Reactome | PSMD14 [ficolin-1-rich granule lumen]

PSMD14 [ficolin-1-rich granule lumen]

Stable Identifier

R-HSA-6800419

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ficolin-1-rich granule lumen

Synonyms

26S proteasome-associated pad1 homolog

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O00487 PSMD14

Gene Names

PSMD14, POH1

Chain

chain:1-310

Reference Genes

BioGPS Gene:10213 PSMD14

COSMIC (genes):PSMD14 PSMD14

CTD Gene:10213 PSMD14

dbSNP Gene:10213 PSMD14

ENSEMBL:ENSG00000115233 PSMD14

HGNC:16889 PSMD14

KEGG:hsa:10213 PSMD14

Monarch:10213 PSMD14

NCBI Gene:10213 PSMD14

OMIM:607173 PSMD14

UCSC:O00487 PSMD14

Reference Transcript

RefSeq:NM_005805.5 PSMD14

Other Identifiers

10213

11733918_a_at

11744362_a_at

16886919

212296_PM_at

212296_at

2512702

2512703

2512704

2512705

2512706

2512708

2512709

2512710

2512717

2512718

2512720

2512721

2512726

2512727

2512728

2512729

2512730

2512731

2512733

2512735

2512740

2512741

2512742

2512743

2512744

2512746

2512747

33247_at

43809_at

8045946

87461_at

A_23_P165691

GE59512

GE743596

GO:0000502

GO:0000724

GO:0003824

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005829

GO:0006281

GO:0006303

GO:0006310

GO:0006508

GO:0006511

GO:0008233

GO:0008237

GO:0008541

GO:0016579

GO:0016787

GO:0022624

GO:0030163

GO:0031597

GO:0034774

GO:0043161

GO:0043226

GO:0045471

GO:0046872

GO:0061133

GO:0061136

GO:0061578

GO:0070536

GO:0070628

GO:0098772

GO:0140096

GO:0140492

GO:1904813

HMNXSV003017627

Hs.178761.0.S1_3p_at

ILMN_1737396

PH_hs_0010617

TC02000970.hg

U86782_at

p27462

Participates

as a member of

Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)

Other forms of this molecule

PSMD14 [cytosol]

PSMD14 [nucleoplasm]

PSMD14 [secretory granule lumen]

PSMD14 [extracellular region]

Inferred To

Psmd14 [ficolin-1-rich granule lumen] (Rattus norvegicus)

psmd14 [ficolin-1-rich granule lumen] (Danio rerio)

psmd14 [ficolin-1-rich granule lumen] (Xenopus tropicalis)

PSMD14 [ficolin-1-rich granule lumen] (Bos taurus)

PSMD14 [ficolin-1-rich granule lumen] (Caenorhabditis elegans)

PSMD14 [ficolin-1-rich granule lumen] (Canis familiaris)

PSMD14 [ficolin-1-rich granule lumen] (Dictyostelium discoideum)

PSMD14 [ficolin-1-rich granule lumen] (Drosophila melanogaster)

PSMD14 [ficolin-1-rich granule lumen] (Gallus gallus)

PSMD14 [ficolin-1-rich granule lumen] (Mus musculus)

PSMD14 [ficolin-1-rich granule lumen] (Plasmodium falciparum)

PSMD14 [ficolin-1-rich granule lumen] (Saccharomyces cerevisiae)

PSMD14 [ficolin-1-rich granule lumen] (Schizosaccharomyces pombe)

PSMD14 [ficolin-1-rich granule lumen] (Sus scrofa)

Cross References

RefSeq

NP_005796.1

Guide to Pharmacology - Targets

2410

OpenTargets

ENSG00000115233

ENSEMBL

ENST00000409682, ENSP00000386541

HPA

ENSG00000115233-PSMD14

PRO

O00487

Pharos - Targets

O00487

GlyGen

O00487

PDB

5VFR, 5VFU, 5T0G, 6MSJ, 5LN3, 5VFT, 7QYB, 6MSD, 7W3F, 7W3C, 7QY7, 7QXX, 5VGZ, 7W39, 5VHS, 5GJR, 7W3B, 5T0J, 7W3J, 7W3H, 5VHF, 6MSB, 5M32, 7W3A, 5VHH, 5VFQ, 5T0H, 6MSK, 5VFS, 6WJD, 7QXN, 7QXP, 5VHI, 7QYA, 5GJQ, 7W3K, 6MSE, 7W3M, 8CVT, 7W3I, 5T0C, 6MSH, 7W37, 5L4K, 6MSG, 6WJN, 7QXW, 5T0I, 5VFP, 7QXU, 7W3G, 7W38

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406)	0.904	16
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.788	6
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.725	5
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.725	5
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.718	6
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.669	3
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.669	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436)	0.648	3
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408)	0.643	3
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.643	4
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.643	3
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.643	4
UniProt:P50222 MEOX2			0.556	3
UniProt:Q8IZU0 FAM9B			0.556	3
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.528	2
UniProt:P48556 PSMD8	2	PSMD8 [cytosol] (R-HSA-68808) PSMD8 [nucleoplasm] (R-HSA-174318)	0.527	2
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.527	3
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.527	2
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.527	3
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	3
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421)	0.527	2
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.527	2
UniProt:Q53HC0 CCD92			0.527	3
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.527	2
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	3
UniProt:Q96EN9 REX1B			0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10

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