Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
CFL1
Stable Identifier
R-HSA-350751
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cofilin-1, COF1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
LIMK phosphorylates CFL1, inactivating it (Homo sapiens)
CFL1 [cytosol] (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema3A PAK dependent Axon repulsion (Homo sapiens)
Phosphorylation of cofilin by LIMK-1 (Homo sapiens)
CFL1 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Release of (inferred) platelet cytosolic components (Homo sapiens)
Platelet releasate (inferred) cytosolic proteins [cytosol] (Homo sapiens)
CFL1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
Expression of Cofilin-1 (Homo sapiens)
CFL1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Phosphorylation of cofilin by LIMK-1 (Homo sapiens)
CFL1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate ROCKs (Homo sapiens)
LIMK phosphorylates CFL1, inactivating it (Homo sapiens)
CFL1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23528 CFL1
Gene Names
CFL1, CFL
Chain
initiator methionine:1, chain:2-166
Reference Genes
BioGPS Gene:1072 CFL1
COSMIC (genes):CFL1 CFL1
CTD Gene:1072 CFL1
dbSNP Gene:1072 CFL1
ENSEMBL:ENSG00000172757 CFL1
ENSEMBL:ENSG00000172757 CFL1
HGNC:1874 CFL1
KEGG Gene (Homo sapiens):hsa:1072 CFL1
Monarch:1072 CFL1
NCBI Gene:1072 CFL1
OMIM:601442 CFL1
Reference Transcript
RefSeq:NM_005507.2 CFL1
Other Identifiers
0000580292
1072
11753645_a_at
11753646_x_at
11754158_a_at
11757818_x_at
11763259_x_at
1555730_a_at
18671394
18671395
18671397
18671403
18671404
18671405
1Q8G
1Q8X
200021_at
200021_PM_at
33659_at
33687
3377891
3377892
3377893
3377894
3377895
3377897
3377899
3377902
37077
3J0S
4BEX
53761
5HVK
5L6W
75185_f_at
7892701
7894264
7895149
7895299
7895945
7896038
7949496
AAA64501
AAH11005
AAH12265
AAH12318
AAH18256
AAP35492
ACJ13657
AK097690
BAA00589
BAG53513
BC011005
BC012265
BC012318
BC018256
BT006846
CAA64685
CAB033687
CAB037077
CCDS8114
CFL1
CFL1-201
CFL1-203
CH471076
D00682
EAW74449
EAW74452
ENSG00000172757
ENSP00000309629
ENSP00000432660
ENST00000308162
ENST00000525451
EntrezGene:1072
EU794603
G3V1A4
g5031634_3p_at
g5031634_3p_x_at
GE79937
GO:0000278
GO:0000281
GO:0000902
GO:0001755
GO:0001842
GO:0003674
GO:0003779
GO:0005102
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005925
GO:0006464
GO:0006468
GO:0007010
GO:0007015
GO:0007049
GO:0007165
GO:0007266
GO:0008092
GO:0008150
GO:0008219
GO:0009615
GO:0009790
GO:0015629
GO:0016020
GO:0016363
GO:0022604
GO:0030010
GO:0030027
GO:0030036
GO:0030042
GO:0030043
GO:0030154
GO:0030836
GO:0030864
GO:0031258
GO:0031982
GO:0032587
GO:0035722
GO:0040011
GO:0042995
GO:0043066
GO:0043200
GO:0043226
GO:0044403
GO:0044794
GO:0048646
GO:0048856
GO:0048870
GO:0051015
GO:0051301
GO:0061001
GO:0070062
HGNC:1874
HPA053761
Hs2.180370.2.S1_3p_s_at
ILMN_1705617
IPR002108
IPR017904
IPR027234
IPR029006
MIM:601442
NM_005507
NP_005498
PF00241
PR00006
SM00102
TC11001945.hg
U21909
uc001ofs.4
uc001oft.4
UPI0000127E2C
V9HWI5
X95404
X95404_at
Participant Of
hasMember
Platelet releasate (inferred) cytosolic proteins [cytosol]
input
LIMK phosphorylates CFL1, inactivating it
Phosphorylation of cofilin by LIMK-1
output
Expression of Cofilin-1
Other forms of this molecule
CFL1 [extracellular region]
p-S3-CFL1 [cytosol]
Cross References
RefSeq
NP_005498.1
GeneCards
P23528
DOCK Blaster
5L6W
,
4BEX
,
5HVK
PRO
P23528
PDB
5L6W
,
1Q8X
,
5HVK
,
4BEX
,
1Q8G
,
3J0S
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63261 ACTG1
3
ACTG1 [cytosol]
(R-HSA-201858)
ACTG1 [lysosomal membrane]
(R-HSA-196169)
ACTG1 [plasma membrane]
(R-HSA-196044)
0.764
8
UniProt:P60709 ACTB
5
ACTB(1-375) [cytosol]
(R-HSA-201861)
ACTB(1-375) [plasma membrane]
(R-HSA-196016)
ACTB(1-375) [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB(1-375) [lysosomal membrane]
(R-HSA-196160)
0.764
6
UniProt:P53667 LIMK1
3
p-T508-LIMK1 [cytosol]
(R-HSA-399816)
LIMK1 [cytosol]
(R-HSA-397785)
p-S,T508-LIMK1 [cytosol]
(R-HSA-419610)
0.722
3
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.656
3
UniProt:P32121 ARRB2
2
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [cytosol]
(R-HSA-416464)
0.577
4
UniProt:P49407 ARRB1
5
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [cytosol]
(R-HSA-264470)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.577
3
UniProt:Q13393 PLD1
4
PLD1 [specific granule membrane]
(R-HSA-6799531)
PLD1 [tertiary granule membrane]
(R-HSA-6800955)
PLD1 [plasma membrane]
(R-HSA-2028998)
PLD1 [endoplasmic reticulum membrane]
(R-HSA-1498795)
0.571
4
UniProt:Q549N0 Q549N0
0.556
3
UniProt:Q1KLZ0 Q1KLZ0
0.556
3
UniProt:P00533 EGFR
58
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.553
2
UniProt:O14939 PLD2
2
PLD2 [endoplasmic reticulum membrane]
(R-HSA-1498791)
PLD2 [plasma membrane]
(R-HSA-2029075)
0.544
2
UniProt:P57058 HUNK
0.524
2
UniProt:P0DOE7 MATRX
0.524
2
UniProt:P54253 ATX1
0.508
5
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.499
2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]
7
PI(3,5)P2 [Golgi membrane]
(R-ALL-1806290)
PI(3,5)P2 [plasma membrane]
(R-ALL-1806224)
PI(3,5)P2 [early endosome membrane]
(R-ALL-1806205)
PI(3,5)P2 [late endosome membrane]
(R-ALL-1806289)
PI(3,5)P2 [phagophore assembly site membrane]
(R-ALL-5692959)
PI(3,5)P2 [endoplasmic reticulum membrane]
(R-ALL-6809774)
PI(3,5)P2 [lysosomal membrane]
(R-ALL-5334668)
0.462
2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]
6
PI(4,5)P2 [Golgi membrane]
(R-ALL-1806165)
PI(4,5)P2 [plasma membrane]
(R-ALL-179856)
PI(4,5)P2 [endoplasmic reticulum membrane]
(R-ALL-2023856)
PI(4,5)P2 [nucleoplasm]
(R-ALL-6810412)
PI(4,5)P2 [cytoplasmic vesicle membrane]
(R-ALL-8874467)
PI(4,5)P2 [early endosome membrane]
(R-ALL-8849966)
0.462
2
© 2018
Reactome
