Reactome | PXLP-K-SPTLC1 [endoplasmic reticulum membrane]

PXLP-K-SPTLC1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-428155

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

serine palmitoyltransferase 1

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External Reference Information

External Reference

UniProt:O15269 SPTLC1

Gene Names

SPTLC1, LCB1

Chain

chain:1-473

Reference Genes

BioGPS Gene:10558 Q6NUL7

COSMIC (genes):SPTLC1 SPTLC1

CTD Gene:10558 Q6NUL7

dbSNP Gene:10558 Q6NUL7

ENSEMBL:ENSG00000090054 SPTLC1

HGNC:11277 O152692

KEGG:hsa:10558 Q6NUL7

Monarch:10558 Q6NUL7

NCBI Gene:10558 Q6NUL7

OMIM:605712 O152692

UCSC:O15269 O152692

Reference Transcript

Participates

as a component of

Inferred To

Spt-I [endoplasmic reticulum membrane] (Drosophila melanogaster)

Sptlc1 [endoplasmic reticulum membrane] (Mus musculus)

Sptlc1 [endoplasmic reticulum membrane] (Rattus norvegicus)

sptlc1 [endoplasmic reticulum membrane] (Danio rerio)

sptlc1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

SPTLC1 [endoplasmic reticulum membrane] (Bos taurus)

SPTLC1 [endoplasmic reticulum membrane] (Canis familiaris)

SPTLC1 [endoplasmic reticulum membrane] (Gallus gallus)

SPTLC1 [endoplasmic reticulum membrane] (Sus scrofa)

Modified Residues

Name

N6-pyridoxal phosphate-L-lysine at unknown position

PsiMod Name

N6-pyridoxal phosphate-L-lysine [MOD:00128]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.

Cross References

RefSeq

NP_001268232.1, NP_006406.1, NP_847894.1

Guide to Pharmacology - Targets

2509

OpenTargets

ENSG00000090054

ENSEMBL

ENSG00000090054, ENSP00000337635, ENST00000690139, ENST00000262554, ENSP00000262554, ENSP00000510483, ENST00000337841

ZINC - Substances

SPTC1_HUMAN

ZINC target

O15269

PRO

O15269

PDB

7K0J, 7K0P, 7YIU, 7K0I, 7K0K, 7K0Q, 6M4N, 7YJ2, 7YJ1, 7K0N, 7K0L, 7YIY, 7CQI, 7CQK, 7K0O, 6M4O, 7K0M

HPA

ENSG00000090054-SPTLC1

GeneCards

SPTLC1

Pharos - Targets

O15269

Orphanet

SPTLC1

ZINC - Predictions - Purchasable

SPTC1_HUMAN

HMDB Protein

HMDBP00886

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 P345Pfs103 [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 L230Afs188 [endoplasmic reticulum membrane] (R-HSA-9628869)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	5

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