Reactome | GNAI3 [plasma membrane]

GNAI3 [plasma membrane]

Stable Identifier

R-HSA-55365

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G(i) alpha-3, Guanine nucleotide-binding protein G(k), alpha subunit

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Signal amplification (Homo sapiens)
    - ADP signalling through P2Y purinoceptor 12 (Homo sapiens)
      - Activated P2Y purinoceptor 12 binds G-protein Gi (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
      - Dissociation of the P2Y purinoceptor 12:Gi complex (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
      - Gi activation by P2Y purinoceptor 12 (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Adenylate cyclase inhibitory pathway (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        Dissociation of the Gi alpha:G olf complex (Homo sapiens)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GDP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        G alpha (i) inhibits adenylate cyclase (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Homo sapiens)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Homo sapiens)
        
        G alpha (i): GTP [plasma membrane] (Homo sapiens)
        
        G alpha (i) [plasma membrane] (Homo sapiens)
        
        GNAI3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08754 GNAI3

Gene Names

GNAI3

Chain

initiator methionine:, chain:2-354

Reference Genes

BioGPS Gene:2773 GNAI3

COSMIC (genes):GNAI3 GNAI3

CTD Gene:2773 GNAI3

dbSNP Gene:2773 GNAI3

ENSEMBL:ENSG00000065135 GNAI3

ENSEMBL_homo_sapiens_GENE:ENSG00000065135.12 GNAI3

HGNC:4387 GNAI3

KEGG Gene (Homo sapiens):2773 GNAI3

Monarch:2773 GNAI3

NCBI Gene:2773 GNAI3

OMIM:139370 GNAI3

UCSC:P08754 GNAI3

Reference Transcript

RefSeq:NM_006496.3 GNAI3

Other Identifiers

11727775_s_at

11727776_at

11727777_at

11727778_a_at

16668272

16668283

16668286

201179_PM_s_at

201179_s_at

201180_PM_s_at

201180_s_at

201181_PM_at

201181_at

2350841

2350842

2350846

2350847

2350848

2350850

2350853

2350854

2350856

2350858

2350859

2350860

2350862

2350864

2350865

2350867

2350869

2350870

2350871

2350873

2350875

2773

3891220

7903703

7903717

84319_at

876_at

A_14_P119691

A_21_P0000999

A_24_P353912

A_33_P3419334

A_33_P3419339

GE79761

GO:0000139

GO:0000166

GO:0001664

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005813

GO:0005815

GO:0005834

GO:0005856

GO:0005886

GO:0006914

GO:0007049

GO:0007165

GO:0007186

GO:0007188

GO:0007193

GO:0007194

GO:0007212

GO:0016020

GO:0016239

GO:0016787

GO:0019001

GO:0019003

GO:0023052

GO:0030496

GO:0031683

GO:0043226

GO:0046039

GO:0046872

GO:0051301

GO:0055086

GO:0070062

GO:1901135

HMNXSV003017600

HMNXSV003023482

HMNXSV003034196

ILMN_1696003

M27543_at

PH_hs_0004215

TC01000947.hg

TC01000948.hg

TC01000949.hg

TC01004606.hg

g183183_3p_a_at

g183224_3p_a_at

g5729849_3p_at

p1100

Participates

as a member of

G alpha (i) [plasma membrane] (Homo sapiens)

Inferred To

Galphai3 [plasma membrane] (Gallus gallus)

Gnai3 [plasma membrane] (Mus musculus)

GNAI3 [plasma membrane] (Bos taurus)

GNAI3 [plasma membrane] (Caenorhabditis elegans)

GNAI3 [plasma membrane] (Canis familiaris)

GNAI3 [plasma membrane] (Danio rerio)

GNAI3 [plasma membrane] (Dictyostelium discoideum)

GNAI3 [plasma membrane] (Drosophila melanogaster)

GNAI3 [plasma membrane] (Saccharomyces cerevisiae)

GNAI3 [plasma membrane] (Schizosaccharomyces pombe)

GNAI3 [plasma membrane] (Sus scrofa)

Guanine nucleotide-binding protein G(k) subunit alpha [plasma membrane] (Rattus norvegicus)

gnai3 [plasma membrane] (Xenopus tropicalis)

Homologues of GNAI3 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_006487.1

OpenTargets

ENSG00000065135

HPA

ENSG00000065135-GNAI3

GeneCards

P08754

ZINC target

P08754

Ensembl

ENSG00000065135, ENSP00000358867, ENST00000369851

PRO

P08754

Pharos - Targets

P08754

Orphanet

21157

HMDB Protein

HMDBP11461

PDB

7X6I, 7KH0, 2V4Z, 7T11, 8GVX, 4G5S, 8JD6, 7T10, 7E9H, 2ODE, 4G5O, 4G5R, 7RA3, 7RGP, 2IHB

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7

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