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COPE [transport vesicle]
Stable Identifier
R-HSA-6808745
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
transport vesicle
Synonyms
Coatomer epsilon subunit
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
trimeric coatomer complex [transport vesicle] (Homo sapiens)
COPE [transport vesicle] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
trimeric coatomer complex [transport vesicle] (Homo sapiens)
COPE [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
trimeric coatomer complex [transport vesicle] (Homo sapiens)
COPE [transport vesicle] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
trimeric coatomer complex [transport vesicle] (Homo sapiens)
COPE [transport vesicle] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
trimeric coatomer complex [transport vesicle] (Homo sapiens)
COPE [transport vesicle] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
trimeric coatomer complex [transport vesicle] (Homo sapiens)
COPE [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
trimeric coatomer complex [transport vesicle] (Homo sapiens)
COPE [transport vesicle] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
trimeric coatomer complex [transport vesicle] (Homo sapiens)
COPE [transport vesicle] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
trimeric coatomer complex [transport vesicle] (Homo sapiens)
COPE [transport vesicle] (Homo sapiens)
Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
trimeric coatomer complex [transport vesicle] (Homo sapiens)
COPE [transport vesicle] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
trimeric coatomer complex [transport vesicle] (Homo sapiens)
COPE [transport vesicle] (Homo sapiens)
Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
coatomer [transport vesicle] (Homo sapiens)
trimeric coatomer complex [transport vesicle] (Homo sapiens)
COPE [transport vesicle] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14579 COPE
Gene Names
COPE
Chain
initiator methionine:, chain:2-308
Reference Genes
BioGPS Gene:11316 COPE
COSMIC (genes):COPE COPE
CTD Gene:11316 COPE
dbSNP Gene:11316 COPE
ENSEMBL:ENSG00000105669 COPE
HGNC:2234 COPE
KEGG:hsa:11316 COPE
Monarch:11316 COPE
NCBI Gene:11316 COPE
OMIM:606942 COPE
UCSC:O14579 COPE
Reference Transcript
RefSeq:NM_199444.1 COPE
RefSeq:NM_199442.1 COPE
RefSeq:NM_007263.3 COPE
Other Identifiers
11316
11737073_a_at
11737074_x_at
11741238_a_at
11741239_x_at
11763391_at
16870493
201264_PM_at
201264_at
220469_PM_at
220469_at
3855325
3855326
3855328
3855329
3855330
3855334
3855335
3855337
3855338
3855339
3855340
3855341
3855342
3855343
3855344
3855348
3855349
3855350
3855351
3855352
3855353
3855354
3855356
3855357
38647_at
72597_at
8035553
A_23_P209088
A_23_P373545
A_24_P399622
GE55214
GE904180
GO:0000139
GO:0005198
GO:0005515
GO:0005654
GO:0005737
GO:0005789
GO:0005794
GO:0005829
GO:0006888
GO:0006890
GO:0006891
GO:0015031
GO:0016020
GO:0016192
GO:0030126
GO:0030133
GO:0030137
GO:0030663
GO:0031410
GO:0043226
GO:0099612
HMNXSV003042948
ILMN_1738103
ILMN_2339627
PH_hs_0001051
PH_hs_0037499
TC19002690.hg
g13376645_3p_at
g6005734_3p_at
g6005734_3p_x_at
Participates
as a component of
trimeric coatomer complex [transport vesicle] (Homo sapiens)
Other forms of this molecule
COPE [endoplasmic reticulum membrane]
COPE [Golgi membrane]
COPE [cytosol]
Inferred To
cope [transport vesicle]
(Danio rerio)
cope [transport vesicle]
(Dictyostelium discoideum)
cope [transport vesicle]
(Xenopus tropicalis)
cope-1 [transport vesicle]
(Caenorhabditis elegans)
COPE [transport vesicle]
(Bos taurus)
COPE [transport vesicle]
(Canis familiaris)
COPE [transport vesicle]
(Gallus gallus)
COPE [transport vesicle]
(Plasmodium falciparum)
COPE [transport vesicle]
(Sus scrofa)
epsilonCOP [transport vesicle]
(Drosophila melanogaster)
SEC28 [transport vesicle]
(Saccharomyces cerevisiae)
sec28 [transport vesicle]
(Schizosaccharomyces pombe)
Cope [transport vesicle]
(Mus musculus)
Cope [transport vesicle]
(Rattus norvegicus)
Cross References
ENSEMBL
ENST00000262812
,
ENST00000349893
,
ENST00000351079
,
ENSP00000343134
,
ENSP00000262812
,
ENSP00000345674
OpenTargets
ENSG00000105669
HPA
ENSG00000105669-COPE
PRO
O14579
Pharos - Targets
O14579
GlyGen
O14579
HMDB Protein
HMDBP08333
PDB
6U3V
,
6TZT
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NTJ5 SACM1L
2
SACM1L [endoplasmic reticulum membrane]
(R-HSA-1604637)
SACM1L [Golgi membrane]
(R-HSA-1806242)
0.643
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
11
UniProt:Q8NBQ5 HSD17B11
1
HSD17B11 [cytosol]
(R-HSA-5693370)
0.527
2
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.483
3
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