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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
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Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
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Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
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FAQ
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Citing us
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Analyse gene expression
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Go!
Unfolded GNB1 [cytosol]
Stable Identifier
R-HSA-6814200
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Unfolded G-protein subunit beta-1
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB1 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB1 [cytosol] (Homo sapiens)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB1 [cytosol] (Homo sapiens)
TRiC/CCT binds unfolded G-protein beta subunit (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB1 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62873 GNB1
Gene Names
GNB1
Chain
initiator methionine:, chain:2-340
Reference Genes
BioGPS Gene:2782 GNB1
COSMIC (genes):GNB1 GNB1
CTD Gene:2782 GNB1
dbSNP Gene:2782 GNB1
ENSEMBL:ENSG00000078369 GNB1
HGNC:4396 GNB1
KEGG:hsa:2782 GNB1
Monarch:2782 GNB1
NCBI Gene:2782 GNB1
OMIM:139380 GNB1
UCSC:P62873 GNB1
Reference Transcript
RefSeq:XM_017001059.1 GNB1
RefSeq:NM_001282538.1 GNB1
RefSeq:XM_017001060.1 GNB1
RefSeq:NM_001282539.1 GNB1
RefSeq:XM_017001061.1 GNB1
RefSeq:NM_002074.4 GNB1
Participates
as a member of
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Other forms of this molecule
GNB1 [cytosol]
GNB1 [plasma membrane]
Partially folded GNB1 [cytosol]
GNB1 [photoreceptor disc membrane]
Inferred To
GNB1 [cytosol]
(Bos taurus)
GNB1 [cytosol]
(Canis familiaris)
GNB1 [cytosol]
(Gallus gallus)
GNB1 [cytosol]
(Sus scrofa)
STE4 [cytosol]
(Saccharomyces cerevisiae)
git5 [cytosol]
(Schizosaccharomyces pombe)
gpb-1 [cytosol]
(Caenorhabditis elegans)
Gbeta76C [cytosol]
(Drosophila melanogaster)
gnb1 [cytosol]
(Xenopus tropicalis)
gnb1b [cytosol]
(Danio rerio)
Gbeta13F [cytosol]
(Drosophila melanogaster)
Homologues of GNB1 [cytosol]
(Drosophila melanogaster)
Gnb1 [cytosol]
(Rattus norvegicus)
gpbA [cytosol]
(Dictyostelium discoideum)
G-protein beta 1 subunit [cytosol]
(Mus musculus)
Cross References
RefSeq
NP_001269467.1
,
XP_016856550.1
,
XP_016856548.1
,
NP_002065.1
,
NP_001269468.1
,
XP_016856549.1
OpenTargets
ENSG00000078369
ENSEMBL
ENSP00000515438
,
ENST00000703711
,
ENST00000703697
,
ENST00000703710
,
ENSP00000515436
,
ENSP00000515437
,
ENST00000703699
,
ENST00000378609
,
ENSP00000515433
,
ENSG00000078369
,
ENSP00000515431
,
ENSP00000515435
,
ENSP00000515434
,
ENSP00000515432
,
ENST00000610897
,
ENST00000703701
,
ENSP00000515427
,
ENSP00000515428
,
ENST00000703702
,
ENST00000703700
,
ENST00000703704
,
ENST00000703703
,
ENSP00000515429
,
ENSP00000515442
,
ENST00000703692
,
ENSP00000367872
,
ENSP00000515440
,
ENSP00000481878
,
ENST00000703706
,
ENSP00000515445
,
ENST00000703708
,
ENSP00000515443
,
ENST00000703694
,
ENST00000703696
,
ENSP00000515444
,
ENST00000703709
,
ENST00000703693
GeneCards
GNB1
HPA
ENSG00000078369-GNB1
PRO
P62873
Pharos - Targets
P62873
GlyGen
P62873
Orphanet
GNB1
HMDB Protein
HMDBP08398
PDB
7WCN
,
7W3Z
,
8I7W
,
8E3Y
,
7F1Z
,
8XQP
,
6CRK
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8UNV
,
5HE0
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8JLJ
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8IOC
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8IRT
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7L1V
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7XXI
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7EW7
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8GEH
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8FEG
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7JVP
,
7AUE
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8IRR
,
8X8N
,
8XQT
,
7YK6
,
8DPH
,
8UGY
,
8GFY
,
8XQR
,
7RMG
,
8H0P
,
7VDM
,
7TYI
,
6XBL
,
8YN5
,
8YW3
,
8IQ4
,
7RAN
,
7VFX
,
7YAC
,
8UNY
,
7VLA
,
5UKM
,
7KI1
,
7JVR
,
8GE9
,
7WXW
,
8FYL
,
8XZI
,
8JLO
,
8THK
,
8HNM
,
8E9Z
,
8XWQ
,
7W0P
,
8JR9
,
7WUJ
,
8HJ5
,
8ZSS
,
8XOF
,
8UNL
,
7TUZ
,
8HMV
,
8UNU
,
8X79
,
6UVA
,
8IC0
,
7TYW
,
8JXW
,
8J6P
,
7EW1
,
8GGE
,
8J21
,
8GUR
,
8ZJD
,
8I7V
,
7BB7
,
7RMI
,
8YUV
,
7T9N
,
7YDM
,
7L0P
,
8XQL
,
6LI3
,
7XJL
,
8YW4
,
8H4I
,
8FYE
,
6NIY
,
8IY9
,
8JSO
,
7CMV
,
8FYX
,
7EB2
,
7KI0
,
8GE8
,
8XZJ
,
8IUK
,
8JLN
,
7XKE
,
7MTS
,
9AXF
,
6XOX
,
8DZQ
,
7F6G
,
7E32
,
8I9L
,
5HE1
,
7XKF
,
8XQN
,
7LLL
,
7VUI
,
8UNW
,
8JZZ
,
6OMM
,
8JXX
,
7W0L
,
8WJX
,
6KPG
,
8GD9
,
9AUC
,
7UM5
,
8J18
,
7LCI
,
8J6R
,
8XJM
,
7EW3
,
7TMW
,
7X9A
,
7SR8
,
8J23
,
8IRV
,
8T3V
,
9BQJ
,
8KFX
,
8W8B
,
8GG4
,
6N4B
,
8ZSP
,
7YAE
,
8SMV
,
8K2X
,
7F9Z
,
7CX3
,
8GEB
,
8FYT
,
7F1Q
,
7WY0
,
8HBD
,
7EO4
,
8ID8
,
8YN2
,
8SG1
,
7EXD
,
8G2Y
,
7TYX
,
6VCB
,
7YFC
,
8HJ0
,
8FU6
,
8UNR
,
6KPF
,
7VUH
,
7W0N
,
7V6A
,
7UM7
,
8J19
,
8K9K
,
8UH3
,
8IZ4
,
7F53
,
8GGA
,
7XA3
,
7X2F
,
7Y64
,
7F8W
,
8KFZ
,
7L0Q
,
6LML
,
7XP6
,
8GE5
,
8GG7
,
8F76
,
7DFL
,
6M1H
,
7EJ8
,
7CX4
,
8GED
,
7Y66
,
7WY5
,
7F0T
,
8ID4
,
8E9Y
,
8FLS
,
8FN0
,
7F4D
,
8F2A
,
8UNN
,
6OT0
,
7XP5
,
8K4N
,
8ZPT
,
8JIM
,
8IBV
,
8IJB
,
8SAI
,
8U84
,
7JOZ
,
8GEJ
,
7CKZ
,
8UWL
,
7RKN
,
8Y52
,
5UKL
,
7F1S
,
8EMX
,
7X9B
,
6WHA
,
7NA8
,
8HQC
,
8FLU
,
7SBF
,
9ERX
,
7VV5
,
7T2G
,
8IOD
,
8IW9
,
7XK8
,
8IED
,
7WU9
,
8GDA
,
8JER
,
7TYL
,
7F58
,
8YRG
,
8W8A
,
8IKH
,
8XVI
,
8VY9
,
7EVY
,
7X5H
,
7RKF
,
7T11
,
8T3O
,
7T8X
,
8IU2
,
8H0Q
,
8GUQ
,
6VN7
,
8GGC
,
8U4P
,
6OSA
,
7F24
,
8DZR
,
7WVX
,
8JII
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8JSP
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7EJA
,
7Y89
,
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,
7W6P
,
7RGP
,
7SF8
,
8IJA
,
5HE3
,
7UM6
,
7EW0
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7YS6
,
8H2G
,
9IQT
,
8FLT
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7TRK
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8GFX
,
7W55
,
7VDL
,
6LFO
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6B3J
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7WF7
,
6OIJ
,
7XZ6
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8WC4
,
8XJN
,
7S3I
,
9BKJ
,
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,
8GDZ
,
8GG1
,
8THL
,
8WSS
,
8IYH
,
7T96
,
8XIP
,
7UTZ
,
8YN3
,
7E33
,
8YW5
,
8U4Q
,
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,
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,
6DDF
,
8JT6
,
7XMT
,
7WVV
,
8VY7
,
8W8Q
,
8J6D
,
8J9N
,
7XOV
,
8XVH
,
7X9Y
,
7W53
,
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,
7VIF
,
8DZP
,
7LD3
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8I95
,
7D76
,
8W87
,
7S8P
,
8GG8
,
8DPF
,
7WUQ
,
8KH4
,
8WP1
,
7W2Z
,
7E2X
,
8EIT
,
8YKY
,
8WC6
,
8GCP
,
6ORV
,
7XZ5
,
8WCB
,
8UO4
,
7XK2
,
8UQO
,
8U81
,
8GE7
,
8GG3
,
7EVZ
,
8U1U
,
7KH0
,
7WU4
,
8SZH
,
7F6I
,
8JPP
,
8JLQ
,
8JLZ
,
8UNP
,
8GDC
,
7F4F
,
8IUL
,
8JHB
,
7E9G
,
6WZG
,
8JGF
,
8JD5
,
8HQM
,
7V69
,
7XKD
,
9EPP
,
7E9H
,
7VIH
,
8GEI
,
8GAG
,
7W7E
,
8HSC
,
7S8N
,
7TRP
,
8GFZ
,
8DWC
,
6XBJ
,
7X2C
,
9GYO
,
8XOI
,
8IRS
,
7EZH
,
8GCM
,
7XV3
,
8IEC
,
7XT8
,
7TYF
,
9AYF
,
8GG2
,
7VL8
,
7YON
,
6LMK
,
8T3Q
,
8WST
,
8HVI
,
8XZG
,
7VUZ
,
9JKQ
,
7Y24
,
7WU2
,
8JLP
,
8XWP
,
9AVG
,
8YUU
,
6P9Y
,
9IIX
,
8JD3
,
8IQ6
,
8GE3
,
7T9I
,
8ZSJ
,
7Y1F
,
6EG8
,
7YOO
,
7WY8
,
8DDW
,
8IA2
,
7VUY
,
8XZH
,
8E9X
,
8HNL
,
8YUT
,
7F8V
,
7CFN
,
8E3Z
,
7XTQ
,
8QJ2
,
8JLK
,
8WC8
,
8JD6
,
6M8S
,
7X10
,
7K7L
,
7XOW
,
8HCQ
,
7WKD
,
8DPI
,
8X2K
,
8F0J
,
7XJJ
,
8HDP
,
8DPG
,
8E9W
,
7RA3
,
8JHY
,
8GE2
,
8GG5
,
4KFM
,
8XVE
,
7TYH
,
7JV5
,
7CMU
,
8GEC
,
8JGG
,
7C2E
,
7Y67
,
8PM2
,
7RBT
,
7EO2
,
7RG9
,
7WCM
,
7CFM
,
8UNO
,
8IW4
,
8I9S
,
8IKL
,
8FY8
,
7F55
,
7D7M
,
8YNA
,
7WYB
,
8FX5
,
8ZQE
,
8J6Q
,
7VGX
,
7EW2
,
8JKB
,
7VIE
,
8POK
,
7RMH
,
8J24
,
8W88
,
7YK7
,
8XOH
,
6GDG
,
7D77
,
8GUS
,
7VUG
,
7Y26
,
7L0S
,
7W57
,
6E3Y
,
8K8J
,
5UZ7
,
7L0R
,
7XP4
,
8ZRK
,
7WVU
,
7EUO
,
8GEE
,
8K6N
,
7F9Y
,
6NI3
,
8IYW
,
8IA7
,
7CX2
,
7YDJ
,
8HJ2
,
6X19
,
8ID9
,
4PNK
,
8U02
,
8H4L
,
8JLR
,
7WUI
,
7TYY
,
7RTB
,
8UNX
,
8KGG
,
7VUJ
,
8IA8
,
7W0M
,
8JXV
,
8HIX
,
7EJK
,
7EJX
,
7EW4
,
8XQS
,
8XJL
,
8EJK
,
7EZM
,
7EZK
,
7U2K
,
7BB6
,
7S1M
,
7JVQ
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8J20
,
8GUT
,
8KFY
,
7YDH
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8YN6
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8GFV
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8GE4
,
7XBX
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6M1I
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7CKX
,
7RKM
,
7WXU
,
8GEA
,
7Y3G
,
8K3Z
,
7NA7
,
7EJ0
,
6OIK
,
6X18
,
8H4K
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8U4N
,
7VV3
,
7XW5
,
8G94
,
8TB0
,
8TZQ
,
8IW7
,
8HJ1
,
8EMW
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8XQO
,
6D9H
,
8GDB
,
8WC3
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,
7W0O
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8J6L
,
8IKG
,
8YY8
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8IRU
,
8K9L
,
8X8L
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8GGF
,
8XIR
,
8F0K
,
8J22
,
6PB0
,
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,
7T90
,
9ASB
,
7WU5
,
8WC5
,
8UO2
,
8IW1
,
8SL3
,
8ITF
,
8U83
,
8IYS
,
8JGB
,
7T10
,
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,
7F54
,
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,
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,
6DDE
,
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,
8IJ3
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,
7F1O
,
8FMZ
,
7XY7
,
7SRR
,
6WHC
,
8GY7
,
8JIL
,
8HOC
,
8XGM
,
8GE1
,
7SF7
,
7T6B
,
7XBW
,
5HE2
,
6PT0
,
8GG6
,
7SCG
,
8I2G
,
8ZSV
,
7S8M
,
8G59
,
8HN8
,
5UKK
,
8ID3
,
7CKW
,
8PJK
,
7DB6
,
8JHN
,
7XW6
,
7XBD
,
8FLR
,
8DZS
,
7VDH
,
7W56
,
7XXH
,
6LFM
,
7E2Y
,
7WZ4
,
8XJO
,
8WC7
,
8K4O
,
9BKK
,
7TYO
,
7W40
,
8UNT
,
8GG0
,
7VL9
,
8IZB
,
8GHV
,
8DDX
,
8YN4
,
7F6H
,
7T94
,
8XIO
,
8UNM
,
7YFD
,
8F2B
,
7XMS
,
7WVY
,
8K4P
,
8IBU
,
8WW2
,
7XY6
,
8HQE
,
6OS9
,
8HMP
,
8EJC
,
7S8O
,
7F1R
,
8ZR5
,
8J6I
,
8XJK
,
7XTA
,
7CKY
,
8ID6
,
7JHJ
,
8GG9
,
6X1A
,
7YKD
,
7T2H
,
7WZ7
,
8G05
,
7CRH
,
8T3S
,
8KH5
,
6XBK
,
7X2D
,
8ZJE
,
8XOG
,
8KGK
,
8WC9
,
7P02
,
8WPU
,
6P9X
,
7WJ5
,
8WOG
,
6WI9
,
8X7A
,
7XMR
,
8WRB
,
7WV9
,
7VKT
,
8U8F
,
8JPN
,
7TRQ
,
8HCX
,
8U4O
,
7F23
,
8HS3
,
7S8L
,
8FLQ
,
8HDO
,
7WVW
,
7F4I
,
8W8R
,
7XTB
,
8JZ7
,
8YN9
,
8HQN
,
8U82
,
7L1U
,
8UNS
,
7LD4
,
7VIG
,
8I97
,
8IUM
,
7TZF
,
7YDP
,
7LLY
,
6XBM
,
7E2Z
,
8XOJ
,
8HPT
,
8H8J
,
6G79
,
8SZG
,
8HTI
,
7XT9
,
8UNZ
,
8GE6
,
8W89
,
9EW2
,
7Y65
,
8SZI
,
8XZF
,
8HNK
,
7Y27
,
7WU3
,
8FN1
,
8UO1
,
8J1A
,
8ZFJ
,
8PKM
,
7RKX
,
7F4H
,
8ZPS
,
7XTC
,
8WCA
,
7K7Z
,
8U7Z
,
6WPW
,
7QVM
,
8IJD
,
8JXT
,
6UUN
,
7V68
,
8Y53
,
7YP7
,
8DWG
,
8K6M
,
8J6J
,
9IJ9
,
8GEF
,
8I9A
,
8INR
,
8U26
,
7U2L
,
8JHI
,
7RYC
,
7XJK
,
8UHB
,
8GFW
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:P63211 GNGT1
3
S-farn-GNGT1 [photoreceptor disc membrane]
(R-HSA-2530520)
GNGT1 [photoreceptor disc membrane]
(R-HSA-55393)
GNGT1 [plasma membrane]
(R-HSA-167428)
0.621
3
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.556
3
UniProt:Q13371 PDCL
2
PDCL [cytosol]
(R-HSA-6813727)
p-S18,S19,S20,S25-PDCL [cytosol]
(R-HSA-6814228)
0.527
3
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.527
10
UniProt:P10824 Gnai1
1
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane]
(R-RNO-421889)
0.488
2
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