Reactome | HUWE1 [extracellular region]

HUWE1

Stable Identifier

R-HSA-6806466

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

E3 ubiquitin-protein ligase HUWE1, HUWE1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q7Z6Z7 HUWE1

Gene Names

HUWE1, KIAA0312, KIAA1578, UREB1, HSPC272

Chain

chain:1-4374

Reference Genes

BioGPS Gene:10075 HUWE1

COSMIC (genes):HUWE1 HUWE1

CTD Gene:10075 HUWE1

dbSNP Gene:10075 HUWE1

ENSEMBL:ENSG00000086758 HUWE1

HGNC:30892 HUWE1

KEGG Gene (Homo sapiens):hsa:10075 HUWE1

Monarch:10075 HUWE1

NCBI Gene:10075 HUWE1

OMIM:300697 HUWE1

UCSC:Q7Z6Z7 HUWE1

Reference Transcript

Other Identifiers

0005420563

0102900152

0103450097

10075

11717751_a_at

11752863_s_at

11754690_a_at

17111262

208598_s_at

214673_s_at

22718

236294_at

2548

2EKK

2MUL

34372_at

34374_g_at

3G1N

3H1D

4009316

4009317

4009318

4009319

4009320

4009321

4009327

4009328

4009329

4009330

4009332

4009333

4009334

4009337

4009338

4009340

4009341

4009342

4009343

4009344

4009346

4009347

4009348

4009350

4009351

4009352

4009353

4009355

4009356

4009357

4009358

4009359

4009360

4009361

4009362

4009363

4009364

4009365

4009366

4009367

4009368

4009373

4009374

4009375

4009377

4009379

4009380

4009381

4009383

4009384

4009388

4009389

4009391

4009392

4009393

4009394

4009395

4009396

4009397

4009398

4009399

4009400

4009401

4009402

4009404

4009406

4009407

4009408

4009409

4009410

4009411

4009412

4009413

4009414

4009415

4009416

4009417

4009418

4009419

4009420

4009421

4009422

4009425

4009426

4009427

4009431

4009432

4009435

4009437

4009441

4009442

4009444

4009445

4009448

4009449

4009451

4009452

4009453

4009454

4009455

4009456

4009457

4009458

4009459

4009460

4009461

4009462

4009463

4009466

4009470

4009476

4009481

4009482

4009483

4009484

5C6H

5LP8

8172914

84360_at

A0A024R9U8

A0A024R9W5

A_19_P00322829

A_23_P219207

A_24_P932016

A_33_P3811287

CAB022718

CCDS35301

ENSG00000086758

ENSP00000262854

ENSP00000340648

ENSP00000479451

ENST00000262854

ENST00000342160

ENST00000612484

EntrezGene:10075

g6692990_3p_a_at

GE53048

GE85820

GE88008

GO:0000209

GO:0003677

GO:0003723

GO:0004842

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006281

GO:0006284

GO:0006513

GO:0006974

GO:0016020

GO:0016567

GO:0016574

GO:0016740

GO:0030154

GO:0034774

GO:0042787

GO:0043312

GO:0061630

GO:0070062

GO:1903955

GO:1904813

HGNC:30892

HPA002548

Hs.136905

Hs.155101.4.S1_3p_a_at

Hs.167040.0.A1_3p_at

Hs.167040.0.A1_3p_x_at

HUWE1

HUWE1-202

HUWE1-203

HUWE1-214

ILMN_1790987

MIM:300697

MIM:300706

NM_031407

NP_113584

PF00627

PF00632

PF02825

PF06012

PF06025

PF14377

SM00119

SM00165

TC0X001067.hg

TC0X002079.hg

uc033eew.2

uc064zlc.1

uc064zld.1

UPI00004A0DAC

UPI000058E4FE

XM_005261965

XM_011530747

XM_011530751

XM_017029191

XM_017029192

XM_017029193

XM_017029194

XM_017029195

XM_017029196

XM_017029197

XM_017029198

XM_017029199

XM_017029200

XM_017029201

XM_017029202

XM_017029203

XM_017029204

XM_017029205

XM_017029206

XP_005262022

XP_011529049

XP_011529053

XP_016884680

XP_016884681

XP_016884682

XP_016884683

XP_016884684

XP_016884685

XP_016884686

XP_016884687

XP_016884688

XP_016884689

XP_016884690

XP_016884691

XP_016884692

XP_016884693

XP_016884694

XP_016884695

Z97054_xpt2_at

Participant Of

hasMember

Other forms of this molecule

HUWE1 [cytosol]

HUWE1 [secretory granule lumen]

HUWE1 [ficolin-1-rich granule lumen]

Inferred To

HUWE1 [extracellular region] (Arabidopsis thaliana)

HUWE1 [extracellular region] (Bos taurus)

HUWE1 [extracellular region] (Caenorhabditis elegans)

HUWE1 [extracellular region] (Canis familiaris)

HUWE1 [extracellular region] (Danio rerio)

HUWE1 [extracellular region] (Dictyostelium discoideum)

HUWE1 [extracellular region] (Drosophila melanogaster)

HUWE1 [extracellular region] (Gallus gallus)

HUWE1 [extracellular region] (Mus musculus)

HUWE1 [extracellular region] (Oryza sativa)

HUWE1 [extracellular region] (Plasmodium falciparum)

HUWE1 [extracellular region] (Rattus norvegicus)

HUWE1 [extracellular region] (Saccharomyces cerevisiae)

HUWE1 [extracellular region] (Schizosaccharomyces pombe)

HUWE1 [extracellular region] (Sus scrofa)

HUWE1 [extracellular region] (Xenopus tropicalis)

Homologues of HUWE1 [extracellular region] (Arabidopsis thaliana)

Homologues of HUWE1 [extracellular region] (Caenorhabditis elegans)

Homologues of HUWE1 [extracellular region] (Canis familiaris)

Homologues of HUWE1 [extracellular region] (Danio rerio)

Homologues of HUWE1 [extracellular region] (Drosophila melanogaster)

Homologues of HUWE1 [extracellular region] (Gallus gallus)

Homologues of HUWE1 [extracellular region] (Oryza sativa)

Homologues of HUWE1 [extracellular region] (Rattus norvegicus)

Homologues of HUWE1 [extracellular region] (Sus scrofa)

Cross References

RefSeq

XP_005262022.1, NP_113584.3

Brenda

2.3.2.26

GeneCards

Q7Z6Z7

DOCK Blaster

5LP8, 3H1D, 3G1N, 5C6H

PRO

Q7Z6Z7

Orphanet

18651

HMDB Protein

HMDBP09257

PDB

5C6H, 5LP8, 2EKK, 2MUL, 3G1N, 3H1D

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N726 CDKN2A	1	p14-ARF [nucleoplasm] (R-HSA-1629813)	0.677	5
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.564	2
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) PolyUb-TP53 [cytosol] (R-HSA-6793681) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.524	3
UniProt:P04792 HSPB1	3	p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009) HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697)	0.508	3
UniProt:P20393 NR1D1	1	NR1D1 [nucleoplasm] (R-HSA-375499)	0.499	3