Reactome | DHX9 [nucleoplasm]

DHX9 [nucleoplasm]

Stable Identifier

R-HSA-53517

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DDX9/NDH II, ATP-dependent RNA helicase A (Nuclear DNA helicase II) (NDH II) (DEAD-box protein 9), ATP-dependent RNA helicase A, Nuclear DNA helicase II, NDH II, DEAH-box protein 9

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q08211 DHX9

Gene Names

DHX9, DDX9, LKP, NDH2

Chain

chain:1-1270

Reference Genes

BioGPS Gene:1660 DHX9

COSMIC (genes):DHX9 DHX9

CTD Gene:1660 DHX9

dbSNP Gene:1660 DHX9

ENSEMBL:ENSG00000135829 DHX9

HGNC:2750 DHX9

KEGG:hsa:1660 DHX9

Monarch:1660 DHX9

NCBI Gene:1660 DHX9

OMIM:603115 DHX9

UCSC:Q08211 DHX9

Reference Transcript

RefSeq:NM_001357.4 DHX9

Other Identifiers

11743106_a_at

11743107_a_at

11752968_a_at

1660

16674767

202420_PM_s_at

202420_s_at

212105_PM_s_at

212105_s_at

212107_PM_s_at

212107_s_at

2370992

2370993

2370994

2370995

2370996

2370997

2371001

2371002

2371003

2371004

2371005

2371006

2371010

2371011

2371012

2371013

2371014

2371015

2371016

2371017

2371018

2371022

2371023

2371025

2371026

2371027

2371028

2371029

2371030

2371031

2371032

2371034

2371036

2371037

2371038

2371039

2371040

2371041

2371042

2371043

2371044

2371047

2371048

2371049

2371050

2371051

2371052

2371053

2371054

2371055

3330497

3330499

3330501

3330505

3494495

3494497

3494506

3494509

3494516

3494518

3494520

3494522

3494524

36153_at

662_at

67983_g_at

7908022

A_23_P97749

A_24_P36847

GO:0000380

GO:0000978

GO:0000993

GO:0001069

GO:0001649

GO:0002376

GO:0003676

GO:0003677

GO:0003678

GO:0003688

GO:0003690

GO:0003697

GO:0003712

GO:0003713

GO:0003723

GO:0003724

GO:0003725

GO:0003727

GO:0003729

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005726

GO:0005730

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006260

GO:0006353

GO:0006355

GO:0006357

GO:0006397

GO:0006417

GO:0006954

GO:0008380

GO:0010501

GO:0012501

GO:0015629

GO:0016020

GO:0016071

GO:0016442

GO:0016604

GO:0016787

GO:0016887

GO:0017111

GO:0030154

GO:0031047

GO:0031490

GO:0032508

GO:0032727

GO:0032728

GO:0032741

GO:0032755

GO:0032760

GO:0032991

GO:0033679

GO:0034458

GO:0035195

GO:0035197

GO:0035613

GO:0036464

GO:0039695

GO:0043022

GO:0043138

GO:0043226

GO:0044806

GO:0045087

GO:0045089

GO:0045142

GO:0045739

GO:0045740

GO:0045944

GO:0046833

GO:0046872

GO:0047429

GO:0048146

GO:0048511

GO:0050434

GO:0050684

GO:0050691

GO:0050729

GO:0051028

GO:0051092

GO:0060090

GO:0060760

GO:0061629

GO:0061676

GO:0065003

GO:0070063

GO:0070269

GO:0070578

GO:0070922

GO:0070934

GO:0070937

GO:0071356

GO:0071360

GO:0097165

GO:0098542

GO:0140097

GO:0140098

GO:0140110

GO:0140657

GO:1900152

GO:1903608

GO:1905172

GO:1990518

GO:1990825

GO:1990841

GO:1990904

GO:2000373

GO:2000765

GO:2000767

HMNXSV003026151

Hs.74578.2.S1_3p_a_at

Hs.74578.2.S2_3p_a_at

ILMN_1656016

L13848_at

TC01001582.hg

TC01004881.hg

g13514819_3p_a_at

Participates

as an input of

Formation of the Spliceosomal E complex (Homo sapiens)

as a component of

as an output of

Formation of the Spliceosomal Bact complex (Homo sapiens)

Other forms of this molecule

DHX9 [cytosol]

p-DHX9 [cytosol]

Inferred To

Ghost homologue of DHX9 [nucleoplasm] (Gallus gallus)

Ghost homologue of DHX9 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of DHX9 [nucleoplasm] (Schizosaccharomyces pombe)

DHX9 [nucleoplasm] (Bos taurus)

DHX9 [nucleoplasm] (Caenorhabditis elegans)

DHX9 [nucleoplasm] (Canis familiaris)

DHX9 [nucleoplasm] (Drosophila melanogaster)

DHX9 [nucleoplasm] (Mus musculus)

DHX9 [nucleoplasm] (Sus scrofa)

dhx9 [nucleoplasm] (Dictyostelium discoideum)

dhx9 [nucleoplasm] (Xenopus tropicalis)

Dhx9 [nucleoplasm] (Rattus norvegicus)

Cross References

ENSEMBL

ENSP00000356520, ENST00000367549, ENSG00000135829

OpenTargets

ENSG00000135829

IntEnz

3.6.4.13

HPA

ENSG00000135829-DHX9

GeneCards

DHX9

PRO

Q08211

Pharos - Targets

Q08211

GlyGen

Q08211

HMDB Protein

HMDBP11707

PDB

3VYY, 3VYX, 3LLM, 8SZP

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.767	11
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.764	8
UniProt:O95793 STAU1			0.677	4
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.65	5
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.643	4
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.643	3
IntAct:EBI-867155 CTE			0.641	3
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.63	9
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.625	4
UniProt:P19525 EIF2AK2	5	EIF2AK2 [cytosol] (R-HSA-168699) p-EIF2AK2 [cytosol] (R-HSA-9833834) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) p-EIF2AK2 [nucleoplasm] (R-HSA-9836332)	0.623	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	14
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.597	4
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.577	8
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [nucleoplasm] (R-HSA-71929) HNRNPA2B1 [extracellular exosome] (R-HSA-8950304)	0.564	3
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.564	3
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.564	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.564	4
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.547	2
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.547	2
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.547	2
UniProt:P19712-PRO_0000038050			0.537	6
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.527	4
UniProt:Q9UPY3 DICER1	1	DICER1 [cytosol] (R-HSA-203820)	0.527	2
UniProt:Q86U42 PABPN1	2	PABPN1 [cytosol] (R-HSA-9822424) PABPN1 [nucleoplasm] (R-HSA-72008)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	6
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.527	2
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.527	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	2
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [specific granule lumen] (R-HSA-6799611)	0.527	2
UniProt:Q9NZB2 F120A			0.527	2
UniProt:Q9HA38 ZMAT3			0.524	3
UniProt:O14980 XPO1	2	XPO1 [cytosol] (R-HSA-165539) XPO1 [nucleoplasm] (R-HSA-165529)	0.499	3
EMBL:M11841 CTE			0.463	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2
UniProt:Q8IUH3 RBM45			0.462	2
IntAct:EBI-6857440 NS3			0.462	2

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