p-T185,Y187 MAPK1 S142L [cytosol]

Stable Identifier
R-HSA-9652808
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
ERK2, Mitogen-activated protein kinase 1 (EC 2.7.1.-) (Extracellular signal- regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1), Mitogen-activated protein kinase 1 , Extracellular signal-regulated kinase 2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1, ERK-2
p-T185,Y187 MAPK1 S142L [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
28481359 Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Zehir, A, Benayed, R, Shah, RH, Syed, A, Middha, S, Kim, HR, Srinivasan, P, Gao, J, Chakravarty, D, Devlin, SM, Hellmann, MD, Barron, DA, Schram, AM, Hameed, M, Dogan, S, Ross, DS, Hechtman, JF, DeLair, DF, Yao, J, Mandelker, DL, Cheng, DT, Chandramohan, R, Mohanty, AS, Ptashkin, RN, Jayakumaran, G, Prasad, M, Syed, MH, Rema, AB, Liu, ZY, Nafa, K, Borsu, L, Sadowska, J, Casanova, J, Bacares, R, Kiecka, IJ, Razumova, A, Son, JB, Stewart, L, Baldi, T, Mullaney, KA, Al-Ahmadie, H, Vakiani, E, Abeshouse, AA, Penson, AV, Jonsson, P, Camacho, N, Chang, MT, Won, HH, Gross, BE, Kundra, R, Heins, ZJ, Chen, HW, Phillips, S, Zhang, H, Wang, J, Ochoa, A, Wills, J, Eubank, M, Thomas, SB, Gardos, SM, Reales, DN, Galle, J, Durany, R, Cambria, R, Abida, W, Cercek, A, Feldman, DR, Gounder, MM, Hakimi, AA, Harding, JJ, Iyer, G, Janjigian, YY, Jordan, EJ, Kelly, CM, Lowery, MA, Morris, LGT, Omuro, AM, Raj, N, Razavi, P, Shoushtari, AN, Shukla, N, Soumerai, TE, Varghese, AM, Yaeger, R, Coleman, J, Bochner, B, Riely, GJ, Saltz, LB, Scher, HI, Sabbatini, PJ, Robson, ME, Klimstra, DS, Taylor, BS, Baselga, J, Schultz, N, Hyman, DM, Arcila, ME, Solit, DB, Ladanyi, M, Berger, MF

Nat. Med. 2017
27760319 Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants

Brenan, L, Andreev, A, Cohen, O, Pantel, S, Kamburov, A, Cacchiarelli, D, Persky, NS, Zhu, C, Bagul, M, Goetz, EM, Burgin, AB, Garraway, LA, Getz, G, Mikkelsen, TS, Piccioni, F, Root, DE, Johannessen, CM

Cell Rep 2016
External Reference Information
External Reference
Gene Names
MAPK1, ERK2, PRKM1, PRKM2
Chain
initiator methionine:1, chain:2-360
Other Identifiers
0000580471
0002850739
0003990647
11715841_at
11715842_a_at
11715843_at
11738871_a_at
11738872_x_at
11751223_a_at
11751224_x_at
11753379_a_at
1552263_at
1552264_a_at
16932831
208351_s_at
212271_at
224621_at
3954239
3954240
3954241
3954242
3954243
3954244
3954245
3954246
3954247
3954248
3954249
3954252
3954256
3954257
3954261
3954262
3954264
3954266
3954273
3954274
45715_at
55528_at
5594
8074791
976_s_at
A_23_P257895
A_24_P237265
GE476071
GE534117
GE56878
GE86009
GO:0000003
GO:0000165
GO:0000166
GO:0000186
GO:0000187
GO:0000902
GO:0001784
GO:0002376
GO:0003674
GO:0003677
GO:0003690
GO:0004672
GO:0004674
GO:0004707
GO:0004708
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005768
GO:0005769
GO:0005770
GO:0005773
GO:0005794
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005901
GO:0005925
GO:0006259
GO:0006412
GO:0006464
GO:0006468
GO:0006810
GO:0006913
GO:0006915
GO:0006935
GO:0006950
GO:0006974
GO:0007010
GO:0007049
GO:0007165
GO:0007166
GO:0007267
GO:0007268
GO:0007411
GO:0007507
GO:0007568
GO:0007611
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008353
GO:0008543
GO:0009058
GO:0009636
GO:0009790
GO:0009887
GO:0010468
GO:0010628
GO:0010800
GO:0014032
GO:0014066
GO:0014069
GO:0015031
GO:0015966
GO:0016020
GO:0016032
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0019233
GO:0019858
GO:0019899
GO:0019901
GO:0019902
GO:0030154
GO:0030168
GO:0030278
GO:0030335
GO:0030424
GO:0030641
GO:0030878
GO:0031143
GO:0031410
GO:0031435
GO:0031647
GO:0031663
GO:0032212
GO:0032496
GO:0032839
GO:0032872
GO:0032991
GO:0033598
GO:0034198
GO:0034614
GO:0034641
GO:0035094
GO:0035556
GO:0035578
GO:0038095
GO:0038096
GO:0038127
GO:0040007
GO:0040011
GO:0042307
GO:0042473
GO:0042592
GO:0042802
GO:0043167
GO:0043204
GO:0043226
GO:0043312
GO:0043330
GO:0043627
GO:0044281
GO:0044403
GO:0045596
GO:0045727
GO:0045893
GO:0046697
GO:0048538
GO:0048646
GO:0048856
GO:0048870
GO:0050852
GO:0050853
GO:0050877
GO:0051090
GO:0051276
GO:0051403
GO:0051493
GO:0051973
GO:0060020
GO:0060045
GO:0060291
GO:0060324
GO:0060425
GO:0060440
GO:0060716
GO:0061308
GO:0070371
GO:0070849
GO:0071276
GO:0071310
GO:0071356
GO:0072584
GO:0072686
GO:0090170
GO:0097011
GO:1900034
GO:1903351
GO:1904355
GO:1904813
GO:2000641
Hs.324473.2.S1_3p_at
Hs.66151.0.S1_3p_at
Hs2.324473.2.S1_3p_at
ILMN_1665276
ILMN_1706677
ILMN_1767320
ILMN_2235283
PH_hs_0016141
PH_hs_0039033
TC22000547.hg
Z11695_at
g4506086_3p_a_at
Participant Of
Other forms of this molecule
Modified Residues
Name
L-serine 142 replaced with L-leucine
Coordinate
142
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-leucine.
A protein modification that effectively removes or replaces an L-serine.
Name
O4'-phospho-L-tyrosine at 185
Coordinate
185
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 187
Coordinate
187
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
bladder carcinoma 4007 carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
Cross References
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
ZINC - Investigational
ZINC - Metabolites
COSMIC
IntEnz
GeneCards
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (47)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P35236 PTPN7  2 0.775 6
 UniProt:P51812 RPS6KA3  7 0.752 5
 UniProt:Q13115 DUSP4  1 0.75 5
 UniProt:Q15349 RPS6KA2  7 0.742 8
 UniProt:Q9BUB5 MKNK1  1 0.697 9
 UniProt:Q15121 PEA15  1 0.675 4
 UniProt:P27361 MAPK3  6 0.669 5
 UniProt:Q15418 RPS6KA1  7 0.669 5
 UniProt:Q9BRK4 LZTS2      0.666 4
 UniProt:Q16539-3 MAPK14      0.656 5
 UniProt:P14921 ETS1  2 0.641 3
 UniProt:P02687 MBP      0.623 2
 UniProt:Q15256 PTPRR      0.621 3
 UniProt:P29353-2 SHC1  6 0.618 4
 UniProt:P35813 PPM1A  2 0.611 19
 UniProt:P28482 MAPK1  18 0.609 3
 UniProt:Q02750 MAP2K1  27 0.609 2
 UniProt:Q9Y296 TRAPPC4  2 0.581 3
 UniProt:Q12913 PTPRJ  2 0.578 7
 UniProt:Q16828 DUSP6  2 0.564 3
 UniProt:P32121 ARRB2  2 0.564 3
 UniProt:Q05922  1 0.558 2
 UniProt:P62487 POLR2G  1 0.556 3
 UniProt:Q6NYC8 PPR18      0.556 3
 UniProt:O76064 RNF8  1 0.556 3
 UniProt:Q99750 MDFI      0.556 3
 UniProt:A0A384NQ31 A0A384NQ31      0.556 3
 UniProt:A2A3K4 PTPC1      0.556 3
 UniProt:Q15256-5 PTPRR      0.556 3
 UniProt:P61764 STXBP1  2 0.556 3
 UniProt:P15882 CHN1  1 0.556 3
 UniProt:Q9UPG8 PLAL2      0.556 3
 UniProt:P25786 PSMA1  2 0.556 3
 UniProt:Q08117-2 TLE5      0.556 3
 IntAct:EBI-16436244 CCSB ORF ID      0.556 3
 UniProt:B2RXF5 ZBT42      0.556 3
 UniProt:P35548 MSX2  1 0.556 3
 UniProt:Q99956 DUSP9  1 0.547 3
 UniProt:P28562 DUSP1  1 0.544 3
 UniProt:Q7L5N1 COPS6  2 0.544 2
 UniProt:Q16690 DUSP5  1 0.543 3
 UniProt:Q9U1H0 CIC      0.527 2
 UniProt:P06239 LCK  4 0.524 2
 UniProt:P53004 BLVRA  1 0.499 2
 UniProt:Q15025 TNIP1  1 0.488 2
 UniProt:P10415 BCL2  1 0.488 2
 UniProt:P46531 NOTCH1  60 0.462 2
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