Reactome | RAB5C [plasma membrane]

RAB5C [plasma membrane]

Stable Identifier

R-HSA-6806265

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ras-related protein Rab-5C, RAB5C_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P51148 RAB5C

Gene Names

RAB5C, RABL

Chain

chain:1-216

Reference Genes

BioGPS Gene:5878 RAB5C

COSMIC (genes):RAB5C RAB5C

CTD Gene:5878 RAB5C

dbSNP Gene:5878 RAB5C

ENSEMBL:ENSG00000108774 RAB5C

HGNC:9785 RAB5C

KEGG:hsa:5878 RAB5C

Monarch:5878 RAB5C

NCBI Gene:5878 RAB5C

OMIM:604037 RAB5C

UCSC:P51148 RAB5C

Reference Transcript

Other Identifiers

11725589_s_at

11739019_x_at

11753521_a_at

16845039

201140_PM_s_at

201140_s_at

201156_PM_s_at

201156_s_at

3295097

34836_at

3757665

3757666

3757667

3757669

3757670

3757671

3757672

3757673

3757674

3757675

3757676

3757677

3757678

3757684

3757686

3757687

3757689

3757691

3757692

5878

8015545

A_23_P107211

A_23_P107214

GE81414

GO:0000166

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005765

GO:0005768

GO:0005769

GO:0005811

GO:0005886

GO:0006886

GO:0006897

GO:0007032

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0016197

GO:0016787

GO:0019003

GO:0030100

GO:0030139

GO:0031410

GO:0031901

GO:0035577

GO:0042470

GO:0043226

GO:0046872

GO:0048227

GO:0070062

GO:0098772

HMNXSV003010354

HMNXSV003047120

Hs.479.0.A1_3p_a_at

ILMN_1769665

ILMN_2399140

PH_hs_0023635

TC17001525.hg

g4759019_3p_a_at

Participates

as a member of

Azurophil granule membrane proteins [plasma membrane] (Homo sapiens)

Other forms of this molecule

RAB5C [azurophil granule membrane]

GGC-RAB5C [clathrin-coated endocytic vesicle membrane]

GGC-RAB5C [macropinosome membrane]

RAB5C [cytosol]

GGC-RAB5C [cytosol]

GGC-RAB5C [early endosome membrane]

RAB5C [early endosome membrane]

RAB5C [cytoplasmic vesicle membrane]

RAB5C [Golgi membrane]

Inferred To

rab-5 [plasma membrane] (Caenorhabditis elegans)

rab5A [plasma membrane] (Dictyostelium discoideum)

RAB5C [plasma membrane] (Canis familiaris)

RAB5C [plasma membrane] (Gallus gallus)

RAB5C [plasma membrane] (Plasmodium falciparum)

Rab5c [plasma membrane] (Mus musculus)

Rab5c [plasma membrane] (Rattus norvegicus)

rab5c [plasma membrane] (Danio rerio)

Rab5 [plasma membrane] (Drosophila melanogaster)

VPS21 [plasma membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_958842.1, XP_011523393.1, XP_011523392.1, NP_001238968.1, NP_004574.2

OpenTargets

ENSG00000108774

ENSEMBL

ENSP00000377440, ENST00000547517, ENSG00000108774, ENST00000346213, ENSP00000447053, ENST00000393860, ENSP00000345689

IntEnz

3.6.5.2

HPA

ENSG00000108774-RAB5C

GeneCards

RAB5C

PRO

P51148

Pharos - Targets

P51148

GlyGen

P51148

PDB

4KYI

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.802	6
UniProt:P20339 RAB5A	7	RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432) GGC-RAB5A [early endosome membrane] (R-HSA-8875323)	0.802	6
UniProt:P24386 CHM	1	CHM [cytosol] (R-HSA-6801097)	0.643	4
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	9

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