Reactome | Polyglycyl-TUBB4B [cytosol]

Polyglycyl-TUBB4B [cytosol]

Stable Identifier

R-HSA-8867452

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBB4B, beta tubulin 2C

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Homo sapiens)
      - Polyglycylated microtubule [cytosol] (Homo sapiens)
        
        Polyglycylated microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglycyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglycyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglycyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglycyl-TUBB4B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P68371 TUBB4B

Gene Names

TUBB4B, TUBB2C

Chain

chain:1-445

Reference Genes

BioGPS Gene:10383 TUBB4B

COSMIC (genes):TUBB4B TUBB4B

CTD Gene:10383 TUBB4B

dbSNP Gene:10383 TUBB4B

ENSEMBL:ENSG00000188229 TUBB4B

HGNC:20771 TUBB4B

KEGG:hsa:10383 TUBB4B

Monarch:10383 TUBB4B

NCBI Gene:10383 TUBB4B

OMIM:602660 TUBB4B

UCSC:P68371 TUBB4B

Reference Transcript

RefSeq:NM_006088.5 TUBB4B

Other Identifiers

10383

11750415_x_at

11755974_s_at

11761932_at

17091695

208977_PM_x_at

208977_x_at

213726_PM_x_at

213726_x_at

33678_i_at

33679_f_at

3988357

4050498

4050499

4050500

4050501

4050502

4050503

4050504

4050505

4050506

4050507

4050508

4050509

8159642

90051_at

956_at

A_23_P312863

GE61196

GO:0000226

GO:0000278

GO:0002376

GO:0003723

GO:0003725

GO:0003824

GO:0003924

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005576

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0005879

GO:0005929

GO:0007010

GO:0007017

GO:0007018

GO:0015630

GO:0016787

GO:0022414

GO:0030317

GO:0035578

GO:0036126

GO:0042267

GO:0042288

GO:0043226

GO:0045171

GO:0046872

GO:0048870

GO:0051082

GO:0070062

GO:0072686

GO:0098542

GO:1903561

HMNXSV003036833

Hs.251653.1.A1_3p_x_at

ILMN_1780769

PH_hs_0033325

TC09000844.hg

g13278848_3p_a_at

Participates

as a candidate of

Polyglycyl beta tubulin [cytosol] (Homo sapiens)

Other forms of this molecule

TUBB4B folding intermediate [cytosol]

TUBB4B unfolded [cytosol]

Polyglutamyl-TUBB4B [cytosol]

TUBB4B [axonemal microtubule]

TUBB4B [extracellular region]

TUBB4B [azurophil granule lumen]

TUBB4B [cytosol]

Inferred To

Polyglycyl-TUBB2A [cytosol] (Dictyostelium discoideum)

Polyglycyl-TUBB2A [cytosol] (Plasmodium falciparum)

Polyglycyl-TUBB4B [cytosol] (Bos taurus)

Polyglycyl-TUBB4B [cytosol] (Mus musculus)

Polyglycyl-TUBB4B [cytosol] (Rattus norvegicus)

TUBB4B [cytosol] (Canis familiaris)

TUBB4B [cytosol] (Sus scrofa)

tubb4a [cytosol] (Xenopus tropicalis)

Modified Residues

Name

L-isoglutamyl-polyglycine at unknown position

PsiMod Name

L-isoglutamyl-polyglycine

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-isoglutamyl-polyglycine.

Cross References

RefSeq

NP_006079.1

Guide to Pharmacology - Targets

2641

ENSEMBL

ENSP00000341289

OpenTargets

ENSG00000188229

ZINC - Substances

TBB4B_HUMAN

ZINC target

P68371

PRO

P68371

GlyGen

P68371

PDB

8J07, 7UNG, 8SH7, 7UN1

HPA

ENSG00000188229-TUBB4B

Pharos - Targets

P68371

Orphanet

TUBB4B

HMDB Protein

HMDBP08046

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	10
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.547	3
UniProt:Q15398 DLGAP5	1	DLGAP5 [cytosol] (R-HSA-264452)	0.527	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.527	2
UniProt:Q07954 LRP1	2	LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-1454844)	0.527	2
UniProt:P36404 ARL2	2	ARL2 [mitochondrial matrix] (R-HSA-5250216) ARL2 [cytosol] (R-HSA-5216230)	0.527	4
UniProt:Q9BTW9 TBCD	1	TBCD [cytosol] (R-HSA-379540)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12

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