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S100A8 [extracellular region]
Stable Identifier
R-HSA-5432846
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
calgranulin-A, calprotectin L1L subunit, cystic fibrosis antigen
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Diseases associated with the TLR signaling cascade (Homo sapiens)
IRAK4 deficiency (TLR2/4) (Homo sapiens)
Defective IRAK4 does not bind MyD88 within the TLR2/4 complex (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Defective IRAK4 variants do not bind MyD88:MAL:BTK:activated TLR2/4 (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
MyD88 deficiency (TLR2/4) (Homo sapiens)
Defective MyD88 does not bind MAL(TIRAP):TLR2/4 (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Defective MyD88 does not oligomerize within the activated TLR2/4 complex (Homo sapiens)
MyD88 variant:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
IKKB phosphorylates SNAP23 (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Metal sequestration by antimicrobial proteins (Homo sapiens)
S100A8:S100A9 binds Mn2+ (Homo sapiens)
S100A8:S100A9:Ca2+ [extracellular region] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region] (Homo sapiens)
S100A8:S100A9:Ca2+ [extracellular region] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
S100A8:S100A9 binds Zn2+ (Homo sapiens)
S100A8:S100A9:Ca2+ [extracellular region] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
S100A8:S100A9:Ca2+:Zn2+ [extracellular region] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Regulation of TLR by endogenous ligand (Homo sapiens)
S100A8:S100A9 binds TLR4:LY96 (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TIRAP:PI(4,5)P2:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Multiple IRAK1 autophosphorylation steps (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (Homo sapiens)
MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TIRAP is phosphorylated by BTK (Homo sapiens)
TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TRAF6 binds to hp- IRAK1 (Homo sapiens)
TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
TRAF6 binds to p-IRAK2 (Homo sapiens)
TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (Homo sapiens)
oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] (Homo sapiens)
activated TLR2/4:p-4Y-TIRAP:PI(4,5)P2:BTK [plasma membrane] (Homo sapiens)
Activated TLR1:2 or TLR 2:6 heterodimers or TLR4 homodimer [plasma membrane] (Homo sapiens)
TLR4:LY96:endogenous ligand [plasma membrane] (Homo sapiens)
TLR4:LY96:S100A8:S100A9 [plasma membrane] (Homo sapiens)
S100A8:S100A9 [extracellular region] (Homo sapiens)
S100A8 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05109 S100A8
Gene Names
S100A8, CAGA, CFAG, MRP8
Chain
chain:1-93
Reference Genes
BioGPS Gene:6279 S100A8
COSMIC (genes):S100A8 S100A8
CTD Gene:6279 S100A8
dbSNP Gene:6279 S100A8
ENSEMBL:ENSG00000143546 S100A8
ENSEMBL_homo_sapiens_GENE:ENSG00000143546.10 S100A8
HGNC:10498 S100A8
KEGG Gene (Homo sapiens):6279 S100A8
Monarch:6279 S100A8
NCBI Gene:6279 S100A8
OMIM:123885 S100A8
UCSC:P05109 S100A8
Reference Transcript
RefSeq:NM_002964.4 S100A8
RefSeq:NM_001319201.1 S100A8
RefSeq:NM_001319197.1 S100A8
RefSeq:NM_001319198.1 S100A8
Other Identifiers
11753823_a_at
16693414
202917_3p_s_at
202917_PM_s_at
202917_s_at
2435993
2435994
2435995
2435997
2436000
2436001
41096_at
6279
7920244
A_23_P434809
GE59677
GO:0002376
GO:0002523
GO:0002544
GO:0002790
GO:0002793
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006351
GO:0006355
GO:0006914
GO:0006915
GO:0006919
GO:0006935
GO:0006954
GO:0007010
GO:0007155
GO:0008017
GO:0008092
GO:0008270
GO:0008289
GO:0010043
GO:0012501
GO:0014002
GO:0016020
GO:0018119
GO:0023052
GO:0030154
GO:0030307
GO:0030312
GO:0030593
GO:0031012
GO:0031410
GO:0032119
GO:0032496
GO:0034121
GO:0034774
GO:0035425
GO:0035662
GO:0036211
GO:0042742
GO:0043226
GO:0045087
GO:0045111
GO:0045471
GO:0046872
GO:0048306
GO:0048856
GO:0048870
GO:0050544
GO:0050729
GO:0050786
GO:0050832
GO:0051092
GO:0051493
GO:0055065
GO:0062023
GO:0070062
GO:0070488
GO:0098542
GO:1990660
GO:2001244
ILMN_1729801
PH_hs_0019619
TC01003261.hg
g9845519_3p_s_at
Participates
as a member of
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
as a component of
S100A8:S100A9 [extracellular region] (Homo sapiens)
Other forms of this molecule
S100A8 [cytosol]
S100A8 [secretory granule lumen]
Inferred To
s100a10b [extracellular region]
(Danio rerio)
LOC119881359 [extracellular region]
(Canis familiaris)
Homologues of S100A8 [extracellular region]
(Danio rerio)
S100A8 [extracellular region]
(Bos taurus)
S100A8 [extracellular region]
(Mus musculus)
S100A8 [extracellular region]
(Rattus norvegicus)
S100A8 [extracellular region]
(Sus scrofa)
s100a10a [extracellular region]
(Danio rerio)
s100a11 [extracellular region]
(Xenopus tropicalis)
S100A10 [extracellular region]
(Gallus gallus)
Cross References
RefSeq
NP_001306127.1
,
NP_002955.2
,
NP_001306126.1
,
NP_001306130.1
OpenTargets
ENSG00000143546
GeneCards
P05109
HPA
ENSG00000143546-S100A8
Ensembl
ENST00000368733
,
ENSP00000357721
,
ENST00000368732
,
ENSP00000357722
,
ENSG00000143546
PRO
P05109
Pharos - Targets
P05109
HMDB Protein
HMDBP01887
PDB
7QUV
,
4XJK
,
5W1F
,
4GGF
,
5HLV
,
1XK4
,
5HLO
,
1MR8
,
6DS2
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.643
11
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
2
UniProt:P35228 NOS2
3
NOS2 [cytosol]
(R-HSA-202107)
NOS2 [nucleoplasm]
(R-HSA-9636250)
NOS2 [peroxisomal matrix]
(R-HSA-9033124)
0.462
4
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