Reactome | PRKCSH [endoplasmic reticulum lumen]

PRKCSH [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-532666

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Glucosidase 2 subunit beta, GLU2B_HUMAN, AGER-2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P14314 PRKCSH

Gene Names

PRKCSH, G19P1

Chain

signal peptide:1-14, chain:15-528

Reference Genes

BioGPS Gene:5589 PRKCSH

COSMIC (genes):PRKCSH PRKCSH

CTD Gene:5589 PRKCSH

dbSNP Gene:5589 PRKCSH

ENSEMBL:ENSG00000130175 PRKCSH

HGNC:9411 PRKCSH

KEGG:hsa:5589 PRKCSH

Monarch:5589 PRKCSH

NCBI Gene:5589 PRKCSH

OMIM:177060 PRKCSH

UCSC:P14314 PRKCSH

Reference Transcript

Other Identifiers

11744126_a_at

16858468

200707_3p_at

200707_PM_at

200707_at

214080_3p_x_at

214080_PM_x_at

214080_x_at

3821201

3821202

3821203

3821204

3821205

3821206

3821207

3821208

3821209

3821210

3821211

3821212

3821214

3821215

3821216

3821217

3821219

3821220

3821221

3821222

3821223

3821224

3821225

3821226

3821227

3821228

3821229

3821230

3821231

3821232

3821233

3821234

3821235

3821236

3821237

3821238

3821239

3821240

3821241

3821242

3821243

39711_at

5589

8025895

A_14_P131637

A_14_P132080

A_24_P396197

GE671537

GE81187

GO:0001701

GO:0001889

GO:0003723

GO:0005080

GO:0005509

GO:0005515

GO:0005783

GO:0005788

GO:0006491

GO:0010977

GO:0017177

GO:0035556

GO:0043226

GO:0043231

GO:0044325

GO:0044877

GO:0046872

GO:0048856

GO:0051219

GO:1901135

HMNXSV003012834

Hs.1432.1.S1_3p_a_at

ILMN_1777794

ILMN_2400512

PH_hs_0040672

TC19000199.hg

TC19001981.hg

U50327_s_at

g4506076_3p_a_at

g4506076_3p_x_at

Participates

as a member of

FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)

as a component of

glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

p-PRKCSH [endoplasmic reticulum lumen]

PRKCSH [plasma membrane]

Inferred To

Prkcsh [endoplasmic reticulum lumen] (Rattus norvegicus)

GCS2beta [endoplasmic reticulum lumen] (Drosophila melanogaster)

PRKCSH [endoplasmic reticulum lumen] (Bos taurus)

PRKCSH [endoplasmic reticulum lumen] (Caenorhabditis elegans)

PRKCSH [endoplasmic reticulum lumen] (Canis familiaris)

PRKCSH [endoplasmic reticulum lumen] (Mus musculus)

PRKCSH [endoplasmic reticulum lumen] (Sus scrofa)

prkcsh [endoplasmic reticulum lumen] (Xenopus tropicalis)

Cross References

RefSeq

XP_011526434.1, NP_001001329.1, NP_001276031.1, NP_002734.2, XP_016882466.1, XP_011526433.1

OpenTargets

ENSG00000130175

ENSEMBL

ENST00000589838, ENSP00000465489, ENST00000591462, ENSG00000130175, ENST00000587327, ENSP00000465461, ENSP00000466012

HPA

ENSG00000130175-PRKCSH

GeneCards

PRKCSH

PRO

P14314

Pharos - Targets

P14314

Orphanet

PRKCSH

GlyGen

P14314

PDB

8D43, 8EMR

HMDB Protein

HMDBP01163

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.527	2
UniProt:O14975 SLC27A2	5	SLC27A2 [cytosol] (R-HSA-9033090) SLC27A2 [endoplasmic reticulum membrane] (R-HSA-193386) SLC27A2 [plasma membrane] (R-HSA-6806316) SLC27A2 [specific granule membrane] (R-HSA-6799565) SLC27A2 [peroxisomal membrane] (R-HSA-389579)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
UniProt:P04578 env	7	ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.462	4