Reactome | GDI2 [azurophil granule lumen]

GDI2 [azurophil granule lumen]

Stable Identifier

R-HSA-6799337

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

GDI2/Rab GDI beta

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P50395 GDI2

Gene Names

GDI2, RABGDIB

Chain

chain:1-445

Reference Genes

BioGPS Gene:2665 GDI2

COSMIC (genes):GDI2 GDI2

CTD Gene:2665 GDI2

dbSNP Gene:2665 GDI2

ENSEMBL:ENSG00000057608 GDI2

HGNC:4227 GDI2

KEGG:hsa:2665 GDI2

Monarch:2665 GDI2

NCBI Gene:2665 GDI2

OMIM:600767 GDI2

UCSC:P50395 GDI2

Reference Transcript

Other Identifiers

11736003_x_at

11740677_a_at

11757439_s_at

16653295

16653307

16653311

16653313

16653361

16653367

16653369

16653371

16653397

16653409

16653413

16653415

16653463

16653469

16653471

16653473

16711442

18670733

18670734

18670735

18670736

18670737

18670738

18670739

18670740

18670741

18670742

18670743

18670744

18670745

18670746

18670747

18670748

18670749

18670750

18670751

18670752

18670753

200008_PM_s_at

200008_s_at

200009_PM_at

200009_at

2341978

2665

3275138

3275140

3275141

3275142

3275143

3275145

3275146

3275147

3275150

3275151

3275152

3275153

3275154

3275164

3275165

3275166

3275167

3275168

3275173

3275174

3275175

3275179

3275180

3275181

3275182

3275186

3275222

3275378

3275382

3275386

3275388

3275612

3275613

3275658

35307_at

69367_at

777_at

7892574

7892630

7893732

7894197

7894252

7894304

7894395

7894505

7894691

7894741

7894826

7895120

7895161

7895263

7895271

7895535

7895691

7895700

7895865

7895985

7896077

7896321

7896492

7896531

7931873

84395_at

A_23_P161446

A_33_P3258988

D13988_at

GE60306

GE79890

GO:0003723

GO:0005092

GO:0005093

GO:0005096

GO:0005515

GO:0005576

GO:0005737

GO:0005794

GO:0005829

GO:0005925

GO:0007165

GO:0007264

GO:0015031

GO:0016020

GO:0016192

GO:0031267

GO:0031982

GO:0034774

GO:0035578

GO:0043226

GO:0045202

GO:0070062

GO:0098772

GO:1902018

GO:1903565

HMNXSV003014995

HMNXSV003052038

ILMN_1754178

PH_hs_0028919

TC10001002.hg

g285974_3p_a_at

g6598322_3p_s_at

Participates

as a member of

Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)

Other forms of this molecule

GDI2 [cytosol]

GDI2 [extracellular region]

GDI2 [secretory granule lumen]

Inferred To

Gdi [azurophil granule lumen] (Drosophila melanogaster)

gdi-1 [azurophil granule lumen] (Caenorhabditis elegans)

gdi2 [azurophil granule lumen] (Danio rerio)

gdi2 [azurophil granule lumen] (Xenopus tropicalis)

GDI2 [azurophil granule lumen] (Bos taurus)

GDI2 [azurophil granule lumen] (Canis familiaris)

GDI2 [azurophil granule lumen] (Dictyostelium discoideum)

GDI2 [azurophil granule lumen] (Gallus gallus)

GDI2 [azurophil granule lumen] (Plasmodium falciparum)

GDI2 [azurophil granule lumen] (Sus scrofa)

gdi1 [azurophil granule lumen] (Schizosaccharomyces pombe)

GDI1 [azurophil granule lumen] (Saccharomyces cerevisiae)

Homologues of GDI2 [azurophil granule lumen] (Bos taurus)

Gdi2 [azurophil granule lumen] (Mus musculus)

Gdi2 [azurophil granule lumen] (Rattus norvegicus)

Cross References

ENSEMBL

ENSP00000369538, ENSP00000369528, ENST00000380181, ENST00000380191

OpenTargets

ENSG00000057608

HPA

ENSG00000057608-GDI2

PRO

P50395

Pharos - Targets

P50395

GlyGen

P50395

HMDB Protein

HMDBP01785

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20339 RAB5A	7	RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125)	0.725	7
UniProt:P20336 RAB3A	9	RAB3A [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372512) RAB3A [plasma membrane] (R-HSA-210461) RAB3A [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917743) RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210466) RAB3A [secretory granule membrane] (R-HSA-6804968) RAB3A [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-379365) RAB3A [cytosol] (R-HSA-8870410) GGC-RAB3A [cytosol] (R-HSA-8870429) GGC-RAB3A [secretory granule membrane] (R-HSA-8875319)	0.643	3
UniProt:P02751 FN1	10	FN1(32-2386) [extracellular region] (R-HSA-54851) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620)	0.527	2
UniProt:Q8BMD2	1	Dzip1 [nucleoplasm] (R-MMU-5635020)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7

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