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P4HA2 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-2980974
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Prolyl 4-hydroxylase subunit alpha-2, P4HA2_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Collagen biosynthesis and modifying enzymes (Homo sapiens)
Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Homo sapiens)
Prolyl 4-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
Prolyl 4-hydroxylase alpha subunits [endoplasmic reticulum lumen] (Homo sapiens)
P4HA2 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15460 P4HA2
Gene Names
P4HA2, UNQ290/PRO330
Chain
signal peptide:1-21, chain:22-535
Reference Genes
BioGPS Gene:8974 P4HA2
COSMIC (genes):P4HA2 P4HA2
CTD Gene:8974 P4HA2
dbSNP Gene:8974 P4HA2
ENSEMBL:ENSG00000072682 P4HA2
HGNC:8547 P4HA2
Monarch:8974 P4HA2
NCBI Gene:8974 P4HA2
OMIM:600608 P4HA2
UCSC:O15460 P4HA2
Reference Transcript
RefSeq:XM_006714728.3 P4HA2
RefSeq:NM_001142599.1 P4HA2
RefSeq:XM_005272119.4 P4HA2
RefSeq:XM_005272118.4 P4HA2
RefSeq:XM_005272120.4 P4HA2
RefSeq:XM_006714729.3 P4HA2
RefSeq:NM_001142598.1 P4HA2
RefSeq:XM_005272117.4 P4HA2
RefSeq:NM_001017974.1 P4HA2
RefSeq:XM_005272116.4 P4HA2
RefSeq:XM_017010011.1 P4HA2
RefSeq:XM_006714730.3 P4HA2
RefSeq:NM_001017973.1 P4HA2
RefSeq:NM_004199.2 P4HA2
Other Identifiers
11717118_a_at
1555027_PM_at
1555027_at
1568611_PM_at
1568611_at
16999712
202733_PM_at
202733_at
2875194
2875195
2875196
2875197
2875198
2875199
2875200
2875201
2875202
2875205
2875206
2875207
2875208
2875209
2875213
2875215
2875217
2875219
2875220
2875221
2875222
2875223
2875224
2875226
2875227
2875231
2875232
2875233
2875234
2875238
2875239
2875240
2875241
2875242
2875243
2875244
2875246
2875248
2875258
2875259
2875260
2875261
2875262
2875267
34390_at
49945_at
75910_at
8113981
8114002
8974
A_23_P18966
A_23_P30363
A_24_P85400
A_32_P62145
A_33_P3394933
GE59538
GO:0003824
GO:0004656
GO:0005506
GO:0005515
GO:0005654
GO:0005783
GO:0005788
GO:0005829
GO:0009055
GO:0016491
GO:0016705
GO:0031418
GO:0043226
GO:0043231
GO:0046872
GO:0051213
GO:0140096
HMNXSV003002878
HMNXSV003030152
HMNXSV003032528
Hs2.104772.1.A1_3p_at
Hs2.374701.1.S1_3p_at
Hs2.374701.1.S1_3p_x_at
ILMN_1795778
ILMN_2280135
ILMN_2381697
PH_hs_0022260
TC05001763.hg
TC05003232.hg
TC05003234.hg
g4758867_3p_at
p13397
Participates
as a member of
Prolyl 4-hydroxylase alpha subunits [endoplasmic reticulum lumen] (Homo sapiens)
Inferred To
P4HA2 [endoplasmic reticulum lumen]
(Bos taurus)
P4HA2 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
P4HA2 [endoplasmic reticulum lumen]
(Canis familiaris)
P4HA2 [endoplasmic reticulum lumen]
(Gallus gallus)
P4HA2 [endoplasmic reticulum lumen]
(Mus musculus)
P4HA2 [endoplasmic reticulum lumen]
(Sus scrofa)
P4ha2 [endoplasmic reticulum lumen]
(Rattus norvegicus)
phy-3 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
phy-4 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
p4ha2 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Homologues of P4HA2 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Cross References
OpenTargets
ENSG00000072682
ENSEMBL
ENSP00000384999
,
ENSP00000166534
,
ENST00000379086
,
ENST00000379100
,
ENSP00000368394
,
ENST00000166534
,
ENST00000379104
,
ENSP00000368379
,
ENST00000360568
,
ENSP00000353772
,
ENST00000401867
,
ENSP00000368398
HPA
ENSG00000072682-P4HA2
PRO
O15460
Pharos - Targets
O15460
GlyGen
O15460
PDB
6EVM
,
6EVN
,
6EVL
,
6EVO
,
6EVP
,
7ZSC
HMDB Protein
HMDBP00302
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.657
4
UniProt:P02452 COL1A1
20
3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023648)
3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023667)
GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023604)
GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022999)
3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023559)
3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023582)
COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1650777)
3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985659)
3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022446)
3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022951)
3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022954)
5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985663)
Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396137)
Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396440)
Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396471)
Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396464)
Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396068)
Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396388)
Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396315)
Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396441)
0.623
3
UniProt:Q2M1P5 KIF7
1
KIF7 [ciliary tip]
(R-HSA-5610395)
0.564
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
4
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