Reactome | REPS1 [cytosol]

REPS1 [cytosol]

Stable Identifier

R-HSA-8862265

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RalBP1-associated Eps domain-containing protein 1, REPS1_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - REPS1 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - REPS1 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - Recruitment of AP-2 complex and clathrin (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        REPS1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96D71 REPS1

Gene Names

REPS1

Chain

chain:1-796

Reference Genes

BioGPS Gene:85021 REPS1

COSMIC (genes):REPS1 REPS1

CTD Gene:85021 REPS1

dbSNP Gene:85021 REPS1

ENSEMBL:ENSG00000135597 REPS1

HGNC:15578 REPS1

KEGG Gene (Homo sapiens):85021 REPS1

Monarch:85021 REPS1

NCBI Gene:85021 REPS1

OMIM:614825 REPS1

UCSC:Q96D71 REPS1

Reference Transcript

Other Identifiers

0006660092

0101940075

11740152_a_at

11755156_a_at

17024227

224366_s_at

2976627

2976628

2976629

2976630

2976631

2976632

2976633

2976634

2976636

2976639

2976643

2976644

2976645

2976646

2976649

2976655

2976659

2976661

2976664

2976666

2976669

2976670

2976671

2976672

2976673

2976674

2976675

2976676

2976677

2976678

2976689

2976690

29961

29962

48119_at

62781_at

8129901

85021

A_23_P70748

AAH12764

AAH21211

AAK34942

AF251052

AL121834

AL590308

AL591033

AL831900

AL832307

BC012764

BC021211

CAD38569

CCDS47488

CCDS5193

CCDS69212

CCDS69213

CH471051

DB263697

E9PMG1

EAW47904

EAW47906

EAW47907

ENSG00000135597

ENSP00000258062

ENSP00000356635

ENSP00000386699

ENSP00000392065

ENST00000258062

ENST00000258062.9

ENST00000367663

ENST00000367663.8

ENST00000409812

ENST00000409812.6

ENST00000450536

ENST00000450536.6

EntrezGene:85021

EntrezGene:REPS1

F2Z3L2

g13625165_3p_s_at

GE512530

GE83275

GO:0003674

GO:0005509

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005886

GO:0005905

GO:0006810

GO:0006898

GO:0008150

GO:0016020

GO:0016192

GO:0017124

GO:0043167

GO:0046872

GO:0061024

H0YDT0

H0YE73

H7C1V2

HGNC:15578

HPA029961

HPA029962

ILMN_1688326

ILMN_2222768

IPR000261

IPR002048

IPR011992

IPR018247

IPR026814

MIM:614825

MIM:617916

NM_001128617

NM_001286611

NM_001286612

NM_031922

NP_001122089

NP_001273540

NP_001273541

NP_114128

PF12763

PH_hs_0023839

REPS1

REPS1-201

REPS1-202

REPS1-203

REPS1-208

SM00027

TC06002164.hg

UPI000020E300

UPI000020E30A

UPI0000374EA5

UPI0001765CA1

XM_005267177

XM_005267178

XM_005267179

XM_011536202

XM_017011387

XM_017011388

XM_017011389

XP_005267234

XP_005267235

XP_005267236

XP_011534504

XP_016866876

XP_016866877

XP_016866878

Participant Of

output

Dissociation of clathrin-associated proteins

hasComponent

input

FCHo proteins bind nascent clathrin-coated pit

Inferred To

Ghost homologue of REPS1 [cytosol] (Rattus norvegicus)

REPS1 [cytosol] (Bos taurus)

REPS1 [cytosol] (Caenorhabditis elegans)

REPS1 [cytosol] (Canis familiaris)

REPS1 [cytosol] (Danio rerio)

REPS1 [cytosol] (Dictyostelium discoideum)

REPS1 [cytosol] (Drosophila melanogaster)

REPS1 [cytosol] (Gallus gallus)

REPS1 [cytosol] (Mus musculus)

REPS1 [cytosol] (Saccharomyces cerevisiae)

REPS1 [cytosol] (Schizosaccharomyces pombe)

REPS1 [cytosol] (Sus scrofa)

REPS1 [cytosol] (Xenopus tropicalis)

Homologues of REPS1 [cytosol] (Saccharomyces cerevisiae)

Homologues of REPS1 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001273540.1, NP_001122089.1, NP_114128.3, NP_001273541.1

OpenTargets

ENSG00000135597

GeneCards

Q96D71

PRO

Q96D71

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9QZS3-2 NUMB			0.499	2
UniProt:Q9QZS3-1 NUMB			0.499	3
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.499	3