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HUWE1 [extracellular region]
Stable Identifier
R-HSA-6806466
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
E3 ubiquitin-protein ligase HUWE1, HUWE1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
HUWE1 [extracellular region] (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
HUWE1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q7Z6Z7 HUWE1
Gene Names
HUWE1, KIAA0312, KIAA1578, UREB1, HSPC272
Chain
chain:1-4374
Reference Genes
BioGPS Gene:10075 HUWE1
COSMIC (genes):HUWE1 HUWE1
CTD Gene:10075 HUWE1
dbSNP Gene:10075 HUWE1
ENSEMBL:ENSG00000086758 HUWE1
ENSEMBL_homo_sapiens_GENE:ENSG00000086758 HUWE1
HGNC:30892 HUWE1
KEGG Gene (Homo sapiens):10075 HUWE1
Monarch:10075 HUWE1
NCBI Gene:10075 HUWE1
OMIM:300697 HUWE1
UCSC:Q7Z6Z7 HUWE1
Reference Transcript
RefSeq:XM_005261965.3 HUWE1
RefSeq:NM_031407.6 HUWE1
Other Identifiers
0005420563
0102900152
0103450097
10075
11717751_a_at
11752863_s_at
11754690_a_at
17111262
208598_s_at
214673_s_at
22718
236294_at
2548
2EKK
2MUL
34372_at
34374_g_at
3G1N
3H1D
4009316
4009317
4009318
4009319
4009320
4009321
4009327
4009328
4009329
4009330
4009332
4009333
4009334
4009337
4009338
4009340
4009341
4009342
4009343
4009344
4009346
4009347
4009348
4009350
4009351
4009352
4009353
4009355
4009356
4009357
4009358
4009359
4009360
4009361
4009362
4009363
4009364
4009365
4009366
4009367
4009368
4009373
4009374
4009375
4009377
4009379
4009380
4009381
4009383
4009384
4009388
4009389
4009391
4009392
4009393
4009394
4009395
4009396
4009397
4009398
4009399
4009400
4009401
4009402
4009404
4009406
4009407
4009408
4009409
4009410
4009411
4009412
4009413
4009414
4009415
4009416
4009417
4009418
4009419
4009420
4009421
4009422
4009425
4009426
4009427
4009431
4009432
4009435
4009437
4009441
4009442
4009444
4009445
4009448
4009449
4009451
4009452
4009453
4009454
4009455
4009456
4009457
4009458
4009459
4009460
4009461
4009462
4009463
4009466
4009470
4009476
4009481
4009482
4009483
4009484
5C6H
5LP8
8172914
84360_at
A0A024R9U8
A0A024R9W5
A0A1B0GXC7
A_19_P00322829
A_23_P219207
A_24_P932016
A_33_P3811287
AAC62492
AAF28950
AAH02602
AAH63505
AAV90838
AAX24125
AAY98258
AB002310
AB046798
AB071605
AF057569
AF161390
AL162050
AL592046
AY772009
AY929612
BAA20771
BAB13404
BAC06833
BC002602
BC063505
CAB022718
CAB82393
CAG33094
CAI39580
CAI42354
CAI42654
CCDS35301
CH471154
CR456813
DQ097177
EAW93161
EAW93162
EAW93163
EAW93166
ENSG00000086758
ENSP00000262854
ENSP00000340648
ENSP00000479451
ENST00000262854
ENST00000342160
ENST00000612484
EntrezGene:10075
g6692990_3p_a_at
GE53048
GE85820
GE88008
GO:0000209
GO:0002376
GO:0003674
GO:0003677
GO:0003723
GO:0004842
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006259
GO:0006281
GO:0006284
GO:0006464
GO:0006511
GO:0006513
GO:0006605
GO:0006810
GO:0006950
GO:0006974
GO:0007005
GO:0008150
GO:0009056
GO:0016020
GO:0016192
GO:0016567
GO:0016574
GO:0016740
GO:0030154
GO:0031410
GO:0034641
GO:0034774
GO:0043226
GO:0043312
GO:0051276
GO:0061630
GO:0070062
GO:1903955
GO:1904813
HGNC:30892
HPA002548
Hs.155101.4.S1_3p_a_at
Hs.167040.0.A1_3p_at
Hs.167040.0.A1_3p_x_at
HUWE1
HUWE1-202
HUWE1-203
HUWE1-214
ILMN_1790987
IPR000569
IPR004170
IPR009060
IPR010309
IPR010314
IPR015940
IPR016024
IPR025527
IPR035983
IPR037197
MIM:300697
MIM:300706
NM_031407
NP_113584
PF00627
PF00632
PF02825
PF06012
PF06025
PF14377
SM00119
SM00165
TC0X001067.hg
TC0X002079.hg
uc033eew.2
uc064zlc.1
uc064zld.1
UPI00004A0DAC
UPI000058E4FE
XM_005261965
XM_011530747
XM_011530751
XM_017029191
XM_017029192
XM_017029193
XM_017029194
XM_017029195
XM_017029196
XM_017029197
XM_017029198
XM_017029199
XM_017029200
XM_017029201
XM_017029202
XM_017029203
XM_017029204
XM_017029205
XM_017029206
XP_005262022
XP_011529049
XP_011529053
XP_016884680
XP_016884681
XP_016884682
XP_016884683
XP_016884684
XP_016884685
XP_016884686
XP_016884687
XP_016884688
XP_016884689
XP_016884690
XP_016884691
XP_016884692
XP_016884693
XP_016884695
Z94044
Z97054
Z97054_xpt2_at
Participant Of
hasMember
Ficolin-rich granule lumen proteins [extracellular region]
Secretory granule lumen proteins [extracellular region]
Other forms of this molecule
HUWE1 [cytosol]
HUWE1 [secretory granule lumen]
HUWE1 [ficolin-1-rich granule lumen]
Inferred To
HUWE1 [extracellular region] (Arabidopsis thaliana)
HUWE1 [extracellular region] (Bos taurus)
HUWE1 [extracellular region] (Caenorhabditis elegans)
HUWE1 [extracellular region] (Canis familiaris)
HUWE1 [extracellular region] (Danio rerio)
HUWE1 [extracellular region] (Dictyostelium discoideum)
HUWE1 [extracellular region] (Drosophila melanogaster)
HUWE1 [extracellular region] (Gallus gallus)
HUWE1 [extracellular region] (Mus musculus)
HUWE1 [extracellular region] (Oryza sativa)
HUWE1 [extracellular region] (Plasmodium falciparum)
HUWE1 [extracellular region] (Rattus norvegicus)
HUWE1 [extracellular region] (Saccharomyces cerevisiae)
HUWE1 [extracellular region] (Schizosaccharomyces pombe)
HUWE1 [extracellular region] (Sus scrofa)
HUWE1 [extracellular region] (Xenopus tropicalis)
Homologues of HUWE1 [extracellular region] (Arabidopsis thaliana)
Homologues of HUWE1 [extracellular region] (Caenorhabditis elegans)
Homologues of HUWE1 [extracellular region] (Canis familiaris)
Homologues of HUWE1 [extracellular region] (Danio rerio)
Homologues of HUWE1 [extracellular region] (Drosophila melanogaster)
Homologues of HUWE1 [extracellular region] (Gallus gallus)
Homologues of HUWE1 [extracellular region] (Oryza sativa)
Homologues of HUWE1 [extracellular region] (Rattus norvegicus)
Homologues of HUWE1 [extracellular region] (Sus scrofa)
Cross References
RefSeq
NP_113584.3
,
XP_005262022.1
OpenTargets
ENSG00000086758
GeneCards
Q7Z6Z7
DOCK Blaster
3H1D
,
3G1N
,
5C6H
,
5LP8
PRO
Q7Z6Z7
BRENDA (Homo sapiens)
2.3.2.26
Orphanet
18651
HMDB Protein
HMDBP09257
PDB
3G1N
,
5LP8
,
5C6H
,
3H1D
,
2MUL
,
6FYH
,
2EKK
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N726 CDKN2A
1
p14-ARF [nucleoplasm]
(R-HSA-1629813)
0.677
5
UniProt:Q93009 USP7
2
USP7 [nucleoplasm]
(R-HSA-3215278)
USP7 [cytosol]
(R-HSA-8853511)
0.564
2
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.524
3
UniProt:P04792 HSPB1
3
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
0.508
3
UniProt:P20393 NR1D1
1
NR1D1 [nucleoplasm]
(R-HSA-375499)
0.499
3
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