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L-selenocysteine residue-GPX1 [cytosol]
Stable Identifier
R-HSA-71673
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GPX1, glutathione peroxidase monomer, GSHC_HUMAN, Glutathione peroxidase 1 , GSHPx-1, Cellular glutathione peroxidase
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
GPX1 tetramer [cytosol] (Homo sapiens)
L-selenocysteine residue-GPX1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of 12-eicosatetraenoic acid derivatives (Homo sapiens)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Homo sapiens)
GPX1/2/4 [cytosol] (Homo sapiens)
GPX1 tetramer [cytosol] (Homo sapiens)
L-selenocysteine residue-GPX1 [cytosol] (Homo sapiens)
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Homo sapiens)
GPX1/2/4 [cytosol] (Homo sapiens)
GPX1 tetramer [cytosol] (Homo sapiens)
L-selenocysteine residue-GPX1 [cytosol] (Homo sapiens)
Synthesis of 15-eicosatetraenoic acid derivatives (Homo sapiens)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Homo sapiens)
GPX1/2/4 [cytosol] (Homo sapiens)
GPX1 tetramer [cytosol] (Homo sapiens)
L-selenocysteine residue-GPX1 [cytosol] (Homo sapiens)
Synthesis of 5-eicosatetraenoic acids (Homo sapiens)
5S-HpETE is reduced to 5S-HETE by GPX1/2/4 (Homo sapiens)
GPX1/2/4 [cytosol] (Homo sapiens)
GPX1 tetramer [cytosol] (Homo sapiens)
L-selenocysteine residue-GPX1 [cytosol] (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Nucleobase catabolism (Homo sapiens)
Purine catabolism (Homo sapiens)
2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
GPX1 tetramer [cytosol] (Homo sapiens)
L-selenocysteine residue-GPX1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07203 GPX1
Gene Names
GPX1
Chain
chain:1-203
Reference Genes
BioGPS Gene:2876 GPX1
COSMIC (genes):GPX1 GPX1
CTD Gene:2876 GPX1
dbSNP Gene:2876 GPX1
ENSEMBL:ENSG00000233276 GPX1
HGNC:4553 GPX1
KEGG Gene (Homo sapiens):2876 GPX1
Monarch:2876 GPX1
NCBI Gene:2876 GPX1
OMIM:138320 GPX1
UCSC:P07203 GPX1
Reference Transcript
RefSeq:NM_000581.3 GPX1
Other Identifiers
0001190047
11725346_x_at
11757455_x_at
16954048
200736_s_at
2674230
2674231
2674232
2674233
2674234
2674235
2674236
2674237
2674238
2674239
2674240
2674241
2876
37033_s_at
4000050
4000052
4000056
4000064
8087405
8180346
A_23_P250671
A_33_P3239849
GE80927
GO:0000302
GO:0001659
GO:0001885
GO:0002376
GO:0002862
GO:0003013
GO:0003674
GO:0004601
GO:0004602
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0006195
GO:0006464
GO:0006629
GO:0006641
GO:0006749
GO:0006790
GO:0006950
GO:0006979
GO:0007005
GO:0007165
GO:0007605
GO:0008150
GO:0008219
GO:0008283
GO:0009056
GO:0009058
GO:0009410
GO:0009609
GO:0009611
GO:0009636
GO:0009650
GO:0010269
GO:0010332
GO:0014902
GO:0016491
GO:0017124
GO:0018158
GO:0019369
GO:0019372
GO:0030154
GO:0033194
GO:0033599
GO:0034599
GO:0034641
GO:0034655
GO:0040007
GO:0040011
GO:0040029
GO:0042311
GO:0042542
GO:0042592
GO:0042744
GO:0043154
GO:0043226
GO:0043403
GO:0043534
GO:0044281
GO:0044403
GO:0045444
GO:0045454
GO:0047066
GO:0048646
GO:0048741
GO:0048856
GO:0048870
GO:0050877
GO:0051186
GO:0051450
GO:0051702
GO:0051897
GO:0055114
GO:0060047
GO:0060055
GO:0061136
GO:0090201
GO:0097413
GO:0098869
GO:1902042
GO:1902176
GO:1902905
ILMN_1749662
ILMN_1787412
PH_hs_0028977
PH_hs_0035460
TC03001407.hg
Y00433_at
g10834975_3p_a_at
Participant Of
hasComponent
GPX1 tetramer [cytosol]
Other forms of this molecule
L-selenoC49-GPX1 [mitochondrial matrix]
Inferred To
GPX1 [cytosol] (Canis familiaris)
GPX1 [cytosol] (Gallus gallus)
L-selenocysteine residue-GPX1 [cytosol] (Sus scrofa)
Gpx1 [cytosol] (Mus musculus)
Gpx1 [cytosol] (Rattus norvegicus)
gpx-5 [cytosol] (Caenorhabditis elegans)
gpx1 [cytosol] (Xenopus tropicalis)
gpx1b [cytosol] (Danio rerio)
Modified Residues
Name
L-selenocysteine residue at 49
Coordinate
49
PsiMod Name
L-selenocysteine residue
PsiMod Definition
A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification.
Cross References
RefSeq
NP_000572.2
Target Pathogen
5b354852be737e166372ee90
OpenTargets
ENSG00000233276
GeneCards
P07203
Ensembl
ENSG00000233276
,
ENST00000419783
,
ENSP00000407375
,
ENSP00000391316
,
ENST00000419349
PRO
P07203
Orphanet
24574
HMDB Protein
HMDBP00828
PDB
2F8A
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