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PSMC6 [nucleoplasm]
Stable Identifier
R-HSA-174319
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S protease regulatory subunit S10B, Proteasome subunit p42, p44, Conserved ATPase domain protein 44, CADp44
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1-G1/S phases (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62333 PSMC6
Gene Names
PSMC6, SUG2
Chain
chain:1-389
Reference Genes
BioGPS Gene:5706 PSMC6
COSMIC (genes):PSMC6 PSMC6
CTD Gene:5706 PSMC6
dbSNP Gene:5706 PSMC6
ENSEMBL:ENSG00000100519 PSMC6
ENSEMBL_homo_sapiens_GENE:ENSG00000100519 PSMC6
HGNC:9553 PSMC6
KEGG Gene (Homo sapiens):5706 PSMC6
Monarch:5706 PSMC6
NCBI Gene:5706 PSMC6
OMIM:602708 PSMC6
UCSC:P62333 PSMC6
Reference Transcript
RefSeq:NM_002806.3 PSMC6
Other Identifiers
0006020059
11720983_s_at
16784228
201699_at
3136120
3136122
3136123
3136124
3136125
3136126
3136128
3535886
3535889
3535890
3535892
3535896
3535897
3535898
3535899
3535904
3535906
3535907
3535910
3535911
3535914
3535916
3535917
3535918
3535919
42823
5706
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
7974380
8150870
949_s_at
A0A087X2I1
A_23_P128930
A_24_P381625
AAB61616
AAH05390
AAP35489
BAA11338
BAG36422
CAG32990
D78275_at
EAW65645
ENSG00000100519
ENSP00000475721
ENST00000606149
EntrezGene:5706
g4506214_3p_at
GO:0000166
GO:0000502
GO:0003674
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006511
GO:0006950
GO:0008150
GO:0008540
GO:0009056
GO:0009058
GO:0016020
GO:0016579
GO:0016787
GO:0016887
GO:0022607
GO:0022624
GO:0030163
GO:0030433
GO:0030674
GO:0031597
GO:0032991
GO:0034641
GO:0036402
GO:0042802
GO:0043167
GO:0043226
GO:0043687
GO:0045899
GO:0065003
GO:0070062
GO:1901800
H0YJE9
H0YJS8
H0YJT1
H0YJY8
HGNC:9553
HPA042823
ILMN_1655316
ILMN_2096759
IPR003593
IPR003959
IPR003960
IPR005937
IPR027417
IPR035263
MIM:602708
PF00004
PSMC6
PSMC6-218
SM00382
TC14000309.hg
uc059bor.1
UPI0000021D23
XM_017021472
XP_016876961
Participant Of
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSMC6 [cytosol]
Inferred To
Homologues of PSMC6 [nucleoplasm] (Arabidopsis thaliana)
Homologues of PSMC6 [nucleoplasm] (Danio rerio)
Homologues of PSMC6 [nucleoplasm] (Drosophila melanogaster)
Homologues of PSMC6 [nucleoplasm] (Gallus gallus)
Homologues of PSMC6 [nucleoplasm] (Oryza sativa)
Homologues of PSMC6 [nucleoplasm] (Sus scrofa)
Homologues of PSMC6 [nucleoplasm] (Taeniopygia guttata)
PSMC6 [nucleoplasm] (Arabidopsis thaliana)
PSMC6 [nucleoplasm] (Bos taurus)
PSMC6 [nucleoplasm] (Caenorhabditis elegans)
PSMC6 [nucleoplasm] (Canis familiaris)
PSMC6 [nucleoplasm] (Danio rerio)
PSMC6 [nucleoplasm] (Dictyostelium discoideum)
PSMC6 [nucleoplasm] (Drosophila melanogaster)
PSMC6 [nucleoplasm] (Gallus gallus)
PSMC6 [nucleoplasm] (Mus musculus)
PSMC6 [nucleoplasm] (Oryza sativa)
PSMC6 [nucleoplasm] (Rattus norvegicus)
PSMC6 [nucleoplasm] (Saccharomyces cerevisiae)
PSMC6 [nucleoplasm] (Sus scrofa)
PSMC6 [nucleoplasm] (Taeniopygia guttata)
PSMC6 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_002797.3
OpenTargets
ENSG00000100519
GeneCards
P62333
PRO
P62333
PDB
5VFR
,
5VHN
,
5VGZ
,
5VHO
,
5VFS
,
5VFT
,
5VHP
,
5M32
,
5LN3
,
5GJR
,
5T0C
,
5VHQ
,
5VHF
,
5VFU
,
5T0G
,
5VHH
,
5GJQ
,
5VHR
,
5VHI
,
5VHS
,
5T0H
,
5VHJ
,
5T0I
,
5VFP
,
5L4G
,
5VHM
,
5VFQ
,
5T0J
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.764
9
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
0.696
7
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.669
4
UniProt:Q13895 BYSL
2
BYSL [cytosol]
(R-HSA-6791518)
BYSL [nucleoplasm]
(R-HSA-6791526)
0.488
2
UniProt:P46109 CRKL
2
p-CRKL [cytosol]
(R-HSA-9024730)
CRKL [cytosol]
(R-HSA-354384)
0.488
2
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