Reactome | SEC23A [cytosol]

SEC23A [cytosol]

Stable Identifier

R-HSA-203972

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein transport protein Sec23A, S23A_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        procollagen VII:SEC24C:SEC23A [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        SEC23:SEC24 [cytosol] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        Loss of SAR1B GTPase (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        SEC23:SEC24 [cytosol] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        Cargo concentration in the ER (Homo sapiens)
        
        Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        SEC23:SEC24 [cytosol] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        MIA2 and MIA3 load procollagen VII into COPII vesicles (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        SEC24A,B:SEC23A bind SEC22B (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        SEC4C,D bind GOSR2 and STX5 (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        procollagen VII:SEC24C:SEC23A [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
      - Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        SEC23:SEC24 [cytosol] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
      - Loss of SAR1B GTPase (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        SEC23:SEC24 [cytosol] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
      - SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
    - Cargo concentration in the ER (Homo sapiens)
      - Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        SEC23:SEC24 [cytosol] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
      - MIA2 and MIA3 load procollagen VII into COPII vesicles (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
      - SEC24A,B:SEC23A bind SEC22B (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
      - SEC4C,D bind GOSR2 and STX5 (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15436 SEC23A

Gene Names

SEC23A

Chain

initiator methionine:, chain:2-765

Reference Genes

BioGPS Gene:10484 SEC23A

COSMIC (genes):SEC23A SEC23A

CTD Gene:10484 SEC23A

dbSNP Gene:10484 SEC23A

ENSEMBL:ENSG00000100934 SEC23A

ENSEMBL_homo_sapiens_GENE:ENSG00000100934.15 SEC23A

HGNC:10701 SEC23A

KEGG Gene (Homo sapiens):10484 SEC23A

Monarch:10484 SEC23A

NCBI Gene:10484 SEC23A

OMIM:610511 SEC23A

UCSC:Q15436 SEC23A

Reference Transcript

RefSeq:NM_006364.3 SEC23A

Other Identifiers

10484

11722354_at

11747925_a_at

11749485_x_at

11752872_a_at

16792226

204344_PM_s_at

204344_s_at

212887_PM_at

212887_at

3561953

3561954

3561959

3561961

3561963

3561964

3561966

3561969

3561970

3561971

3561974

3561975

3561977

3561979

3561981

3561983

3561984

3561985

3561986

3561990

3561992

3561993

3561994

3561996

39099_at

7978718

A_23_P140170

A_23_P348894

GE79967

GO:0000139

GO:0005096

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006886

GO:0006888

GO:0008270

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0030127

GO:0030134

GO:0031410

GO:0043226

GO:0046872

GO:0048471

GO:0061024

GO:0070971

GO:0072659

GO:0090110

GO:0090114

GO:0098772

HMNXSV003029895

Hs.321403.0.S1_3p_at

ILMN_1790311

ILMN_2129309

PH_hs_0040483

TC14001063.hg

X97064_at

g5454041_3p_s_at

Participates

as an input of

as a component of

as an output of

Disassembly of COPII coated vesicle (Homo sapiens)

Other forms of this molecule

p-S738,T744 SEC23A [cytosol]

SEC23A [ER to Golgi transport vesicle membrane]

SEC23A [endoplasmic reticulum membrane]

Inferred To

sec23 [cytosol] (Dictyostelium discoideum)

sec-23 [cytosol] (Caenorhabditis elegans)

Sec23 [cytosol] (Drosophila melanogaster)

Sec23a [cytosol] (Rattus norvegicus)

SEC23A [cytosol] (Bos taurus)

SEC23A [cytosol] (Canis familiaris)

SEC23A [cytosol] (Danio rerio)

SEC23A [cytosol] (Gallus gallus)

SEC23A [cytosol] (Mus musculus)

SEC23A [cytosol] (Saccharomyces cerevisiae)

SEC23A [cytosol] (Schizosaccharomyces pombe)

SEC23A [cytosol] (Sus scrofa)

SEC23A [cytosol] (Xenopus tropicalis)

pfsec23 [cytosol] (Plasmodium falciparum)

Cross References

RefSeq

NP_006355.2

OpenTargets

ENSG00000100934

GeneCards

Q15436

HPA

ENSG00000100934-SEC23A

Ensembl

ENSP00000444193, ENST00000537403, ENST00000307712, ENSG00000100934, ENSP00000306881

PRO

Q15436

Pharos - Targets

Q15436

Orphanet

15265

PDB

5VNH, 5KYX, 2NUT, 3EFO, 5VNI, 5KYY, 5VNJ, 3EG9, 8HR0, 5VNK, 2NUP, 5VNL, 2YRC, 5VNM, 5VNN, 2YRD, 3EGD, 5KYN, 5VNO, 5VNE, 5KYU, 5VNF, 3EGX, 5VNG, 5KYW

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P53992 SEC24C	4	p-SEC24C [cytosol] (R-HSA-5694551) SEC24C [ER to Golgi transport vesicle membrane] (R-HSA-204026) SEC24C [cytosol] (R-HSA-203988) SEC24C [endoplasmic reticulum membrane] (R-HSA-203987)	0.811	8
UniProt:O94855 SEC24D	4	p-SEC24D [cytosol] (R-HSA-5694554) SEC24D [ER to Golgi transport vesicle membrane] (R-HSA-204020) SEC24D [cytosol] (R-HSA-203990) SEC24D [endoplasmic reticulum membrane] (R-HSA-204004)	0.688	5
UniProt:O95487 SEC24B	4	p-SEC24B [cytosol] (R-HSA-5685746) SEC24B [ER to Golgi transport vesicle membrane] (R-HSA-204021) SEC24B [cytosol] (R-HSA-204001) SEC24B [endoplasmic reticulum membrane] (R-HSA-203982)	0.669	4
UniProt:Q9Y6Y8 SEC23IP	2	SEC23IP [cytosol] (R-HSA-5688156) SEC23IP [COPII-coated ER to Golgi transport vesicle] (R-HSA-5688153)	0.666	5
UniProt:Q15437 SC23B			0.666	6
UniProt:P55735 SEC13	4	SEC13 [lysosomal membrane] (R-HSA-9638246) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [cytosol] (R-HSA-203981) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994)	0.636	3
UniProt:Q00536 CDK16			0.581	3
UniProt:O94855-2 SEC24D			0.556	3
UniProt:Q9P2R7 SUCLA2	1	SUCLA2 [mitochondrial matrix] (R-HSA-156624)	0.556	3
UniProt:O75477 ERLIN1	1	ERLIN1 [endoplasmic reticulum membrane] (R-HSA-8866518)	0.556	3
UniProt:P48165 GJA8	1	GJA8 [endoplasmic reticulum membrane] (R-HSA-190702)	0.556	3
UniProt:Q15637-4 SF1			0.556	3
UniProt:Q9GZY8-5 MFF			0.556	3
UniProt:Q6ZS10 CL17A			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
UniProt:A2RRN7 A2RRN7			0.556	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:O43557 TNFSF14	1	TNFSF14 [plasma membrane] (R-HSA-5667149)	0.556	3
UniProt:Q96B21 TM45B			0.556	3
UniProt:Q9UPX6 MNAR1			0.556	3
UniProt:Q12983 BNIP3			0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q6ZMZ0 RNF19B	1	RNF19B [cytosol] (R-HSA-975969)	0.556	3
UniProt:Q9Y2W2 WBP11	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.556	3
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.556	3
UniProt:Q969F0 FATE1			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:Q5JRA6 MIA3	3	MIA3 [endoplasmic reticulum membrane] (R-HSA-5689472) p-MIA3 [endoplasmic reticulum lumen] (R-HSA-8957064) MIA3 [endoplasmic reticulum lumen] (R-HSA-8956743)	0.556	3
UniProt:Q14203-5 DCTN1			0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.556	3
UniProt:O95486 SEC24A	4	SEC24A [endoplasmic reticulum membrane] (R-HSA-203992) SEC24A [cytosol] (R-HSA-203978) SEC24A [ER to Golgi transport vesicle membrane] (R-HSA-204022) p-SEC24A [cytosol] (R-HSA-5685743)	0.527	3
UniProt:Q96M27 PRRC1			0.527	3
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	2
UniProt:O94979 SEC31A	5	SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713475) SEC31A(1-989)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713478) SEC31A [ER to Golgi transport vesicle membrane] (R-HSA-204010) SEC31A [endoplasmic reticulum membrane] (R-HSA-204000) SEC31A [cytosol] (R-HSA-203983)	0.508	2
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.499	20
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10

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