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PDIA3 [phagocytic vesicle]
Stable Identifier
R-HSA-1236870
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
phagocytic vesicle
Synonyms
ERp57, Protein disulfide-isomerase A3, PDIA3_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
Fusion of ERC and phagosome (Homo sapiens)
Class I MHC HC:B2M:Erp57 [phagocytic vesicle membrane] (Homo sapiens)
PDIA3 [phagocytic vesicle] (Homo sapiens)
Peptide loading on MHC class I in phagosome (Homo sapiens)
Class I MHC HC:B2M:Erp57 [phagocytic vesicle membrane] (Homo sapiens)
PDIA3 [phagocytic vesicle] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30101 PDIA3
Gene Names
PDIA3, ERP57, ERP60, GRP58
Chain
signal peptide:1-24, chain:25-505
Reference Genes
BioGPS Gene:2923 PDIA3
COSMIC (genes):PDIA3 PDIA3
CTD Gene:2923 PDIA3
dbSNP Gene:2923 PDIA3
ENSEMBL:ENSG00000167004 PDIA3
HGNC:4606 PDIA3
KEGG:hsa:2923 PDIA3
Monarch:2923 PDIA3
NCBI Gene:2923 PDIA3
OMIM:602046 PDIA3
UCSC:P30101 PDIA3
Reference Transcript
RefSeq:NM_005313.4 PDIA3
Other Identifiers
11743440_at
11743441_s_at
208612_PM_at
208612_at
227033_PM_at
227033_at
229453_PM_at
229453_at
2356689
2923
3591553
3591611
3591612
3591613
3591614
3591617
3591618
3591619
3591621
3591626
3591627
3591628
3591629
3591630
3591631
3591632
3591634
3591635
3591636
3591637
3591638
3591639
3591640
3591641
3591642
3591643
3591645
3591647
38986_at
48098_at
57668_s_at
74821_s_at
7904881
7983274
A_14_P109966
A_14_P111425
A_14_P119353
A_23_P99883
A_33_P3223923
GE57097
GE81490
GO:0002250
GO:0002376
GO:0002502
GO:0003723
GO:0003756
GO:0003824
GO:0004197
GO:0004629
GO:0005515
GO:0005615
GO:0005634
GO:0005737
GO:0005783
GO:0005788
GO:0005925
GO:0006457
GO:0007155
GO:0009986
GO:0015035
GO:0015036
GO:0016491
GO:0016787
GO:0016853
GO:0031410
GO:0034975
GO:0034976
GO:0042470
GO:0042802
GO:0042824
GO:0043226
GO:0043231
GO:0045335
GO:0055038
GO:0061779
GO:0065003
GO:0070062
GO:0070527
GO:0097191
GO:0098761
GO:0140096
GO:2001238
HMNXSV003010789
Hs.289101.1.A1_3p_at
Hs.296178.1.A1_3p_at
ILMN_1669753
PH_hs_0023683
PH_hs_0032616
TC15000335.hg
Z49835_s_at
g1208426_3p_at
Participates
as a component of
Class I MHC HC:B2M:Erp57 [phagocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
PDIA3 [recycling endosome membrane]
PDIA3 [endoplasmic reticulum lumen]
Inferred To
PDIA3 [phagocytic vesicle]
(Bos taurus)
PDIA3 [phagocytic vesicle]
(Canis familiaris)
PDIA3 [phagocytic vesicle]
(Gallus gallus)
PDIA3 [phagocytic vesicle]
(Sus scrofa)
Pdia3 [phagocytic vesicle]
(Mus musculus)
Pdia3 [phagocytic vesicle]
(Rattus norvegicus)
Cross References
RefSeq
NP_005304.3
Guide to Pharmacology - Targets
3293
ENSEMBL
ENST00000300289
,
ENSP00000300289
OpenTargets
ENSG00000167004
HPA
ENSG00000167004-PDIA3
PRO
P30101
Pharos - Targets
P30101
GlyGen
P30101
PDB
3F8U
,
7QNG
,
2ALB
,
2DMM
,
6ENY
,
7QPD
,
2H8L
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.725
12
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.703
6
UniProt:Q96HE7 ERO1A
1
ERO1L [endoplasmic reticulum lumen]
(R-HSA-265076)
0.667
3
UniProt:Q03518 TAP1
3
TAP1 [endoplasmic reticulum membrane]
(R-HSA-947474)
TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863953)
TAP1 [phagocytic vesicle membrane]
(R-HSA-1236845)
0.623
5
UniProt:P10909 CLU
4
CLU(23-449) [extracellular region]
(R-HSA-349732)
CLU(23-449) [platelet alpha granule lumen]
(R-HSA-349733)
CLU(228-449) [extracellular region]
(R-HSA-6810626)
CLU(23-227) [extracellular region]
(R-HSA-6810660)
0.59
2
UniProt:P27797 CALR
6
CALR [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
0.589
2
UniProt:P24643 CALX
0.558
3
UniProt:Q13586 STIM1
1
STIM1 [endoplasmic reticulum membrane]
(R-HSA-434675)
0.543
3
UniProt:P05111 INHA
1
INHA [extracellular region]
(R-HSA-1449702)
0.527
2
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.527
2
UniProt:P02452 COL1A1
20
3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023648)
3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023667)
GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023604)
GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022999)
3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023559)
3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023582)
COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1650777)
3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985659)
3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022446)
3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022951)
3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022954)
5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985663)
Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396137)
Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396440)
Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396471)
Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396464)
Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396068)
Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396388)
Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396315)
Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396441)
0.499
2
UniProt:Q2HXL6 EDEM3
0.462
2
UniProt:P04578 env
7
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
0.462
2
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