Reactome | CFL1 [cytosol]

CFL1 [cytosol]

Stable Identifier

R-HSA-350751

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cofilin-1, COF1_HUMAN

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of Cofilin-1 (Homo sapiens)
        
        CFL1 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - Phosphorylation of cofilin by LIMK-1 (Homo sapiens)
        
        CFL1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23528 CFL1

Gene Names

CFL1, Cofilin-1, CFL

Chain

initiator methionine:, chain:2-166

Reference Genes

BioGPS Gene:1072 CFL1

COSMIC (genes):CFL1 CFL1

CTD Gene:1072 CFL1

dbSNP Gene:1072 CFL1

ENSEMBL:ENSG00000172757 CFL1

HGNC:1874 CFL1

KEGG:hsa:1072 CFL1

Monarch:1072 CFL1

NCBI Gene:1072 CFL1

OMIM:601442 CFL1

UCSC:P23528 CFL1

Reference Transcript

RefSeq:NM_005507.3 CFL1

Other Identifiers

1072

11753645_a_at

11753646_x_at

11754158_a_at

11757818_x_at

11763259_x_at

1555730_PM_a_at

1555730_a_at

16654131

16654135

16654139

16654207

16654209

16654211

16654213

16654215

16654217

16654233

16654235

16654237

16654239

16654241

16654243

18671389

18671390

18671391

18671392

18671393

18671394

18671395

18671396

18671397

18671398

18671399

18671400

18671401

18671402

18671403

18671404

18671405

18671406

18671407

200021_PM_at

200021_at

236792_PM_at

236792_at

33659_at

3377887

3377888

3377889

3377890

3377891

3377892

3377893

3377894

3377895

3377896

3377897

3377898

3377899

3377900

3377901

3377902

3377904

3377905

3377906

3377910

3377912

3377914

3377916

75185_f_at

76366_at

76368_at

7892701

7894264

7895149

7895299

7895945

7896038

7949496

A_21_P0011012

GE79937

GE833765

GO:0000281

GO:0000910

GO:0003779

GO:0005515

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0007010

GO:0007266

GO:0008092

GO:0009615

GO:0015629

GO:0016020

GO:0016363

GO:0022604

GO:0030027

GO:0030036

GO:0030042

GO:0030043

GO:0030424

GO:0030426

GO:0031258

GO:0031982

GO:0032587

GO:0040019

GO:0042995

GO:0043066

GO:0043226

GO:0044794

GO:0051014

GO:0051015

GO:0051293

GO:0061001

GO:0070062

HMNXSV003014976

HMNXSV003053161

Hs.121449.0.A1_3p_at

Hs2.180370.2.S1_3p_s_at

ILMN_1705617

TC11001944.hg

TC11001945.hg

X95404_at

g5031634_3p_at

g5031634_3p_x_at

Participates

as an output of

Expression of Cofilin-1 (Homo sapiens)

as a member of

Platelet releasate (inferred) cytosolic proteins [cytosol] (Homo sapiens)

as an input of

Other forms of this molecule

p-S3-CFL1 [cytosol]

CFL1 [extracellular region]

Cross References

RefSeq

NP_005498.1

OpenTargets

ENSG00000172757

ENSEMBL

ENSP00000432660, ENSP00000309629, ENST00000525451, ENSG00000172757, ENST00000308162

HPA

ENSG00000172757-CFL1

GeneCards

CFL1

PRO

P23528

Pharos - Targets

P23528

GlyGen

P23528

PDB

4BEX, 6UC4, 6UBY, 6UC0, 3J0S, 6VAO, 5L6W, 1Q8X, 1Q8G, 5HVK

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.933	11
UniProt:P63261 ACTG1	3	ACTG1 [plasma membrane] (R-HSA-196044) ACTG1 [lysosomal membrane] (R-HSA-196169) ACTG1 [cytosol] (R-HSA-201858)	0.831	10
UniProt:P53667 LIMK1	3	LIMK1 [cytosol] (R-HSA-397785) p-T508-LIMK1 [cytosol] (R-HSA-399816) p-S,T508-LIMK1 [cytosol] (R-HSA-419610)	0.722	3
UniProt:P54253 ATX1			0.703	11
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.668	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.656	3
UniProt:P40123 CAP2	1	CAP2 [cytosol] (R-HSA-428863)	0.643	4
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.577	3
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.577	4
UniProt:Q13393 PLD1	4	PLD1 [endoplasmic reticulum membrane] (R-HSA-1498795) PLD1 [plasma membrane] (R-HSA-2028998) PLD1 [specific granule membrane] (R-HSA-6799531) PLD1 [tertiary granule membrane] (R-HSA-6800955)	0.571	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	10
UniProt:P68032 ACTC1	1	ACTC1 [cytosol] (R-HSA-390536)	0.564	2
UniProt:Q1KLZ0 Q1KLZ0			0.556	3
UniProt:Q549N0 Q549N0			0.556	3
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:Q15303 ERBB4			0.553	2
UniProt:Q9Y281 COF2			0.547	3
UniProt:O14939 PLD2	2	PLD2 [plasma membrane] (R-HSA-2029075) PLD2 [endoplasmic reticulum membrane] (R-HSA-1498791)	0.544	2
UniProt:P0DOE7 M	5	p-S95,T205-M [cytosol] (R-RSY-9831678) p-S95,T205-M [nucleoplasm] (R-RSY-9831706) M [nucleoplasm] (R-RSY-9831711) Nascent M [cytosol] (R-RSY-9828672) p-S95,T205-M [viral tegument] (R-RSY-9836531)	0.524	2
UniProt:P57058 HUNK			0.524	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2

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