Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
NEDD4L [nucleoplasm]
Stable Identifier
R-HSA-2176420
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
E3 ubiquitin-protein ligase NEDD4-like, NED4L_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
NEDD4L ubiquitin ligase binds SMAD7 (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
SMAD7:NEDD4L [nucleoplasm] (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
SMAD7:NEDD4L complex translocates to the cytosol (Homo sapiens)
SMAD7:NEDD4L [nucleoplasm] (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
NEDD4L [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96PU5 NEDD4L
Gene Names
NEDD4L, KIAA0439, NEDL3
Chain
initiator methionine:, chain:2-975
Reference Genes
BioGPS Gene:23327 NEDD4L
COSMIC (genes):NEDD4L NEDD4L
CTD Gene:23327 NEDD4L
dbSNP Gene:23327 NEDD4L
ENSEMBL:ENSG00000049759 NEDD4L
HGNC:7728 NEDD4L
KEGG:hsa:23327 NEDD4L
Monarch:23327 NEDD4L
NCBI Gene:23327 NEDD4L
OMIM:606384 NEDD4L
UCSC:Q96PU5 NEDD4L
Reference Transcript
RefSeq:NM_001243960.1 NEDD4L
RefSeq:NM_015277.5 NEDD4L
RefSeq:NM_001144969.1 NEDD4L
RefSeq:NM_001144964.1 NEDD4L
RefSeq:XM_017025679.1 NEDD4L
RefSeq:NM_001144966.2 NEDD4L
RefSeq:NM_001144965.1 NEDD4L
RefSeq:NM_001144967.2 NEDD4L
RefSeq:NM_001144971.1 NEDD4L
RefSeq:NM_001144968.1 NEDD4L
RefSeq:NM_001144970.2 NEDD4L
Participates
as a component of
Smad7:NEDD4L [nucleoplasm] (Homo sapiens)
SMAD7:NEDD4L [nucleoplasm] (Homo sapiens)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Homo sapiens)
as an input of
NEDD4L binds Smad7 (Homo sapiens)
NEDD4L ubiquitin ligase binds SMAD7 (Homo sapiens)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)
as an output of
NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)
Other forms of this molecule
NEDD4L [cytosol]
Inferred To
Nedd4 [nucleoplasm]
(Drosophila melanogaster)
Nedd4l [nucleoplasm]
(Mus musculus)
Nedd4l [nucleoplasm]
(Rattus norvegicus)
NEDD4L [nucleoplasm]
(Bos taurus)
NEDD4L [nucleoplasm]
(Caenorhabditis elegans)
NEDD4L [nucleoplasm]
(Canis familiaris)
NEDD4L [nucleoplasm]
(Gallus gallus)
NEDD4L [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001138441.1
,
NP_001138436.1
,
NP_001138442.1
,
NP_001138443.1
,
NP_001138437.1
,
XP_016881168.1
,
NP_001138440.1
,
NP_001230889.1
,
NP_056092.2
,
NP_001138439.1
,
NP_001138438.1
OpenTargets
ENSG00000049759
ENSEMBL
ENSP00000502003
,
ENSP00000383199
,
ENSP00000393395
,
ENSP00000348847
,
ENSP00000502688
,
ENSP00000502325
,
ENST00000400345
,
ENST00000456173
,
ENST00000382850
,
ENST00000675502
,
ENST00000675865
,
ENST00000675801
,
ENSP00000411947
,
ENSP00000501665
,
ENSP00000350569
,
ENST00000435432
,
ENSP00000256830
,
ENST00000357895
,
ENST00000356462
,
ENSG00000049759
,
ENST00000431212
,
ENST00000674517
,
ENSP00000389406
,
ENST00000676226
,
ENSP00000372301
,
ENST00000586263
,
ENSP00000405440
,
ENST00000256830
,
ENSP00000468546
,
ENST00000456986
,
ENSP00000502428
GeneCards
NEDD4L
HPA
ENSG00000049759-NEDD4L
PRO
Q96PU5
Pharos - Targets
Q96PU5
GlyGen
Q96PU5
Orphanet
NEDD4L
HMDB Protein
HMDBP02282
PDB
2LAJ
,
2LTY
,
2MPT
,
7LP1
,
5HPK
,
3JVZ
,
7LP4
,
6ZC9
,
6ZBT
,
2ONI
,
7LP2
,
2NSQ
,
7NMZ
,
3JW0
,
7LP5
,
2LB2
,
7LP3
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.758
5
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.745
5
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.727
6
UniProt:Q96B67 ARRD3
0.702
4
UniProt:Q9BZD6 TMG4
0.656
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
8
UniProt:Q15038 DAZP2
0.556
3
UniProt:Q15884 EREP1
0.547
4
UniProt:Q13571 LAPM5
0.547
2
UniProt:Q8NCT1 ARRD4
0.527
2
UniProt:Q8N5I2 ARRD1
0.527
4
UniProt:Q4VCS5 AMOT
0.527
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.483
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text