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GGC-RAB5A [macropinosome membrane]
Stable Identifier
R-HSA-9837697
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
macropinosome membrane
Synonyms
Ras-related protein Rab-5A, RAB5A_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
Respiratory syncytial virus (RSV) attachment and entry (Homo sapiens)
hRSV A enters host cell through macropinocytosis (Homo sapiens)
GGC-RAB5 [macropinosome membrane] (Homo sapiens)
GGC-RAB5A [macropinosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20339 RAB5A
Gene Names
RAB5A, RAB5
Chain
chain:1-215
Reference Genes
BioGPS Gene:5868 RAB5A
COSMIC (genes):RAB5A RAB5A
CTD Gene:5868 RAB5A
dbSNP Gene:5868 RAB5A
ENSEMBL:ENSG00000144566 RAB5A
HGNC:9783 RAB5A
Monarch:5868 RAB5A
NCBI Gene:5868 RAB5A
OMIM:179512 RAB5A
UCSC:P20339 RAB5A
Reference Transcript
RefSeq:NM_001292048.1 RAB5A
RefSeq:NM_004162.4 RAB5A
Other Identifiers
11722789_a_at
11722790_s_at
11748693_a_at
11748694_x_at
16938253
206113_PM_s_at
206113_s_at
209089_PM_at
209089_at
240990_PM_at
240990_at
2613387
2613388
2613389
2613390
2613391
2613392
2613393
2613394
2613406
2613407
2613408
2613413
2613414
2613415
2613416
2613417
2613421
2613422
2613423
2613424
2613425
36110_at
5868
600_at
8078214
A_14_P110757
A_14_P114610
A_23_P212545
A_24_P208809
GE57902
GO:0000166
GO:0001726
GO:0003824
GO:0003924
GO:0003925
GO:0005515
GO:0005525
GO:0005654
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005856
GO:0005886
GO:0006886
GO:0006897
GO:0006909
GO:0008021
GO:0010008
GO:0012505
GO:0015031
GO:0015629
GO:0016192
GO:0016787
GO:0019001
GO:0019003
GO:0030139
GO:0030424
GO:0030425
GO:0030669
GO:0030670
GO:0030672
GO:0031410
GO:0031623
GO:0031901
GO:0032009
GO:0036465
GO:0036477
GO:0042470
GO:0042995
GO:0043025
GO:0043195
GO:0043226
GO:0043231
GO:0043679
GO:0044788
GO:0045022
GO:0045121
GO:0045335
GO:0045921
GO:0048169
GO:0051036
GO:0051489
GO:0060070
GO:0070062
GO:0098559
GO:0098772
GO:0098842
GO:0150093
GO:2000300
GO:2000785
HMNXSV003030000
Hs.254431.0.A1_3p_at
ILMN_1805800
M28215_at
PH_hs_0004227
TC03000111.hg
g12654846_3p_at
g4759003_3p_a_at
Participates
as a candidate of
GGC-RAB5 [macropinosome membrane] (Homo sapiens)
Other forms of this molecule
RAB5A [cytosol]
RAB5A [endosome membrane]
RAB5A [early endosome membrane]
GGC-RAB5A [cytosol]
GGC-RAB5A [early endosome membrane]
GGC-RAB5A [clathrin-coated endocytic vesicle membrane]
Modified Residues
Name
S-geranylgeranyl-L-cysteine at 212
Coordinate
212
PsiMod Name
S-geranylgeranyl-L-cysteine [MOD:00113]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.
Name
S-geranylgeranyl-L-cysteine at 213
Coordinate
213
PsiMod Name
S-geranylgeranyl-L-cysteine [MOD:00113]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.
Cross References
OpenTargets
ENSG00000144566
ENSEMBL
ENSP00000273047
,
ENST00000422242
,
ENST00000273047
,
ENSP00000411941
IntEnz
3.6.5.2
HPA
ENSG00000144566-RAB5A
PRO
P20339
Pharos - Targets
P20339
HMDB Protein
HMDBP08510
PDB
1TU3
,
1R2Q
,
1TU4
,
1N6H
,
1N6L
,
1N6O
,
3MJH
,
1N6N
,
1N6K
,
1N6I
,
1N6P
,
1N6R
,
7BL1
,
4Q9U
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.841
23
UniProt:Q01968 OCRL
4
OCRL [Golgi membrane]
(R-HSA-434339)
OCRL [cytoplasmic vesicle membrane]
(R-HSA-434214)
OCRL [plasma membrane]
(R-HSA-3769049)
OCRL [cytosol]
(R-HSA-1806196)
0.799
11
UniProt:Q9UH99 SUN2
1
SUN2 [nuclear envelope]
(R-HSA-912382)
0.798
6
UniProt:Q15075 EEA1
1
EEA1 [endosome membrane]
(R-HSA-187893)
0.765
4
UniProt:P51148 RAB5C
10
GGC-RAB5C [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871129)
RAB5C [Golgi membrane]
(R-HSA-434334)
RAB5C [cytoplasmic vesicle membrane]
(R-HSA-434198)
RAB5C [early endosome membrane]
(R-HSA-8854157)
GGC-RAB5C [early endosome membrane]
(R-HSA-8875331)
GGC-RAB5C [cytosol]
(R-HSA-8870436)
RAB5C [cytosol]
(R-HSA-8870413)
GGC-RAB5C [macropinosome membrane]
(R-HSA-9837694)
RAB5C [plasma membrane]
(R-HSA-6806265)
RAB5C [azurophil granule membrane]
(R-HSA-6799338)
0.744
5
UniProt:P31150 GDI1
1
GDI1 [cytosol]
(R-HSA-195106)
0.725
7
UniProt:P50395 GDI2
4
GDI2 [cytosol]
(R-HSA-195089)
GDI2 [azurophil granule lumen]
(R-HSA-6799337)
GDI2 [extracellular region]
(R-HSA-6806176)
GDI2 [secretory granule lumen]
(R-HSA-6800904)
0.725
7
UniProt:P24386 CHM
1
CHM [cytosol]
(R-HSA-6801097)
0.671
5
UniProt:Q92696 RABGGTA
2
RABGGTA [plasma membrane]
(R-HSA-6801086)
RABGGTA [cytosol]
(R-HSA-8870418)
0.671
5
UniProt:P26374 CHML
1
CHML [cytosol]
(R-HSA-8870443)
0.671
5
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
10
UniProt:P53611 RABGGTB
2
RABGGTB [plasma membrane]
(R-HSA-6801098)
RABGGTB [cytosol]
(R-HSA-8870419)
0.569
3
UniProt:P23727
3
PIK3R1 [cytosol]
(R-BTA-3080572)
PIK3R1 [cytosol]
(R-BTA-74789)
PIK3R1 [plasma membrane]
(R-BTA-198365)
0.558
5
UniProt:Q6IAA8 LAMTOR1
5
LAMTOR1 [lysosomal membrane]
(R-HSA-5653582)
LAMTOR1 [ficolin-1-rich granule membrane]
(R-HSA-6801003)
LAMTOR1 [plasma membrane]
(R-HSA-6806270)
LAMTOR1 [azurophil granule membrane]
(R-HSA-6799633)
LAMTOR1 [specific granule membrane]
(R-HSA-6799631)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
UniProt:Q9Y3D0 CIAO2B
1
FAM96B [cytosol]
(R-HSA-2161124)
0.556
3
UniProt:Q6ZQX7-4 Q6ZQX74
0.556
3
UniProt:Q9UQM7 CAMK2A
6
p-T286-CAMK2A [cytosol]
(R-HSA-445368)
CAMK2A [cytosol]
(R-HSA-4332329)
p-T286-CAMK2A [endocytic vesicle membrane]
(R-HSA-416999)
p-T286,T305,T306-CAMK2A [cytosol]
(R-HSA-4332334)
p-T286-CAMK2A [nucleoplasm]
(R-HSA-444797)
p-T286-CAMK2A [plasma membrane]
(R-HSA-432796)
0.556
3
UniProt:P15923-3 TCF3
0.556
3
UniProt:Q8TAB5 CA216
0.556
3
UniProt:Q9NS73-5 MBIP
0.556
3
UniProt:Q9H7C4 SYNCI
0.556
3
UniProt:Q96HB5 CC120
0.556
3
UniProt:O60506-4 SYNCRIP
0.556
3
UniProt:P17024 ZNF20
1
ZNF20 [nucleoplasm]
(R-HSA-975024)
0.556
3
UniProt:O15287 FANCG
2
FANCG [nucleoplasm]
(R-HSA-419532)
FANCG [cytosol]
(R-HSA-420788)
0.556
3
UniProt:O15273 TCAP
1
TCAP [cytosol]
(R-HSA-390571)
0.556
3
UniProt:Q96PV4 PNMA5
0.556
3
UniProt:Q9P2R3 ANKFY1
1
ANKFY1 [endosome membrane]
(R-HSA-9693267)
0.544
2
UniProt:O95260 ATE1
0.527
3
UniProt:Q6ZMI0 PPR21
0.525
2
UniProt:Q8NEU8 DP13B
0.519
2
UniProt:Q15836 VAMP3
6
VAMP3 [recycling endosome membrane]
(R-HSA-2029063)
VAMP3 [phagocytic vesicle membrane]
(R-HSA-2029013)
VAMP3 [plasma membrane]
(R-HSA-8867599)
VAMP3 [trans-Golgi network membrane]
(R-HSA-6814624)
VAMP3 [transport vesicle]
(R-HSA-6814625)
VAMP3 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869130)
0.483
2
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