Reactome | RPL30 [cytosol]

RPL30 [cytosol]

Stable Identifier

R-HSA-72452

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L30, P04645

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62888 RPL30

Gene Names

RPL30

Chain

chain:1-115

Reference Genes

BioGPS Gene:6156 RPL30

COSMIC (genes):RPL30 RPL30

CTD Gene:6156 RPL30

dbSNP Gene:6156 RPL30

ENSEMBL:ENSG00000156482 RPL30

HGNC:10333 RPL30

KEGG:hsa:6156 RPL30

Monarch:6156 RPL30

NCBI Gene:6156 RPL30

OMIM:180467 RPL30

UCSC:P62888 RPL30

Reference Transcript

RefSeq:NM_000989.4 RPL30

Other Identifiers

11720954_s_at

11753659_x_at

11757151_s_at

11757356_x_at

16656503

16656505

16656507

16656511

16656513

17079416

17079434

18670704

18670705

18670706

18670707

18670708

18670709

18670710

18670711

18670712

18670713

18670714

18670715

18670716

18670717

18670718

200062_PM_s_at

200062_s_at

228047_PM_at

228047_at

3145954

3145955

3145956

3145957

3145958

3145959

3145960

3145961

3145962

3145963

3145964

3145965

3145966

3145967

3145968

3145969

3145970

3145971

3145973

3145975

31708_at

3450959

6156

63602_at

63603_s_at

7892900

7893201

7894594

7894723

7895170

7895839

7895861

7895964

7896174

7896369

8151935

A_23_P123330

A_24_P29818

GE823635

GO:0002181

GO:0002376

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0014069

GO:0016020

GO:0022625

GO:0022626

GO:0031640

GO:0043226

GO:0045202

GO:0050829

GO:0061844

GO:0070062

GO:0098542

GO:1990904

HMNXSV003001718

HMNXSV003011025

Hs.111222.1.S1_3p_at

ILMN_1754303

PH_hs_0030028

PH_hs_0037308

RNA33504|snoRNA_scaRNA_100_132

TC08001459.hg

TC08001460.hg

g388034_3p_s_at

Participates

as a component of

Inferred To

rpl30 [cytosol] (Danio rerio)

rpl30 [cytosol] (Dictyostelium discoideum)

rpl30 [cytosol] (Xenopus tropicalis)

RpL30 [cytosol] (Drosophila melanogaster)

RPL30 [cytosol] (Bos taurus)

RPL30 [cytosol] (Canis familiaris)

RPL30 [cytosol] (Gallus gallus)

RPL30 [cytosol] (Plasmodium falciparum)

RPL30 [cytosol] (Saccharomyces cerevisiae)

RPL30 [cytosol] (Sus scrofa)

rpl-30 [cytosol] (Caenorhabditis elegans)

Rpl30 [cytosol] (Mus musculus)

Rpl30 [cytosol] (Rattus norvegicus)

rpl3001 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_000980.1

OpenTargets

ENSG00000156482

ENSEMBL

ENSP00000428085, ENST00000287038, ENSG00000156482, ENSP00000287038, ENST00000521291

HPA

ENSG00000156482-RPL30

GeneCards

RPL30

PRO

P62888

Pharos - Targets

P62888

GlyGen

P62888

PDB

7BHP, 8FL3, 9G8M, 8QFD, 6IP5, 6ZMI, 8G6J, 8IR1, 8XSX, 8OJ5, 6QZP, 6Z6M, 8QOI, 9C3H, 8IPX, 6Y2L, 8K2C, 8JDM, 6OLG, 6XA1, 6LU8, 8INF, 8FLB, 8FKZ, 8FLF, 4V6X, 8FL6, 8YOO, 8FL9, 6OM7, 7XNX, 7F5S, 8IDY, 8XSY, 7OW7, 5T2C, 6LSR, 6ZME, 8G5Z, 6W6L, 8JDJ, 8G5Y, 8Y0W, 8FKY, 6Y6X, 8FLE, 8GLP, 7QVP, 6Y57, 8FL4, 6IP8, 6OLZ, 3VI6, 8IE3, 8IFD, 8XSZ, 8OHD, 6Z6L, 6LSS, 8IPY, 8OJ0, 6OLI, 8JDK, 6OLF, 8FLC, 8G60, 6ZM7, 8FLD, 8INE, 5AJ0, 8A3D, 8UKB, 8FL7, 8IPD, 4UG0, 6ZMO, 8FL2, 8YOP, 8QYX, 6IP6, 5LKS, 8IFE, 7XNY, 8OJ8, 6Z6N, 9GMO, 6OM0, 6OLE, 8JDL, 6LQM, 8FLA, 8Y0X, 8G61, 8IR3, 6Y0G, 8INK, 8IDT

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.59	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	6
UniProt:P40429 RPL13A	2	RPL13A [cytosol] (R-HSA-72412) p-RPL13A [cytosol] (R-HSA-156829)	0.547	2
UniProt:Q9Y221 NIP7	1	NIP7 [nucleoplasm] (R-HSA-6797236)	0.527	3
UniProt:P62277 RPS13	2	RPS13 [cytosol] (R-HSA-72331) RPS13 [nucleoplasm] (R-HSA-6791198)	0.527	3
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.527	2
UniProt:O96028 NSD2	2	WHSC1 [nucleoplasm] (R-HSA-1183215) p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	3
UniProt:Q15361 TTF1	1	TTF1 [nucleoplasm] (R-HSA-74974)	0.527	2
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.527	3
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	3
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	3
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.495	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12

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