Reactome | IRS4 [plasma membrane]

IRS4 [plasma membrane]

Stable Identifier

R-HSA-2424297

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Insulin receptor substrate 4, IRS4_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
9553137	Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells Lienhard, GE, Fantin, VR, Keller, SR, Sparling, JD, Lavan, BE, Slot, JW	J. Biol. Chem.	1998

External Reference Information

External Reference

UniProt:O14654 IRS4

Gene Names

IRS4

Chain

chain:1-1257

Reference Genes

BioGPS Gene:8471 IRS4

COSMIC (genes):IRS4 IRS4

CTD Gene:8471 IRS4

dbSNP Gene:8471 IRS4

ENSEMBL:ENSG00000133124 IRS4

HGNC:6128 IRS4

KEGG:hsa:8471 IRS4

Monarch:8471 IRS4

NCBI Gene:8471 IRS4

OMIM:300904 IRS4

UCSC:O14654 IRS4

Reference Transcript

RefSeq:NM_003604.2 IRS4

Other Identifiers

11737665_at

1560652_PM_at

1560652_at

17113257

17113260

207403_PM_at

207403_at

33604_at

4017687

4017688

4017689

4017690

4017695

4017696

4017697

4017698

4017699

4017700

4017701

4017702

4017703

4017704

4017705

4017706

4017707

4017708

4056189

4056191

4056192

4056193

4056194

4056195

4056196

4056197

8174444

8471

ADDON002835.hg

A_21_P0006544

A_23_P85039

GE470462

GE79471

GO:0005158

GO:0005515

GO:0005829

GO:0005886

GO:0007165

GO:0008286

GO:0043548

HMNXSV003018490

HMNXSV003031383

Hs2.407141.1.S1_3p_at

ILMN_1712774

PH_hs_0009726

TC0X001269.hg

TC0X002182.hg

g4504732_3p_at

p29536

Participates

as a member of

Other forms of this molecule

p-Y-IRS4 [plasma membrane]

Inferred To

IRS4 [plasma membrane] (Bos taurus)

IRS4 [plasma membrane] (Canis familiaris)

IRS4 [plasma membrane] (Gallus gallus)

IRS4 [plasma membrane] (Sus scrofa)

Irs4 [plasma membrane] (Mus musculus)

Cross References

RefSeq

NP_003595.1

ENSEMBL

ENSP00000505547, ENST00000564206

OpenTargets

ENSG00000133124

HPA

ENSG00000133124-IRS4

PRO

O14654

Pharos - Targets

O14654

GlyGen

O14654

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.745	6
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.671	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.649	6
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.643	3
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.569	3
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	4
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.462	8

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