Reactome | CFL1 [cytosol]

CFL1 [cytosol]

Stable Identifier

R-HSA-350751

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cofilin-1, COF1_HUMAN

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of Cofilin-1 (Homo sapiens)
        
        CFL1 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - Phosphorylation of cofilin by LIMK-1 (Homo sapiens)
        
        CFL1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23528 CFL1

Gene Names

CFL1, CFL

Chain

initiator methionine:1, chain:2-166

Reference Genes

BioGPS Gene:1072 CFL1

COSMIC (genes):CFL1 CFL1

CTD Gene:1072 CFL1

dbSNP Gene:1072 CFL1

ENSEMBL:ENSG00000172757 CFL1

HGNC:1874 CFL1

KEGG Gene (Homo sapiens):1072 CFL1

Monarch:1072 CFL1

NCBI Gene:1072 CFL1

OMIM:601442 CFL1

Reference Transcript

RefSeq:NM_005507.2 CFL1

Other Identifiers

0000580292

1072

11753645_a_at

11753646_x_at

11754158_a_at

11757818_x_at

11763259_x_at

1555730_a_at

18671394

18671395

18671397

18671403

18671404

18671405

200021_PM_at

200021_at

33659_at

3377891

3377892

3377893

3377894

3377895

3377897

3377899

3377902

75185_f_at

7892701

7894264

7895149

7895299

7895945

7896038

7949496

GE79937

GO:0000902

GO:0003674

GO:0003779

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0007010

GO:0007049

GO:0007165

GO:0007266

GO:0008092

GO:0008150

GO:0008219

GO:0009615

GO:0009790

GO:0015629

GO:0016020

GO:0016032

GO:0016363

GO:0022604

GO:0030027

GO:0030036

GO:0030042

GO:0030043

GO:0030154

GO:0031258

GO:0031982

GO:0032587

GO:0034330

GO:0035722

GO:0040011

GO:0040019

GO:0042995

GO:0043066

GO:0043226

GO:0044403

GO:0044794

GO:0048856

GO:0048870

GO:0051014

GO:0051015

GO:0051293

GO:0061001

GO:0070062

HMNXSV003014976

Hs2.180370.2.S1_3p_s_at

ILMN_1705617

TC11001945.hg

X95404_at

g5031634_3p_at

g5031634_3p_x_at

Participates

as an output of

Expression of Cofilin-1 (Homo sapiens)

as a member of

Platelet releasate (inferred) cytosolic proteins [cytosol] (Homo sapiens)

as an input of

Other forms of this molecule

p-S3-CFL1 [cytosol]

CFL1 [extracellular region]

Cross References

RefSeq

NP_005498.1

Target Pathogen

5b354852be737e166372e996

OpenTargets

ENSG00000172757

HPA

ENSG00000172757-CFL1

GeneCards

P23528

Ensembl

ENST00000308162, ENSP00000432660, ENSG00000172757, ENSP00000309629, ENST00000525451

PRO

P23528

PDB

5L6W, 4BEX, 6UBY, 6VAO, 6UC0, 1Q8X, 3J0S, 5HVK, 1Q8G, 6UC4

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.87	9
UniProt:P63261 ACTG1	3	ACTG1 [cytosol] (R-HSA-201858) ACTG1 [lysosomal membrane] (R-HSA-196169) ACTG1 [plasma membrane] (R-HSA-196044)	0.781	9
UniProt:P53667 LIMK1	3	p-T508-LIMK1 [cytosol] (R-HSA-399816) LIMK1 [cytosol] (R-HSA-397785) p-S,T508-LIMK1 [cytosol] (R-HSA-419610)	0.722	3
UniProt:P54253 ATX1			0.703	11
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.668	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.656	3
UniProt:P49407 ARRB1	5	PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.577	3
UniProt:P32121 ARRB2	2	PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [cytosol] (R-HSA-416464)	0.577	4
UniProt:Q13393 PLD1	4	PLD1 [tertiary granule membrane] (R-HSA-6800955) PLD1 [specific granule membrane] (R-HSA-6799531) PLD1 [plasma membrane] (R-HSA-2028998) PLD1 [endoplasmic reticulum membrane] (R-HSA-1498795)	0.571	4
UniProt:Q549N0 Q549N0			0.556	3
UniProt:Q1KLZ0 Q1KLZ0			0.556	3
UniProt:Q96CV9 OPTN	4	OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525)	0.556	3
UniProt:Q15303 ERBB4			0.553	2
UniProt:O14939 PLD2	2	PLD2 [endoplasmic reticulum membrane] (R-HSA-1498791) PLD2 [plasma membrane] (R-HSA-2029075)	0.544	2
UniProt:P57058 HUNK			0.524	2
UniProt:P0DOE7 MATRX			0.524	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.499	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2

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