MyrG-p-Y419-SRC [plasma membrane]

Stable Identifier
R-HSA-1810408
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-Y419-N-myristoyl-SRC
Icon
MyrG-p-Y419-SRC [plasma membrane] icon
MyrG-p-Y419-SRC [plasma membrane] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P12931 SRC
Gene Names
SRC, SRC1
Chain
initiator methionine:1, chain:2-536
Reference Genes
BioGPS Gene:6714 SRC
COSMIC (genes):SRC SRC
CTD Gene:6714 SRC
dbSNP Gene:6714 SRC
ENSEMBL:ENSG00000197122 SRC
ENSEMBL:ENSG00000197122.13 SRC
HGNC:11283 SRC
KEGG Gene (Homo sapiens):6714 SRC
Monarch:6714 SRC
NCBI Gene:6714 SRC
OMIM:190090 SRC
UCSC:P12931 SRC
Reference Transcript
Other Identifiers
11723135_s_at
11723136_x_at
1558211_PM_s_at
1558211_s_at
16913413
1938_at
213324_PM_at
213324_at
221284_PM_s_at
221284_s_at
3884193
3884196
3884198
3884199
3884200
3884202
3884203
3884207
3884209
3884210
3884214
3884215
3884216
3884221
3884223
3884227
3884228
3884229
38904_at
6714
8062377
A_14_P111562
A_23_P308603
GE81507
GO:0000166
GO:0001545
GO:0001819
GO:0002102
GO:0002223
GO:0002376
GO:0002862
GO:0003013
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005080
GO:0005102
GO:0005158
GO:0005178
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005743
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005901
GO:0005925
GO:0005975
GO:0006351
GO:0006355
GO:0006468
GO:0006629
GO:0006914
GO:0006954
GO:0007010
GO:0007049
GO:0007155
GO:0007165
GO:0007172
GO:0007173
GO:0007179
GO:0007229
GO:0007283
GO:0007611
GO:0009410
GO:0009612
GO:0010447
GO:0010628
GO:0010632
GO:0010634
GO:0010641
GO:0010907
GO:0010954
GO:0012501
GO:0014068
GO:0014856
GO:0014911
GO:0016004
GO:0016020
GO:0016192
GO:0016236
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0018105
GO:0018108
GO:0019899
GO:0019901
GO:0019904
GO:0020037
GO:0022407
GO:0022414
GO:0023052
GO:0030054
GO:0030154
GO:0030168
GO:0030331
GO:0030900
GO:0031234
GO:0031295
GO:0031333
GO:0031410
GO:0031648
GO:0031667
GO:0031954
GO:0032148
GO:0032200
GO:0032211
GO:0032587
GO:0032869
GO:0033146
GO:0033625
GO:0034330
GO:0034332
GO:0034446
GO:0034614
GO:0035306
GO:0035332
GO:0035556
GO:0035635
GO:0036035
GO:0036120
GO:0036211
GO:0038083
GO:0038096
GO:0038128
GO:0042060
GO:0042169
GO:0042476
GO:0042542
GO:0043025
GO:0043065
GO:0043066
GO:0043114
GO:0043149
GO:0043154
GO:0043226
GO:0043274
GO:0043393
GO:0043406
GO:0043552
GO:0044294
GO:0044325
GO:0044877
GO:0045056
GO:0045087
GO:0045121
GO:0045124
GO:0045296
GO:0045453
GO:0045737
GO:0045747
GO:0045780
GO:0045785
GO:0045892
GO:0045893
GO:0046579
GO:0046628
GO:0046777
GO:0046875
GO:0048010
GO:0048011
GO:0048013
GO:0048041
GO:0048471
GO:0048477
GO:0048856
GO:0048870
GO:0050731
GO:0050839
GO:0050847
GO:0050877
GO:0050900
GO:0051057
GO:0051117
GO:0051219
GO:0051222
GO:0051385
GO:0051450
GO:0051602
GO:0051604
GO:0051895
GO:0051897
GO:0051902
GO:0051974
GO:0060065
GO:0060444
GO:0060491
GO:0060576
GO:0065003
GO:0070062
GO:0070102
GO:0070161
GO:0070301
GO:0070374
GO:0070542
GO:0070555
GO:0070700
GO:0070851
GO:0071222
GO:0071253
GO:0071375
GO:0071393
GO:0071398
GO:0071456
GO:0071498
GO:0071560
GO:0071803
GO:0071897
GO:0071902
GO:0086098
GO:0090263
GO:0097060
GO:0097110
GO:0098542
GO:0098609
GO:0098772
GO:0098962
GO:0098978
GO:0099091
GO:0140096
GO:1900182
GO:1902533
GO:1902737
GO:1903997
GO:1904385
GO:1904707
GO:1990646
GO:2000256
GO:2000386
GO:2000394
GO:2000573
GO:2000588
GO:2000641
GO:2000811
GO:2001237
GO:2001243
GO:2001286
HMNXSV003035331
Hs.198298.0.S1_3p_at
Hs2.383588.1.A1_3p_s_at
ILMN_1685898
ILMN_1729987
K03218_at
PH_hs_0033377
TC20000273.hg
TC20001205.hg
g4885608_3p_a_at
Participates
as a component of
as an output of
as an input of
as a member of
as a candidate of
This entity regulates
Negatively
Positively
Other forms of this molecule
SRC [cytosol]
p-Y419-SRC [cytosol]
p-Y419-SRC [nucleoplasm]
MyrG-SRC [plasma membrane]
MyrG,p-Y530-SRC [plasma membrane]
Inferred To
phospho-MyrG-p-Y419-SRC [plasma membrane] (Bos taurus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Caenorhabditis elegans)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Danio rerio)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Drosophila melanogaster)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Mus musculus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Rattus norvegicus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Sus scrofa)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Xenopus tropicalis)
Modified Residues
Name
N-myristoylglycine at 2
Coordinate
2
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Name
O4'-phospho-L-tyrosine at 419
Coordinate
419
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
ZINC - Metabolites
GeneCards
HPA
Ensembl
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (73)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P18031 PTPN1  2 0.937 14
 UniProt:Q05397 PTK2  11 0.924 9
 UniProt:P00533 EGFR  20 0.9 9
 UniProt:P03372 ESR1  8 0.848 12
 UniProt:P22681 CBL  20 0.845 8
 UniProt:Q9H5V8 CDCP1      0.793 5
 UniProt:P27986 PIK3R1  16 0.779 7
 UniProt:P35968 KDR  4 0.77 6
 UniProt:Q13444 ADAM15  1 0.75 4
 UniProt:P15941 MUC1  19 0.748 5
 UniProt:P04626 ERBB2  20 0.708 11
 UniProt:P08581 MET  7 0.702 4
 UniProt:P56945 BCAR1  4 0.688 3
 UniProt:Q01973 ROR1  2 0.682 9
 UniProt:P07948 LYN  7 0.669 4
 UniProt:P07900 HSP90AA1  8 0.669 3
 UniProt:Q9H204 MED28  1 0.656 3
 UniProt:P18433 PTPRA  1 0.656 4
 UniProt:Q8WUM4 PDCD6IP  1 0.653 7
 UniProt:P55196 AFDN      0.65 7
 UniProt:Q14289 PTK2B  3 0.643 3
 UniProt:P49407 ARRB1  5 0.623 3
 UniProt:Q16543 CDC37  1 0.623 5
 UniProt:Q92569 PIK3R3  2 0.621 3
 UniProt:P07550 ADRB2  5 0.611 3
 UniProt:Q9ULH1 ASAP1  1 0.609 3
 UniProt:P35326 SPRR2A  2 0.602 3
 UniProt:Q62884 Q62884      0.602 3
 UniProt:P61978 HNRNPK  2 0.593 6
 UniProt:Q68CZ2 TNS3  1 0.591 13
 UniProt:P27635 RPL10  1 0.591 6
 UniProt:P16284 PECAM1  4 0.59 3
 UniProt:P00519 ABL1  5 0.589 2
 UniProt:Q07666 KHDRBS1  3 0.573 3
 UniProt:P01112 HRAS  20 0.571 2
 UniProt:P06241 FYN  6 0.564 3
 UniProt:P68400 CSNK2A1  2 0.564 2
 UniProt:P32121 ARRB2  2 0.564 2
 UniProt:P34152 Ptk2  2 0.564 2
 UniProt:O43184 ADAM12  1 0.558 2
 UniProt:Q8R5G7  1 0.558 3
 UniProt:Q9BR61 ACBD6  1 0.558 4
 linoleoyl-CoA [ChEBI:15530]  2 0.558 2
 myristoyl-CoA [ChEBI:15532]  3 0.558 2
 UniProt:P27986-2 PIK3R1      0.556 3
 UniProt:Q13829 TNFAIP1  1 0.556 3
 UniProt:Q9UNY5 ZN232      0.556 3
 UniProt:Q14693 LPIN1  3 0.556 3
 UniProt:O14796 SH2D1B  1 0.556 3
 UniProt:Q13322-4 GRB10      0.556 3
 UniProt:Q6XD76 ASCL4      0.556 3
 UniProt:Q8TBB1 LNX1  1 0.556 6
 UniProt:Q15907 RAB11B  3 0.556 3
 UniProt:O60880 SH2D1A  1 0.556 3
 UniProt:Q14457 BECN1  3 0.556 3
 UniProt:Q9UIH9 KLF15  1 0.556 3
 UniProt:P97288  1 0.544 2
 UniProt:P35222 CTNNB1  20 0.544 2
 UniProt:O14672 ADAM10  6 0.544 3
 UniProt:P25962  1 0.544 2
 UniProt:P08238 HSP90AB1  6 0.527 2
 UniProt:P40763 STAT3  12 0.527 5
 UniProt:P19367 HK1  4 0.524 2
 UniProt:P12814 ACTN1  3 0.524 2
 UniProt:Q13177 PAK2  11 0.524 2
 UniProt:P12830 CDH1  8 0.499 2
 UniProt:Q9H3S7 PTPN23  1 0.499 2
 ChEBI:39112 BOSUTINIB      0.499 2
 ChEBI:45783 IMATINIB      0.499 2
 UniProt:Q9Y6K9 IKBKG  12 0.499 3
 UniProt:P13569 CFTR  17 0.483 4
 UniProt:O15455 TLR3  6 0.463 2
 UniProt:P23743 DGKA  1 0.462 2
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