Reactome | nascent MT-CO2 [mitochondrial inner membrane]

nascent MT-CO2 [mitochondrial inner membrane]

Stable Identifier

R-HSA-164302

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - Cytoprotection by HMOX1 (Homo sapiens)
      - CO binds to Cytochrome c oxidase (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO2:heme a:CuA:Mg2+ [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO2 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO2:heme a:CuA:Mg2+ [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO2 [mitochondrial inner membrane] (Homo sapiens)
      - Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO2:heme a:CuA:Mg2+ [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO2 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO2:heme a:CuA:Mg2+ [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO2 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO2:heme a:CuA:Mg2+ [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO2 [mitochondrial inner membrane] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO2:heme a:CuA:Mg2+ [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO2 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO2:heme a:CuA:Mg2+ [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO2 [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase:CO [mitochondrial inner membrane] (Homo sapiens)
        
        Cytochrome c oxidase [mitochondrial inner membrane] (Homo sapiens)
        
        COX catalytic core [mitochondrial inner membrane] (Homo sapiens)
        
        MT-CO2:heme a:CuA:Mg2+ [mitochondrial inner membrane] (Homo sapiens)
        
        nascent MT-CO2 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P00403 MT-CO2

Gene Names

MT-CO2, COII, COX2, COXII, MTCO2

Chain

chain:1-227

Reference Genes

BioGPS Gene:4513 MT-CO2

COSMIC (genes):MT-CO2 MT-CO2

CTD Gene:4513 MT-CO2

dbSNP Gene:4513 MT-CO2

ENSEMBL:ENSG00000198712 MT-CO2

HGNC:7421 MT-CO2

KEGG:hsa:4513 MT-CO2

Monarch:4513 MT-CO2

NCBI Gene:4513 MT-CO2

OMIM:516040 MT-CO2

UCSC:P00403 MT-CO2

Reference Transcript

RefSeq:NC_012920.1 MT-CYB

Other Identifiers

11758423_s_at

1553567_3p_s_at

1553567_PM_s_at

1553567_s_at

1553569_PM_at

1553569_at

1553570_PM_x_at

1553570_x_at

17100659

17100661

17100663

17126266

17126268

2315231

2315232

2315316

2315317

2315318

2315319

2492706

2492708

2868799

4037628

4037629

4037631

4037633

4037634

4037635

4037637

4037639

4037640

4037641

4037642

4037643

4037644

4513

7896750

7896752

8043375

8113356

8165663

8165665

8165667

A_23_P337726

A_23_P402751

A_33_P3410700

GO:0001666

GO:0003824

GO:0004129

GO:0005215

GO:0005507

GO:0005515

GO:0005739

GO:0005743

GO:0005759

GO:0006091

GO:0006123

GO:0007595

GO:0016020

GO:0016491

GO:0022900

GO:0031966

GO:0042773

GO:0043226

GO:0045277

GO:0045333

GO:0046872

GO:0055085

GO:1902600

HMNXSV003022003

HMNXSV003032141

HMNXSV003041642

Hs2Affx.1.41.S1_3p_s_at

Hs2Affx.1.43.S1_3p_x_at

PH_hs_0033947

PH_hs_0036541

RNA143496|tRNA_413_70

RNA143539|tRNA_456_68

TC01000013.hg

TC0M000005.hg

TC0M000021.hg

TC0M000022.hg

p26926

Participates

as a member of

Substrate of YME1L1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)

as a component of

Other forms of this molecule

nascent MT-CO2 [mitochondrial matrix]

Inferred To

mt-co2 [mitochondrial inner membrane] (Xenopus tropicalis)

Ghost homologue of nascent MT-CO2 [mitochondrial inner membrane] (Canis familiaris)

nascent MT-CO2 [mitochondrial inner membrane] (Bos taurus)

nascent MT-CO2 [mitochondrial inner membrane] (Danio rerio)

nascent MT-CO2 [mitochondrial inner membrane] (Drosophila melanogaster)

nascent MT-CO2 [mitochondrial inner membrane] (Gallus gallus)

nascent MT-CO2 [mitochondrial inner membrane] (Mus musculus)

nascent MT-CO2 [mitochondrial inner membrane] (Rattus norvegicus)

MT-CO2 [mitochondrial inner membrane] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000354876, ENST00000361739, ENSG00000198712

OpenTargets

ENSG00000198712

ZINC - Substances

COX2_HUMAN

ZINC - Biogenic

COX2_HUMAN

ZINC target

P00403

PRO

P00403

GlyGen

P00403

PDB

3VRJ, 5Z62

ZINC - Metabolites

COX2_HUMAN

GeneCards

MT-CO2

HPA

ENSG00000198712-MT-CO2

Pharos - Targets

P00403

Orphanet

MT-CO2

ZINC - Predictions - Purchasable

COX2_HUMAN

HMDB Protein

HMDBP07035

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13073 COX4I1	2	COX4I1 [mitochondrial intermembrane space] (R-HSA-9865413) COX4I1 [mitochondrial inner membrane] (R-HSA-164305)	0.731	5
UniProt:P14854 COX6B1	1	COX6B1 [mitochondrial inner membrane] (R-HSA-164299)	0.564	3
UniProt:P09669 COX6C	2	COX6C(3-75) [mitochondrial intermembrane space] (R-HSA-9865411) COX6C(3-75) [mitochondrial inner membrane] (R-HSA-164298)	0.564	3
UniProt:P20674 COX5A	2	COX5A [mitochondrial intermembrane space] (R-HSA-9865415) COX5A [mitochondrial inner membrane] (R-HSA-164308)	0.564	3
UniProt:P14406 COX7A2	1	COX7A2 [mitochondrial inner membrane] (R-HSA-5336134)	0.564	3
UniProt:P15954 COX7C	1	COX7C [mitochondrial inner membrane] (R-HSA-164306)	0.564	3
UniProt:Q9NZ94-2 NLGN3			0.543	4
UniProt:P49281-3 SLC11A2			0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7
UniProt:Q15118 PDK1	1	PDK1 [mitochondrial matrix] (R-HSA-203944)	0.463	2