP14(153-242) [cytosol] (R-HSA-8847687)	0.527	6
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.527	10
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	10
UniProt:Q9Y3U8 RPL36	1	RPL36 [cytosol] (R-HSA-72464)	0.527	7
UniProt:Q12904 AIMP1	1	AIMP1(1-312) [cytosol] (R-HSA-379609)	0.527	8
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.527	10
UniProt:P14174 MIF	3	MIF [secretory granule lumen] (R-HSA-6803282) MIF [extracellular region] (R-HSA-212594) MIF [ficolin-1-rich granule lumen] (R-HSA-6803289)	0.527	9
UniProt:Q9P2E9 RRBP1	2	RRBP1(1-1264)-p-6Y ALK(1106-1620) fusion [endoplasmic reticulum membrane] (R-HSA-9702011) RRBP1(1-1264)-ALK(1106-1620) fusion [endoplasmic reticulum membrane] (R-HSA-9702005)	0.527	4
UniProt:Q13155 AIMP2	1	AIMP2 [cytosol] (R-HSA-379576)	0.527	10
UniProt:P04632 CAPNS1	2	CAPNS1 [plasma membrane] (R-HSA-3828034) CAPNS1 [cytosol] (R-HSA-3288229)	0.527	4
UniProt:P57088 TMM33			0.527	11
UniProt:P35232 PHB1	2	PHB [cytosol] (R-HSA-5672944) PHB [mitochondrial inner membrane] (R-HSA-8953720)	0.527	9
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.527	9
UniProt:Q9BR76 COR1B			0.527	4
UniProt:O00622 CCN1	2	p-CYR61 [endoplasmic reticulum lumen] (R-HSA-8956919) CYR61 [endoplasmic reticulum lumen] (R-HSA-5173201)	0.527	10
UniProt:P53618 COPB1	8	COPB1 [endoplasmic reticulum membrane] (R-HSA-6810955) COPB1 [tertiary granule membrane] (R-HSA-6800175) COPB1 [secretory granule membrane] (R-HSA-6800914) COPB1 [plasma membrane] (R-HSA-6806431) COPB1 [ficolin-1-rich granule membrane] (R-HSA-6800972) COPB1 [transport vesicle] (R-HSA-6808736) COPB1 [cytosol] (R-HSA-199995) COPB1 [Golgi membrane] (R-HSA-6808735)	0.527	3
UniProt:P09382 LGALS1	2	p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003) LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711)	0.527	10
UniProt:P62273 RPS29	2	RPS29 [nucleoplasm] (R-HSA-6798725) RPS29 [cytosol] (R-HSA-72367)	0.527	9
UniProt:P16615 ATP2A2	2	ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962) ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903)	0.527	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.527	10
UniProt:Q14257 RCN2			0.527	10
UniProt:Q9BQE3 TUBA1C	9	AcK-TUBA1C [cytosol] (R-HSA-5618314) Ac K40 TUBA1C [axonemal microtubule] (R-HSA-5624856) TUBA1C folding intermediate [cytosol] (R-HSA-392798) TUBA1C unfolded [cytosol] (R-HSA-392772) L-isoglutamyl polyglycyl-TUBA1C [cytosol] (R-HSA-8867405) Polyglutamyl-TUBA1C [cytosol] (R-HSA-8867401) TUBA1C(1-448) [cytosol] (R-HSA-8955579) TUBA1C [axonemal microtubule] (R-HSA-5610439) TUBA1C [cytosol] (R-HSA-190590)	0.527	6
UniProt:Q14254 FLOT2	1	FLOT2 [plasma membrane] (R-HSA-8849895)	0.527	9
UniProt:Q13045 FLII			0.527	7
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	9
UniProt:O43852 CALU	3	CALU [endoplasmic reticulum lumen] (R-HSA-350695) p-CALU [endoplasmic reticulum lumen] (R-HSA-8956931) CALU [extracellular region] (R-HSA-350739)	0.527	2
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.527	10
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.527	10
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.527	8
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [extracellular exosome] (R-HSA-8950304) HNRNPA2B1 [nucleoplasm] (R-HSA-71929)	0.527	10
UniProt:P43490 NAMPT	1	NAMPT [cytosol] (R-HSA-197188)	0.527	10
UniProt:P63000 RAC1	6	RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.527	9
UniProt:P32119 PRDX2	2	p-T89-PRDX2 [cytosol] (R-HSA-8868574) PRDX2 [cytosol] (R-HSA-3341292)	0.527	9
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.527	9
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.527	4
UniProt:O14980 XPO1	2	XPO1 [nucleoplasm] (R-HSA-165529) XPO1 [cytosol] (R-HSA-165539)	0.527	12
UniProt:P54652 HSPA2	2	HSPA2 [nucleoplasm] (R-HSA-912480) HSPA2 [cytosol] (R-HSA-3371408)	0.527	4
UniProt:Q08211 DHX9	2	DHX9 [cytosol] (R-HSA-847700) DHX9 [nucleoplasm] (R-HSA-53517)	0.527	10
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697)	0.527	10
UniProt:P22061 PCMT1	1	PCMT1 [cytosol] (R-HSA-5676580)	0.527	11
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302)	0.527	10
UniProt:P67809 YBX1	3	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	10
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.527	7
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.527	6
UniProt:P06733 ENO1	1	ENO1 [cytosol] (R-HSA-71437)	0.527	9
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.527	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.527	11
UniProt:O43852-1 CALU			0.524	2
UniProt:P07384 CAPN1	4	CAPN1 [plasma membrane] (R-HSA-3828038) CAPN1 [cytosol] (R-HSA-3288367) CAPN1 [extracellular region] (R-HSA-6806485) CAPN1 [ficolin-1-rich granule lumen] (R-HSA-6801284)	0.499	3
UniProt:P51790-2 CLCN3			0.499	2
UniProt:Q9BUN8 DERL1	1	DERL1 [endoplasmic reticulum membrane] (R-HSA-6781898)	0.499	2
UniProt:P11274 BCR	4	BCR [cytosol] (R-HSA-195200) BCR(1-584)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604524) pY177-BCR(1-584)-p-FGFR1(419-822) fusion [cytosol] (R-HSA-1839041) BCR(1-584)-p-FGFR1(419-822) fusion [cytosol] (R-HSA-1838979)	0.491	2
UniProt:P16615-1 ATP2A2			0.471	6
UniProt:Q7LBE3-1 SLC26A9			0.463	2
UniProt:Q5XXA6 ANO1	1	ANO1 [plasma membrane] (R-HSA-2684927)	0.463	2
UniProt:P51572 BCAP31	6	BCAP31 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(238-246) [cytosol] (R-HSA-351912) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333)	0.463	3

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