Reactome | RPS29 [cytosol]

RPS29 [cytosol]

Stable Identifier

R-HSA-72367

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 29, P30054, 40S ribosomal protein S29

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS29 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62273 RPS29

Gene Names

RPS29

Chain

initiator methionine:, chain:2-56

Reference Genes

BioGPS Gene:6235 RPS29

COSMIC (genes):RPS29 RPS29

CTD Gene:6235 RPS29

dbSNP Gene:6235 RPS29

ENSEMBL:ENSG00000213741 RPS29

ENSEMBL_homo_sapiens_GENE:ENSG00000213741.11 RPS29

HGNC:10419 RPS29

KEGG Gene (Homo sapiens):6235 RPS29

Monarch:6235 RPS29

NCBI Gene:6235 RPS29

OMIM:603633 RPS29

UCSC:P62273 RPS29

Reference Transcript

Other Identifiers

11730323_at

11757080_s_at

11757629_x_at

16792486

201094_PM_at

201094_at

2368513

238824_PM_at

238824_at

35278_at

3563312

3563314

3563316

3563318

3563319

3563320

3563321

3563328

3563329

3563331

3563332

3563338

3563339

61585_at

6235

63222_at

7978824

7978831

82813_at

A_23_P76961

A_24_P548354

A_33_P3282840

GE530023

GE757943

GE841870

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005791

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0008270

GO:0015935

GO:0022627

GO:0043226

GO:0046872

GO:0070062

GO:0098556

GO:1990904

HMNXSV003027734

Hs.145569.0.A1_3p_at

ILMN_1694742

ILMN_1738243

ILMN_2298818

ILMN_2415722

PH_hs_0008655

TC14001098.hg

U14973_at

g4506716_3p_at

Participates

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

RPS29 [nucleoplasm]

Inferred To

rps29 [cytosol] (Danio rerio)

rps29 [cytosol] (Schizosaccharomyces pombe)

rps29 [cytosol] (Xenopus tropicalis)

RPS29 [cytosol] (Bos taurus)

RPS29 [cytosol] (Canis familiaris)

RPS29 [cytosol] (Dictyostelium discoideum)

RPS29 [cytosol] (Drosophila melanogaster)

RPS29 [cytosol] (Gallus gallus)

RPS29 [cytosol] (Mus musculus)

RPS29 [cytosol] (Plasmodium falciparum)

RPS29 [cytosol] (Rattus norvegicus)

RPS29 [cytosol] (Sus scrofa)

RPS29A [cytosol] (Saccharomyces cerevisiae)

rps-29 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001023.1, NP_001025172.1

OpenTargets

ENSG00000213741

HPA

ENSG00000213741-RPS29

GeneCards

P62273

Ensembl

ENSG00000213741, ENSP00000245458, ENSP00000495033, ENST00000556230, ENST00000396020, ENST00000245458, ENSP00000379339

PRO

P62273

Pharos - Targets

P62273

Orphanet

22967

PDB

8GLP, 6ZP4, 8OZ0, 6OLG, 8IFE, 5VYC, 8G6J, 6ZUO, 6Z6N, 4UG0, 7QP6, 6ZM7, 6ZOL, 6ZN5, 5OA3, 7XNX, 7TQL, 6ZLW, 5AJ0, 6Z6M, 6ZMW, 6ZVJ, 8JDJ, 6Y57, 6G51, 8T4S, 6ZMT, 6OM7, 6ZXE, 6FEC, 8G5Y, 8JDL, 8PPK, 8G61, 5A2Q, 6ZMO, 6Y2L, 6ZXH, 6Y0G, 8PPL, 6IP5, 6G5I, 6OLI, 8Y0X, 6ZV6, 6ZME, 5LKS, 6OLF, 6XA1, 8IFD, 5T2C, 7K5I, 6ZON, 7QP7, 6OLE, 7XNY, 6G53, 7A09, 8JDK, 6Z6L, 7R4X, 6ZOJ, 6ZXD, 6OLZ, 6ZXF, 5FLX, 8JDM, 8G5Z, 6ZVH, 6QZP, 6OM0, 8G60, 6IP8, 6YBS, 6ZXG, 4V6X, 6ZMI, 6G5H, 6IP6, 8Y0W

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.607	3
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	9

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