Reactome | ENO1 [cytosol]

ENO1 [cytosol]

Stable Identifier

R-HSA-71437

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

enolase 1, (alpha), Alpha enolase , 2-phospho-D-glycerate hydro-lyase, Non- neural enolase, NNE, Enolase 1, Phosphopyruvate hydratase

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Mycobacterium tuberculosis (Homo sapiens)
      - Response of Mtb to phagocytosis (Homo sapiens)
        
        Manipulation of host energy metabolism (Homo sapiens)
        
        EsxA binds ENO1 (Homo sapiens)
        
        ENO1 [cytosol] (Homo sapiens)
        
        EsxA:ENO1 [cytosol] (Homo sapiens)
        
        ENO1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P06733 ENO1

Gene Names

ENO1, ENO1L1, MBPB1, MPB1

Chain

initiator methionine:, chain:2-434

Reference Genes

BioGPS Gene:2023 ENO1

COSMIC (genes):ENO1 ENO1

CTD Gene:2023 ENO1

dbSNP Gene:2023 ENO1

ENSEMBL:ENSG00000074800 ENO1

ENSEMBL_homo_sapiens_GENE:ENSG00000074800.16 ENO1

HGNC:3350 ENO1

KEGG Gene (Homo sapiens):2023 ENO1

Monarch:2023 ENO1

NCBI Gene:2023 ENO1

OMIM:172430 ENO1

UCSC:P06733 ENO1

Reference Transcript

Other Identifiers

11728640_s_at

11747799_x_at

11754551_x_at

201231_3p_s_at

201231_PM_s_at

201231_s_at

2023

2035_s_at

217294_PM_s_at

217294_s_at

2386864

2395498

2395499

2395500

2395502

2395503

2395504

2395505

2395506

2395507

2395510

2395512

2395518

2395522

2395524

7912198

A_23_P137391

A_24_P105501

GE61364

GO:0000015

GO:0000122

GO:0000287

GO:0000977

GO:0001222

GO:0001227

GO:0003012

GO:0003677

GO:0003714

GO:0003723

GO:0003824

GO:0004634

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005640

GO:0005737

GO:0005829

GO:0005886

GO:0005938

GO:0005975

GO:0006091

GO:0006094

GO:0006096

GO:0006351

GO:0006355

GO:0009615

GO:0009986

GO:0010756

GO:0012501

GO:0016020

GO:0016829

GO:0023052

GO:0030308

GO:0031430

GO:0042803

GO:0043226

GO:0045296

GO:0045892

GO:0045933

GO:0046872

GO:0051020

GO:0051604

GO:0055086

GO:0061621

GO:0070062

GO:0140110

GO:1901135

GO:1903298

GO:2001171

HMNXSV003013234

Hs.254105.1.A1_3p_a_at

ILMN_1710756

M14328_s_at

PH_hs_0025283

TC01002175.hg

g4503570_3p_s_at

Participates

as a component of

as an input of

EsxA binds ENO1 (Homo sapiens)

as a member of

ENO monomers [cytosol] (Homo sapiens)

Inferred To

ENO1 [cytosol] (Caenorhabditis elegans)

ENO1 [cytosol] (Canis familiaris)

ENO1 [cytosol] (Danio rerio)

ENO1 [cytosol] (Dictyostelium discoideum)

ENO1 [cytosol] (Drosophila melanogaster)

ENO1 [cytosol] (Gallus gallus)

ENO1 [cytosol] (Plasmodium falciparum)

ENO1 [cytosol] (Saccharomyces cerevisiae)

ENO1 [cytosol] (Schizosaccharomyces pombe)

ENO1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001188412.1, NP_001419.1

OpenTargets

ENSG00000074800

ZINC - Substances

ENOA_HUMAN

HPA

ENSG00000074800-ENO1

GeneCards

P06733

Ensembl

ENSP00000234590, ENSG00000074800, ENST00000234590

ZINC target

P06733

PRO

P06733

Pharos - Targets

P06733

ZINC - Predictions - Purchasable

ENOA_HUMAN

HMDB Protein

HMDBP01087

PDB

5NIG, 5NI9, 3B97, 2PSN, 5OCK, 5JLZ, 5LAX

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09104 ENO2	1	ENO2 [cytosol] (R-HSA-71429)	0.708	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	21
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.692	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	13
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.571	3
UniProt:P13929 ENO3	1	ENO3 [cytosol] (R-HSA-71433)	0.564	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:P03496 NS	2	NS1 [nucleoplasm] (R-FLU-169113) NS1 [cytosol] (R-FLU-169118)	0.547	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:P22303 ACHE	2	ACHE [extracellular region] (R-HSA-372506) ACHE [plasma membrane] (R-HSA-1524050)	0.527	2
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	2

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