Reactome | COPE [transport vesicle]

COPE [transport vesicle]

Stable Identifier

R-HSA-6808745

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

transport vesicle

Synonyms

Coatomer epsilon subunit

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        trimeric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPE [transport vesicle] (Homo sapiens)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        trimeric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPE [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        trimeric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPE [transport vesicle] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        trimeric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPE [transport vesicle] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        trimeric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPE [transport vesicle] (Homo sapiens)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        trimeric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPE [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        trimeric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPE [transport vesicle] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        trimeric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPE [transport vesicle] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        trimeric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPE [transport vesicle] (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        trimeric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPE [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        trimeric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPE [transport vesicle] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        coatomer [transport vesicle] (Homo sapiens)
        
        trimeric coatomer complex [transport vesicle] (Homo sapiens)
        
        COPE [transport vesicle] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14579 COPE

Gene Names

COPE

Chain

initiator methionine:, chain:2-308

Reference Genes

BioGPS Gene:11316 COPE

COSMIC (genes):COPE COPE

CTD Gene:11316 COPE

dbSNP Gene:11316 COPE

ENSEMBL:ENSG00000105669 COPE

HGNC:2234 COPE

KEGG:hsa:11316 COPE

Monarch:11316 COPE

NCBI Gene:11316 COPE

OMIM:606942 COPE

UCSC:O14579 COPE

Reference Transcript

Other Identifiers

11316

11737073_a_at

11737074_x_at

11741238_a_at

11741239_x_at

11763391_at

16870493

201264_PM_at

201264_at

220469_PM_at

220469_at

3855325

3855326

3855328

3855329

3855330

3855334

3855335

3855337

3855338

3855339

3855340

3855341

3855342

3855343

3855344

3855348

3855349

3855350

3855351

3855352

3855353

3855354

3855356

3855357

38647_at

72597_at

8035553

A_23_P209088

A_23_P373545

A_24_P399622

GE55214

GE904180

GO:0000139

GO:0005198

GO:0005515

GO:0005654

GO:0005737

GO:0005789

GO:0005794

GO:0005829

GO:0006888

GO:0006890

GO:0006891

GO:0015031

GO:0016020

GO:0016192

GO:0030126

GO:0030133

GO:0030137

GO:0030663

GO:0031410

GO:0043226

GO:0099612

HMNXSV003042948

ILMN_1738103

ILMN_2339627

PH_hs_0001051

PH_hs_0037499

TC19002690.hg

g13376645_3p_at

g6005734_3p_at

g6005734_3p_x_at

Participates

as a component of

trimeric coatomer complex [transport vesicle] (Homo sapiens)

Other forms of this molecule

COPE [endoplasmic reticulum membrane]

COPE [Golgi membrane]

COPE [cytosol]

Inferred To

cope [transport vesicle] (Danio rerio)

cope [transport vesicle] (Dictyostelium discoideum)

cope [transport vesicle] (Xenopus tropicalis)

cope-1 [transport vesicle] (Caenorhabditis elegans)

COPE [transport vesicle] (Bos taurus)

COPE [transport vesicle] (Canis familiaris)

COPE [transport vesicle] (Gallus gallus)

COPE [transport vesicle] (Plasmodium falciparum)

COPE [transport vesicle] (Sus scrofa)

epsilonCOP [transport vesicle] (Drosophila melanogaster)

SEC28 [transport vesicle] (Saccharomyces cerevisiae)

sec28 [transport vesicle] (Schizosaccharomyces pombe)

Cope [transport vesicle] (Mus musculus)

Cope [transport vesicle] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000262812, ENST00000349893, ENST00000351079, ENSP00000343134, ENSP00000262812, ENSP00000345674

OpenTargets

ENSG00000105669

HPA

ENSG00000105669-COPE

PRO

O14579

Pharos - Targets

O14579

GlyGen

O14579

HMDB Protein

HMDBP08333

PDB

6U3V, 6TZT

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.643	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	11
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.527	2
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.483	3

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