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PSMA4 [nucleoplasm]
Stable Identifier
R-HSA-174324
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit alpha type 4 , Proteasome component C9, Macropain subunit C9, Multicatalytic endopeptidase complex subunit C9, Proteasome subunit L
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA4 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA4 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA4 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA4 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA4 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA4 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25789 PSMA4
Gene Names
PSMA4, HC9, PSC9
Chain
chain:1-261
Reference Genes
BioGPS Gene:5685 PSMA4
COSMIC (genes):PSMA4 PSMA4
CTD Gene:5685 PSMA4
dbSNP Gene:5685 PSMA4
ENSEMBL:ENSG00000041357 PSMA4
HGNC:9533 PSMA4
KEGG Gene (Homo sapiens):5685 PSMA4
Monarch:5685 PSMA4
NCBI Gene:5685 PSMA4
OMIM:176846 PSMA4
UCSC:P25789 PSMA4
Reference Transcript
RefSeq:NM_002789.5 PSMA4
RefSeq:NM_001102667.2 PSMA4
RefSeq:NM_001330676.1 PSMA4
RefSeq:NM_001102668.2 PSMA4
Other Identifiers
0002510605
11721905_a_at
11721906_s_at
11742892_s_at
1449_at
1450_g_at
16803540
203396_at
3603411
3603412
3603413
3603418
3603420
3603421
3603422
3603423
3603425
3603426
3603427
3603428
3603429
3603430
3603431
3603433
47202_at
5685
7985202
A_24_P124992
D00763_at
GE62733
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0000932
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0004175
GO:0004298
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0006464
GO:0006508
GO:0006511
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008233
GO:0009056
GO:0009058
GO:0010498
GO:0010499
GO:0010972
GO:0016032
GO:0016579
GO:0016787
GO:0019773
GO:0030154
GO:0031145
GO:0031146
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0038061
GO:0038095
GO:0043161
GO:0043226
GO:0043231
GO:0043488
GO:0043687
GO:0044281
GO:0044403
GO:0048856
GO:0050852
GO:0051603
GO:0055085
GO:0060071
GO:0061418
GO:0070062
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
ILMN_1682098
ILMN_2198376
TC15000731.hg
g4506184_3p_at
Participant Of
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSMA4 [cytosol]
Inferred To
Prosalpha3 [nucleoplasm] (Drosophila melanogaster)
Proteasome subunit alpha type-4 [nucleoplasm] (Mus musculus)
PSMA4 [nucleoplasm] (Sus scrofa)
psma4 [nucleoplasm] (Danio rerio)
psma4 [nucleoplasm] (Xenopus tropicalis)
Psma4 [nucleoplasm] (Rattus norvegicus)
psmA4 [nucleoplasm] (Dictyostelium discoideum)
pas-3 [nucleoplasm] (Caenorhabditis elegans)
Ghost homologue of PSMA4 [nucleoplasm] (Canis familiaris)
Cross References
RefSeq
NP_001096137.1
,
NP_001317605.1
,
NP_001096138.1
,
NP_002780.1
OpenTargets
ENSG00000041357
HPA
ENSG00000041357-PSMA4
GeneCards
P25789
Ensembl
ENSG00000041357
,
ENSP00000044462
,
ENST00000413382
,
ENST00000044462
,
ENSP00000402118
,
ENSP00000453887
,
ENST00000559082
PRO
P25789
PDB
5LF4
,
6MSG
,
5VFP
,
5GJQ
,
5LF6
,
5LN3
,
5A0Q
,
5GJR
,
5VFQ
,
5VFR
,
5LF7
,
6MSH
,
6RGQ
,
5LEX
,
5T0C
,
6MSJ
,
5M32
,
6REY
,
5LEY
,
6XMJ
,
5VFS
,
5LF0
,
5T0G
,
5L4G
,
5LEZ
,
6MSB
,
5LE5
,
4R67
,
6E5B
,
5VFT
,
6KWY
,
6MSK
,
5T0H
,
5LF1
,
6AVO
,
6R70
,
6MSD
,
5VFU
,
5T0I
,
5LF3
,
4R3O
,
6MSE
,
5VFO
,
5T0J
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
4
UniProt:Q16665 HIF1A
7
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
HN-HIF1A [cytosol]
(R-HSA-1234110)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.576
4
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.527
3
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