Reactome | YBX1 [nucleoplasm]

YBX1 [nucleoplasm]

Stable Identifier

R-HSA-72041

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

YB-1, Y box transcription factor, Nuclease sensitive element binding protein 1, Y box binding protein-1, Y-box transcription factor, CCAAT-binding transcription factor I subunit A, CBF-A, Enhancer factor I subunit A, EFI-A, DNA-binding protein B, DBPB

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P67809 YBX1

Gene Names

YBX1, NSEP1, YB1

Chain

initiator methionine:, chain:2-324

Reference Genes

BioGPS Gene:4904 YBX1

COSMIC (genes):YBX1 YBX1

CTD Gene:4904 YBX1

dbSNP Gene:4904 YBX1

ENSEMBL:ENSG00000065978 YBX1

ENSEMBL_homo_sapiens_GENE:ENSG00000065978.19 YBX1

HGNC:8014 YBX1

KEGG Gene (Homo sapiens):4904 YBX1

Monarch:4904 YBX1

NCBI Gene:4904 YBX1

OMIM:154030 YBX1

UCSC:P67809 YBX1

Reference Transcript

RefSeq:NM_004559.4 YBX1

Other Identifiers

11756972_x_at

16663317

208627_PM_s_at

208627_s_at

208628_PM_s_at

208628_s_at

2332635

2332667

2332668

2332669

2332670

2332671

2332672

2332673

2332679

2332680

2332689

2332691

2332692

2332694

2332695

2332697

2332698

3066582

3066583

3066590

3205034

3205037

3205038

3205039

3205040

3205042

32340_s_at

3568965

3568967

3568969

4904

7900585

A_23_P34767

GE57491

GO:0000122

GO:0000932

GO:0001701

GO:0002181

GO:0003676

GO:0003677

GO:0003682

GO:0003690

GO:0003697

GO:0003723

GO:0003729

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005689

GO:0005737

GO:0005783

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006397

GO:0008380

GO:0008544

GO:0010468

GO:0010494

GO:0016071

GO:0017148

GO:0030154

GO:0035198

GO:0043226

GO:0043231

GO:0045202

GO:0045944

GO:0048255

GO:0048598

GO:0048856

GO:0050658

GO:0051020

GO:0051031

GO:0051154

GO:0051781

GO:0062153

GO:0070062

GO:0070934

GO:0070937

GO:0071204

GO:0098761

GO:1900152

GO:1903608

GO:1990124

GO:1990428

GO:1990837

GO:1990904

GO:2000767

GO:2000773

HMNXSV003006738

Hs.74497.1.S1_3p_a_at

Hs.74497.2.S1_3p_a_at

Hs.74497.2.S1_3p_x_at

ILMN_1669424

ILMN_2124769

J03827_at

PH_hs_0028962

TC01000531.hg

Participates

as a component of

as a member of

Alternative Splicing Factors [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-S32,S36-YBX1 [nucleoplasm]

p-S32,S36-YBX1 [cytosol]

YBX1 [cytosol]

YBX1 [extracellular region]

Inferred To

Homologues of YBX1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of YBX1 [nucleoplasm] (Canis familiaris)

Ybx1 [nucleoplasm] (Mus musculus)

Ybx1 [nucleoplasm] (Rattus norvegicus)

cey-4 [nucleoplasm] (Caenorhabditis elegans)

YBX1 [nucleoplasm] (Bos taurus)

YBX1 [nucleoplasm] (Canis familiaris)

YBX1 [nucleoplasm] (Gallus gallus)

YBX1 [nucleoplasm] (Sus scrofa)

ybx1 [nucleoplasm] (Danio rerio)

ybx1 [nucleoplasm] (Xenopus tropicalis)

LOC479011 [nucleoplasm] (Canis familiaris)

cey-1 [nucleoplasm] (Caenorhabditis elegans)

cey-3 [nucleoplasm] (Caenorhabditis elegans)

yps [nucleoplasm] (Drosophila melanogaster)

cey-2 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_004550.2

OpenTargets

ENSG00000065978

HPA

ENSG00000065978-YBX1

GeneCards

P67809

Ensembl

ENSP00000361626, ENST00000321358, ENSG00000065978

PRO

P67809

Pharos - Targets

P67809

PDB

6LMS, 5YTS, 6KTC, 5YTT, 6A6L, 5YTV, 1H95, 5YTX, 6KUG, 6LMR

Interactors (124)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.918	13
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.816	12
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.773	5
UniProt:P16989 YBOX3			0.773	5
UniProt:O43390 HNRNPR	1	HNRNPR [nucleoplasm] (R-HSA-71951)	0.773	5
UniProt:O60506 HNRPQ			0.773	5
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.767	11
UniProt:Q96EY7 PTCD3	1	PTCD3 [mitochondrial inner membrane] (R-HSA-5368165)	0.744	4
UniProt:P05455 SSB	1	SSB [nucleoplasm] (R-HSA-58418)	0.708	4
UniProt:Q4G0J3 LARP7			0.706	5
UniProt:Q6ZN17 LN28B			0.695	4
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.69	6
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.677	8
UniProt:Q12906 ILF3	3	p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [cytosol] (R-HSA-450564) ILF3 [nucleoplasm] (R-HSA-9760401)	0.662	6
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [specific granule lumen] (R-HSA-6799611)	0.662	6
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.643	4
UniProt:P16403 H1-2	1	HIST1H1C [nucleoplasm] (R-HSA-211237)	0.643	4
UniProt:Q9BYC9 MRPL20	1	MRPL20 [mitochondrial inner membrane] (R-HSA-5368243)	0.643	3
UniProt:Q9Y6H1 CHCHD2	2	2xHC-CHCHD2 [mitochondrial intermembrane space] (R-HSA-6800100) CHCHD2 [mitochondrial intermembrane space] (R-HSA-1307777)	0.643	4
UniProt:P49406 MRPL19	1	MRPL19 [mitochondrial inner membrane] (R-HSA-5368215)	0.643	3
UniProt:P09001 MRPL3	1	MRPL3 [mitochondrial inner membrane] (R-HSA-5368242)	0.643	3
UniProt:Q9P0M9 MRPL27	1	MRPL27 [mitochondrial inner membrane] (R-HSA-5368189)	0.643	3
UniProt:P82650 MRPS22	1	MRPS22 [mitochondrial inner membrane] (R-HSA-5368259)	0.643	3
UniProt:Q9BYD6 MRPL1	1	MRPL1 [mitochondrial inner membrane] (R-HSA-5368196)	0.643	3
UniProt:P51398 DAP3	1	DAP3 [mitochondrial inner membrane] (R-HSA-5368174)	0.643	3
UniProt:Q7Z6M2 FBX33			0.641	6
UniProt:Q9Y6M1 IGF2BP2	1	IGF2BP2 [cytosol] (R-HSA-428302)	0.63	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	13
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.613	6
UniProt:P19712-PRO_0000038050			0.599	4
UniProt:Q99IB8-PRO_0000045599			0.577	3
UniProt:P62310 LSM3	2	LSM3 [nucleoplasm] (R-HSA-6806807) LSM3 [cytosol] (R-HSA-429894)	0.573	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	11
UniProt:P13693 TCTP			0.567	4
UniProt:P37108 SRP14	4	SRP14 [cytosol] (R-HSA-264941) SRP14 [secretory granule lumen] (R-HSA-6800938) SRP14 [extracellular region] (R-HSA-6806495) SRP14 [ficolin-1-rich granule lumen] (R-HSA-6800439)	0.564	2
UniProt:Q7Z2W4 ZC3HAV1	2	ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol] (R-HSA-6802506) ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802557)	0.564	4
UniProt:Q96AG4 LRC59			0.564	2
UniProt:Q14694 USP10	3	USP10 [nucleoplasm] (R-HSA-3222218) K63polyUb-USP10 [cytosol] (R-HSA-6782986) USP10 [cytosol] (R-HSA-6782974)	0.564	2
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.564	2
UniProt:Q9NUL7 DDX28			0.564	2
UniProt:Q7L2E3 DHX30			0.564	2
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.564	2
UniProt:Q9Y2T7 YBOX2			0.564	2
IntAct:EBI-6857440 NS3			0.558	3
UniProt:Q86U42 PABPN1	2	PABPN1 [cytosol] (R-HSA-9822424) PABPN1 [nucleoplasm] (R-HSA-72008)	0.558	4
UniProt:O95613 PCNT	8	PCNT [cytosol] (R-HSA-380290) PolyUb-Misfolded PCNT [late endosome lumen] (R-HSA-9660016) PCNT [cilium] (R-HSA-9639683) Misfolded PCNT [cilium] (R-HSA-9639705) Misfolded PCNT [cytosol] (R-HSA-9640102) Ub-Misfolded PCNT [cytosol] (R-HSA-9641122) PolyUb-Misfolded PCNT [cytosol] (R-HSA-9641112) PolyUb-Misfolded PCNT [lysosomal lumen] (R-HSA-9660027)	0.556	4
UniProt:Q13148 TADBP			0.556	6
UniProt:Q9C0C9 UBE2O	1	UBE2O [cytosol] (R-HSA-947641)	0.547	2
UniProt:O76021 RL1D1			0.527	2
UniProt:P16401 H1-5	1	HIST1H1B [nucleoplasm] (R-HSA-211248)	0.527	2
UniProt:P82675 MRPS5	1	MRPS5 [mitochondrial inner membrane] (R-HSA-5368176)	0.527	2
UniProt:Q9HCE1 MOV10	1	MOV10 [cytosol] (R-HSA-427772)	0.527	2
UniProt:P14866 HNRNPL	1	HNRNPL [nucleoplasm] (R-HSA-71947)	0.527	3
UniProt:Q9Y2Q9 MRPS28	1	MRPS28 [mitochondrial inner membrane] (R-HSA-5368201)	0.527	2
UniProt:O95503 CBX6	1	CBX6 [nucleoplasm] (R-HSA-3229071)	0.527	2
UniProt:Q9UKV8 AGO2	2	AGO2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.527	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	4
UniProt:Q16540 MRPL23	1	MRPL23 [mitochondrial inner membrane] (R-HSA-5368179)	0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:Q7Z2W9 MRPL21	1	MRPL21 [mitochondrial inner membrane] (R-HSA-5368231)	0.527	2
UniProt:Q9H361 PABP3			0.527	2
UniProt:Q5T653 MRPL2	1	MRPL2 [mitochondrial inner membrane] (R-HSA-5368170)	0.527	3
UniProt:Q14103-4 HNRNPD	2	Ub-HNRNPD-4 [cytosol] (R-HSA-451232) HNRNPD-4 [cytosol] (R-HSA-450442)	0.527	3
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	3
UniProt:Q9H9J2 MRPL44	1	MRPL44 [mitochondrial inner membrane] (R-HSA-5368245)	0.527	2
UniProt:Q1KMD3 HNRL2			0.527	2
UniProt:Q9Y2R9 MRPS7	1	MRPS7 [mitochondrial inner membrane] (R-HSA-5368191)	0.527	2
UniProt:P08865 RPSA	2	RPSA [nucleoplasm] (R-HSA-6798722) RPSA [cytosol] (R-HSA-72389)	0.527	3
UniProt:Q96DV4 MRPL38	1	MRPL38 [mitochondrial inner membrane] (R-HSA-5368202)	0.527	2
UniProt:Q8WWM7 ATX2L			0.527	2
UniProt:Q9BZE1 MRPL37	1	MRPL37 [mitochondrial inner membrane] (R-HSA-5368240)	0.527	2
UniProt:O60812 HNRC1			0.527	3
UniProt:Q8TCC3 MRPL30	1	MRPL30 [mitochondrial inner membrane] (R-HSA-5368184)	0.527	3
UniProt:Q15020 SART3			0.527	3
UniProt:Q9Y6G3 MRPL42	1	MRPL42 [mitochondrial inner membrane] (R-HSA-5368237)	0.527	2
UniProt:Q9NX20 MRPL16	1	MRPL16 [mitochondrial inner membrane] (R-HSA-5368216)	0.527	2
UniProt:P62241 RPS8	2	RPS8 [nucleoplasm] (R-HSA-6791203) RPS8 [cytosol] (R-HSA-72385)	0.527	2
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.527	2
UniProt:O00425 IGF2BP3	1	IGF2BP3 [cytosol] (R-HSA-428313)	0.527	3
UniProt:Q9NQ50 MRPL40	1	MRPL40 [mitochondrial inner membrane] (R-HSA-5368222)	0.527	2
UniProt:Q9NRX2 MRPL17	1	MRPL17 [mitochondrial inner membrane] (R-HSA-5368217)	0.527	2
UniProt:Q96KR1 ZFR			0.527	2
UniProt:Q13405 MRPL49	1	MRPL49 [mitochondrial inner membrane] (R-HSA-5368260)	0.527	2
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.527	2
UniProt:Q9NZM5 NOP53			0.527	2
UniProt:P33469 NCAP			0.527	3
UniProt:O75534 CSDE1			0.527	2
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	2
UniProt:P52815 MRPL12	2	MRPL12 [mitochondrial matrix] (R-HSA-9839674) MRPL12 [mitochondrial inner membrane] (R-HSA-5368256)	0.527	2
UniProt:P15880 RPS2	3	RPS2 [nucleoplasm] (R-HSA-6790655) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [cytosol] (R-HSA-72347)	0.527	3
UniProt:Q9H0U6 MRPL18	1	MRPL18 [mitochondrial inner membrane] (R-HSA-5368207)	0.527	2
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.527	2
UniProt:Q15527 SURF2			0.527	3
UniProt:Q7RTS1 BHA15			0.527	4
UniProt:Q92615 LAR4B			0.527	3
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	2
UniProt:Q66K89 E4F1			0.527	2
UniProt:Q15646 OASL	1	OASL [cytosol] (R-HSA-1015678)	0.527	2
UniProt:Q9BYD2 MRPL9	1	MRPL9 [mitochondrial inner membrane] (R-HSA-5368262)	0.527	2
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.527	4
UniProt:Q92665 MRPS31	1	MRPS31 [mitochondrial inner membrane] (R-HSA-5368198)	0.527	2
UniProt:Q9UL18 AGO1	2	EIF2C1 [nucleoplasm] (R-HSA-5578686) EIF2C1 [cytosol] (R-HSA-210616)	0.527	4
UniProt:Q9P015 MRPL15	1	MRPL15 [mitochondrial inner membrane] (R-HSA-5368193)	0.527	2
UniProt:Q13310 PABP4			0.527	2
UniProt:P62847 RPS24	2	RPS24 [nucleoplasm] (R-HSA-6791186) RPS24 [cytosol] (R-HSA-72355)	0.527	2
UniProt:Q9BYD1 MRPL13	1	MRPL13 [mitochondrial inner membrane] (R-HSA-5368244)	0.527	3
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [extracellular exosome] (R-HSA-8950304) HNRNPA2B1 [nucleoplasm] (R-HSA-71929)	0.527	2
UniProt:Q9NZB2 F120A			0.527	2
UniProt:Q659C4 LAR1B			0.527	2
UniProt:Q92552 MRPS27	1	MRPS27 [mitochondrial inner membrane] (R-HSA-5368214)	0.527	2
UniProt:O75127 PTCD1			0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	2
UniProt:O95758 PTBP3			0.527	2
UniProt:Q9NXG2 THUMPD1	1	THUMPD1 [nucleoplasm] (R-HSA-6791004)	0.527	3
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.527	2
UniProt:Q13601 KRR1	1	KRR1 [nucleoplasm] (R-HSA-6790611)	0.527	3
IntAct:EBI-5333277 DSDNA			0.499	4
IntAct:EBI-5333321 DSDNA			0.499	3
UniProt:Q8NC51 SERB1			0.499	2
IntAct:EBI-5333296 DSDNA			0.499	2
UniProt:Q99697 PITX2	1	PITX2 [nucleoplasm] (R-HSA-8864726)	0.499	3
UniProt:O75526 RMXL2			0.499	2
UniProt:P12956 XRCC6	5	XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [nucleoplasm] (R-HSA-58272)	0.483	2
UniProt:Q8IUH3 RBM45			0.462	2

Cite Us!