Reactome | HSPA8 [ficolin-1-rich granule lumen]

HSPA8 [ficolin-1-rich granule lumen]

Stable Identifier

R-HSA-6801494

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ficolin-1-rich granule lumen

Synonyms

Heat shock cognate 71 kDa protein, HSP7C_HUMAN, HSC70

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P11142 HSPA8

Gene Names

HSPA8, HSC70, HSP73, HSPA10

Chain

initiator methionine:, chain:2-646

Reference Genes

BioGPS Gene:3312 HSPA8

COSMIC (genes):HSPA8 HSPA8

CTD Gene:3312 HSPA8

dbSNP Gene:3312 HSPA8

ENSEMBL:ENSG00000109971 HSPA8

ENSEMBL_homo_sapiens_GENE:ENSG00000109971.14 HSPA8

HGNC:5241 HSPA8

KEGG Gene (Homo sapiens):3312 HSPA8

Monarch:3312 HSPA8

NCBI Gene:3312 HSPA8

OMIM:600816 HSPA8

UCSC:P11142 HSPA8

Reference Transcript

Other Identifiers

11720916_s_at

11741210_a_at

11741211_x_at

11756622_a_at

11762261_x_at

1179_at

1180_g_at

16745525

208687_PM_x_at

208687_x_at

210338_PM_s_at

210338_s_at

221891_PM_x_at

221891_x_at

224187_PM_x_at

224187_x_at

2989994

3011035

3312

33820_g_at

3395420

3395421

3395422

3395424

3395427

3395428

3395432

3395433

3395437

3395438

3395439

3395441

3395442

3395444

3395445

3395449

3395450

3395452

3395453

3395454

3395455

3401658

4020036

4020040

4020043

4020046

40637_at

44833_s_at

73372_r_at

7952325

A_23_P24594

A_24_P287129

A_24_P295745

A_32_P13728

A_33_P3390758

GE79248

GO:0000166

GO:0000398

GO:0000974

GO:0001664

GO:0003723

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005681

GO:0005730

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005776

GO:0005829

GO:0005886

GO:0005925

GO:0006351

GO:0006355

GO:0006397

GO:0006457

GO:0006886

GO:0006914

GO:0006986

GO:0007018

GO:0008380

GO:0009267

GO:0016020

GO:0016071

GO:0016192

GO:0016787

GO:0016887

GO:0019899

GO:0023026

GO:0030163

GO:0030425

GO:0030674

GO:0031072

GO:0031410

GO:0031625

GO:0031647

GO:0034774

GO:0042026

GO:0042470

GO:0043195

GO:0043202

GO:0043226

GO:0043254

GO:0044183

GO:0045296

GO:0045892

GO:0046034

GO:0051082

GO:0051085

GO:0051087

GO:0055086

GO:0055131

GO:0060090

GO:0061024

GO:0061202

GO:0061635

GO:0061684

GO:0061738

GO:0061740

GO:0065003

GO:0070062

GO:0071383

GO:0072318

GO:0072562

GO:0098575

GO:0099523

GO:0099524

GO:0101031

GO:0140104

GO:0140545

GO:0140597

GO:0140657

GO:0140662

GO:1900226

GO:1901135

GO:1902904

GO:1904589

GO:1904764

GO:1904813

GO:1990832

GO:1990833

GO:1990904

HMNXSV003019988

Hs.180414.3.A1_3p_a_at

ILMN_1686367

ILMN_2413084

PH_hs_0039202

PH_hs_0040139

TC11002390.hg

g11526572_3p_a_at

Participates

as a member of

Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)

Other forms of this molecule

Me3K561-HSPA8 [nucleoplasm]

HSPA8 [secretory granule lumen]

HSPA8 [extracellular region]

HSPA8 [nucleoplasm]

HSPA8 [plasma membrane]

HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

HSPA8 [late endosome lumen]

HSPA8 [lysosomal lumen]

HSPA8 [cytosol]

Inferred To

LOC607182 [ficolin-1-rich granule lumen] (Canis familiaris)

Homologues of HSPA8 [ficolin-1-rich granule lumen] (Schizosaccharomyces pombe)

ssa2 [ficolin-1-rich granule lumen] (Schizosaccharomyces pombe)

ssa1 [ficolin-1-rich granule lumen] (Schizosaccharomyces pombe)

hsp-1 [ficolin-1-rich granule lumen] (Caenorhabditis elegans)

Hsc70-4 [ficolin-1-rich granule lumen] (Drosophila melanogaster)

hspa8 [ficolin-1-rich granule lumen] (Xenopus tropicalis)

HSPA8 [ficolin-1-rich granule lumen] (Bos taurus)

HSPA8 [ficolin-1-rich granule lumen] (Danio rerio)

HSPA8 [ficolin-1-rich granule lumen] (Gallus gallus)

HSPA8 [ficolin-1-rich granule lumen] (Mus musculus)

HSPA8 [ficolin-1-rich granule lumen] (Plasmodium falciparum)

HSPA8 [ficolin-1-rich granule lumen] (Rattus norvegicus)

HSPA8 [ficolin-1-rich granule lumen] (Sus scrofa)

SSA2 [ficolin-1-rich granule lumen] (Saccharomyces cerevisiae)

hspB [ficolin-1-rich granule lumen] (Dictyostelium discoideum)

Cross References

RefSeq

NP_694881.1, XP_011541100.1, NP_006588.1

Guide to Pharmacology - Targets

2543

OpenTargets

ENSG00000109971

ZINC - Substances

HSP7C_HUMAN

ZINC target

P11142

ZINC - Biogenic

HSP7C_HUMAN

PRO

P11142

PDB

3FZF, 4H5W, 5AQM, 3FZH, 6ZYJ, 5AQN, 5AQV, 3LDQ, 5AQL, 4H5V, 6B1I, 5AQU, 3AGZ, 5AQT, 3AGY, 4H5R, 5AQK, 4H5T, 5AQJ, 5AQS, 3ESK, 5AQQ, 3FZM, 5AQR, 5AQH, 4H5N, 4KBQ, 5AQI, 4HWI, 5AQO, 3FZK, 3FZL, 5AQP, 5AQF, 3M3Z, 6B1M, 6B1N, 5AQG

ZINC - Metabolites

HSP7C_HUMAN

HPA

ENSG00000109971-HSPA8

GeneCards

P11142

Ensembl

ENST00000453788, ENSG00000109971, ENST00000227378, ENSP00000437125, ENSP00000404372, ENST00000534624, ENSP00000227378, ENST00000532636, ENSP00000432083

Pharos - Targets

P11142

ZINC - Predictions - Purchasable

HSP7C_HUMAN

HMDB Protein

HMDBP13799

Interactors (160)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NZL4 HPBP1			0.924	15
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.871	9
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.823	10
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.813	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.803	7
UniProt:P34932 HSPA4	2	HSPA4 [cytosol] (R-HSA-5251946) HSPA4 [nucleoplasm] (R-HSA-5251998)	0.787	7
UniProt:O14976 GAK	3	GAK [cytoplasmic vesicle membrane] (R-HSA-434203) GAK [Golgi membrane] (R-HSA-434340) GAK [cytosol] (R-HSA-8868619)	0.763	9
UniProt:Q99933 BAG1	1	BAG1 [cytosol] (R-HSA-5255443)	0.719	13
UniProt:O00635 TRIM38	1	TRIM38 [cytosol] (R-HSA-5624325)	0.718	6
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.709	5
UniProt:Q3B7T1 EDRF1			0.671	6
UniProt:O75165 DNAJC13	3	DNAJC13 [secretory granule membrane] (R-HSA-6800951) DNAJC13 [plasma membrane] (R-HSA-6806255) DNAJC13 [azurophil granule membrane] (R-HSA-6799140)	0.671	6
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.671	5
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.671	6
UniProt:Q9UL15 BAG5	1	BAG5 [cytosol] (R-HSA-5255453)	0.671	9
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.669	4
UniProt:Q15750 TAB1	6	TAB1(445-504) [cytosol] (R-HSA-9729691) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.669	3
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.667	6
UniProt:P54253 ATX1			0.666	13
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.666	8
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.666	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	14
UniProt:Q8TDR0 TRAF3IP1	2	TRAF3IP1 [ciliary tip] (R-HSA-5625404) TRAF3IP1 [cilium] (R-HSA-5617603)	0.664	5
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.659	4
UniProt:Q99592 ZBT18			0.643	3
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.643	5
UniProt:Q96CP2 FWCH2			0.643	3
UniProt:Q9NVT9 ARMC1			0.643	4
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.643	3
UniProt:P00338 LDHA	2	PolyUb-LDHA [cytosol] (R-HSA-9861549) LDHA [cytosol] (R-HSA-70502)	0.639	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	22
UniProt:P38260 FES1			0.61	4
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.597	3
UniProt:Q92731 ESR2	5	PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.597	3
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB [nucleoplasm] (R-HSA-3321990) ACTB [cytosol] (R-HSA-201861) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [plasma membrane] (R-HSA-196016)	0.573	2
UniProt:Q99IB8-PRO_0000045603			0.57	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	11
UniProt:Q9BQC3 DPH2	1	DPH2 [cytosol] (R-HSA-5358368)	0.569	4
UniProt:Q99615 DNAJC7	2	DNAJC7 [cytosol] (R-HSA-5252099) DNAJC7 [nucleoplasm] (R-HSA-5255408)	0.569	3
UniProt:Q9H4A3 WNK1	1	WNK1 [cytosol] (R-HSA-2672391)	0.569	5
UniProt:Q9BZG8 DPH1	1	DPH1 [cytosol] (R-HSA-5358384)	0.569	4
UniProt:O95757 HSPA4L	2	HSPA4L [cytosol] (R-HSA-5251943) HSPA4L [nucleoplasm] (R-HSA-5252053)	0.569	4
UniProt:Q9H6T0 ESRP2	1	ESRP2 [nucleoplasm] (R-HSA-6803474)	0.564	2
UniProt:P57723 PCBP4	1	PCBP4 [cytosol] (R-HSA-6803382)	0.564	2
UniProt:Q8IZP0 ABI1	2	p-5S-ABI1 [cytosol] (R-HSA-2029034) ABI1 [cytosol] (R-HSA-1671643)	0.564	2
UniProt:Q14164 IKBKE	5	monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521)	0.564	2
UniProt:Q9ULK5 VANGL2	2	VANGL2 [plasma membrane] (R-HSA-3965373) pS5,S82,S84-VANGL2 [plasma membrane] (R-HSA-4551547)	0.564	2
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.564	3
UniProt:Q9BQI3 EIF2AK1	3	p-T-EIF2AK1 [cytosol] (R-HSA-9648892) p-T,T486,T488-EIF2AK1 [cytosol] (R-HSA-9648894) EIF2AK1 [cytosol] (R-HSA-9840382)	0.564	2
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.564	3
UniProt:P50552 VASP	1	VASP [cytosol] (R-HSA-446323)	0.564	2
UniProt:P01308-PRO_0000015820 INS			0.558	2
UniProt:P10636-6 MAPT			0.558	3
UniProt:P01893 HLA-H	8	HLA-H [azurophil granule membrane] (R-HSA-6799339) HLA-H [phagocytic vesicle membrane] (R-HSA-8855901) HLA-H [recycling endosome membrane] (R-HSA-8863855) HLA-H [early endosome membrane] (R-HSA-8855898) HLA-H [plasma membrane] (R-HSA-6806266) HLA-H [Golgi membrane] (R-HSA-8855895) HLA-H [ER to Golgi transport vesicle membrane] (R-HSA-8855892) HLA-H [lumenal side of endoplasmic reticulum membrane] (R-HSA-8855907)	0.558	2
UniProt:O60260-5 PRKN			0.556	9
UniProt:P41220 RGS2	1	RGS2 [plasma membrane] (R-HSA-939787)	0.553	2
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.547	2
UniProt:Q8N163 CCAR2	2	DBC1 [nucleoplasm] (R-HSA-3371479) p-T454-DBC1 [nucleoplasm] (R-HSA-3371569)	0.547	2
UniProt:Q96MN9 ZN488			0.527	3
UniProt:Q99439 CNN2	3	CNN2 [specific granule lumen] (R-HSA-6799532) CNN2 [extracellular region] (R-HSA-6806300) CNN2 [tertiary granule lumen] (R-HSA-6800942)	0.527	2
UniProt:Q9H9A6 LRC40			0.527	2
UniProt:Q00341 HDLBP	1	HDLBP [plasma membrane] (R-HSA-8858026)	0.527	2
UniProt:Q96BH1 RNF25	1	RNF25 [cytosol] (R-HSA-975976)	0.527	2
UniProt:P30679 GNA15	1	GNA15 [plasma membrane] (R-HSA-167450)	0.527	2
UniProt:Q9Y2I8 WDR37			0.527	5
UniProt:Q6ZMN8 CCNI2			0.527	2
UniProt:Q15555 MARE2			0.527	3
UniProt:Q9BYJ1 ALOXE3	1	ALOXE3 [cytosol] (R-HSA-8942204)	0.527	2
UniProt:P0DPA2 VSIG8			0.527	2
UniProt:Q9BXA7 TSSK1			0.527	2
UniProt:Q8IVL6 P3H3	1	LEPREL2 [endoplasmic reticulum lumen] (R-HSA-1650821)	0.527	2
UniProt:Q5TEC6 H37			0.527	2
UniProt:P40121 CAPG			0.527	2
UniProt:Q9Y6J9 TAF6L	1	TAF6L [nucleoplasm] (R-HSA-212393)	0.527	2
UniProt:Q53H47 SETMR			0.527	2
UniProt:P68871 HBB	8	CO-H+-HBB [cytosol] (R-HSA-1237013) HBB [ficolin-1-rich granule lumen] (R-HSA-6801015) HBB [tertiary granule lumen] (R-HSA-6800191) HBB [endocytic vesicle lumen] (R-HSA-2230936) HBB [extracellular region] (R-HSA-2168872) HBB [late endosome lumen] (R-HSA-9631108) HBB [cytosol] (R-HSA-1008196) HBB [lysosomal lumen] (R-HSA-9625193)	0.527	2
UniProt:O15530 PDPK1	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.527	4
UniProt:P00748 F12	11	F12 T328K (373-615) [extracellular region] (R-HSA-9655053) F12 T328R (373-615) [extracellular region] (R-HSA-9655055) F12 T328R (329-615) [extracellular region] (R-HSA-9653243) F12 T328K (329-615) [extracellular region] (R-HSA-9653252) F12 T328K(20-328) [extracellular region] (R-HSA-9653230) F12 T328R(20-328) [extracellular region] (R-HSA-9653225) F12 T328R [plasma membrane] (R-HSA-9653226) F12 T328K [plasma membrane] (R-HSA-9653238) factor XIIa heavy chain [extracellular region] (R-HSA-158285) factor XII [plasma membrane] (R-HSA-158214) factor XIIa light chain [extracellular region] (R-HSA-158320)	0.527	3
UniProt:Q96FZ2 HMCES			0.527	3
UniProt:P57076 CF298			0.527	3
UniProt:Q7L4E1 MIGA2	1	MIGA2 [mitochondrial outer membrane] (R-HSA-8954402)	0.527	2
UniProt:Q53H54 TRMT12	1	TRMT12 [cytoplasm] (R-HSA-6782860)	0.527	2
UniProt:Q8IYG6 LRC56			0.527	3
UniProt:Q8TDN2 KCNV2	1	KCNV2 [plasma membrane] (R-HSA-977505)	0.527	2
UniProt:Q9H7S9 ZNF703	1	ZNF703 [nucleoplasm] (R-HSA-2454149)	0.527	2
UniProt:P53367 ARFP1			0.527	3
UniProt:Q8N4P2 IFT70B	2	TTC30B [ciliary tip] (R-HSA-5637970) TTC30B [cilium] (R-HSA-5637971)	0.527	2
UniProt:Q8N239 KLH34			0.527	3
UniProt:Q9H6A0 DENND2D	1	DENND2D [cytosol] (R-HSA-8876071)	0.527	2
UniProt:Q6UXT9 ABH15			0.527	3
UniProt:P31350 RRM2	1	RRM2 [cytosol] (R-HSA-73639)	0.527	2
UniProt:Q6P158 DHX57			0.527	3
UniProt:A2VCK2 DCD2B			0.527	2
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.527	2
UniProt:Q6ZMP0 THSD4	3	THSD4 [endoplasmic reticulum lumen] (R-HSA-5173065) glc-fuc-THSD4 [endoplasmic reticulum lumen] (R-HSA-5173066) O-fuc-THSD4 [endoplasmic reticulum lumen] (R-HSA-5173088)	0.527	2
UniProt:Q2TAL8 QRIC1			0.527	3
UniProt:Q9H6K1 ILRUN			0.527	3
UniProt:Q9NVX7 KBTB4			0.527	2
UniProt:P55039 DRG2	2	3OHK21-DRG2 [cytosol] (R-HSA-9629595) DRG2 [cytosol] (R-HSA-9629597)	0.527	2
UniProt:Q9Y490 TLN1	4	TLN1 [extracellular region] (R-HSA-350693) TLN1(434-2541) [cytosol] (R-HSA-9855156) TLN1(1-433) [cytosol] (R-HSA-9855031) TLN1 [cytosol] (R-HSA-350713)	0.527	2
UniProt:P61011 SRP54	1	SRP54 [cytosol] (R-HSA-264977)	0.527	2
UniProt:Q309B1 TR16L			0.527	2
UniProt:Q96E22 NUS1	1	NUS1 [endoplasmic reticulum membrane] (R-HSA-6806946)	0.527	3
UniProt:Q8N4N3 KLH36			0.527	2
UniProt:Q9NZV8 KCND2	1	KCND2 [plasma membrane] (R-HSA-977453)	0.527	2
UniProt:Q38SD2 LRRK1			0.527	2
UniProt:Q2T9J0 TYSND1	4	TYSND1(111-566) [peroxisomal matrix] (R-HSA-9033589) TYSND1(1-110) [peroxisomal matrix] (R-HSA-9033587) TYSND1 [peroxisomal matrix] (R-HSA-8933309) TYSND1 [cytosol] (R-HSA-9033586)	0.527	2
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.527	2
UniProt:Q9NYQ3 HAO2	2	HAO2 [cytosol] (R-HSA-9033093) HAO2 [peroxisomal matrix] (R-HSA-6787806)	0.527	2
UniProt:Q6JEL2 KLH10			0.527	3
UniProt:Q96DF8 ESS2			0.527	2
UniProt:Q9NX65 ZSCAN32	1	ZSCAN32 [nucleoplasm] (R-HSA-1247547)	0.527	2
UniProt:P56555 DSCR4			0.527	2
UniProt:Q8N831 TSYL6			0.527	2
UniProt:Q14249 NUCG			0.527	3
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.527	3
UniProt:P69905 HBA1	4	CO-H+-HBA1 [cytosol] (R-HSA-1237026) HBA1 [cytosol] (R-HSA-1008268) HBA1 [endocytic vesicle lumen] (R-HSA-2230966) HBA1 [extracellular region] (R-HSA-2168862)	0.527	2
UniProt:Q9UJ71 CD207	3	CD207 [plasma membrane] (R-HSA-1216519) CD207 [clathrin-coated endocytic vesicle membrane] (R-HSA-1236762) CD207 [early endosome membrane] (R-HSA-1236852)	0.527	2
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.527	2
UniProt:Q99742 NPAS1			0.527	3
UniProt:Q9H0B6 KLC2	1	KLC2 [cytosol] (R-HSA-983191)	0.527	2
UniProt:P63092 GNAS	1	GNAS2 [plasma membrane] (R-HSA-164387)	0.527	2
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.527	2
UniProt:Q9Y5Z7 HCFC2	1	HCFC2 [nucleoplasm] (R-HSA-9821232)	0.527	3
UniProt:P22612 PRKACG	3	PRKACG [ciliary base] (R-HSA-5610405) PRKACG [cytosol] (R-HSA-57848) PRKACG [nucleoplasm] (R-HSA-111938)	0.527	2
UniProt:Q12874 SF3A3	1	SF3A3 [nucleoplasm] (R-HSA-71966)	0.527	2
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.527	3
UniProt:P27540 ARNT	1	ARNT [nucleoplasm] (R-HSA-1234098)	0.527	2
UniProt:A6NED2 RCCD1	2	3OHR141-RCCD1 [cytosol] (R-HSA-9629871) RCCD1 [cytosol] (R-HSA-9629873)	0.527	2
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.527	2
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.527	2
UniProt:Q8WXB1 METTL21A	1	METTL21A [nucleoplasm] (R-HSA-8876682)	0.527	3
UniProt:Q9UNU6 CYP8B1	1	CYP8B1 [endoplasmic reticulum membrane] (R-HSA-192012)	0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:Q96SI1 KCTD15	1	KCTD15 [nucleoplasm] (R-HSA-8864337)	0.527	2
UniProt:Q15813 TBCE	1	TBCE [cytosol] (R-HSA-379539)	0.527	2
UniProt:Q12948 FOXC1	1	FOXC1 [nucleoplasm] (R-HSA-3927815)	0.527	2
UniProt:P02768 ALB	7	ALB(19-609) [extracellular region] (R-HSA-114609) ALB [platelet alpha granule lumen] (R-HSA-49865) salicyl-ALB [extracellular region] (R-HSA-9750694) acetyl-ALB [extracellular region] (R-HSA-9749660) ALB [extracellular region] (R-HSA-194115) p-ALB [endoplasmic reticulum lumen] (R-HSA-8956930) ALB [endoplasmic reticulum lumen] (R-HSA-8956690)	0.527	2
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	3
UniProt:Q9Y6A5 TACC3	1	TACC3 [cytosol] (R-HSA-2160956)	0.527	2
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.527	3
UniProt:Q7Z6Z6 PNPLA5	1	PNPLA5 [cytosol] (R-HSA-8848346)	0.527	3
UniProt:Q6NZI2 PTRF	2	PTRF [nucleoplasm] (R-HSA-74981) CAVIN1 [plasma membrane] (R-HSA-9714278)	0.527	2
UniProt:P03485 M	6	M1 [plasma membrane] (R-FLU-195782) M1 [extracellular region] (R-FLU-169241) M1 [endocytic vesicle membrane] (R-FLU-189168) M1 [endosome lumen] (R-FLU-189155) M1 [cytosol] (R-FLU-169073) M1 [nucleoplasm] (R-FLU-186959)	0.524	4
UniProt:Q9NQ11 ATP13A2	1	ATP13A2 [lysosomal lumen] (R-HSA-939762)	0.508	2
UniProt:Q8AZK7 EBNA5			0.499	3
UniProt:P40692 MLH1	3	MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 [nucleoplasm] (R-HSA-912495)	0.499	2
UniProt:P14598 NCF1	4	NCF1 [cytosol] (R-HSA-1222296) p-6S-NCF1 [phagolysosome] (R-HSA-1996220) p-S345-NCF1 [cytosol] (R-HSA-9626824) p-6S-NCF1 [cytosol] (R-HSA-9626854)	0.499	2
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	4
UniProt:Q15131 CDK10			0.499	2
UniProt:Q9GZX7 AICDA	1	AICDA [nucleoplasm] (R-HSA-452477)	0.499	2
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.499	4
UniProt:P61764 STXBP1	2	STXBP1 [cytosol] (R-HSA-6794256) STXBP1 [plasma membrane] (R-HSA-2980862)	0.499	2
UniProt:Q99IB8-PRO_0000045599			0.488	2
UniProt:O15013 ARHGEF10	1	ARHGEF10 [cytosol] (R-HSA-8873917)	0.483	3
UniProt:Q9H9T3 ELP3	1	ELP3 [nucleoplasm] (R-HSA-3318364)	0.483	2
UniProt:O75190 DNAJB6	2	DNAJB6 [cytosol] (R-HSA-5252014) DNAJB6 [nucleoplasm] (R-HSA-5255425)	0.482	2
UniProt:O95801 TTC4			0.482	2

Cite Us!