Reactome | RUVBL1 [nucleoplasm]

RUVBL1 [nucleoplasm]

Stable Identifier

R-HSA-418323

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Pontin, RuvB-like 1, RUVB1_HUMAN, Tip49a

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y265 RUVBL1

Gene Names

RUVBL1, INO80H, NMP238, TIP49, TIP49A

Chain

chain:1-456

Reference Genes

BioGPS Gene:8607 RUVBL1

COSMIC (genes):RUVBL1 RUVBL1

CTD Gene:8607 RUVBL1

dbSNP Gene:8607 RUVBL1

ENSEMBL:ENSG00000175792 RUVBL1

ENSEMBL_homo_sapiens_GENE:ENSG00000175792.12 RUVBL1

HGNC:10474 RUVBL1

KEGG Gene (Homo sapiens):8607 RUVBL1

Monarch:8607 RUVBL1

NCBI Gene:8607 RUVBL1

OMIM:603449 RUVBL1

UCSC:Q9Y265 RUVBL1

Reference Transcript

Other Identifiers

11715833_a_at

11715834_x_at

11747775_x_at

16958812

201614_PM_s_at

201614_s_at

2694138

2694139

2694140

2694141

2694143

2694146

2694148

2694149

2694150

2694151

2694153

2694154

2694155

2694158

2694160

2694161

40124_at

8090448

8607

A_24_P148811

A_32_P30693

GE62349

GO:0000166

GO:0000228

GO:0000492

GO:0000723

GO:0000786

GO:0000812

GO:0001094

GO:0003678

GO:0003713

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006260

GO:0006275

GO:0006281

GO:0006282

GO:0006310

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0006974

GO:0007049

GO:0007283

GO:0008094

GO:0012501

GO:0016020

GO:0016363

GO:0016787

GO:0016887

GO:0017025

GO:0022414

GO:0023052

GO:0031011

GO:0032200

GO:0032508

GO:0033044

GO:0035267

GO:0042981

GO:0043226

GO:0043531

GO:0045296

GO:0045739

GO:0045893

GO:0045995

GO:0048856

GO:0050821

GO:0051117

GO:0051276

GO:0051301

GO:0051726

GO:0060382

GO:0065003

GO:0070062

GO:0071339

GO:0090263

GO:0097255

GO:0101031

GO:0120293

GO:0140097

GO:0140110

GO:0140657

GO:1904507

GO:1904874

GO:1905168

GO:1990062

GO:1990904

GO:2000779

HMNXSV003038690

ILMN_1656540

ILMN_1693108

ILMN_1791945

PH_hs_0014095

TC03001751.hg

g4506752_3p_s_at

Participates

as a component of

as an input of

Beta-catenin recruits TRRAP/KAT5 HAT components (Homo sapiens)

This entity regulates

Positively

Biogenesis and assembly of the telomerase RNP (Homo sapiens)

Inferred To

ruvbl1 [nucleoplasm] (Xenopus tropicalis)

RUVBL1 [nucleoplasm] (Bos taurus)

RUVBL1 [nucleoplasm] (Caenorhabditis elegans)

RUVBL1 [nucleoplasm] (Canis familiaris)

RUVBL1 [nucleoplasm] (Danio rerio)

RUVBL1 [nucleoplasm] (Drosophila melanogaster)

RUVBL1 [nucleoplasm] (Gallus gallus)

RUVBL1 [nucleoplasm] (Mus musculus)

RUVBL1 [nucleoplasm] (Rattus norvegicus)

RUVBL1 [nucleoplasm] (Schizosaccharomyces pombe)

RUVBL1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_003698.1, NP_001306013.1

OpenTargets

ENSG00000175792

ZINC - Substances

RUVB1_HUMAN

ZINC target

Q9Y265

PRO

Q9Y265

PDB

2C9O, 6HTS, 7OLE, 5OAF, 8X1C, 2XSZ, 6QI8, 8X15, 6IGM, 7P6X, 8X19, 7ZI4, 6K0R, 6QI9, 6FO1, 7AHO

IntEnz

3.6.4.12

GeneCards

Q9Y265

HPA

ENSG00000175792-RUVBL1

Ensembl

ENST00000322623, ENSP00000318297, ENSG00000175792

Pharos - Targets

Q9Y265

ZINC - Predictions - Purchasable

RUVB1_HUMAN

HMDB Protein

HMDBP11929

Interactors (68)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.969	42
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.857	9
UniProt:Q9NWS0 PIHD1			0.855	14
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.853	10
UniProt:O96019 ACTL6A	1	ACTL6A [nucleoplasm] (R-HSA-2980912)	0.848	12
UniProt:Q15906 CFL1	1	VPS72 [nucleoplasm] (R-HSA-3321992)	0.84	11
UniProt:Q8NBZ0 INO80E	1	INO80E [nucleoplasm] (R-HSA-5689552)	0.837	10
UniProt:O60832 DKC1	1	DKC1 [nucleoplasm] (R-HSA-163102)	0.824	10
UniProt:O43257 ZNHI1			0.812	9
UniProt:Q9NV56 MRGBP	1	MRGBP [nucleoplasm] (R-HSA-3322953)	0.812	9
UniProt:Q9H9F9 ACTR5	1	ACTR5 [nucleoplasm] (R-HSA-5688913)	0.788	7
UniProt:O95619 YEATS4	1	YEATS4 [nucleoplasm] (R-HSA-3322940)	0.788	7
UniProt:Q9BVM2 DPCD			0.744	6
UniProt:Q9H6R7 WDCP	2	WDCP(1-680)-p-7Y-ALK(1061-1620) fusion [cytosol] (R-HSA-9700468) WDCP(1-680)-ALK(1061-1620) fusion [cytosol] (R-HSA-9700460)	0.744	6
UniProt:Q9UHR6 ZNHI2			0.742	9
UniProt:Q9H6T3 RPAP3			0.725	6
UniProt:Q9NXR8 ING3	1	ING3 [nucleoplasm] (R-HSA-3215168)	0.725	6
UniProt:O94763 RMP			0.725	6
UniProt:Q9GZN1 ARP6			0.725	6
UniProt:Q9ULG1 INO80	1	INO80 [nucleoplasm] (R-HSA-5688910)	0.725	6
UniProt:Q9Y4A5 TRRAP	1	TRRAP [nucleoplasm] (R-HSA-3322951)	0.725	7
UniProt:Q96L91 EP400	1	EP400 [nucleoplasm] (R-HSA-3321987)	0.725	7
UniProt:O95905 ECD			0.677	8
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.644	11
UniProt:Q52LR7 EPC2			0.643	5
UniProt:Q9NPF5 DMAP1	1	DMAP1 [nucleoplasm] (R-HSA-212166)	0.643	5
UniProt:Q9NUG6 PDRG1			0.643	5
UniProt:Q05BQ5 MBTD1			0.643	6
UniProt:Q9C086 INO80B	1	INO80B [nucleoplasm] (R-HSA-5689599)	0.643	6
UniProt:Q6ZRS2 SRCAP			0.643	5
UniProt:Q9H0E9 BRD8	1	BRD8 [nucleoplasm] (R-HSA-3321977)	0.643	5
UniProt:Q53TQ3 INO80D	1	INO80D [nucleoplasm] (R-HSA-5689559)	0.643	3
UniProt:Q9H981 ACTR8	1	ACTR8 [nucleoplasm] (R-HSA-5689565)	0.643	5
UniProt:Q9H2F5 EPC1	1	EPC1 [nucleoplasm] (R-HSA-3321978)	0.643	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.619	10
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	15
UniProt:O43156 TTI1			0.597	7
UniProt:Q14164 IKBKE	5	monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521)	0.589	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	10
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.569	3
UniProt:Q92993-2 KAT5			0.527	2
UniProt:P0C0S5 H2AZ1	1	H2AFZ [extracellular region] (R-HSA-977575)	0.527	4
UniProt:Q9Y4R8 TELO2			0.527	2
UniProt:Q15649 ZNHI3			0.527	4
UniProt:O94805 ACTL6B	1	ACTL6B [nucleoplasm] (R-HSA-5225616)	0.527	3
UniProt:O14802 POLR3A	2	POLR3A [cytosol] (R-HSA-1964433) POLR3A [nucleoplasm] (R-HSA-83700)	0.527	3
UniProt:Q9NWK9 BCD1			0.527	4
UniProt:Q6P4R8 NFRKB	1	NFRKB [nucleoplasm] (R-HSA-5689578)	0.527	4
UniProt:Q8N5I9 NOPC1			0.527	4
UniProt:Q6PI98 INO80C	1	INO80C [nucleoplasm] (R-HSA-5689605)	0.527	4
UniProt:P0C1Z6 TFPT	1	TFPT [nucleoplasm] (R-HSA-5689542)	0.527	4
UniProt:Q96A08 H2BC1	9	HIST1H2BA [nucleoplasm] (R-HSA-181916) Ub-122-HIST1H2BA [nucleoplasm] (R-HSA-3364020) AcK22-HIST1H2BA [nucleoplasm] (R-HSA-4568647) AcK17-HIST1H2BA [nucleoplasm] (R-HSA-4568631) AcK14-HIST1H2BA [nucleoplasm] (R-HSA-4568615) AcK7-HIST1H2BA [nucleoplasm] (R-HSA-4568624) HIST1H2BA [extracellular region] (R-HSA-977582) AcK-HIST1H2BA [nucleoplasm] (R-HSA-4549263) Ub-HIST1H2BA [nucleoplasm] (R-HSA-6782561)	0.527	4
UniProt:Q9UHK0 NUFP1			0.527	3
UniProt:Q8N5S9 CAMKK1	4	p-CAMKK1 [nucleoplasm] (R-HSA-444232) CAMKK1 [nucleoplasm] (R-HSA-442775) CAMKK1 [cytosol] (R-HSA-9619232) p-CAMKK1 [cytosol] (R-HSA-9619356)	0.527	2
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.527	4
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.527	5
UniProt:Q6PI26 SHQ1	1	SHQ1 [nucleoplasm] (R-HSA-9671152)	0.527	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:Q9Y2X3 NOP58	3	polySUMO2-K467,K497-NOP58 [nucleoplasm] (R-HSA-4570460) monoSUMO1-K467,K497-NOP58 [nucleoplasm] (R-HSA-4570470) NOP58 [nucleoplasm] (R-HSA-4570488)	0.527	2
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.527	4
UniProt:G3I183 G3I183			0.524	2
UniProt:O75665 OFD1	1	OFD1 [cytosol] (R-HSA-380318)	0.508	3
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.499	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.499	3
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.483	2
UniProt:P03366 POL			0.462	2
UniProt:Q12692	1	HTZ1 [nucleoplasm] (R-SCE-8862427)	0.462	2

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