Reactome | CCT6A [cytosol]

CCT6A [cytosol]

Stable Identifier

R-HSA-390454

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit zeta (TCP-1-zeta)

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOBTB GTPase Cycle (Homo sapiens)
        
        RHOBTB2 GTPase cycle (Homo sapiens)
        
        RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)
        
        RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
        
        CCT6A [cytosol] (Homo sapiens)
        
        RHOBTB2:GTP:RHOBTB2 interacting proteins [endosome membrane] (Homo sapiens)
        
        RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
        
        CCT6A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P40227 CCT6A

Gene Names

CCT6A, CCT6, CCTZ

Chain

initiator methionine:1, chain:2-531

Reference Genes

BioGPS Gene:908 CCT6A

COSMIC (genes):CCT6A CCT6A

CTD Gene:908 CCT6A

dbSNP Gene:908 CCT6A

ENSEMBL:ENSG00000146731.11 CCT6A

HGNC:1620 CCT6A

KEGG Gene (Homo sapiens):908 CCT6A

Monarch:908 CCT6A

NCBI Gene:908 CCT6A

OMIM:104613 CCT6A

UCSC:P40227 CCT6A

Reference Transcript

Other Identifiers

0004590176

11715530_a_at

17046254

201326_PM_at

201326_at

201327_3p_s_at

201327_PM_s_at

201327_s_at

2849406

3003194

3003195

3003197

3003198

3003201

3003202

3003203

3003204

3003205

3003206

3003209

3003211

3003213

3003216

3003217

3003218

3003220

3003222

3003223

3003224

3003225

3003226

3003227

3003229

3003230

3003231

3003232

3004860

3004873

3004878

3005181

3005188

38416_at

8132943

908

A_23_P158148

GE57707

GO:0000166

GO:0003723

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0006457

GO:0016787

GO:0016887

GO:0032200

GO:0032212

GO:0032991

GO:0043226

GO:0044183

GO:0050821

GO:0051082

GO:0061077

GO:0070062

GO:0071987

GO:0140657

GO:0140662

GO:1904851

GO:1904871

GO:1904874

HMNXSV003035459

Hs.82916.0.S2_3p_at

ILMN_1719611

ILMN_1722502

L27706_at

PH_hs_0004742

TC07000338.hg

g4502642_3p_s_at

Participates

as a candidate of

RHOBTB2 interacting proteins [cytosol] (Homo sapiens)

as a member of

CCT6 [cytosol] (Homo sapiens)

Inferred To

CCT6 [cytosol] (Drosophila melanogaster)

CCT6 [cytosol] (Gallus gallus)

CCT6 [cytosol] (Saccharomyces cerevisiae)

cct6 [cytosol] (Dictyostelium discoideum)

cct6 [cytosol] (Schizosaccharomyces pombe)

cct-6 [cytosol] (Caenorhabditis elegans)

CCT6A [cytosol] (Bos taurus)

CCT6A [cytosol] (Canis familiaris)

CCT6A [cytosol] (Danio rerio)

CCT6A [cytosol] (Plasmodium falciparum)

CCT6A [cytosol] (Sus scrofa)

Cct6a [cytosol] (Mus musculus)

Cct6a [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001009186.1, NP_001753.1

OpenTargets

ENSG00000146731

HPA

ENSG00000146731-CCT6A

GeneCards

P40227

Ensembl

ENSG00000146731, ENSP00000352019, ENST00000335503, ENSP00000275603, ENST00000275603

PRO

P40227

Pharos - Targets

P40227

PDB

7NVN, 6NRA, 6QB8, 7LUM, 7NVO, 6NRB, 6NR8, 7LUP, 6NRC, 7NVL, 6NR9, 6NRD, 7NVM

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.725	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128fs3 [cytosol] (R-HSA-3642173) TGFBR2 K128fs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:P17612 PRKACA	3	PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	5
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.527	3
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.527	3
UniProt:P52333 JAK3	6	p-Y980 JAK3 [cytosol] (R-HSA-9701438) JAK3 [endosome] (R-HSA-8983184) p-Y-JAK3 [cytosol] (R-HSA-9006854) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978) p-JAK3 [cytosol] (R-HSA-8982856) JAK3 [cytosol] (R-HSA-451893)	0.527	2
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.527	2

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