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TPR M489P [nucleoplasm]
Stable Identifier
R-HSA-5661477
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Tpr
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) (Homo sapiens)
Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)
Defective NPC [nuclear envelope] (Homo sapiens)
TPR mutants [nucleoplasm] (Homo sapiens)
TPR M489P [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P12270 TPR
Gene Names
TPR
Chain
initiator methionine:, chain:2-2363
Reference Genes
BioGPS Gene:7175 TPR
COSMIC (genes):TPR TPR
CTD Gene:7175 TPR
dbSNP Gene:7175 TPR
ENSEMBL:ENSG00000047410 TPR
HGNC:12017 TPR
KEGG:hsa:7175 TPR
Monarch:7175 TPR
NCBI Gene:7175 TPR
OMIM:189940 TPR
UCSC:P12270 TPR
Reference Transcript
RefSeq:NM_003292.2 TPR
Other Identifiers
11727481_at
11727482_a_at
11727483_a_at
11727484_a_at
11727485_at
1557227_PM_s_at
1557227_s_at
16697299
201730_PM_s_at
201730_s_at
201731_PM_s_at
201731_s_at
215220_PM_s_at
215220_s_at
228709_PM_at
228709_at
2448233
2448234
2448235
2448236
2448237
2448238
2448239
2448240
2448241
2448244
2448247
2448248
2448249
2448251
2448252
2448254
2448255
2448256
2448257
2448259
2448260
2448261
2448262
2448264
2448265
2448266
2448267
2448268
2448269
2448270
2448271
2448272
2448273
2448274
2448275
2448276
2448277
2448278
2448279
2448280
2448281
2448282
2448283
2448284
2448285
2448286
2448287
2448288
2448289
2448290
2448291
2448292
2448293
2448294
2448295
2448296
2448297
2448298
2448300
2448301
2448302
2448303
2448305
2448307
2448308
2448309
2448310
2448311
2448312
2448313
2448314
2448315
2448316
2448317
2448318
2448319
2448320
2448321
2448322
421_at
7175
75951_r_at
7922912
A_23_P45875
A_24_P179611
A_33_P3361771
GE59926
GE903194
GO:0000122
GO:0000775
GO:0000776
GO:0003682
GO:0003723
GO:0003729
GO:0005198
GO:0005515
GO:0005634
GO:0005635
GO:0005643
GO:0005654
GO:0005694
GO:0005737
GO:0005819
GO:0005856
GO:0005868
GO:0006355
GO:0006404
GO:0006405
GO:0006406
GO:0006606
GO:0006886
GO:0006913
GO:0006999
GO:0007094
GO:0008092
GO:0010965
GO:0015031
GO:0015631
GO:0016020
GO:0017056
GO:0031072
GO:0031453
GO:0031965
GO:0031990
GO:0032880
GO:0034399
GO:0034605
GO:0035457
GO:0042307
GO:0042405
GO:0042803
GO:0043226
GO:0044615
GO:0045947
GO:0046827
GO:0046832
GO:0051019
GO:0051028
GO:0051301
GO:0070840
GO:0070849
GO:0072686
GO:0090267
GO:0090316
GO:1901673
HMNXSV003017559
Hs.169750.0.S1_3p_a_at
Hs.218791.1.A1_3p_at
Hs.306642.0.S1_3p_s_at
Hs2.433856.1.S1_3p_s_at
ILMN_1730999
PH_hs_0022811
TC01003636.hg
TC01005999.hg
X66397_at
g4507658_3p_a_at
Participates
as a member of
TPR mutants [nucleoplasm] (Homo sapiens)
Other forms of this molecule
TPR L458P [nucleoplasm]
TPR(2-629)-p-7Y-ALK(1058-1620) fusion [cytosol]
TPR(2-629)-ALK(1058-1620) fusion [cytosol]
TPR [nucleoplasm]
Modified Residues
Name
L-methionine 489 replaced with L-proline
Coordinate
489
PsiMod
L-methionine removal [MOD:01643]
A protein modification that effectively removes or replaces an L-methionine.
L-proline residue [MOD:00024]
A protein modification that effectively converts a source amino acid residue to L-proline.
Disease
Name
Identifier
Synonyms
papillary carcinoma
DOID:3113
Papillary carcinoma (morphologic abnormality), Papillary carcinoma, Papillary carcinoma NOS (morphologic abnormality)
Cross References
RefSeq
NP_003283.2
ENSEMBL
ENSP00000356448
,
ENST00000613151
,
ENSP00000483425
,
ENST00000367478
OpenTargets
ENSG00000047410
HPA
ENSG00000047410-TPR
PRO
P12270
Pharos - Targets
P12270
GlyGen
P12270
Orphanet
TPR
PDB
5TO5
,
5TVB
,
5TO6
,
5TO7
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Z1B5
1
Mad2l1 [cytosol]
(R-MMU-141400)
0.564
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.524
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
7
UniProt:Q12906 ILF3
3
ILF3 [nucleoplasm]
(R-HSA-9760401)
ILF3 [cytosol]
(R-HSA-450564)
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
0.483
2
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