Reactome | RPS3 [nucleoplasm]

RPS3 [nucleoplasm]

Stable Identifier

R-HSA-6798714

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S small ribosomal protein 3, P23396, 40S ribosomal protein S3

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P23396 RPS3

Gene Names

RPS3, OK/SW-cl.26

Chain

initiator methionine:1, chain:2-243

Reference Genes

BioGPS Gene:6188 RPS3

COSMIC (genes):RPS3 RPS3

CTD Gene:6188 RPS3

dbSNP Gene:6188 RPS3

ENSEMBL:ENSG00000149273 RPS3

HGNC:10420 RPS3

KEGG:hsa:6188 RPS3

Monarch:6188 RPS3

NCBI Gene:6188 RPS3

OMIM:600454 RPS3

UCSC:P23396 RPS3

Reference Transcript

Other Identifiers

11757129_at

11757130_x_at

11757131_at

11757264_s_at

16729103

16729126

17118802

208692_PM_at

208692_at

214208_at

2940643

2940649

3340547

3340548

3340549

3340550

3340551

3340552

3340553

3340554

3340555

3340556

3340557

3340558

3340559

3340560

3340561

3340562

3340563

3340564

3340565

3340566

3340567

3340568

3340569

3340570

3340571

3340572

3340574

3340577

34645_at

6188

63493_at

7942586

7942592

7942594

A_14_P112056

A_21_P0000223

A_23_P139376

A_24_P218765

A_33_P3578325

GE79155

GE84158

GO:0000977

GO:0002181

GO:0003677

GO:0003684

GO:0003723

GO:0003729

GO:0003735

GO:0003824

GO:0003906

GO:0004520

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005739

GO:0005743

GO:0005759

GO:0005783

GO:0005819

GO:0005829

GO:0005840

GO:0005856

GO:0005886

GO:0005925

GO:0006281

GO:0006284

GO:0006355

GO:0006412

GO:0006413

GO:0006417

GO:0006915

GO:0006974

GO:0007010

GO:0007059

GO:0008017

GO:0008092

GO:0010628

GO:0014069

GO:0015631

GO:0015935

GO:0016020

GO:0016787

GO:0016829

GO:0017148

GO:0019899

GO:0019900

GO:0019901

GO:0022626

GO:0022627

GO:0030544

GO:0031116

GO:0031334

GO:0031397

GO:0032079

GO:0032357

GO:0032358

GO:0032587

GO:0032743

GO:0034614

GO:0042104

GO:0042981

GO:0043226

GO:0044390

GO:0044877

GO:0045202

GO:0045738

GO:0045739

GO:0050862

GO:0051018

GO:0051092

GO:0051225

GO:0051301

GO:0051536

GO:0051879

GO:0061481

GO:0070062

GO:0070181

GO:0070301

GO:0071159

GO:0071356

GO:0072686

GO:0097100

GO:0140078

GO:0140097

GO:0140297

GO:1901224

GO:1902231

GO:1905053

GO:1990904

GO:2001235

HMNXSV003006450

HMNXSV003035177

HMNXSV003045985

Hs.59728.0.A1_3p_at

ILMN_1713832

ILMN_1760714

ILMN_1767869

PH_hs_0030001

PH_hs_0036216

PH_hs_0036296

RNA33435|snoRNA_scaRNA_31_146

TC11000806.hg

TC11000807.hg

TC11000808.hg

X55715_at

g555940_3p_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RPS3 [cytosol]

Inferred To

RpS3 [nucleoplasm] (Drosophila melanogaster)

RPS3 [nucleoplasm] (Bos taurus)

RPS3 [nucleoplasm] (Canis familiaris)

RPS3 [nucleoplasm] (Plasmodium falciparum)

RPS3 [nucleoplasm] (Saccharomyces cerevisiae)

RPS3 [nucleoplasm] (Sus scrofa)

rps3 [nucleoplasm] (Danio rerio)

rps3 [nucleoplasm] (Dictyostelium discoideum)

rps3 [nucleoplasm] (Schizosaccharomyces pombe)

rps3 [nucleoplasm] (Xenopus tropicalis)

Rps3 [nucleoplasm] (Mus musculus)

Rps3 [nucleoplasm] (Rattus norvegicus)

rps-3 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000996.2, NP_001243731.1, NP_001247435.1, NP_001247436.1

OpenTargets

ENSG00000149273

ENSEMBL

ENSG00000149273, ENSP00000433821, ENST00000531188, ENST00000278572, ENSP00000278572, ENSP00000436971, ENST00000524851, ENST00000527446, ENSP00000434643

GeneCards

RPS3

HPA

ENSG00000149273-RPS3

PRO

P23396

Pharos - Targets

P23396

GlyGen

P23396

PDB

8G6J, 8XSX, 5FLX, 6Z6M, 6QZP, 8QOI, 8ZDD, 5VYC, 6ZOJ, 6ZME, 8JDM, 6OLG, 6XA1, 6ZUO, 8XXM, 4V6X, 8PJ3, 8PJ4, 8PPK, 6ZXH, 6ZLW, 9G8M, 9G8O, 6ZXE, 7QP7, 7XNY, 8IFE, 5LKS, 6IP5, 6ZON, 6Z6N, 6ZVJ, 6G53, 6ZMW, 6ZMI, 9C3H, 8T4S, 8K2C, 6Y2L, 5OA3, 8JDL, 8PJ6, 6OLE, 8Y0X, 8G61, 8XXL, 6Y0G, 8PJ2, 7R4X, 8XP3, 6ZXF, 9BLN, 8PJ1, 8YOP, 4UG0, 7QP6, 6IP6, 8IFD, 8XSZ, 6ZOL, 6G51, 6Z6L, 6ZN5, 8ZDC, 6ZMO, 6OM0, 8JDK, 8G60, 6ZM7, 6OLF, 6G5H, 7K5I, 8PPL, 8PJ5, 5AJ0, 8UKB, 6YBS, 6Y57, 6OLZ, 7TQL, 6ZXG, 8XP2, 6ZVH, 6ZP4, 6OM7, 7XNX, 8XSY, 5T2C, 6ZV6, 6ZMT, 8ZDB, 1WH9, 6OLI, 8G5Z, 8JDJ, 8G5Y, 6G5I, 8Y0W, 8XXN, 8GLP, 9BKD, 6FEC, 7QVP, 5A2Q, 7A09, 8OZ0, 8YOO, 6IP8, 6ZXD

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.797	8
UniProt:Q96GA3 LTV1	2	LTV1 [nucleoplasm] (R-HSA-6791566) LTV1 [cytosol] (R-HSA-6791520)	0.795	6
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.787	5
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.706	4
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.686	8
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.677	6
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.643	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.643	6
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.642	4
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.623	5
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.623	3
UniProt:Q00341 HDLBP	2	HDLBP [plasma membrane] (R-HSA-8858026) HDLBP [endoplasmic reticulum membrane] (R-HSA-9948214)	0.615	3
UniProt:Q5VYS8 TUT7	1	TUT7 [cytosol] (R-HSA-8941313)	0.615	3
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.602	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.59	4
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.59	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P16104 H2AX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	3
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.527	2
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.527	2
UniProt:Q9H6S0 YTHDC2	1	YTHDC2 [nucleoplasm] (R-HSA-9935827)	0.527	2
UniProt:Q96MU7 YTHDC1	1	YTHDC1 [nucleoplasm] (R-HSA-9935812)	0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	2
UniProt:Q9H2U1 DHX36	1	DHX36 [cytosol] (R-HSA-3134862)	0.527	2
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.527	2
UniProt:Q9UPY3 DICER1	1	DICER1 [cytosol] (R-HSA-203820)	0.527	2
UniProt:Q01523 DEFA5	5	DEFA5(1-94) [Golgi lumen] (R-HSA-1467267) DEFA5(20-94) [Golgi lumen] (R-HSA-1467208) DEFA5(20-94) [secretory granule lumen] (R-HSA-1471358) DEFA5(20-94) [extracellular region] (R-HSA-1471344) DEFA5(?-94) [extracellular region] (R-HSA-1462017)	0.527	2
UniProt:P08865 RPSA	3	RPSA [cytosol] (R-HSA-72389) RPSA [plasma membrane] (R-HSA-9922472) RPSA [nucleoplasm] (R-HSA-6798722)	0.527	3
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.527	3
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	3
UniProt:Q07157 TJP1	6	TJP1 [cytosol] (R-HSA-532659) TJP1 [Golgi-associated vesicle membrane] (R-HSA-3209843) TJP1 [plasma membrane] (R-HSA-3209845) TJP1 (?-?) [plasma membrane] (R-HSA-3209844) TJP1 [cell junction] (R-HSA-8936023) TJP1 [nucleoplasm] (R-HSA-9921246)	0.483	2
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.483	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	12
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.483	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2

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