Reactome | PSMA4 [nucleoplasm]

PSMA4 [nucleoplasm]

Stable Identifier

R-HSA-174324

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit alpha type 4 , Proteasome component C9, Macropain subunit C9, Multicatalytic endopeptidase complex subunit C9, Proteasome subunit L

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMA4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25789 PSMA4

Gene Names

PSMA4, HC9, PSC9

Chain

chain:1-261

Reference Genes

BioGPS Gene:5685 PSMA4

COSMIC (genes):PSMA4 PSMA4

CTD Gene:5685 PSMA4

dbSNP Gene:5685 PSMA4

ENSEMBL:ENSG00000041357.16 PSMA4

HGNC:9533 PSMA4

KEGG Gene (Homo sapiens):5685 PSMA4

Monarch:5685 PSMA4

NCBI Gene:5685 PSMA4

OMIM:176846 PSMA4

UCSC:P25789 PSMA4

Reference Transcript

Other Identifiers

0002510605

11721905_a_at

11721906_s_at

11742892_s_at

1449_at

1450_g_at

16803540

203396_PM_at

203396_at

3603411

3603412

3603413

3603418

3603420

3603421

3603422

3603423

3603425

3603426

3603427

3603428

3603429

3603430

3603431

3603433

47202_at

5685

7985202

A_24_P124992

D00763_at

GE62733

GO:0000502

GO:0000932

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006511

GO:0008150

GO:0010498

GO:0019773

GO:0030163

GO:0032991

GO:0043161

GO:0043226

GO:0043231

GO:0051603

GO:0070062

HMNXSV003000223

ILMN_1682098

ILMN_2198376

TC15000731.hg

g4506184_3p_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMA4 [cytosol]

Inferred To

Prosalpha3 [nucleoplasm] (Drosophila melanogaster)

Proteasome subunit alpha type-4 [nucleoplasm] (Mus musculus)

PSMA4 [nucleoplasm] (Bos taurus)

PSMA4 [nucleoplasm] (Canis familiaris)

PSMA4 [nucleoplasm] (Gallus gallus)

PSMA4 [nucleoplasm] (Sus scrofa)

psma4 [nucleoplasm] (Xenopus tropicalis)

Psma4 [nucleoplasm] (Rattus norvegicus)

psmA4 [nucleoplasm] (Dictyostelium discoideum)

zgc:56176 [nucleoplasm] (Danio rerio)

pas-3 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001317605.1, NP_001096138.1, NP_002780.1, NP_001096137.1

OpenTargets

ENSG00000041357

GeneCards

P25789

HPA

ENSG00000041357-PSMA4

Ensembl

ENSP00000044462, ENSG00000041357, ENSP00000453887, ENST00000413382, ENST00000044462, ENSP00000402118, ENST00000559082

PRO

P25789

Pharos - Targets

P25789

PDB

6MSJ, 5T0H, 5L4G, 7AWE, 6MSH, 6RGQ, 5VFT, 5T0G, 4R67, 7LXV, 4R3O, 5GJR, 5M32, 6AVO, 6MSG, 5VFS, 5T0C, 5GJQ, 5LN3, 6MSE, 7NHT, 6R70, 5VFP, 7V5M, 5T0J, 5T0I, 6XMJ, 5LF0, 6REY, 5LEZ, 5VFU, 5LEY, 5A0Q, 5LEX, 5LF7, 6E5B, 6WJN, 5VFR, 6KWY, 5LF6, 7V5G, 6MSD, 7B12, 5LF4, 5VFQ, 6MSB, 6WJD, 5LF3, 7PG9, 6MSK, 5LF1, 5VFO, 5LE5

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.576	4
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.527	3
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.495	2