Reactome | NEDD4L [nucleoplasm]

NEDD4L [nucleoplasm]

Stable Identifier

R-HSA-2176420

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase NEDD4-like, NED4L_HUMAN

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External Reference Information

External Reference

UniProt:Q96PU5 NEDD4L

Gene Names

NEDD4L, KIAA0439, NEDL3

Chain

initiator methionine:, chain:2-975

Reference Genes

BioGPS Gene:23327 NEDD4L

COSMIC (genes):NEDD4L NEDD4L

CTD Gene:23327 NEDD4L

dbSNP Gene:23327 NEDD4L

ENSEMBL:ENSG00000049759 NEDD4L

HGNC:7728 NEDD4L

KEGG:hsa:23327 NEDD4L

Monarch:23327 NEDD4L

NCBI Gene:23327 NEDD4L

OMIM:606384 NEDD4L

UCSC:Q96PU5 NEDD4L

Reference Transcript

Participates

as a component of

as an input of

as an output of

NEDD4L ubiquitinates SMAD2/3 (Homo sapiens)

Other forms of this molecule

NEDD4L [cytosol]

Inferred To

Nedd4 [nucleoplasm] (Drosophila melanogaster)

Nedd4l [nucleoplasm] (Mus musculus)

Nedd4l [nucleoplasm] (Rattus norvegicus)

NEDD4L [nucleoplasm] (Bos taurus)

NEDD4L [nucleoplasm] (Caenorhabditis elegans)

NEDD4L [nucleoplasm] (Canis familiaris)

NEDD4L [nucleoplasm] (Gallus gallus)

NEDD4L [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001138441.1, NP_001138436.1, NP_001138442.1, NP_001138443.1, NP_001138437.1, XP_016881168.1, NP_001138440.1, NP_001230889.1, NP_056092.2, NP_001138439.1, NP_001138438.1

OpenTargets

ENSG00000049759

ENSEMBL

ENSP00000502003, ENSP00000383199, ENSP00000393395, ENSP00000348847, ENSP00000502688, ENSP00000502325, ENST00000400345, ENST00000456173, ENST00000382850, ENST00000675502, ENST00000675865, ENST00000675801, ENSP00000411947, ENSP00000501665, ENSP00000350569, ENST00000435432, ENSP00000256830, ENST00000357895, ENST00000356462, ENSG00000049759, ENST00000431212, ENST00000674517, ENSP00000389406, ENST00000676226, ENSP00000372301, ENST00000586263, ENSP00000405440, ENST00000256830, ENSP00000468546, ENST00000456986, ENSP00000502428

GeneCards

NEDD4L

HPA

ENSG00000049759-NEDD4L

PRO

Q96PU5

Pharos - Targets

Q96PU5

GlyGen

Q96PU5

Orphanet

NEDD4L

HMDB Protein

HMDBP02282

PDB

2LAJ, 2LTY, 2MPT, 7LP1, 5HPK, 3JVZ, 7LP4, 6ZC9, 6ZBT, 2ONI, 7LP2, 2NSQ, 7NMZ, 3JW0, 7LP5, 2LB2, 7LP3

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.758	5
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.745	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.727	6
UniProt:Q96B67 ARRD3			0.702	4
UniProt:Q9BZD6 TMG4			0.656	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	8
UniProt:Q15038 DAZP2			0.556	3
UniProt:Q15884 EREP1			0.547	4
UniProt:Q13571 LAPM5			0.547	2
UniProt:Q8NCT1 ARRD4			0.527	2
UniProt:Q8N5I2 ARRD1			0.527	4
UniProt:Q4VCS5 AMOT			0.527	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.483	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	2

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