Reactome | PPP6C [nucleoplasm]

PPP6C [nucleoplasm]

Stable Identifier

R-HSA-9686576

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00743 PPP6C

Gene Names

PPP6C, PPP6

Chain

chain:1-305, initiator methionine:1, chain:2-305

Reference Genes

BioGPS Gene:5537 PPP6C

COSMIC (genes):PPP6C PPP6C

CTD Gene:5537 PPP6C

dbSNP Gene:5537 PPP6C

ENSEMBL:ENSG00000119414 PPP6C

HGNC:9323 PPP6C

KEGG:hsa:5537 PPP6C

Monarch:5537 PPP6C

NCBI Entrez Gene:5537 PPP6C

OMIM:612725 PPP6C

UCSC:O00743 PPP6C

Reference Transcript

Other Identifiers

11727048_s_at

11727049_s_at

11727050_a_at

11729600_a_at

11729601_a_at

11740707_a_at

11748125_a_at

17098395

203529_PM_at

203529_at

206174_PM_s_at

206174_s_at

225426_PM_at

225426_at

225429_PM_at

225429_at

3225344

3225349

3225350

3225351

3225352

3225353

3225354

3225358

3225359

3225360

3225361

3225362

3225366

3225368

3225371

3225375

3225376

37581_at

53149_at

5537

64005_at

8164155

A_23_P355385

A_23_P94623

A_24_P369154

A_24_P81298

GE58721

GO:0000082

GO:0002376

GO:0003824

GO:0004721

GO:0004722

GO:0005515

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006470

GO:0016787

GO:0045087

GO:0046872

GO:0048208

GO:0065003

GO:0098542

GO:0140096

GO:0140896

GO:0160049

HMNXSV003028937

Hs.7256.1.A1_3p_at

Hs.7256.1.A2_3p_at

ILMN_1664921

PH_hs_0017306

PH_hs_0036088

TC09001588.hg

X92972_at

g5729987_3p_s_at

g7706488_3p_at

Participates

as a component of

PP6-PPP6R3 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PPP6C [cytosol]

Inferred To

PPP6C [nucleoplasm] (Bos taurus)

PPP6C [nucleoplasm] (Canis familiaris)

PPP6C [nucleoplasm] (Mus musculus)

PPP6C [nucleoplasm] (Rattus norvegicus)

PPP6C [nucleoplasm] (Sus scrofa)

ppp6c [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001116841.1, NP_001116827.1, NP_002712.1

ENSEMBL

ENST00000451402, ENSP00000392147, ENSP00000362648, ENSP00000411744, ENSG00000119414, ENST00000373547, ENST00000415905

OpenTargets

ENSG00000119414

GeneCards

PPP6C

HPA

ENSG00000119414-PPP6C

PRO

O00743

Pharos - Targets

O00743

GlyGen

O00743

HMDB Protein

HMDBP08688

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-MAP3K7 [cytosol] (R-HSA-168163) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.602	4
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.553	4
UniProt:P78527 PRKDC	4	PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766)	0.527	2
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	4

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