Reactome | EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol]

EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol]

Stable Identifier

R-HSA-9710850

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Elongation factor 1-gamma, EF1G_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Autophosphorylation of ALK fusions (Homo sapiens)
        
        p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
        
        EEF1G(1-343)-6Y ALK(1106-1620) fusion dimer [cytosol] (Homo sapiens)
        
        EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
28659337	Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with the variant RNF213-, ATIC- and TPM3-ALK fusions is characterized by copy number gain of the rearranged ALK gene Ferreiro, JF, Tousseyn, T, Uyttebroeck, A, Michaux, L, Devos, T, Cools, J, Geerdens, E, Jacobs, K, Wlodarska, I, Doms, K, Bempt, MV, van der Krogt, JA, Pierre, P, Vandenberghe, P, Pluys, U, Mentens, N	Haematologica	2017

External Reference Information

External Reference

UniProt:P26641 EEF1G

Gene Names

EEF1G, EF1G, PRO1608

Chain

initiator methionine:, chain:2-437

Reference Genes

BioGPS Gene:1937 EEF1G

COSMIC (genes):EEF1G EEF1G

CTD Gene:1937 EEF1G

dbSNP Gene:1937 EEF1G

ENSEMBL:ENSG00000254772 EEF1G

HGNC:3213 EEF1G

KEGG:hsa:1937 EEF1G

Monarch:1937 EEF1G

NCBI Gene:1937 EEF1G

OMIM:130593 EEF1G

UCSC:P26641 EEF1G

Reference Transcript

RefSeq:NM_001404.4 EEF1G

Participates

as a component of

EEF1G(1-343)-6Y ALK(1106-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

EEF1G [cytosol]

EEF1G(1-343)-ALK(1106-1620) fusion [cytosol]

Modified Residues

Name

Insertion of residues 1106 to 1620 at 344 from UniProt:Q9UM73 ALK

Coordinate

344

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1359

Coordinate

1359

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
anaplastic large cell lymphoma	DOID:0050744

Cross References

OpenTargets

ENSG00000254772

ENSEMBL

ENSG00000254772, ENSP00000331901, ENST00000329251

HPA

ENSG00000254772-EEF1G

GeneCards

EEF1G

PRO

P26641

Pharos - Targets

P26641

GlyGen

P26641

PDB

5DQS, 1PBU, 5JPO

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24534 EEF1B2	1	EEF1B2 [cytosol] (R-HSA-156926)	0.885	12
UniProt:P29692 EEF1D	1	EEF1D [cytosol] (R-HSA-156914)	0.813	8
UniProt:P29692-2 EEF1D			0.666	4
UniProt:P68104 EEF1A1	7	EEF1A1 [lysosomal membrane] (R-HSA-9626022) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [secretory granule lumen] (R-HSA-6801479) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212)	0.643	5
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.643	5
UniProt:P26640 VARS1	1	VARS [cytosol] (R-HSA-379648)	0.643	4
UniProt:Q05639 EEF1A2	1	EEF1A2 [cytosol] (R-HSA-3907261)	0.643	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	14
UniProt:Q16512 PKN1	3	p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613) p-T774-PKN1 [nucleoplasm] (R-HSA-5625721)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q8WUW1 BRK1	1	BRK1 [cytosol] (R-HSA-1671645)	0.556	3
UniProt:P31930 UQCRC1	1	UQCRC1 [mitochondrial inner membrane] (R-HSA-164284)	0.556	3
UniProt:P32601 DSS4			0.556	3
UniProt:P40560 YIA1			0.556	3
UniProt:Q9HB07 MYG1			0.556	3
UniProt:P49090	1	ASNS [cytosol] (R-SCE-70597-2)	0.556	3
UniProt:P32497	1	NIP1 [cytosol] (R-SCE-72550)	0.556	3
UniProt:P14679-2 P146792			0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q13011 ECH1	3	ECH1 [mitochondrial matrix] (R-HSA-9838037) ECH1(1-328) [peroxisomal matrix] (R-HSA-9033140) ECH1(1-328) [cytosol] (R-HSA-9033152)	0.553	2
UniProt:O15357 INPPL1	1	INPPL1 [cytosol] (R-HSA-913354)	0.527	3
UniProt:Q9NPJ1 MKKS	1	MKKS [cytosol] (R-HSA-5624086)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.527	2
UniProt:P48039 MTNR1A	1	MTNR1A [plasma membrane] (R-HSA-419316)	0.527	2
UniProt:P49589 CARS1	3	CARS [cytosol] (R-HSA-379602) CARS1(2-606)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711977) CARS1(2-606)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711974)	0.527	3
UniProt:Q969Q1 TRIM63	1	TRIM63 [cytosol] (R-HSA-976020)	0.508	2
UniProt:A0A096LP01 SIM26			0.462	2

Cite Us!