Reactome | p-T558-MSN [cytosol]

p-T558-MSN [cytosol]

Stable Identifier

R-HSA-9663005

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

fullName evidence="28"Moesin, MOES_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P26038 MSN

Gene Names

MSN

Chain

initiator methionine:1, chain:2-577

Reference Genes

BioGPS Gene:4478 MSN

COSMIC (genes):MSN MSN

CTD Gene:4478 MSN

dbSNP Gene:4478 MSN

ENSEMBL:ENSG00000147065 MSN

ENSEMBL:ENSG00000147065.18 MSN

HGNC:7373 MSN

KEGG Gene (Homo sapiens):4478 MSN

Monarch:4478 MSN

NCBI Gene:4478 MSN

OMIM:309845 MSN

Reference Transcript

RefSeq:NM_002444.2 MSN

Other Identifiers

11715716_at

11715717_s_at

11749374_a_at

17104259

200600_PM_at

200600_at

2804475

2804476

2804477

2804484

2804487

2804488

2804490

3979660

3979680

3979685

3979686

3979687

3979688

3979689

3979690

3979691

3979693

3979694

3979695

3979697

3979698

3979699

3979700

40771_at

4478

8167965

A_23_P73589

A_23_P73593

GE79525

GO:0001771

GO:0001931

GO:0002376

GO:0003723

GO:0003725

GO:0003779

GO:0005102

GO:0005198

GO:0005200

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005902

GO:0005912

GO:0005925

GO:0007010

GO:0007155

GO:0007159

GO:0007163

GO:0008092

GO:0008360

GO:0008361

GO:0009986

GO:0010628

GO:0016020

GO:0016192

GO:0016323

GO:0016324

GO:0019899

GO:0019901

GO:0022612

GO:0022614

GO:0030154

GO:0030163

GO:0030175

GO:0031143

GO:0031528

GO:0031982

GO:0042098

GO:0042995

GO:0043226

GO:0045177

GO:0045198

GO:0045732

GO:0048471

GO:0048856

GO:0048870

GO:0050839

GO:0050900

GO:0061028

GO:0065003

GO:0070062

GO:0070489

GO:0071394

GO:0071803

GO:0071944

GO:0072562

GO:0072678

GO:1902115

GO:1902966

GO:2000401

GO:2000643

HMNXSV003005143

HMNXSV003026763

ILMN_1659895

M69066_at

PH_hs_0029317

PH_hs_0035636

TC0X000353.hg

g4505256_3p_at

Participates

as a component of

Stereocilium shaft [cytosol] (Homo sapiens)

Other forms of this molecule

MSN [cytosol]

MSN(2-448)-ALK(1064-1620) fusion [cytosol]

MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol]

Modified Residues

Name

O-phospho-L-threonine at 558

Coordinate

558

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_002435.1

OpenTargets

ENSG00000147065

HPA

ENSG00000147065-MSN

GeneCards

P26038

Ensembl

ENST00000360270, ENSG00000147065, ENSP00000353408

PRO

P26038

Pharos - Targets

P26038

Orphanet

24718

PDB

1E5W, 6TXQ, 1EF1, 1SGH, 8CIU, 8CIS, 8CIT, 6TXS, 8CIR

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.956	19
UniProt:O14745 NHRF1			0.684	4
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.569	5
UniProt:P97820	1	MAP4K4 [cytosol] (R-MMU-3214893)	0.558	2
UniProt:P25791-3 LMO2			0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P53779 MAPK10	3	MAPK10 [cytosol] (R-HSA-450352) p-T221,Y223-MAPK10 [cytosol] (R-HSA-450214) p-T221,Y223-MAPK10 [nucleoplasm] (R-HSA-450311)	0.527	2
UniProt:P54274 TERF1	1	TERF1 [nucleoplasm] (R-HSA-164618)	0.508	2
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.499	20
UniProt:P16070 CD44	2	CD44 [secretory granule membrane] (R-HSA-6804776) CD44 [plasma membrane] (R-HSA-1031688)	0.463	6
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
UniProt:P08567 PLEK	2	PLEK [extracellular region] (R-HSA-350741) PLEK [cytosol] (R-HSA-350715)	0.462	3
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

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