Reactome | NEDD4L [nucleoplasm]

NEDD4L [nucleoplasm]

Stable Identifier

R-HSA-2176420

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase NEDD4-like, NED4L_HUMAN

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External Reference Information

External Reference

UniProt:Q96PU5 NEDD4L

Gene Names

NEDD4L, KIAA0439, NEDL3

Chain

initiator methionine:1, chain:2-975

Reference Genes

BioGPS Gene:23327 NEDD4L

COSMIC (genes):NEDD4L NEDD4L

CTD Gene:23327 NEDD4L

dbSNP Gene:23327 NEDD4L

ENSEMBL:ENSG00000049759 NEDD4L

ENSEMBL:ENSG00000049759.20 NEDD4L

HGNC:7728 NEDD4L

KEGG Gene (Homo sapiens):23327 NEDD4L

Monarch:23327 NEDD4L

NCBI Gene:23327 NEDD4L

OMIM:606384 NEDD4L

UCSC:Q96PU5 NEDD4L

Reference Transcript

Other Identifiers

11722423_a_at

11722424_a_at

11722425_s_at

11741140_s_at

11741141_x_at

11741547_a_at

11758571_s_at

16852573

212445_PM_s_at

212445_s_at

212448_PM_at

212448_at

226974_PM_at

226974_at

23327

241396_PM_at

241396_at

3789948

3789949

3789950

3789951

3789952

3789953

3789968

3789978

3789990

3790002

3790007

3790012

3790022

3790023

3790024

3790028

3790041

3790042

3790043

3790046

3790047

3790048

3790049

3790050

3790052

3790055

3790056

3790058

3790059

3790061

3790064

3790070

3790073

3790074

3790076

3790080

3790082

3790085

3790088

3790089

3790096

3790099

3790100

3790103

3790104

3790105

3790106

3790107

3790108

3790109

3790110

3790111

3790157

3790158

3790160

39356_at

51287_at

67652_at

8021376

A_14_P110610

A_23_P27279

A_23_P387856

A_24_P108311

A_24_P782308

A_33_P3391005

GE53186

GO:0003012

GO:0003013

GO:0003254

GO:0003824

GO:0004842

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005771

GO:0005794

GO:0005829

GO:0005886

GO:0006511

GO:0006513

GO:0015459

GO:0016192

GO:0016567

GO:0016740

GO:0017080

GO:0019870

GO:0019871

GO:0030154

GO:0030163

GO:0031410

GO:0031647

GO:0034220

GO:0034765

GO:0036211

GO:0042391

GO:0043161

GO:0043226

GO:0044325

GO:0045732

GO:0048814

GO:0048856

GO:0055085

GO:0060306

GO:0061630

GO:0070062

GO:0070936

GO:0086005

GO:0098772

GO:0140096

GO:1901016

GO:1901017

GO:1901380

GO:1902305

GO:1902306

GO:1903861

GO:2000009

GO:2000650

GO:2001288

HMNXSV003057322

Hs.12017.1.S1_3p_a_at

Hs.12017.1.S2_3p_at

Hs.3731.0.S1_3p_at

ILMN_1733627

PH_hs_0023225

TC18000202.hg

TC18000730.hg

TC18000731.hg

Participates

as a component of

as an input of

as an output of

NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)

Other forms of this molecule

NEDD4L [cytosol]

Inferred To

nedd4l [nucleoplasm] (Xenopus tropicalis)

Nedd4 [nucleoplasm] (Drosophila melanogaster)

Nedd4l [nucleoplasm] (Mus musculus)

NEDD4L [nucleoplasm] (Bos taurus)

NEDD4L [nucleoplasm] (Caenorhabditis elegans)

NEDD4L [nucleoplasm] (Canis familiaris)

NEDD4L [nucleoplasm] (Danio rerio)

NEDD4L [nucleoplasm] (Gallus gallus)

NEDD4L [nucleoplasm] (Rattus norvegicus)

NEDD4L [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001138436.1, NP_001138439.1, NP_001138441.1, NP_001138437.1, NP_001138442.1, NP_001138443.1, NP_001138438.1, NP_001138440.1, NP_001230889.1, NP_056092.2, XP_016881168.1

OpenTargets

ENSG00000049759

HPA

ENSG00000049759-NEDD4L

GeneCards

Q96PU5

Ensembl

ENST00000676226, ENSP00000502003, ENST00000674517, ENSP00000383199, ENSP00000348847, ENSP00000502325, ENSP00000502688, ENSP00000393395, ENST00000675801, ENSG00000049759, ENST00000431212, ENSP00000411947, ENSP00000501665, ENST00000675502, ENST00000675865, ENST00000357895, ENSP00000350569, ENST00000356462, ENST00000456986, ENSP00000372301, ENST00000435432, ENSP00000256830, ENST00000456173, ENST00000382850, ENST00000400345, ENSP00000502428, ENST00000256830, ENSP00000389406, ENSP00000405440, ENSP00000468546, ENST00000586263

PRO

Q96PU5

Pharos - Targets

Q96PU5

Orphanet

24755

HMDB Protein

HMDBP02282

PDB

7NMZ, 2LAJ, 3JVZ, 7LP2, 5HPK, 7LP5, 7LP1, 2NSQ, 6ZC9, 3JW0, 2ONI, 2LTY, 7LP4, 7LP3, 2MPT, 6ZBT, 2LB2

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q4VCS5 AMOT			0.564	2
UniProt:Q15038 DAZP2			0.556	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.547	2
UniProt:Q9BZD6 TMG4			0.544	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6
UniProt:Q96B67 ARRD3			0.482	2

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