Reactome | KIF5B [cytosol]

KIF5B [cytosol]

Stable Identifier

R-HSA-265181

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitous kinesin heavy chain, Kinesin-1 heavy chain, ubiquitous form, uKHC

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate KTN1 (Homo sapiens)
        
        KTN1 binds Kinesin-1 (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        Kinesin-1 heavy chain [cytosol] (Homo sapiens)
        
        KIF5B [cytosol] (Homo sapiens)
        
        RHOA,RHOG,RAC1,CDC42:GTP:KTN1:Kinesin-1 [endoplasmic reticulum membrane] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        Kinesin-1 heavy chain [cytosol] (Homo sapiens)
        
        KIF5B [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        Kinesin-1 heavy chain [cytosol] (Homo sapiens)
        
        KIF5B [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        Kinesin-1 heavy chain [cytosol] (Homo sapiens)
        
        KIF5B [cytosol] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        Kinesin-1 heavy chain [cytosol] (Homo sapiens)
        
        KIF5B [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Kinesin-1 [cytosol] (Homo sapiens)
        
        Kinesin-1 heavy chain [cytosol] (Homo sapiens)
        
        KIF5B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P33176 KIF5B

Gene Names

KIF5B, KNS, KNS1

Chain

initiator methionine:, chain:2-963

Reference Genes

BioGPS Gene:3799 KIF5B

COSMIC (genes):KIF5B KIF5B

CTD Gene:3799 KIF5B

dbSNP Gene:3799 KIF5B

ENSEMBL:ENSG00000170759 KIF5B

ENSEMBL_homo_sapiens_GENE:ENSG00000170759.11 KIF5B

HGNC:6324 KIF5B

KEGG Gene (Homo sapiens):3799 KIF5B

Monarch:3799 KIF5B

NCBI Gene:3799 KIF5B

OMIM:602809 KIF5B

Reference Transcript

RefSeq:NM_004521.2 KIF5B

Other Identifiers

11736059_a_at

11736060_a_at

11746185_a_at

11757809_s_at

16713085

201991_PM_s_at

201991_s_at

201992_PM_s_at

201992_s_at

224662_PM_at

224662_at

3283990

3283992

3283993

3283994

3283995

3283997

3283998

3283999

3284000

3284001

3284002

3284004

3284005

3284006

3284010

3284012

3284014

3284017

3284018

3284019

3284020

3284022

3284023

3284024

3284025

3284026

3284027

3284028

3284029

3284033

3284035

3284036

3284037

34732_at

3799

57037_at

7932911

A_23_P86403

A_33_P3292332

A_33_P3292337

GE59917

GO:0000166

GO:0002376

GO:0003774

GO:0003777

GO:0003824

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0005764

GO:0005765

GO:0005773

GO:0005815

GO:0005829

GO:0005856

GO:0005871

GO:0005874

GO:0005929

GO:0006886

GO:0007005

GO:0007018

GO:0007028

GO:0007411

GO:0008017

GO:0008092

GO:0008574

GO:0016020

GO:0016787

GO:0016887

GO:0023052

GO:0030139

GO:0030154

GO:0031410

GO:0031982

GO:0032230

GO:0032418

GO:0032839

GO:0034451

GO:0035253

GO:0035617

GO:0042267

GO:0042391

GO:0042802

GO:0043005

GO:0043226

GO:0043227

GO:0043268

GO:0044877

GO:0045296

GO:0045335

GO:0047496

GO:0047497

GO:0048471

GO:0048489

GO:0048856

GO:0051642

GO:0071346

GO:0072383

GO:0072659

GO:0098542

GO:0098971

GO:0099641

GO:0101004

GO:0140657

GO:0160040

GO:1903078

GO:1904115

GO:1990048

GO:1990049

HMNXSV003023944

Hs.149436.0.A1_3p_a_at

Hs.149436.1.A1_3p_at

ILMN_1788160

PH_hs_0008995

TC10001160.hg

X65873_at

g4758647_3p_a_at

Participates

as a member of

KIF5B-like proteins [cytosol] (Homo sapiens)

as a candidate of

Kinesin-1 heavy chain [cytosol] (Homo sapiens)

Other forms of this molecule

KIF5B(2-575)-p-7Y-ALK(1063-1620) fusion [cytosol]

KIF5B(2-575)-ALK(1063-1620) fusion [cytosol]

Inferred To

KIF5B [cytosol] (Bos taurus)

KIF5B [cytosol] (Caenorhabditis elegans)

KIF5B [cytosol] (Canis familiaris)

KIF5B [cytosol] (Drosophila melanogaster)

KIF5B [cytosol] (Mus musculus)

KIF5B [cytosol] (Rattus norvegicus)

KIF5B [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_004512.1

OpenTargets

ENSG00000170759

GeneCards

P33176

HPA

ENSG00000170759-KIF5B

ZINC target

P33176

Ensembl

ENSP00000307078, ENSG00000170759, ENST00000302418

PRO

P33176

Pharos - Targets

P33176

PDB

8IXB, 3J8Y, 3J8X, 5LT4, 8IXD, 4LNU, 4HNA, 2P4N, 1MKJ, 8IXE, 5LT1, 5LT0, 7RIK, 6OJQ, 5LT2, 1BG2, 8IXF, 8IXA, 8IXG, 5LT3

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.895	7
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.806	5
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	3
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.556	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	2
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.527	2
UniProt:O14977 AZIN1	1	AZIN1 [cytosol] (R-HSA-350615)	0.527	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	9