Reactome | CCT6A [cytosol]

CCT6A [cytosol]

Stable Identifier

R-HSA-390454

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit zeta (TCP-1-zeta)

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOBTB GTPase Cycle (Homo sapiens)
        
        RHOBTB2 GTPase cycle (Homo sapiens)
        
        RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)
        
        RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
        
        CCT6A [cytosol] (Homo sapiens)
        
        RHOBTB2:GTP:RHOBTB2 interacting proteins [endosome membrane] (Homo sapiens)
        
        RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
        
        CCT6A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P40227 CCT6A

Gene Names

CCT6A, CCT6, CCTZ

Chain

initiator methionine:1, chain:2-531

Reference Genes

BioGPS Gene:908 CCT6A

COSMIC (genes):CCT6A CCT6A

CTD Gene:908 CCT6A

dbSNP Gene:908 CCT6A

ENSEMBL:ENSG00000146731 CCT6A

HGNC:1620 CCT6A

KEGG Gene (Homo sapiens):908 CCT6A

Monarch:908 CCT6A

NCBI Gene:908 CCT6A

OMIM:104613 CCT6A

UCSC:P40227 CCT6A

Reference Transcript

Other Identifiers

0004590176

11715530_a_at

17046254

201326_at

201327_3p_s_at

201327_s_at

2849406

3003194

3003195

3003197

3003198

3003201

3003202

3003203

3003204

3003205

3003206

3003209

3003211

3003213

3003216

3003217

3003218

3003220

3003222

3003223

3003224

3003225

3003226

3003227

3003229

3003230

3003231

3003232

3004860

3004873

3004878

3005181

3005188

38416_at

8132943

908

A_23_P158148

GE57707

GO:0000166

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0006259

GO:0006457

GO:0008150

GO:0009058

GO:0016887

GO:0032212

GO:0032991

GO:0034641

GO:0042592

GO:0043167

GO:0043226

GO:0044183

GO:0050821

GO:0051082

GO:0051276

GO:0070062

GO:0071987

GO:1904851

GO:1904871

GO:1904874

HMNXSV003035459

Hs.82916.0.S2_3p_at

ILMN_1719611

ILMN_1722502

L27706_at

PH_hs_0004742

TC07000338.hg

g4502642_3p_s_at

Participates

as a candidate of

RHOBTB2 interacting proteins [cytosol] (Homo sapiens)

as a member of

CCT6 [cytosol] (Homo sapiens)

Inferred To

CCT6 [cytosol] (Drosophila melanogaster)

CCT6 [cytosol] (Saccharomyces cerevisiae)

cct6 [cytosol] (Dictyostelium discoideum)

cct6 [cytosol] (Schizosaccharomyces pombe)

cct6a [cytosol] (Danio rerio)

cct-6 [cytosol] (Caenorhabditis elegans)

CCT6A [cytosol] (Canis familiaris)

CCT6A [cytosol] (Plasmodium falciparum)

CCT6A [cytosol] (Sus scrofa)

Cct6a [cytosol] (Mus musculus)

Cct6a [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001753.1, NP_001009186.1

OpenTargets

ENSG00000146731

GeneCards

P40227

HPA

ENSG00000146731-CCT6A

Ensembl

ENSG00000146731, ENST00000335503, ENSP00000352019, ENSP00000275603, ENST00000275603

PRO

P40227

Pharos - Targets

P40227

GlyGen

P40227

PDB

6NRC, 7LUP, 6QB8, 6NRD, 6NR8, 6NRA, 7LUM, 6NR9, 6NRB

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.643	3
UniProt:P17612 PRKACA	3	PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:P05067 APP	20	APP(672-711) [extracellular region] (R-HSA-976740) APP-C99 [cytosol] (R-HSA-9617603) APP(672-711) [cytosol] (R-HSA-877188) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(688-770) [plasma membrane] (R-HSA-9010028) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-687) [extracellular region] (R-HSA-9010033) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 D522N [plasma membrane] (R-HSA-3640907) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 [plasma membrane] (R-HSA-170842) TGFBR2 K128fs3 [cytosol] (R-HSA-3642173) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 K128fs35 [cytosol] (R-HSA-3642166) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 R528C [plasma membrane] (R-HSA-3640899)	0.556	3
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.527	3
UniProt:P52333 JAK3	6	p-JAK3 [cytosol] (R-HSA-8982856) JAK3 [cytosol] (R-HSA-451893) JAK3 [endosome] (R-HSA-8983184) p-Y-JAK3 [cytosol] (R-HSA-9006854) p-Y980 JAK3 [cytosol] (R-HSA-9701438) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978)	0.527	2
UniProt:O43815 STRN	5	STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9700467) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN [cytosol] (R-HSA-9037081)	0.527	2
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249)	0.527	2
UniProt:P13569 CFTR	17	CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR [plasma membrane] (R-HSA-383188) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR [endosome membrane] (R-HSA-6782965) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) CFTR N1303K [plasma membrane] (R-HSA-5678983) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) ub-CFTR F508del [cytosol] (R-HSA-8866838) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	5
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.527	3