Reactome | p-S158,S221-ELAVL1 [nucleoplasm]

p-S158,S221-ELAVL1 [nucleoplasm]

Stable Identifier

R-HSA-450576

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HuR with phosphoserine221 and phosphoserine158, ELAV-like protein 1, ELAV1_HUMAN, ELAVL1, HuR

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15717 ELAVL1

Gene Names

ELAVL1, HUR

Chain

initiator methionine:, chain:2-326

Reference Genes

BioGPS Gene:1994 ELAVL1

COSMIC (genes):ELAVL1 ELAVL1

CTD Gene:1994 ELAVL1

dbSNP Gene:1994 ELAVL1

ENSEMBL:ENSG00000066044 ELAVL1

HGNC:3312 ELAVL1

KEGG:hsa:1994 ELAVL1

Monarch:1994 ELAVL1

NCBI Gene:1994 ELAVL1

OMIM:603466 ELAVL1

UCSC:Q15717 ELAVL1

Reference Transcript

RefSeq:NM_001419.2 ELAVL1

Other Identifiers

11716528_at

11716529_a_at

11716530_at

11716531_at

11747207_a_at

16868053

1994

201726_PM_at

201726_at

201727_PM_s_at

201727_s_at

227746_PM_at

227746_at

244660_PM_at

244660_at

3848687

3848688

3848690

3848691

3848692

3848693

3848694

3848695

3848696

3848697

3848698

3848699

3848700

3848701

3848702

3848705

3848709

3848711

3848712

3848720

3848721

3848734

3848741

39384_at

59058_at

59834_at

8033479

A_23_P208477

A_23_P388681

A_32_P200165

GE59120

GE787419

GO:0000512

GO:0000932

GO:0003676

GO:0003723

GO:0003725

GO:0003729

GO:0003730

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005829

GO:0006606

GO:0006886

GO:0006913

GO:0010494

GO:0016020

GO:0016441

GO:0016528

GO:0019901

GO:0031047

GO:0031410

GO:0032930

GO:0035198

GO:0035925

GO:0042803

GO:0043226

GO:0045727

GO:0048255

GO:0051260

GO:0060965

GO:0061157

GO:0065003

GO:0070935

GO:0098794

GO:0098978

GO:0106222

GO:1990904

GO:2000036

HMNXSV003012794

Hs.129572.0.A1_3p_at

Hs.184492.0.A1_3p_at

ILMN_1764873

PH_hs_0029372

TC19001125.hg

U38175_at

g13097227_3p_at

g4503550_3p_a_at

Participates

as an input of

p-S158,221-HuR binds mRNA (Homo sapiens)

as a component of

HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm] (Homo sapiens)

as an output of

PKCalpha phosphorylates HuR (Homo sapiens)

Other forms of this molecule

ELAVL1 [nucleoplasm]

p-S221,S318-ELAVL1 [nucleoplasm]

ELAVL1 [cytosol]

p-S221,S318-ELAVL1 [cytosol]

p-S158,S221-ELAVL1 [cytosol]

Inferred To

phospho-Rbp9 [nucleoplasm] (Drosophila melanogaster)

phospho-ELAVL1 [nucleoplasm] (Bos taurus)

phospho-ELAVL1 [nucleoplasm] (Canis familiaris)

phospho-ELAVL1 [nucleoplasm] (Gallus gallus)

phospho-ELAVL1 [nucleoplasm] (Sus scrofa)

phospho-Elavl1 [nucleoplasm] (Mus musculus)

phospho-Elavl1 [nucleoplasm] (Rattus norvegicus)

phospho-elav [nucleoplasm] (Drosophila melanogaster)

phospho-fne [nucleoplasm] (Drosophila melanogaster)

phospho-elavl1 [nucleoplasm] (Xenopus tropicalis)

Homologues of p-S158,S221-ELAVL1 [nucleoplasm] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-serine at 158

Coordinate

158

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 221

Coordinate

221

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001410.2

OpenTargets

ENSG00000066044

ENSEMBL

ENST00000596459, ENSP00000472197, ENST00000407627, ENSP00000385269

HPA

ENSG00000066044-ELAVL1

ZINC - Substances

ELAV1_HUMAN

ZINC - Biogenic

ELAV1_HUMAN

ZINC target

Q15717

PRO

Q15717

Pharos - Targets

Q15717

GlyGen

Q15717

ZINC - Predictions - Purchasable

ELAV1_HUMAN

PDB

4FXV, 6GD1, 6GD2, 4ED5, 6GD3, 6G2K, 5SZW, 6GC5, 4EGL, 3HI9

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54253 ATX1			0.666	7
UniProt:Q13148 TADBP			0.61	7
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.597	4
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.577	5
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:Q15717 ELAVL1	6	ELAVL1 [nucleoplasm] (R-HSA-450601) p-S158,S221-ELAVL1 [nucleoplasm] (R-HSA-450576) p-S221,S318-ELAVL1 [nucleoplasm] (R-HSA-450532) ELAVL1 [cytosol] (R-HSA-450582) p-S221,S318-ELAVL1 [cytosol] (R-HSA-450448) p-S158,S221-ELAVL1 [cytosol] (R-HSA-450376)	0.553	2
UniProt:Q99IB8-PRO_0000045602			0.547	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.527	4
IntAct:EBI-25438148 LNC			0.524	3
IntAct:EBI-20218130 CALM2			0.524	3
IntAct:EBI-20218183 CD9			0.524	3
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.483	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	5
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:Q8IUH3 RBM45			0.462	2

Cite Us!