Reactome | DHX9 [nucleoplasm]

DHX9 [nucleoplasm]

Stable Identifier

R-HSA-53517

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DDX9/NDH II, ATP-dependent RNA helicase A (Nuclear DNA helicase II) (NDH II) (DEAD-box protein 9), ATP-dependent RNA helicase A, Nuclear DNA helicase II, NDH II, DEAH-box protein 9

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q08211 DHX9

Gene Names

DHX9, DDX9, LKP, NDH2

Chain

chain:1-1270

Reference Genes

BioGPS Gene:1660 DHX9

COSMIC (genes):DHX9 DHX9

CTD Gene:1660 DHX9

dbSNP Gene:1660 DHX9

ENSEMBL:ENSG00000135829.17 DHX9

HGNC:2750 DHX9

KEGG Gene (Homo sapiens):1660 DHX9

Monarch:1660 DHX9

NCBI Gene:1660 DHX9

OMIM:603115 DHX9

UCSC:Q08211 DHX9

Reference Transcript

RefSeq:NM_001357.4 DHX9

Other Identifiers

11743106_a_at

11743107_a_at

11752968_a_at

1660

16674767

202420_PM_s_at

202420_s_at

212105_PM_s_at

212105_s_at

212107_PM_s_at

212107_s_at

2370992

2370996

2370997

2371001

2371002

2371003

2371010

2371012

2371013

2371014

2371015

2371016

2371022

2371023

2371025

2371026

2371027

2371028

2371030

2371032

2371034

2371036

2371037

2371038

2371041

2371042

2371043

2371044

2371047

2371048

2371049

2371050

2371051

2371052

2371053

2371054

2371055

3330497

3330499

3330501

3330505

3494495

3494497

3494506

3494509

3494516

3494518

3494520

3494522

3494524

36153_at

662_at

67983_g_at

7908022

A_23_P97749

A_24_P36847

GO:0000166

GO:0000228

GO:0000380

GO:0000978

GO:0000993

GO:0001069

GO:0001649

GO:0002181

GO:0002376

GO:0003676

GO:0003677

GO:0003678

GO:0003688

GO:0003690

GO:0003697

GO:0003712

GO:0003713

GO:0003723

GO:0003724

GO:0003725

GO:0003727

GO:0003729

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005726

GO:0005730

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005840

GO:0005844

GO:0005856

GO:0006260

GO:0006281

GO:0006351

GO:0006353

GO:0006355

GO:0006357

GO:0006397

GO:0006417

GO:0006913

GO:0006954

GO:0008380

GO:0010501

GO:0012501

GO:0015629

GO:0016020

GO:0016071

GO:0016442

GO:0016604

GO:0016787

GO:0016887

GO:0017111

GO:0030154

GO:0031047

GO:0031490

GO:0032508

GO:0032727

GO:0032728

GO:0032741

GO:0032755

GO:0032760

GO:0032991

GO:0033679

GO:0034458

GO:0035197

GO:0035613

GO:0036464

GO:0039695

GO:0042788

GO:0043138

GO:0043226

GO:0044806

GO:0045087

GO:0045089

GO:0045142

GO:0045739

GO:0045740

GO:0045944

GO:0046833

GO:0046872

GO:0047429

GO:0048146

GO:0048511

GO:0050434

GO:0050684

GO:0050691

GO:0050729

GO:0051028

GO:0051092

GO:0060760

GO:0061629

GO:0061676

GO:0065003

GO:0070063

GO:0070269

GO:0070578

GO:0070922

GO:0070934

GO:0070937

GO:0071356

GO:0071360

GO:0097165

GO:0098542

GO:0098795

GO:0140097

GO:0140098

GO:0140110

GO:0140657

GO:1900152

GO:1903608

GO:1904973

GO:1905172

GO:1905538

GO:1905698

GO:1990518

GO:1990825

GO:1990841

GO:1990904

GO:2000373

GO:2000637

GO:2000765

GO:2000767

HMNXSV003026151

Hs.74578.2.S1_3p_a_at

Hs.74578.2.S2_3p_a_at

ILMN_1656016

L13848_at

TC01001582.hg

TC01004881.hg

g13514819_3p_a_at

Participates

as an output of

Formation of the Spliceosomal Bact complex (Homo sapiens)

as a component of

as an input of

Formation of the Spliceosomal E complex (Homo sapiens)

Other forms of this molecule

DHX9 [cytosol]

Inferred To

Ghost homologue of DHX9 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of DHX9 [nucleoplasm] (Gallus gallus)

Ghost homologue of DHX9 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of DHX9 [nucleoplasm] (Schizosaccharomyces pombe)

DHX9 [nucleoplasm] (Bos taurus)

DHX9 [nucleoplasm] (Caenorhabditis elegans)

DHX9 [nucleoplasm] (Canis familiaris)

DHX9 [nucleoplasm] (Danio rerio)

DHX9 [nucleoplasm] (Drosophila melanogaster)

DHX9 [nucleoplasm] (Mus musculus)

DHX9 [nucleoplasm] (Sus scrofa)

dhx9 [nucleoplasm] (Xenopus tropicalis)

Dhx9 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001348.2

OpenTargets

ENSG00000135829

IntEnz

3.6.4.13

GeneCards

Q08211

HPA

ENSG00000135829-DHX9

Ensembl

ENSG00000135829, ENST00000367549, ENSP00000356520

PRO

Q08211

Pharos - Targets

Q08211

HMDB Protein

HMDBP11707

PDB

3VYY, 3VYX, 3LLM

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.764	8
UniProt:P67809 YBX1	3	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.702	10
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.643	4
IntAct:EBI-867155 CTE			0.641	3
UniProt:Q04206 RELA	6	polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.625	4
UniProt:O95793 STAU1			0.577	3
UniProt:P19712-PRO_0000038050			0.537	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10
UniProt:Q9UKV8 AGO2	2	AGO2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.527	3
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	2
UniProt:Q9HA38 ZMAT3			0.524	3
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.512	8
UniProt:P19525 EIF2AK2	1	EIF2AK2 [cytosol] (R-HSA-168699)	0.499	2
UniProt:O14980 XPO1	2	XPO1 [nucleoplasm] (R-HSA-165529) XPO1 [cytosol] (R-HSA-165539)	0.499	3
EMBL:M11841 CTE			0.463	2
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.462	3
IntAct:EBI-6857440 NS3			0.462	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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