Reactome | YWHAH [cytosol]

YWHAH [cytosol]

Stable Identifier

R-HSA-1445107

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

14-3-3 eta, 14-3-3 protein eta, 1433F_HUMAN

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G2/M Checkpoints (Homo sapiens)
    - G2/M DNA damage checkpoint (Homo sapiens)
      - Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Homo sapiens)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- MITF-M-regulated melanocyte development (Homo sapiens)
  - Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
    - p-S173 MITF-M binds YWHA dimers (Homo sapiens)
      - YWHAB dimer, YWHAE dimer, YWHAG dimer, YWHAH dimer, YWHAZ dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
      - p-S173 MITF-M:YWHA dimer [cytosol] (Homo sapiens)
        
        YWHAB dimer, YWHAE dimer, YWHAG dimer, YWHAH dimer, YWHAZ dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-1 Infection (Homo sapiens)
        
        SARS-CoV-1-host interactions (Homo sapiens)
        
        SARS-CoV-1 targets host intracellular signalling and regulatory pathways (Homo sapiens)
        
        SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        14-3-3 dimer:SUMO1-K62-p-S177-Ncap dimer [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 targets host intracellular signalling and regulatory pathways (Homo sapiens)
        
        SARS-CoV-2 N binds to 14-3-3 proteins (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        14-3-3 dimer:N [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Activation of BH3-only proteins (Homo sapiens)
      - Activation of BAD and translocation to mitochondria (Homo sapiens)
        
        Activation of BAD by calcineurin (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        Sequestration of BAD protein by 14-3-3 (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PKNs (Homo sapiens)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
    - 14-3-3 Binds p-S237-TBC1D1 (Homo sapiens)
      - 14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
      - p-S237-TBC1D1:14-3-3 [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
    - 14-3-3 binds p-5S,T642-AS160 (TBC1D4) (Homo sapiens)
      - 14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
      - p-5S,T642-AS160:14-3-3:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
        
        Phospho AS160:14-3-3 [cytoplasmic vesicle membrane] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q04917 YWHAH

Gene Names

YWHAH, YWHA1

Chain

initiator methionine:1, chain:2-246

Reference Genes

BioGPS Gene:7533 YWHAH

COSMIC (genes):YWHAH YWHAH

CTD Gene:7533 YWHAH

dbSNP Gene:7533 YWHAH

ENSEMBL:ENSG00000128245 YWHAH

HGNC:12853 YWHAH

KEGG:hsa:7533 YWHAH

Monarch:7533 YWHAH

NCBI Gene:7533 YWHAH

OMIM:113508 YWHAH

UCSC:Q04917 YWHAH

Reference Transcript

RefSeq:NM_003405.4 YWHAH

Other Identifiers

11715593_s_at

11756255_x_at

1424_s_at

16929347

201020_PM_at

201020_at

3943208

3943209

3943210

3943211

3943213

3943215

3943218

3943219

3943220

3943221

3943222

7533

8072577

A_14_P109968

A_23_P103070

D78577_s_at

GE60439

GO:0002028

GO:0003779

GO:0005159

GO:0005515

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006355

GO:0006629

GO:0006713

GO:0006886

GO:0007165

GO:0008092

GO:0008104

GO:0014704

GO:0017080

GO:0019899

GO:0019904

GO:0021762

GO:0035259

GO:0042802

GO:0042921

GO:0044325

GO:0045202

GO:0045664

GO:0045893

GO:0046982

GO:0048167

GO:0048856

GO:0050774

GO:0070062

GO:0086010

GO:0098772

GO:0098793

GO:0098978

GO:0099171

GO:0150048

HMNXSV003032556

ILMN_1728512

PH_hs_0023146

TC22000233.hg

g4507950_3p_at

Participates

as a component of

YWHAH dimer [cytosol] (Homo sapiens)

Inferred To

YWHAH [cytosol] (Bos taurus)

YWHAH [cytosol] (Canis familiaris)

YWHAH [cytosol] (Gallus gallus)

YWHAH [cytosol] (Sus scrofa)

14-3-3zeta [cytosol] (Drosophila melanogaster)

14-3-3 eta [cytosol] (Mus musculus)

Ywhah [cytosol] (Rattus norvegicus)

ywhah [cytosol] (Danio rerio)

ywhah [cytosol] (Xenopus tropicalis)

ftt-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_003396.1

OpenTargets

ENSG00000128245

ENSEMBL

ENSP00000248975, ENSG00000128245, ENST00000248975

GeneCards

YWHAH

HPA

ENSG00000128245-YWHAH

PRO

Q04917

Pharos - Targets

Q04917

GlyGen

Q04917

PDB

7NMZ, 2C74, 2C63

Interactors (114)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.936	27
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.91	13
UniProt:P27448 MARK3	1	MARK3 [cytosol] (R-HSA-5672591)	0.906	13
UniProt:P46937 YAP1	8	YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.894	11
UniProt:P56524 HDAC4	3	HDAC4 [nucleoplasm] (R-HSA-351581) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029)	0.886	10
UniProt:Q02241 KIF23	3	KIF23 [nucleoplasm] (R-HSA-156709) p-S911,S912-KIF23 [nucleoplasm] (R-HSA-156695) KIF23 [cytosol] (R-HSA-1015863)	0.886	9
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.879	12
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.879	12
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.877	11
UniProt:P30305 CDC25B	4	CDC25B [nucleoplasm] (R-HSA-69734) CDC25B [cytosol] (R-HSA-157412) p-S-CDC25B [nucleoplasm] (R-HSA-9929936) p-S50,T69,S160,S321,S470-CDC25B [cytosol] (R-HSA-8863644)	0.869	8
UniProt:P49815 TSC2	4	p-S1387-TSC2 [cytosol] (R-HSA-3132769) TSC2 [cytosol] (R-HSA-2980548) p-S939,T1462-TSC2 [cytosol] (R-HSA-199484) p-S939,S1130,T1462-TSC2 [cytosol] (R-HSA-165164)	0.851	8
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.845	8
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.837	7
UniProt:P30307 CDC25C	8	p-S198-CDC25C [nucleoplasm] (R-HSA-156668) CDC25C [cytosol] (R-HSA-157879) p-S198-CDC25C [cytosol] (R-HSA-8981697) CDC25C [nucleoplasm] (R-HSA-69741) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654)	0.837	7
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 F53C [cytosol] (R-HSA-9652028) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 F53L [cytosol] (R-HSA-9652031)	0.837	8
UniProt:Q96B36 AKT1S1	4	AKT1S1 [cytosol] (R-HSA-200155) p-S183,T246-AKT1S1 [cytosol] (R-HSA-200163) p-T246-AKT1S1 [cytosol] (R-HSA-377124) AKT1S1 [nucleoplasm] (R-HSA-5083637)	0.837	7
UniProt:P00519 ABL1	6	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y393-ABL1 [cytosol] (R-HSA-9865161)	0.827	6
UniProt:Q9UQC2 GAB2	5	p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y643-GAB2 [cytosol] (R-HSA-9677149)	0.802	7
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.802	9
UniProt:Q86TI0 TBC1D1	2	TBC1D1 [cytoplasmic vesicle membrane] (R-HSA-1454718) p-S237-TBC1D1 [cytosol] (R-HSA-1454673)	0.802	7
UniProt:O75044 SRGAP2	1	SRGAP2 [cytosol] (R-HSA-195131)	0.802	6
UniProt:P26045 PTPN3	3	PTPN3 [cytosol] (R-HSA-8867650) p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [plasma membrane] (R-HSA-5490317)	0.802	6
UniProt:Q9Y4H2 IRS2	4	IRS2 [plasma membrane] (R-HSA-2428927) IRS2 [cytosol] (R-HSA-57528) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.802	8
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826)	0.788	5
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.784	6
UniProt:Q13009 TIAM1	2	TIAM1 [cytosol] (R-HSA-195013) p-Y829-TIAM1 [cytosol] (R-HSA-3928461)	0.774	5
UniProt:O43524 FOXO3	11	FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010)	0.774	6
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.745	6
UniProt:Q12778 FOXO1	5	FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651)	0.745	6
UniProt:P40818 USP8	2	p-T945-USP8 [cytosol] (R-HSA-1358714) USP8 [cytosol] (R-HSA-917720)	0.745	7
UniProt:P47974 ZFP36L2	1	ZFP36L2 [cytosol] (R-HSA-9819194)	0.745	7
UniProt:Q96PU5 NEDD4L	2	NEDD4L [nucleoplasm] (R-HSA-2176420) NEDD4L [cytosol] (R-HSA-976003)	0.745	5
UniProt:Q9NRR6 INPP5E	2	INPP5E [cilium] (R-HSA-5624872) INPP5E [cytosol] (R-HSA-1604585)	0.744	4
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.738	4
UniProt:Q92574 TSC1	2	TSC1 [cytosol] (R-HSA-5672338) TSC1 [plasma membrane] (R-HSA-165169)	0.725	4
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.725	5
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.725	4
UniProt:Q9UBF8 PI4KB	2	PI4KB [Golgi membrane] (R-HSA-1806202) PI4KB [cytosol] (R-HSA-1604615)	0.725	5
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.725	5
UniProt:Q70EL4 USP43	1	USP43 [nucleoplasm] (R-HSA-5653784)	0.725	4
UniProt:Q96L34 MARK4	1	MARK4 [cytosol] (R-HSA-5626653)	0.723	7
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.708	4
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.706	4
UniProt:Q9H0H5 RACGAP1	1	RACGAP1 [cytosol] (R-HSA-195122)	0.706	4
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.706	4
UniProt:Q15643 TRIP11	4	TRIP11 [transport vesicle] (R-HSA-8847847) TRIP11 [Golgi membrane] (R-HSA-5617602) TRIP11(2-1724)-FLT3(594-993) fusion [cytosol] (R-HSA-9703323) TRIP11(2-1724)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703304)	0.706	5
UniProt:Q9HC77 CPAP	2	CENPJ [cytosol] (R-HSA-380291) p-S589,S595-CENPJ [cytosol] (R-HSA-6801670)	0.706	4
UniProt:Q9UQ84 EXO1	1	EXO1 [nucleoplasm] (R-HSA-5357514)	0.706	5
UniProt:Q96ST8 CEP89	1	CEP89 [cytosol] (R-HSA-5620930)	0.68	6
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.671	6
UniProt:Q9UDY2 TJP2	4	TJP2 [nucleoplasm] (R-HSA-2064410) TJP2 [cytosol] (R-HSA-2064412) TJP2(?-?) [plasma membrane] (R-HSA-351897) TJP2 [plasma membrane] (R-HSA-351862)	0.671	4
UniProt:P21359 NF1	20	NF1 R816* [cytosol] (R-HSA-6802424) NF1 F1464L [cytosol] (R-HSA-6802410) NF1 K1444E [cytosol] (R-HSA-6802414) NF1 L1187I [cytosol] (R-HSA-6802417) NF1 R1276P [cytosol] (R-HSA-6802420) NF1 R1412S [cytosol] (R-HSA-6802421) NF1 R2517* [cytosol] (R-HSA-9647532) NF1 Q616Gfs4 [cytosol] (R-HSA-9647468) NF1 R2450 [cytosol] (R-HSA-9647535) NF1 R2637* [cytosol] (R-HSA-9647529) NF1 R2637Q [cytosol] (R-HSA-9647525) NF1 R304* [cytosol] (R-HSA-9647522) NF1 R1276* [cytosol] (R-HSA-9647550) NF1 C845Vfs33 [cytosol] (R-HSA-9647486) NF1(2-2839) [cytosol] (R-HSA-947770) ub-NF1(2-2839) [cytosol] (R-HSA-5658418) NF1 R69Nfs7 [cytosol] (R-HSA-9647505) NF1 R440* [cytosol] (R-HSA-9647511) NF1 R440Q [cytosol] (R-HSA-9647508) NF1 G849E fs*29 [cytosol] (R-HSA-9656596)	0.671	4
UniProt:Q92597 NDRG1	1	NDRG1 [cytosol] (R-HSA-5628834)	0.671	4
UniProt:P30304 CDC25A	20	CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) PolyUb-p-S76,S79,T80,S82-CDC25A [nucleoplasm] (R-HSA-9944031) PolyUb-p-S76,S79,S82,S124-CDC25A [nucleoplasm] (R-HSA-9944025) PolyUb-p-S76,S79,S82,S124,S178,S279,S293-CDC25A [nucleoplasm] (R-HSA-9944029) PolyUb-p-S76,S79,T80,S82,S88-CDC25A [nucleoplasm] (R-HSA-9944023) PolyUb-p-S76,S79,S82,S88,S124-CDC25A [nucleoplasm] (R-HSA-9944028) PolyUb-p-S76,S79,S82,S88,S124,S178,S279,S293-CDC25A [nucleoplasm] (R-HSA-9944027) p-S76,S79,S82,S124-CDC25A [nucleoplasm] (R-HSA-9944026) p-S76,S79,T80,S82-CDC25A [nucleoplasm] (R-HSA-9944024) p-S76,S79,S82,S124,S178,S279,S293-CDC25A [nucleoplasm] (R-HSA-9944032) p-S76,S79,T80,S82,S88-CDC25A [nucleoplasm] (R-HSA-9943707) p-S76,S79,S82,S88,S124-CDC25A [nucleoplasm] (R-HSA-9943704) p-S76,S79,S82,S88,S124,S178,S279,S293-CDC25A [nucleoplasm] (R-HSA-9943711) p-S76,S124-CDC25A [nucleoplasm] (R-HSA-9942581) p-S76,T80-CDC25A [nucleoplasm] (R-HSA-9943698) p-S76,S124,S178,S279,S293-CDC25A [nucleoplasm] (R-HSA-143488) p-S124,S178,S293-CDC25A [nucleoplasm] (R-HSA-9941808) p-T80-CDC25A [nucleoplasm] (R-HSA-9943689) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634)	0.671	4
UniProt:P35568 IRS1	5	p-Y-IRS1 [plasma membrane] (R-HSA-198366) p-Y-IRS1 [cytosol] (R-HSA-74772) IRS1 [cytosol] (R-HSA-74769) IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090)	0.671	4
UniProt:Q08495 DMTN	1	DMTN [cytosol] (R-HSA-5216222)	0.671	6
UniProt:P30291 WEE1	4	WEE1 [nucleoplasm] (R-HSA-69253) p-WEE1 [nucleoplasm] (R-HSA-156491) p-S53-WEE1 [nucleoplasm] (R-HSA-156694) p-T187,T190-WEE1 [nucleoplasm] (R-HSA-9929669)	0.671	4
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.646	4
UniProt:Q9H1K1 ISCU	1	ISCU [cytosol] (R-HSA-9771680)	0.643	3
UniProt:Q13322 GRB10	2	GRB10 [cytosol] (R-HSA-110009) p-Y GRB10 [cytosol] (R-HSA-9706168)	0.643	4
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.643	3
UniProt:Q9BZ23 PANK2	1	PANK2(141-570) [mitochondrial intermembrane space] (R-HSA-196803)	0.643	3
UniProt:Q5SQI0 ATAT1	1	ATAT [cytosol] (R-HSA-5618184)	0.643	4
UniProt:Q9P2Y5 UVRAG	2	UVRAG [cytosol] (R-HSA-5668884) UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510)	0.643	3
UniProt:Q9GZV5 WWTR1	3	WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773) p-S89-WWTR1 [cytosol] (R-HSA-2028665)	0.643	3
UniProt:P98177 FOXO4	8	FOXO4 [nucleoplasm] (R-HSA-5690183) p-T32,S197,S262-FOXO4 [nucleoplasm] (R-HSA-199314) p-T32,S197,S262-FOXO4 [cytosol] (R-HSA-9614415) SOH-C481-FOXO4 [nucleoplasm] (R-HSA-9617655) CREBBP-S-S-FOXO4 [nucleoplasm] (R-HSA-9617679) EP300-S-S-FOXO4 [nucleoplasm] (R-HSA-9617681) Ac-K-FOXO4 [nucleoplasm] (R-HSA-9617761) PolyUb-FOXO4 [nucleoplasm] (R-HSA-6782501)	0.643	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.643	6
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.643	3
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.643	3
UniProt:Q14966 ZNF638	1	ZNF638 [nucleoplasm] (R-HSA-8939429)	0.643	3
UniProt:Q9NYA4 MTMR4	2	MTMR4 [cytosol] (R-HSA-1604658) MTMR4 [early endosome membrane] (R-HSA-2187404)	0.615	4
UniProt:Q14739 LBR	4	LBR [nuclear envelope] (R-HSA-194637) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811) LBR [endoplasmic reticulum membrane] (R-HSA-9714334) LBR [endosome membrane] (R-HSA-9715094)	0.615	4
UniProt:Q6N021 TET2	1	TET2 [nucleoplasm] (R-HSA-5221011)	0.615	3
UniProt:O43166 SIPA1L1	1	SPAR [cytosol] (R-HSA-6794278)	0.615	4
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.615	6
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.615	4
UniProt:P56945 BCAR1	4	p-Y12-BCAR1 [cytosol] (R-HSA-5218739) BCAR1 [cytosol] (R-HSA-201625) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) p-Y-BCAR1 [cytosol] (R-HSA-372645)	0.615	4
UniProt:A7KAX9 ARHGAP32	1	ARHGAP32 [cytosol] (R-HSA-195134)	0.615	4
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.615	4
UniProt:P49674 CSNK1E	2	CSNK1E [cytosol] (R-HSA-205877) CSNK1E [nucleoplasm] (R-HSA-421306)	0.604	3
UniProt:O60565 GREM1	1	GREM1 [extracellular region] (R-HSA-9831023)	0.593	5
UniProt:O00443 PIK3C2A	3	PIK3C2A [cytosol] (R-HSA-1604624) PIK3C2A [cytoplasmic vesicle membrane] (R-HSA-432683) PIK3C2A [Golgi membrane] (R-HSA-432679)	0.569	4
UniProt:Q9NQC7 CYLD	3	CYLD [cytosol] (R-HSA-741420) p-S418-CYLD [cytosol] (R-HSA-5212667) K48polyUb-K338, K530-CYLD [cytosol] (R-HSA-9818664)	0.569	3
UniProt:Q92538 GBF1	4	GBF1 [cytosol] (R-HSA-6807751) GBF1 [endoplasmic reticulum lumen] (R-HSA-9947748) GBF1 [lipid droplet] (R-HSA-9954446) GBF1 [Golgi membrane] (R-HSA-199994)	0.569	4
UniProt:O15530 PDPK1	3	PDPK1 [plasma membrane] (R-HSA-61459) PDPK1 [cytosol] (R-HSA-202210) p-S241-PDPK1 [cytosol] (R-HSA-9860799)	0.564	3
UniProt:Q9P0N9 TBC1D7	1	TBC1D7 [cytosol] (R-HSA-8854154)	0.527	2
UniProt:Q13356 PPIL2	2	PPIL2 [Golgi lumen] (R-HSA-204475) PPIL2 [nucleoplasm] (R-HSA-9769562)	0.527	2
UniProt:Q9Y3M2 CBY1	3	pS20-CBY1 [nucleoplasm] (R-HSA-3769356) CBY1 [nucleoplasm] (R-HSA-3769210) pS20-CBY1 [cytosol] (R-HSA-3769354)	0.527	2
UniProt:Q9NXD2 MTMR10	1	MTMR10 [cytosol] (R-HSA-6810028)	0.527	2
UniProt:Q7Z3C6 ATG9A	1	ATG9A [phagophore assembly site membrane] (R-HSA-5671732)	0.527	2
UniProt:O15294 OGT	2	OGT [cytosol] (R-HSA-9687814) OGT [nucleoplasm] (R-HSA-3321845)	0.527	2
UniProt:Q9HCG8 CWC22	1	CWC22 [nucleoplasm] (R-HSA-8865956)	0.527	2
UniProt:O43318 MAP3K7	10	p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [endosome membrane] (R-HSA-450315) p-MAP3K7 [cytosol] (R-HSA-168163) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [plasma membrane] (R-HSA-9012677) PolyUb-MAP3K7 [cytosol] (R-HSA-6782968)	0.527	2
UniProt:Q6PJF5 RHBDF2	2	iRHOM2 [endoplasmic reticulum membrane] (R-HSA-9662859) iRHOM2 [Golgi lumen] (R-HSA-9673787)	0.527	2
UniProt:P19484 TFEB	1	TFEB [nucleoplasm] (R-HSA-9857368)	0.527	3
UniProt:Q6VY07 PACS1	1	PACS1 [cytosol] (R-HSA-167634)	0.527	2
UniProt:Q2M1P5 KIF7	1	KIF7 [ciliary tip] (R-HSA-5610395)	0.527	2
UniProt:Q7L7X3 TAOK1	1	TAOK1 [cytosol] (R-HSA-376248)	0.527	2
UniProt:Q3MII6 TBC1D25	1	TBC1D25 [autophagosome] (R-HSA-8854607)	0.527	2
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.527	2
UniProt:Q13496 MTM1	1	MTM1 [cytosol] (R-HSA-1604646)	0.527	2
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) OPTN [Golgi membrane] (R-HSA-2161111) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.527	2
UniProt:O75030 MITF	2	MITF [nucleoplasm] (R-HSA-201592) monoSUMO1-K289,423-MITF [nucleoplasm] (R-HSA-3232153)	0.527	2
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.527	2
UniProt:Q9BZF9 UACA	1	UACA [cytosol] (R-HSA-6804636)	0.527	2
UniProt:Q8IUC4 RHPN2	1	RHPN2 [cytosol] (R-HSA-5667007)	0.527	2
UniProt:O14757 CHEK1	3	p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838) CHEK1 [nucleoplasm] (R-HSA-113826) CHEK1 [cytosol] (R-HSA-205285)	0.527	2
UniProt:P29074 PTPN4	2	PTPN4 [nucleoplasm] (R-HSA-9008925) PTPN4 [cytosol] (R-HSA-8877173)	0.527	2
UniProt:Q9JIR4	1	Rims1 [cytosol] (R-RNO-210407)	0.527	3
UniProt:P48552 NRIP1	2	NRIP1 [nucleoplasm] (R-HSA-4086031) monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057)	0.489	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	11
UniProt:P10636 MAPT	3	MAPT [cytosol] (R-HSA-201574) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642)	0.483	2
UniProt:P48729 CSNK1A1	3	CSNK1A1 [nucleoplasm] (R-HSA-9943726) CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.483	2
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.462	3

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