Reactome | CCT6A [cytosol]

CCT6A [cytosol]

Stable Identifier

R-HSA-390454

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit zeta (TCP-1-zeta)

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOBTB GTPase Cycle (Homo sapiens)
        
        RHOBTB2 GTPase cycle (Homo sapiens)
        
        RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)
        
        RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
        
        CCT6A [cytosol] (Homo sapiens)
        
        RHOBTB2:GTP:RHOBTB2 interacting proteins [endosome membrane] (Homo sapiens)
        
        RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
        
        CCT6A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P40227 CCT6A

Gene Names

CCT6A, CCT6, CCTZ

Chain

initiator methionine:, chain:2-531

Reference Genes

BioGPS Gene:908 CCT6A

COSMIC (genes):CCT6A CCT6A

CTD Gene:908 CCT6A

dbSNP Gene:908 CCT6A

ENSEMBL:ENSG00000146731 CCT6A

HGNC:1620 CCT6A

KEGG:hsa:908 CCT6A

Monarch:908 CCT6A

NCBI Gene:908 CCT6A

OMIM:104613 CCT6A

UCSC:P40227 CCT6A

Reference Transcript

Other Identifiers

11715530_a_at

11757143_s_at

17046254

17046282

17046526

17046588

201326_PM_at

201326_at

201327_3p_s_at

201327_PM_s_at

201327_s_at

2512222

2849406

3003194

3003195

3003197

3003198

3003201

3003202

3003203

3003204

3003205

3003206

3003207

3003208

3003209

3003210

3003211

3003212

3003213

3003214

3003215

3003216

3003217

3003218

3003219

3003220

3003221

3003222

3003223

3003224

3003225

3003226

3003227

3003229

3003230

3003231

3003232

3004860

3004873

3004878

3005181

3005185

3005188

3005198

38416_at

8132943

8132962

8133072

8133108

908

A_21_P0000313

A_23_P158148

GE57707

GE84453

GO:0003723

GO:0003824

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005832

GO:0005874

GO:0006457

GO:0016787

GO:0016887

GO:0032212

GO:0043226

GO:0044183

GO:0050821

GO:0051082

GO:0051086

GO:0061077

GO:0070062

GO:0071987

GO:0140535

GO:0140657

GO:0140662

GO:1904851

GO:1904871

GO:1904874

HMNXSV003035459

HMNXSV003042437

Hs.82916.0.S2_3p_at

ILMN_1719611

ILMN_1722502

L27706_at

PH_hs_0004742

RNA33495|snoRNA_scaRNA_91_133

TC07000338.hg

TC07000340.hg

TC07000390.hg

TC07000400.hg

g4502642_3p_s_at

Participates

as a candidate of

RHOBTB2 interacting proteins [cytosol] (Homo sapiens)

as a member of

CCT6 [cytosol] (Homo sapiens)

Inferred To

CCT6 [cytosol] (Drosophila melanogaster)

CCT6 [cytosol] (Gallus gallus)

CCT6 [cytosol] (Saccharomyces cerevisiae)

cct6 [cytosol] (Dictyostelium discoideum)

cct6 [cytosol] (Schizosaccharomyces pombe)

cct6a [cytosol] (Danio rerio)

cct6a [cytosol] (Xenopus tropicalis)

cct-6 [cytosol] (Caenorhabditis elegans)

CCT6A [cytosol] (Bos taurus)

CCT6A [cytosol] (Canis familiaris)

CCT6A [cytosol] (Plasmodium falciparum)

CCT6A [cytosol] (Sus scrofa)

Cct6a [cytosol] (Mus musculus)

Cct6a [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001753.1, NP_001009186.1

OpenTargets

ENSG00000146731

ENSEMBL

ENSP00000275603, ENST00000275603, ENSG00000146731, ENSP00000352019, ENST00000335503

HPA

ENSG00000146731-CCT6A

GeneCards

CCT6A

PRO

P40227

Pharos - Targets

P40227

GlyGen

P40227

PDB

7NVN, 8I9U, 7TRG, 8SHT, 8SHQ, 7NVM, 8IB8, 6NRB, 8SHN, 8SHO, 7TTT, 8SGC, 8SG9, 8SHL, 8SHD, 8SHE, 7X0A, 7LUM, 8SGQ, 7TUB, 6NR9, 7X7Y, 7WZ3, 8I1U, 8SFE, 7NVO, 8HKI, 7NVL, 7X0V, 6NRA, 7X0S, 6NRD, 6NRC, 8SHP, 7WU7, 7TTN, 7X3J, 8SG8, 8SHA, 8SHF, 8SHG, 6QB8, 8SH9, 7LUP, 7X3U, 6NR8, 7X6Q, 8SGL, 8SFF

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.725	4
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.725	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.643	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	9
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:O94953 KDM4B	2	K48PolyUb-KDM4B [nucleoplasm] (R-HSA-5683074) KDM4B [nucleoplasm] (R-HSA-3214396)	0.527	2
UniProt:Q00535 CDK5	4	CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586)	0.527	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.527	6
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:Q9BQA1 WDR77	3	WDR77 [cytosol] (R-HSA-191823) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [nucleoplasm] (R-HSA-5205610)	0.527	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.527	3
UniProt:O00628 PEX7	2	PEX7 [peroxisomal membrane] (R-HSA-9033493) PEX7 [cytosol] (R-HSA-9033107)	0.527	3
UniProt:P52333 JAK3	6	JAK3 [cytosol] (R-HSA-451893) p-Y-JAK3 [cytosol] (R-HSA-9006854) p-JAK3 [cytosol] (R-HSA-8982856) JAK3 [endosome] (R-HSA-8983184) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978) p-Y980 JAK3 [cytosol] (R-HSA-9701438)	0.527	2
UniProt:Q8NCC3 PLA2G15	1	PLA2G15 [extracellular region] (R-HSA-8933312)	0.499	2

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