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GNB1 [plasma membrane]
Stable Identifier
R-HSA-164347
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
G-protein beta1 (GBB1) subunit
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
Glucagon-like Peptide 1 is secreted from intestinal L cells (Homo sapiens)
Gustducin [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Olfactory Signaling Pathway (Homo sapiens)
GNAL exchanges GDP for GTP in odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 (Homo sapiens)
odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 [plasma membrane] (Homo sapiens)
GNAL:GDP:GNB1:GNG13 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13 [plasma membrane] (Homo sapiens)
GNAL:GTP:GNB1:GNG13 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Homo sapiens)
GNAL:GDP:GNB1:GNG13 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 [plasma membrane] (Homo sapiens)
GNAL:GDP:GNB1:GNG13 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13 dissociates yielding GNAL:GTP (G alpha-olf:GTP), odorant:OlfactoryReceptor, and GNB1:GNG13 (Homo sapiens)
GNB1:GNG13 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13 [plasma membrane] (Homo sapiens)
GNAL:GTP:GNB1:GNG13 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
Bitter compound binds bitter taste receptor (TAS2R) (Homo sapiens)
TAS2R:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
GNAT3 exchanges GDP for GTP in L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
GNAT3 exchanges GDP for GTP in TAS1R2:TAS1R3:sweet compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
TAS1R2:TAS1R3:Sweet compound:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet compound:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
GNAT3 exchanges GDP for GTP in TAS2R:bitter compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
GNB1,3:GNG13 binds PLCB2:Ca2+ (Homo sapiens)
GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
GNB1,3:GNG13:PLCB2:Ca2+ [plasma membrane] (Homo sapiens)
GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)
GNB1,3:GNG13:PLCB2:Ca2+ [plasma membrane] (Homo sapiens)
GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP and GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)
GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Homo sapiens)
TAS1R2:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet compound:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:sweet compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R2:TAS1R3:sweet compound, GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)
GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet compound:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
TAS2R:bitter compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding (Homo sapiens)
GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein activation (Homo sapiens)
The receptor:G-protein complex binds GTP (Homo sapiens)
Opioid:MOR:G-protein complex [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein [plasma membrane] (Homo sapiens)
G-protein beta subunit [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
The receptor:G-protein complex releases GDP (Homo sapiens)
Opioid:MOR:G-protein complex [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein [plasma membrane] (Homo sapiens)
G-protein beta subunit [plasma membrane] (Homo sapiens)
GNB1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62873 GNB1
Gene Names
GNB1
Chain
initiator methionine:, chain:2-340
Reference Genes
COSMIC (genes):GNB1 GNB1
dbSNP Gene:2782 GNB1
ENSEMBL:ENSG00000078369 GNB1
Participates
as a component of
GNAL:GDP:GNB1:GNG13 [plasma membrane] (Homo sapiens)
GNB1:GNG13 [plasma membrane] (Homo sapiens)
GNAL:GTP:GNB1:GNG13 [plasma membrane] (Homo sapiens)
as a member of
G-protein beta subunit [plasma membrane] (Homo sapiens)
GNB1,3 [plasma membrane] (Homo sapiens)
Other forms of this molecule
GNB1 [photoreceptor disc membrane]
Unfolded GNB1 [cytosol]
Partially folded GNB1 [cytosol]
GNB1 [cytosol]
Inferred To
Gbeta13F [plasma membrane]
(Drosophila melanogaster)
gpb-1 [plasma membrane]
(Caenorhabditis elegans)
G-protein beta 1 subunit [plasma membrane]
(Mus musculus)
G-protein beta 1 subunit [plasma membrane]
(Rattus norvegicus)
Gbeta76C [plasma membrane]
(Drosophila melanogaster)
gnb1b [plasma membrane]
(Danio rerio)
gnb1 [plasma membrane]
(Xenopus tropicalis)
GNB1 [plasma membrane]
(Bos taurus)
GNB1 [plasma membrane]
(Canis familiaris)
GNB1 [plasma membrane]
(Gallus gallus)
GNB1 [plasma membrane]
(Sus scrofa)
Homologues of GNB1 [plasma membrane]
(Drosophila melanogaster)
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:P63211 GNGT1
3
S-farn-GNGT1 [photoreceptor disc membrane]
(R-HSA-2530520)
GNGT1 [photoreceptor disc membrane]
(R-HSA-55393)
GNGT1 [plasma membrane]
(R-HSA-167428)
0.621
3
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.556
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.527
10
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:Q13371 PDCL
2
p-S18,S19,S20,S25-PDCL [cytosol]
(R-HSA-6814228)
PDCL [cytosol]
(R-HSA-6813727)
0.527
3
UniProt:P10824 Gnai1
1
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane]
(R-RNO-421889)
0.488
2
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