Reactome | HUWE1 [extracellular region]

HUWE1 [extracellular region]

Stable Identifier

R-HSA-6806466

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

E3 ubiquitin-protein ligase HUWE1, HUWE1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q7Z6Z7 HUWE1

Gene Names

HUWE1, KIAA0312, KIAA1578, UREB1, HSPC272

Chain

chain:1-4374

Reference Genes

BioGPS Gene:10075 HUWE1

COSMIC (genes):HUWE1 HUWE1

CTD Gene:10075 HUWE1

dbSNP Gene:10075 HUWE1

ENSEMBL:ENSG00000086758 HUWE1

HGNC:30892 HUWE1

KEGG Gene (Homo sapiens):10075 HUWE1

Monarch:10075 HUWE1

NCBI Gene:10075 HUWE1

OMIM:300697 HUWE1

UCSC:Q7Z6Z7 HUWE1

Reference Transcript

Other Identifiers

0005420563

0102900152

0103450097

10075

11717751_a_at

11752863_s_at

11754690_a_at

17111262

208598_s_at

214673_s_at

236294_at

34372_at

34374_g_at

4009316

4009317

4009318

4009319

4009320

4009321

4009327

4009328

4009329

4009330

4009332

4009333

4009334

4009337

4009338

4009340

4009341

4009342

4009343

4009344

4009346

4009347

4009348

4009350

4009351

4009352

4009353

4009355

4009356

4009357

4009358

4009359

4009360

4009361

4009362

4009363

4009364

4009365

4009366

4009367

4009368

4009373

4009374

4009375

4009377

4009379

4009380

4009381

4009383

4009384

4009388

4009389

4009391

4009392

4009393

4009394

4009395

4009396

4009397

4009398

4009399

4009400

4009401

4009402

4009404

4009406

4009407

4009408

4009409

4009410

4009411

4009412

4009413

4009414

4009415

4009416

4009417

4009418

4009419

4009420

4009421

4009422

4009425

4009426

4009427

4009431

4009432

4009435

4009437

4009441

4009442

4009444

4009445

4009448

4009449

4009451

4009452

4009453

4009454

4009455

4009456

4009457

4009458

4009459

4009460

4009461

4009462

4009463

4009466

4009470

4009476

4009477

4009478

4009481

4009482

4009483

4009484

8172914

84360_at

A_19_P00319331

A_19_P00322829

A_23_P219207

A_24_P932016

A_33_P3811287

GE53048

GE85820

GE88008

GO:0000139

GO:0000209

GO:0002376

GO:0003674

GO:0003677

GO:0003723

GO:0004842

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0006259

GO:0006281

GO:0006284

GO:0006464

GO:0006513

GO:0006605

GO:0006810

GO:0006914

GO:0006950

GO:0006974

GO:0007005

GO:0007030

GO:0008150

GO:0009056

GO:0010637

GO:0015031

GO:0016020

GO:0016192

GO:0016567

GO:0016574

GO:0016740

GO:0030154

GO:0031398

GO:0031410

GO:0032922

GO:0034641

GO:0034774

GO:0043161

GO:0043226

GO:0043312

GO:0045732

GO:0048511

GO:0048856

GO:0051276

GO:0061024

GO:0061025

GO:0061630

GO:0070062

GO:0098779

GO:1903955

GO:1904813

HMNXSV003007258

Hs.155101.4.S1_3p_a_at

Hs.167040.0.A1_3p_at

Hs.167040.0.A1_3p_x_at

ILMN_1790987

TC0X001067.hg

TC0X002079.hg

Z97054_xpt2_at

g6692990_3p_a_at

Participates

as a member of

Other forms of this molecule

HUWE1 [secretory granule lumen]

HUWE1 [ficolin-1-rich granule lumen]

HUWE1 [cytosol]

Inferred To

ptr1 [extracellular region] (Schizosaccharomyces pombe)

HUWE1 [extracellular region] (Canis familiaris)

HUWE1 [extracellular region] (Dictyostelium discoideum)

HUWE1 [extracellular region] (Drosophila melanogaster)

HUWE1 [extracellular region] (Plasmodium falciparum)

HUWE1 [extracellular region] (Sus scrofa)

eel-1 [extracellular region] (Caenorhabditis elegans)

Huwe1 [extracellular region] (Mus musculus)

TOM1 [extracellular region] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_113584.3, XP_005262022.1

OpenTargets

ENSG00000086758

IntEnz

2.3.2.26

GeneCards

Q7Z6Z7

HPA

ENSG00000086758-HUWE1

Ensembl

ENSP00000340648, ENST00000342160, ENSP00000479451, ENSP00000262854, ENSG00000086758, ENST00000262854, ENST00000612484

PRO

Q7Z6Z7

Pharos - Targets

Q7Z6Z7

GlyGen

Q7Z6Z7

Orphanet

18651

HMDB Protein

HMDBP09257

PDB

2MUL, 2EKK, 3G1N, 6PFL, 6FYH, 6MIW, 3H1D, 5LP8, 5C6H

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N726 CDKN2A	12	p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R21RfsTER47 [cytosol] (R-HSA-9646285) p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF [cytosol] (R-HSA-9645669) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756)	0.677	5
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.564	2
UniProt:P04637 TP53	20	TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 [cytosol] (R-HSA-8869337) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 L348S [nucleoplasm] (R-HSA-9726366) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 K351E [nucleoplasm] (R-HSA-9726258) Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L330R [nucleoplasm] (R-HSA-9726133) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 L344R [nucleoplasm] (R-HSA-9726073)	0.524	3
UniProt:P04792 HSPB1	3	p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563)	0.508	3
UniProt:P20393 NR1D1	1	NR1D1 [nucleoplasm] (R-HSA-375499)	0.499	3