Reactome | HAUS8 [cytosol]

HAUS8 [cytosol]

Stable Identifier

R-HSA-8855198

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HAUS augmin-like complex subunit 8, HEC1/NDC80-interacting centrosome-associated protein 1, Sarcoma antigen NY-SAR-48, HICE1, HAUS8_HUMAN

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        HAUS complex [cytosol] (Homo sapiens)
        
        HAUS8 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BT25 HAUS8

Gene Names

HAUS8, HICE1

Chain

initiator methionine:, chain:2-410

Reference Genes

BioGPS Gene:93323 HAUS8

COSMIC (genes):HAUS8 HAUS8

CTD Gene:93323 HAUS8

dbSNP Gene:93323 HAUS8

ENSEMBL:ENSG00000131351 HAUS8

HGNC:30532 HAUS8

KEGG:hsa:93323 HAUS8

Monarch:93323 HAUS8

NCBI Gene:93323 HAUS8

OMIM:613434 HAUS8

UCSC:Q9BT25 HAUS8

Reference Transcript

Other Identifiers

11726373_a_at

16870131

226308_PM_at

226308_at

3854220

3854221

3854222

3854223

3854224

3854226

3854228

3854229

3854230

3854231

3854232

3854233

3854237

3854239

3854242

3854243

3854244

3854245

3854246

3854247

3854248

3854249

52841_at

8035236

93323

A_23_P141965

A_33_P3242124

GE552911

GO:0000922

GO:0003674

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005880

GO:0007010

GO:0007098

GO:0008017

GO:0008092

GO:0010968

GO:0043226

GO:0051225

GO:0051301

GO:0070652

GO:1990498

HMNXSV003040965

Hs.69280.0.S1_3p_at

ILMN_1768020

ILMN_2365528

PH_hs_0004095

TC19001269.hg

Participates

as a component of

HAUS complex [cytosol] (Homo sapiens)

Inferred To

HAUS8 [cytosol] (Bos taurus)

HAUS8 [cytosol] (Canis familiaris)

HAUS8 [cytosol] (Gallus gallus)

HAUS8 [cytosol] (Sus scrofa)

Haus8 [cytosol] (Mus musculus)

Haus8 [cytosol] (Rattus norvegicus)

Ghost homologue of HAUS8 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001011699.1, NP_219485.1

ENSEMBL

ENSP00000395298, ENST00000593360, ENST00000448593, ENST00000253669, ENSP00000253669, ENSG00000131351, ENSP00000470829

OpenTargets

ENSG00000131351

GeneCards

HAUS8

HPA

ENSG00000131351-HAUS8

PRO

Q9BT25

Pharos - Targets

Q9BT25

GlyGen

Q9BT25

PDB

7SQK

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:Q6VN20 RANBP10	1	RANBP10 [cytosol] (R-HSA-8851865)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	4

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