Reactome | ITCH [cytosol]

ITCH [cytosol]

Stable Identifier

R-HSA-975995

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase Itchy homolog, ITCH_HUMAN, AIP4

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-1 Infection (Homo sapiens)
        
        SARS-CoV-1-host interactions (Homo sapiens)
        
        SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
        
        SARS-CoV-1 9b recruits ITCH to MAVS (Homo sapiens)
        
        9b:K48polyUb-MAVS:PCBP2:ITCH [mitochondrial outer membrane] (Homo sapiens)
        
        ITCH [cytosol] (Homo sapiens)
        
        ITCH [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96J02 ITCH

Gene Names

ITCH

Chain

initiator methionine:, chain:2-903

Reference Genes

BioGPS Gene:83737 ITCH

COSMIC (genes):ITCH ITCH

CTD Gene:83737 ITCH

dbSNP Gene:83737 ITCH

ENSEMBL:ENSG00000078747 ITCH

HGNC:13890 ITCH

KEGG:hsa:83737 ITCH

Monarch:83737 ITCH

NCBI Gene:83737 ITCH

OMIM:606409 ITCH

UCSC:Q96J02 ITCH

Reference Transcript

Participates

as a component of

as an input of

as an output of

as a member of

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Other forms of this molecule

Ub-C871-ITCH [cytosol]

Inferred To

ITCH [cytosol] (Bos taurus)

ITCH [cytosol] (Canis familiaris)

ITCH [cytosol] (Dictyostelium discoideum)

ITCH [cytosol] (Gallus gallus)

ITCH [cytosol] (Plasmodium falciparum)

ITCH [cytosol] (Sus scrofa)

pub1 [cytosol] (Schizosaccharomyces pombe)

RSP5 [cytosol] (Saccharomyces cerevisiae)

Su(dx) [cytosol] (Drosophila melanogaster)

itchb [cytosol] (Danio rerio)

itch [cytosol] (Xenopus tropicalis)

pub3 [cytosol] (Schizosaccharomyces pombe)

wwp-1 [cytosol] (Caenorhabditis elegans)

Homologues of ITCH [cytosol] (Dictyostelium discoideum)

Homologues of ITCH [cytosol] (Schizosaccharomyces pombe)

Itch [cytosol] (Mus musculus)

Itch [cytosol] (Rattus norvegicus)

pub2 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001244067.1, XP_016883578.1, XP_016883580.1, NP_001244066.1, NP_001311127.1, NP_113671.3, NP_001311126.1

OpenTargets

ENSG00000078747

ENSEMBL

ENSP00000499786, ENST00000665346, ENSP00000445608, ENST00000262650, ENSP00000262650, ENST00000696974, ENST00000535650, ENSG00000078747, ENSP00000363998, ENSP00000513011, ENST00000374864

GeneCards

ITCH

HPA

ENSG00000078747-ITCH

PRO

Q96J02

Pharos - Targets

Q96J02

GlyGen

Q96J02

Orphanet

ITCH

HMDB Protein

HMDBP13430

PDB

5SXP, 2YSF, 3TUG, 5DZD, 5DWS, 4ROF, 5C7M, 5CQ2, 2DMV, 2P4R, 2NQ3, 2KYK

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96B67 ARRD3			0.768	5
UniProt:O15350 TP73	3	TP73 [nucleoplasm] (R-HSA-6798094) TP73 [cytosol] (R-HSA-8957239) PolyUb-TP73 [cytosol] (R-HSA-8957256)	0.75	5
UniProt:Q8N5I2 ARRD1			0.738	5
UniProt:Q9NW97 TMM51			0.688	4
UniProt:Q15884 EREP1			0.659	4
UniProt:Q96BR1 SGK3	1	SGK3 [cytosol] (R-HSA-2682351)	0.645	5
UniProt:Q8N0X7 SPART			0.643	3
UniProt:O15350-1 TP73			0.639	5
UniProt:Q9Y5X1 SNX9	3	SNX9 [cytosol] (R-HSA-8867737) SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.623	7
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	15
UniProt:P08151 GLI1	9	GLI1 [ciliary tip] (R-HSA-5610360) GLI1 [ciliary base] (R-HSA-5610357) p-GLI1 [nucleoplasm] (R-HSA-5635042) 2p-GLI1 [nucleoplasm] (R-HSA-5635057) p-GLI1 [ciliary tip] (R-HSA-5635040) GLI1 [cytosol] (R-HSA-445457) pS-GLI1 [ciliary base] (R-HSA-5610497) ub-pS-GLI1 [ciliary base] (R-HSA-5610514) ub-GLI1 [cytosol] (R-HSA-5635833)	0.602	4
UniProt:Q9ULV8 CBLC			0.602	5
UniProt:O75113 N4BP1	3	N4BP1(1-490) [cytosol] (R-HSA-9757922) N4BP1(1-424) [cytosol] (R-HSA-9757940) N4BP1 [cytosol] (R-HSA-9757941)	0.591	3
UniProt:Q16655 MLANA	1	MLANA [melanosome membrane] (R-HSA-9825829)	0.59	2
UniProt:P13285 LMP2			0.59	3
UniProt:Q14511 CASL			0.581	3
UniProt:Q9BTU6 PI4K2A	1	PI4K2A [cytosol] (R-HSA-1604617)	0.571	5
UniProt:Q96BY9 SARAF			0.564	2
UniProt:Q9Y3C5 RNF11			0.544	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.527	2
UniProt:Q9H0M0 WWP1	1	WWP1 [cytosol] (R-HSA-976037)	0.527	2
UniProt:Q8WVE6 TM171			0.527	2
UniProt:Q96G27 WBP1			0.527	2
UniProt:Q5JRV8 T255A			0.527	2
UniProt:Q6UXU6 TMM92			0.527	2
UniProt:Q8NCT1 ARRD4			0.527	2
UniProt:Q99962 SH3GL2	4	SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189)	0.526	3
UniProt:Q9QZS3-2 NUMB			0.524	2
UniProt:Q9H3D4 TP63	1	TP63 [nucleoplasm] (R-HSA-2997585)	0.499	2
UniProt:P70444	4	Bid [mitochondrial outer membrane] (R-MMU-114266) Bid [cytosol] (R-MMU-141373) Bid [cytosol] (R-MMU-50825) Bid [cytosol] (R-MMU-139953)	0.471	2
UniProt:Q9EPK8 Trpv4	1	Trpv4 [plasma membrane] (R-MMU-9858833)	0.463	2
UniProt:Q86Y01 DTX1	1	DTX1 [cytosol] (R-HSA-1604437)	0.463	2

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