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SPTAN1 [cytosol]
Stable Identifier
R-HSA-201601
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
spectrin alpha chain, brain/alpha II fodrin
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Nephrin family interactions (Homo sapiens)
Interaction of nephrin with adherens junction-associated proteins (Homo sapiens)
Nephrin dimer:adherins junction-associated proteins [plasma membrane] (Homo sapiens)
adherens junction-associated proteins [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
adherens junction-associated proteins [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Interaction between L1 and Ankyrins (Homo sapiens)
Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin [plasma membrane] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin [plasma membrane] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)
L1 dimer:Ankyrin:Spectrin:F-actin [plasma membrane] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
NCAM signaling for neurite out-growth (Homo sapiens)
Autophosphorylation of NCAM1 bound Fyn (Homo sapiens)
Fyn:NCAM1:RPTP-alpha [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Dephosphorylation of NCAM1 bound pFyn (Homo sapiens)
Fyn:NCAM1:RPTP-alpha [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Homo sapiens)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Phosphorylation of FAK by Src kinase (Homo sapiens)
Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
pFAK (391) bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Recruitment of FAK to NCAM1:Fyn in lipid rafts (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
pFAK (391) bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Recruitment of Grb2 to pFAK:NCAM1 (Homo sapiens)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
SOS binds Grb2 bound to pFAK:NCAM1 (Homo sapiens)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Caspase-mediated cleavage of cytoskeletal proteins (Homo sapiens)
Caspase mediated cleavage of alpha-II-Fodrin (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Sensory Perception (Homo sapiens)
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by inner hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (IHC) [plasma membrane] (Homo sapiens)
Inner hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Stereocilium cuticular plate [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Stereocilium rootlet [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Sensory processing of sound by outer hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (OHC) [plasma membrane] (Homo sapiens)
Outer hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Stereocilium cuticular plate [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Stereocilium rootlet [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOU GTPase cycle (Homo sapiens)
RHOU binds effectors at the plasma membrane (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
RHOU:GTP:RHOU effectors [plasma membrane] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
RHOV GTPase cycle (Homo sapiens)
RHOV binds effectors at the plasma membrane (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
RHOV:GTP:RHOV effectors [plasma membrane] (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
SPTAN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13813 SPTAN1
Gene Names
SPTAN1, NEAS, SPTA2
Chain
chain:1-2472
Reference Genes
BioGPS Gene:6709 SPTAN1
COSMIC (genes):SPTAN1 SPTAN1
CTD Gene:6709 SPTAN1
dbSNP Gene:6709 SPTAN1
ENSEMBL:ENSG00000197694 SPTAN1
ENSEMBL:ENSG00000197694.19 SPTAN1
HGNC:11273 SPTAN1
KEGG Gene (Homo sapiens):6709 SPTAN1
Monarch:6709 SPTAN1
NCBI Gene:6709 SPTAN1
OMIM:182810 SPTAN1
UCSC:Q13813 SPTAN1
Reference Transcript
RefSeq:NM_003127.3 SPTAN1
RefSeq:NM_001195532.1 SPTAN1
RefSeq:NM_001130438.2 SPTAN1
Other Identifiers
11715963_a_at
11715964_x_at
11751947_a_at
11758363_s_at
17089735
208611_PM_s_at
208611_s_at
215235_PM_at
215235_at
3190559
3190563
3190564
3190566
3190567
3190568
3190569
3190570
3190571
3190572
3190573
3190574
3190576
3190578
3190579
3190580
3190581
3190582
3190583
3190584
3190585
3190586
3190588
3190589
3190592
3190593
3190595
3190596
3190597
3190600
3190601
3190602
3190603
3190604
3190605
3190606
3190608
3190609
3190610
3190613
3190615
3190616
3190618
3190619
3190620
3190621
3190622
3190624
3190627
3190628
3190630
3190631
3190636
3190638
3190639
3190640
3190642
3190644
3190645
3190646
33833_at
6709
8158317
89935_at
A_14_P112681
A_14_P136143
A_23_P20832
A_33_P3373560
GE81239
GO:0003779
GO:0005198
GO:0005200
GO:0005509
GO:0005515
GO:0005516
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005938
GO:0007010
GO:0008091
GO:0008092
GO:0015629
GO:0015630
GO:0016020
GO:0030036
GO:0030054
GO:0030864
GO:0031410
GO:0035580
GO:0042995
GO:0043226
GO:0043231
GO:0045296
GO:0046872
GO:0051015
GO:0051693
GO:0065003
GO:0070062
GO:1903561
GO:1904724
HMNXSV003023914
Hs.77196.2.A1_3p_a_at
J05243_at
PH_hs_0024438
TC09000695.hg
Participates
as a candidate of
RHOV effectors [cytosol] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
as a component of
Stereocilium rootlet [cytosol] (Homo sapiens)
Stereocilium cuticular plate [cytosol] (Homo sapiens)
as a member of
adherens junction-associated proteins [cytosol] (Homo sapiens)
Spectrin alpha chain [cytosol] (Homo sapiens)
as an input of
Caspase mediated cleavage of alpha-II-Fodrin (Homo sapiens)
Other forms of this molecule
SPTAN1(1-1185) [cytosol]
SPTAN1(1186-2472) [cytosol]
SPTAN1 [specific granule lumen]
SPTAN1 [extracellular region]
SPTAN1 [tertiary granule lumen]
Inferred To
spc-1 [cytosol]
(Caenorhabditis elegans)
Spectrin alpha chain, brain [cytosol]
(Mus musculus)
Spectrin alpha chain, brain [cytosol]
(Rattus norvegicus)
Homologues of SPTAN1 [cytosol]
(Dictyostelium discoideum)
sptan1 [cytosol]
(Xenopus tropicalis)
ain1 [cytosol]
(Schizosaccharomyces pombe)
abpD [cytosol]
(Dictyostelium discoideum)
SPTAN1 [cytosol]
(Bos taurus)
SPTAN1 [cytosol]
(Canis familiaris)
SPTAN1 [cytosol]
(Danio rerio)
SPTAN1 [cytosol]
(Dictyostelium discoideum)
SPTAN1 [cytosol]
(Drosophila melanogaster)
SPTAN1 [cytosol]
(Gallus gallus)
SPTAN1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001123910.1
,
NP_001182461.1
,
NP_003118.2
OpenTargets
ENSG00000197694
GeneCards
Q13813
HPA
ENSG00000197694-SPTAN1
Ensembl
ENSP00000350882
,
ENSP00000361816
,
ENST00000372731
,
ENST00000358161
,
ENST00000372739
,
ENSG00000197694
,
ENSP00000361824
PRO
Q13813
Pharos - Targets
Q13813
Orphanet
19240
HMDB Protein
HMDBP08004
PDB
2FOT
,
5FWB
,
5FW9
,
3F31
,
3FB2
,
6ZEH
,
5FWC
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRI5 DISC1
0.667
3
UniProt:Q01082 SPTBN1
3
SPTBN1(2-159)-FLT3(570-993) fusion [cytosol]
(R-HSA-9703316)
SPTBN1(2-159)-p-6Y-FLT3(570-993) fusion [cytosol]
(R-HSA-9703317)
SPTBN1 [cytosol]
(R-HSA-420048)
0.609
8
UniProt:P40692 MLH1
3
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.602
7
UniProt:Q9UI08 EVL
1
EVL [cytosol]
(R-HSA-426403)
0.593
4
UniProt:Q00597 FANCC
2
FANCC [nucleoplasm]
(R-HSA-419530)
FANCC [cytosol]
(R-HSA-420801)
0.589
2
UniProt:Q9NV70 EXOC1
2
EXOC1 [plasma membrane]
(R-HSA-2872284)
EXOC1 [cytosol]
(R-HSA-5623375)
0.553
2
UniProt:P42224 STAT1
7
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
STAT1 [cytosol]
(R-HSA-629622)
0.547
2
UniProt:O15287 FANCG
2
FANCG [cytosol]
(R-HSA-420788)
FANCG [nucleoplasm]
(R-HSA-419532)
0.508
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
13
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE
0.462
2
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