Reactome | nascent EEF2 [cytosol]

nascent EEF2 [cytosol]

Stable Identifier

R-HSA-5358472

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

nascent eEF2

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External Reference Information

External Reference

UniProt:P13639 EEF2

Gene Names

EEF2, EF2

Chain

initiator methionine:, chain:2-858

Reference Genes

BioGPS Gene:1938 EEF2

COSMIC (genes):EEF2 EEF2

CTD Gene:1938 EEF2

dbSNP Gene:1938 EEF2

ENSEMBL:ENSG00000167658 EEF2

ENSEMBL_homo_sapiens_GENE:ENSG00000167658.16 EEF2

HGNC:3214 EEF2

KEGG Gene (Homo sapiens):1938 EEF2

Monarch:1938 EEF2

NCBI Gene:1938 EEF2

OMIM:130610 EEF2

UCSC:P13639 EEF2

Reference Transcript

RefSeq:NM_001961.3 EEF2

Other Identifiers

11715781_a_at

11715782_a_at

11715783_x_at

11748763_a_at

11748764_x_at

11751022_x_at

11757678_s_at

16867212

18671261

18671262

18671263

18671264

18671265

18671266

18671267

18671268

18671269

18671270

18671271

18671273

18671274

18671275

18671276

1938

200094_PM_s_at

200094_s_at

204102_PM_s_at

204102_s_at

36587_at

3846539

3846540

3846541

3846542

3846543

3846544

3846545

3846548

3846549

3846551

3846553

3846555

3846556

3846557

3846559

3846561

3846562

3846563

3846564

3846565

3846567

3846568

3846569

3846570

8032730

A_24_P87763

GE60349

GO:0000166

GO:0002244

GO:0003723

GO:0003746

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005840

GO:0005886

GO:0006412

GO:0006414

GO:0016020

GO:0016235

GO:0016787

GO:0019901

GO:0030154

GO:0031410

GO:0034774

GO:0043022

GO:0043226

GO:0045182

GO:0045202

GO:0045296

GO:0045727

GO:0048856

GO:0070062

GO:1904813

GO:1990904

HMNXSV003054355

ILMN_1738383

PH_hs_0004308

TC19001054.hg

X51466_at

g4503482_3p_a_at

Participates

as an input of

DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Homo sapiens)

Other forms of this molecule

EEF2 [ficolin-1-rich granule lumen]

EEF2 [extracellular region]

EEF2 [secretory granule lumen]

EEF2 [cytosol]

aminocarboxypropyl EEF2 [cytosol]

Me-diphthine EEF2 [cytosol]

diphthine EEF2 [cytosol]

ADP-ribo-EEF2 [cytosol]

Me3K525-EEF2 [cytosol]

Inferred To

EEF2 [cytosol] (Canis familiaris)

EEF2 [cytosol] (Gallus gallus)

eef2.1 [cytosol] (Xenopus tropicalis)

nascent EEF2 [cytosol] (Bos taurus)

nascent EEF2 [cytosol] (Caenorhabditis elegans)

nascent EEF2 [cytosol] (Danio rerio)

nascent EEF2 [cytosol] (Dictyostelium discoideum)

nascent EEF2 [cytosol] (Drosophila melanogaster)

nascent EEF2 [cytosol] (Mus musculus)

nascent EEF2 [cytosol] (Plasmodium falciparum)

nascent EEF2 [cytosol] (Rattus norvegicus)

nascent EEF2 [cytosol] (Saccharomyces cerevisiae)

nascent EEF2 [cytosol] (Schizosaccharomyces pombe)

nascent EEF2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001952.1

Guide to Pharmacology - Targets

2756

OpenTargets

ENSG00000167658

GeneCards

P13639

HPA

ENSG00000167658-EEF2

Ensembl

ENSG00000167658, ENSP00000307940, ENST00000309311

PRO

P13639

Pharos - Targets

P13639

Orphanet

22496

HMDB Protein

HMDBP02947

PDB

8Y0X, 8Y0W, 6Z6N, 6D9J, 4V6X, 6Z6M

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	21
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	8
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:P59665 DEFA1	9	omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(1-94) [Golgi lumen] (R-HSA-1467215) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(65-94) [extracellular region] (R-HSA-1462022) DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038)	0.527	2
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:Q99714 HSD17B10	1	HSD17B10 [mitochondrial matrix] (R-HSA-70831)	0.499	3

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