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PRKCSH [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-532666
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Glucosidase 2 subunit beta, GLU2B_HUMAN, AGER-2
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of spike protein (Homo sapiens)
ER-alpha glucosidases bind ER-alpha glucosidase inhibitors (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
PRKCSH [endoplasmic reticulum lumen] (Homo sapiens)
ER-alpha glucosidases:ER-alpha glucosidase inhibitors [endoplasmic reticulum lumen] (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
PRKCSH [endoplasmic reticulum lumen] (Homo sapiens)
N-glycan trimming of Spike (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
PRKCSH [endoplasmic reticulum lumen] (Homo sapiens)
ER-alpha glucosidases:ER-alpha glucosidase inhibitors [endoplasmic reticulum lumen] (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
PRKCSH [endoplasmic reticulum lumen] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of spike protein (Homo sapiens)
ER-alpha glucosidases bind ER-alpha glucosidase inhibitors (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
PRKCSH [endoplasmic reticulum lumen] (Homo sapiens)
ER-alpha glucosidases:ER-alpha glucosidase inhibitors [endoplasmic reticulum lumen] (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
PRKCSH [endoplasmic reticulum lumen] (Homo sapiens)
N-glycan glucose trimming of Spike (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
PRKCSH [endoplasmic reticulum lumen] (Homo sapiens)
ER-alpha glucosidases:ER-alpha glucosidase inhibitors [endoplasmic reticulum lumen] (Homo sapiens)
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
PRKCSH [endoplasmic reticulum lumen] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Homo sapiens)
Calnexin/calreticulin cycle (Homo sapiens)
Removal of the third glucose by glucosidase II and release from the chaperone (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
PRKCSH [endoplasmic reticulum lumen] (Homo sapiens)
Removal of the second glucose by glucosidase II (Homo sapiens)
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
PRKCSH [endoplasmic reticulum lumen] (Homo sapiens)
Post-translational protein phosphorylation (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
PRKCSH [endoplasmic reticulum lumen] (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
PRKCSH [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14314 PRKCSH
Gene Names
PRKCSH, G19P1
Chain
signal peptide:1-14, chain:15-528
Reference Genes
BioGPS Gene:5589 PRKCSH
COSMIC (genes):PRKCSH PRKCSH
CTD Gene:5589 PRKCSH
dbSNP Gene:5589 PRKCSH
ENSEMBL:ENSG00000130175 PRKCSH
HGNC:9411 PRKCSH
KEGG:hsa:5589 PRKCSH
Monarch:5589 PRKCSH
NCBI Gene:5589 PRKCSH
OMIM:177060 PRKCSH
UCSC:P14314 PRKCSH
Reference Transcript
RefSeq:NM_001001329.2 PRKCSH
RefSeq:XM_017026977.1 PRKCSH
RefSeq:XM_011528132.1 PRKCSH
RefSeq:NM_001289102.1 PRKCSH
RefSeq:XM_011528131.1 PRKCSH
RefSeq:NM_002743.3 PRKCSH
Other Identifiers
11744126_a_at
16858468
200707_3p_at
200707_PM_at
200707_at
214080_3p_x_at
214080_PM_x_at
214080_x_at
3821201
3821202
3821203
3821204
3821205
3821206
3821207
3821208
3821209
3821210
3821211
3821212
3821214
3821215
3821216
3821217
3821219
3821220
3821221
3821222
3821223
3821224
3821225
3821226
3821227
3821228
3821229
3821230
3821231
3821232
3821233
3821234
3821235
3821236
3821237
3821238
3821239
3821240
3821241
3821242
3821243
39711_at
5589
8025895
A_14_P131637
A_14_P132080
A_24_P396197
GE671537
GE81187
GO:0001701
GO:0001889
GO:0003723
GO:0005080
GO:0005509
GO:0005515
GO:0005783
GO:0005788
GO:0006491
GO:0010977
GO:0017177
GO:0035556
GO:0043226
GO:0043231
GO:0044325
GO:0044877
GO:0046872
GO:0048856
GO:0051219
GO:1901135
HMNXSV003012834
Hs.1432.1.S1_3p_a_at
ILMN_1777794
ILMN_2400512
PH_hs_0040672
TC19000199.hg
TC19001981.hg
U50327_s_at
g4506076_3p_a_at
g4506076_3p_x_at
Participates
as a member of
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
as a component of
glucosidase II [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
p-PRKCSH [endoplasmic reticulum lumen]
PRKCSH [plasma membrane]
Inferred To
Prkcsh [endoplasmic reticulum lumen]
(Rattus norvegicus)
GCS2beta [endoplasmic reticulum lumen]
(Drosophila melanogaster)
PRKCSH [endoplasmic reticulum lumen]
(Bos taurus)
PRKCSH [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
PRKCSH [endoplasmic reticulum lumen]
(Canis familiaris)
PRKCSH [endoplasmic reticulum lumen]
(Mus musculus)
PRKCSH [endoplasmic reticulum lumen]
(Sus scrofa)
prkcsh [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011526434.1
,
NP_001001329.1
,
NP_001276031.1
,
NP_002734.2
,
XP_016882466.1
,
XP_011526433.1
OpenTargets
ENSG00000130175
ENSEMBL
ENST00000589838
,
ENSP00000465489
,
ENST00000591462
,
ENSG00000130175
,
ENST00000587327
,
ENSP00000465461
,
ENSP00000466012
HPA
ENSG00000130175-PRKCSH
GeneCards
PRKCSH
PRO
P14314
Pharos - Targets
P14314
Orphanet
PRKCSH
GlyGen
P14314
PDB
8D43
,
8EMR
HMDB Protein
HMDBP01163
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14965 AURKA
6
p-T288-AURKA [cytosol]
(R-HSA-2574832)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
0.527
2
UniProt:O14975 SLC27A2
5
SLC27A2 [cytosol]
(R-HSA-9033090)
SLC27A2 [endoplasmic reticulum membrane]
(R-HSA-193386)
SLC27A2 [plasma membrane]
(R-HSA-6806316)
SLC27A2 [specific granule membrane]
(R-HSA-6799565)
SLC27A2 [peroxisomal membrane]
(R-HSA-389579)
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
12
UniProt:P04578 env
7
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
0.462
4
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