Reactome | NCL [macropinosome membrane]

NCL [macropinosome membrane]

Stable Identifier

R-HSA-9837666

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

macropinosome membrane

Synonyms

Nucleolin, NUCL_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P19338 NCL

Gene Names

NCL

Chain

initiator methionine:, chain:2-710

Reference Genes

BioGPS Gene:4691 NCL

COSMIC (genes):NCL NCL

CTD Gene:4691 NCL

dbSNP Gene:4691 NCL

ENSEMBL:ENSG00000115053 NCL

ENSEMBL_homo_sapiens_GENE:ENSG00000115053.17 NCL

HGNC:7667 NCL

KEGG Gene (Homo sapiens):4691 NCL

Monarch:4691 NCL

NCBI Gene:4691 NCL

OMIM:164035 NCL

UCSC:P19338 NCL

Reference Transcript

RefSeq:NM_005381.2 NCL

Other Identifiers

11745154_a_at

11745155_s_at

16909491

200610_PM_s_at

200610_s_at

241892_PM_at

241892_at

2603459

2603461

2603462

2603463

2603465

2603466

2603467

2603468

2603471

2603473

2603474

2603477

2603479

2603481

2603483

2603485

2603486

2603487

2603488

2603489

2603490

2603491

2603492

2603493

2603495

2603496

2603498

32590_at

4691

8059689

A_23_P5551

GE81501

GO:0001525

GO:0001533

GO:0003676

GO:0003677

GO:0003723

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005681

GO:0005694

GO:0005730

GO:0005737

GO:0005886

GO:0005938

GO:0006351

GO:0006355

GO:0016020

GO:0016071

GO:0017148

GO:0023052

GO:0036211

GO:0036464

GO:0042162

GO:0042731

GO:0042802

GO:0043226

GO:0043560

GO:0044547

GO:0045944

GO:0046627

GO:0048026

GO:0048027

GO:0048856

GO:0050730

GO:0070062

GO:0071364

GO:1901838

GO:1990830

GO:1990904

HMNXSV003009139

Hs.253767.0.A1_3p_at

ILMN_1695422

ILMN_2121437

M60858_rna1_at

PH_hs_0004572

TC02002859.hg

g4885510_3p_a_at

Participates

as a component of

Other forms of this molecule

NCL [plasma membrane]

NCL [nucleoplasm]

Cross References

RefSeq

NP_005372.2

OpenTargets

ENSG00000115053

GeneCards

P19338

HPA

ENSG00000115053-NCL

Ensembl

ENSP00000318195, ENST00000322723, ENSG00000115053

PRO

P19338

Pharos - Targets

P19338

PDB

2KRR, 2FC8, 2FC9

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P39060-PRO_0000005794 COL18A1			0.784	12
ChEBI:28304 HEPARIN			0.722	3
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.71	8
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.643	5
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.643	4
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.615	3
UniProt:P11387 TOP1	2	monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.59	3
UniProt:P68400 CSNK2A1	2	CSNK2A1 [nucleoplasm] (R-HSA-6805057) CSNK2A1 [cytosol] (R-HSA-201713)	0.59	2
UniProt:O95793 STAU1			0.577	3
UniProt:P16401 H1-5	1	HIST1H1B [nucleoplasm] (R-HSA-211248)	0.564	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.558	2
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.558	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.547	2
UniProt:O75940 SMNDC1	1	SMNDC1 [nucleoplasm] (R-HSA-8865958)	0.536	2
UniProt:Q99608 NDN	1	NDN [nucleoplasm] (R-HSA-6789966)	0.536	2
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:Q4G0J3 LARP7			0.527	2
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:Q9CR42 ANKR1			0.524	2
UniProt:Q14684-1 RRP1B			0.512	4
UniProt:Q9UQ80 PA2G4	2	PA2G4 [extracellular region] (R-HSA-6806200) PA2G4 [azurophil granule lumen] (R-HSA-6799205)	0.499	2
UniProt:Q8AZK7 EBNA5			0.499	2
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	3
UniProt:Q9Y6D6 BIG1			0.499	5
IntAct:EBI-1549316 PROBE			0.499	2
IntAct:EBI-1549314 PROBE			0.499	2
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.499	3
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.483	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	2
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.463	2
UniProt:P27958-PRO_0000037577			0.463	4
UniProt:P61586 RHOA	6	RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cytosol] (R-HSA-194866) RHOA [cell junction] (R-HSA-2134503) RHOA [plasma membrane] (R-HSA-194510)	0.463	3
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.463	3
UniProt:Q01130 SRSF2	1	SRSF2 [nucleoplasm] (R-HSA-72033)	0.463	2
UniProt:Q8N0X7 SPART			0.462	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
IntAct:EBI-5333170 SSRNA			0.462	3
IntAct:EBI-5333168 SSRNA			0.462	4
IntAct:EBI-5333262 SSDNA			0.462	4

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