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CCT6A [cytosol]
Stable Identifier
R-HSA-390454
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
T-complex protein 1 subunit zeta (TCP-1-zeta)
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Association of TriC/CCT with target proteins during biosynthesis (Homo sapiens)
Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
CCT/TRiC:substrate complex [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
PDCL binds G-protein beta and TRiC/CCT (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
PDCL promotes G-protein beta 5 folding (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
PDCL releases folded G-beta from TRiC/CCT (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
RGS proteins bind GNB5 and CCT/TRiC (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
Release of GNB5:RGS dimers from CCT/TRiC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
TRiC/CCT binds unfolded G-protein beta subunit (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (Homo sapiens)
Folding of actin by CCT/TriC (Homo sapiens)
Exchange of ADP for ATP in CCT/TriC:actin complex (Homo sapiens)
CCT/TRiC:ADP:actin [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
CCT/TRiC:ATP:actin [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
Hydrolysis of ATP and release of folded actin from CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
CCT/TRiC:ATP:actin [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
Formation of tubulin folding intermediates by CCT/TriC (Homo sapiens)
ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex (Homo sapiens)
CCT/TRiC:ADP:non-native tubulin [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
Prefoldin mediated transfer of substrate to CCT/TriC (Homo sapiens)
Actin/tubulin:prefoldin complex associates with CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
actin/tubulin-bound CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT6 [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOBTB GTPase Cycle (Homo sapiens)
RHOBTB2 GTPase cycle (Homo sapiens)
RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
RHOBTB2:GTP:RHOBTB2 interacting proteins [endosome membrane] (Homo sapiens)
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
CCT6A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40227 CCT6A
Gene Names
CCT6A, CCT6, CCTZ
Chain
initiator methionine:1, chain:2-531
Reference Genes
BioGPS Gene:908 CCT6A
COSMIC (genes):CCT6A CCT6A
CTD Gene:908 CCT6A
dbSNP Gene:908 CCT6A
ENSEMBL:ENSG00000146731.11 CCT6A
HGNC:1620 CCT6A
KEGG Gene (Homo sapiens):908 CCT6A
Monarch:908 CCT6A
NCBI Gene:908 CCT6A
OMIM:104613 CCT6A
UCSC:P40227 CCT6A
Reference Transcript
RefSeq:NM_001762.3 CCT6A
RefSeq:NM_001009186.1 CCT6A
Other Identifiers
0004590176
11715530_a_at
17046254
201326_PM_at
201326_at
201327_3p_s_at
201327_PM_s_at
201327_s_at
2849406
3003194
3003195
3003197
3003198
3003201
3003202
3003203
3003204
3003205
3003206
3003209
3003211
3003213
3003216
3003217
3003218
3003220
3003222
3003223
3003224
3003225
3003226
3003227
3003229
3003230
3003231
3003232
3004860
3004873
3004878
3005181
3005188
38416_at
8132943
908
A_23_P158148
GE57707
GO:0000166
GO:0003723
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0005832
GO:0005856
GO:0005874
GO:0006457
GO:0016787
GO:0016887
GO:0032200
GO:0032212
GO:0032991
GO:0043226
GO:0044183
GO:0050821
GO:0051082
GO:0061077
GO:0070062
GO:0071987
GO:0140657
GO:0140662
GO:1904851
GO:1904871
GO:1904874
HMNXSV003035459
Hs.82916.0.S2_3p_at
ILMN_1719611
ILMN_1722502
L27706_at
PH_hs_0004742
TC07000338.hg
g4502642_3p_s_at
Participates
as a candidate of
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
as a member of
CCT6 [cytosol] (Homo sapiens)
Inferred To
CCT6 [cytosol]
(Drosophila melanogaster)
CCT6 [cytosol]
(Gallus gallus)
CCT6 [cytosol]
(Saccharomyces cerevisiae)
cct6 [cytosol]
(Dictyostelium discoideum)
cct6 [cytosol]
(Schizosaccharomyces pombe)
cct-6 [cytosol]
(Caenorhabditis elegans)
CCT6A [cytosol]
(Bos taurus)
CCT6A [cytosol]
(Canis familiaris)
CCT6A [cytosol]
(Danio rerio)
CCT6A [cytosol]
(Plasmodium falciparum)
CCT6A [cytosol]
(Sus scrofa)
Cct6a [cytosol]
(Mus musculus)
Cct6a [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001009186.1
,
NP_001753.1
OpenTargets
ENSG00000146731
HPA
ENSG00000146731-CCT6A
GeneCards
P40227
Ensembl
ENSG00000146731
,
ENSP00000352019
,
ENST00000335503
,
ENSP00000275603
,
ENST00000275603
PRO
P40227
Pharos - Targets
P40227
PDB
7NVN
,
6NRA
,
6QB8
,
7LUM
,
7NVO
,
6NRB
,
6NR8
,
7LUP
,
6NRC
,
7NVL
,
6NR9
,
6NRD
,
7NVM
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.725
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128fs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128fs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.556
3
UniProt:P17612 PRKACA
3
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.556
3
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.527
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.527
5
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.527
2
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.527
3
UniProt:Q9BUR4 WRAP53
2
WRAP53 [nucleoplasm]
(R-HSA-418386)
Unfolded WRAP53 [cytosol]
(R-HSA-6813830)
0.527
3
UniProt:P52333 JAK3
6
p-Y980 JAK3 [cytosol]
(R-HSA-9701438)
JAK3 [endosome]
(R-HSA-8983184)
p-Y-JAK3 [cytosol]
(R-HSA-9006854)
p-Y904,939-JAK3 [plasma membrane]
(R-HSA-8985978)
p-JAK3 [cytosol]
(R-HSA-8982856)
JAK3 [cytosol]
(R-HSA-451893)
0.527
2
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
0.527
2
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