Reactome | RPL30 [cytosol]

RPL30 [cytosol]

Stable Identifier

R-HSA-72452

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L30, P04645

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Influenza Infection (Homo sapiens)
    - Influenza Life Cycle (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL30 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62888 RPL30

Gene Names

RPL30

Chain

chain:1-115

Reference Genes

BioGPS Gene:6156 RPL30

COSMIC (genes):RPL30 RPL30

CTD Gene:6156 RPL30

dbSNP Gene:6156 RPL30

ENSEMBL:ENSG00000156482 RPL30

HGNC:10333 RPL30

KEGG Gene (Homo sapiens):6156 RPL30

Monarch:6156 RPL30

NCBI Gene:6156 RPL30

OMIM:180467 RPL30

UCSC:P62888 RPL30

Reference Transcript

RefSeq:NM_000989.3 RPL30

Other Identifiers

11720954_s_at

11753659_x_at

11757356_x_at

18670705

18670707

18670713

18670715

18670716

18670717

200062_PM_s_at

200062_s_at

2651

3145954

3145955

3145956

3145960

3145961

3145966

3145968

3145969

3145970

31708_at

3450959

3VI6

4UG0

4V6X

5AJ0

5LKS

5T2C

6156

63603_s_at

6EK0

7892900

7893201

7895170

7895861

7895964

7896174

7896369

8151935

A0A024R9D3

A0A0B4J213

A0A0C4DH44

A_23_P123330

AAC15858

AAH32700

AAH95426

AB070559

AK312102

BAB79491

BAG35038

BC032700

BC095426

CAA55820

CCDS34928

CH471060

E5RI99

E5RJH3

EAW91770

EAW91771

ENSG00000156482

ENSP00000287038

ENSP00000428085

ENST00000287038

ENST00000287038.7

ENST00000521291

ENST00000521291.5

EntrezGene:6156

EntrezGene:RPL30

g388034_3p_s_at

GO:0000184

GO:0002181

GO:0002376

GO:0003674

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0006413

GO:0006605

GO:0006614

GO:0006810

GO:0006950

GO:0008150

GO:0009056

GO:0009058

GO:0014069

GO:0016020

GO:0019083

GO:0022625

GO:0031640

GO:0032991

GO:0034641

GO:0034655

GO:0042788

GO:0043226

GO:0044403

GO:0050829

GO:0061844

GO:0070062

HGNC:10333

HPA002651

ILMN_1754303

IPR000231

IPR004038

IPR022991

IPR029064

IPR039109

L05095

MIM:180467

NM_000989

NP_000980

PF01248

RPL30

RPL30-201

RPL30-209

UPI0000001623

X79238

Participant Of

hasComponent

Inferred To

Ghost homologue of RPL30 [cytosol] (Gallus gallus)

Ghost homologue of RPL30 [cytosol] (Xenopus tropicalis)

RPL30 [cytosol] (Bos taurus)

RPL30 [cytosol] (Caenorhabditis elegans)

RPL30 [cytosol] (Canis familiaris)

RPL30 [cytosol] (Danio rerio)

RPL30 [cytosol] (Dictyostelium discoideum)

RPL30 [cytosol] (Drosophila melanogaster)

RPL30 [cytosol] (Mus musculus)

RPL30 [cytosol] (Plasmodium falciparum)

RPL30 [cytosol] (Saccharomyces cerevisiae)

RPL30 [cytosol] (Schizosaccharomyces pombe)

RPL30 [cytosol] (Sus scrofa)

Rpl30 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_000980.1

OpenTargets

ENSG00000156482

GeneCards

P62888

PRO

P62888

PDB

6OLE, 6OLI, 6OM7, 5LKS, 4UG0, 4V6X, 6IP8, 6EK0, 6QZP, 6IP6, 5T2C, 6OLG, 5AJ0, 6IP5, 6OLZ, 6OM0, 3VI6, 6OLF

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.59	3