Reactome | CLTCL1 [cytosol]

CLTCL1 [cytosol]

Stable Identifier

R-HSA-8856822

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Clathrin heavy chain 2, CLH2_HUMAN

Locations in the PathwayBrowser

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - clathrin:HSPA8:ADP [cytosol] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - Recruitment of AP-2 complex and clathrin (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        clathrin triskelion [cytosol] (Homo sapiens)
        
        Clathrin heavy chain [cytosol] (Homo sapiens)
        
        CLTCL1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53675 CLTCL1

Gene Names

CLTCL1, CLH22, CLTCL, CLTD

Chain

initiator methionine:1, chain:2-1640

Reference Genes

BioGPS Gene:8218 CLTCL1

COSMIC (genes):CLTCL1 CLTCL1

CTD Gene:8218 CLTCL1

dbSNP Gene:8218 CLTCL1

ENSEMBL:ENSG00000070371 CLTCL1

ENSEMBL:ENSG00000070371.16 CLTCL1

HGNC:2093 CLTCL1

KEGG Gene (Homo sapiens):8218 CLTCL1

Monarch:8218 CLTCL1

NCBI Gene:8218 CLTCL1

OMIM:601273 CLTCL1

UCSC:P53675 CLTCL1

Reference Transcript

Other Identifiers

11724989_a_at

11724990_s_at

11750172_a_at

11750173_x_at

16932217

205944_PM_s_at

205944_s_at

33330_at

3952565

3952567

3952569

3952571

3952582

3952583

3952585

3952586

3952587

3952588

3952589

3952591

3952592

3952597

3952600

3952601

3952603

3952604

3952605

3952606

3952607

3952608

3952609

3952610

3952612

3952613

3952614

3952615

3952616

3952617

3952619

3952624

3952626

3952627

3952630

3952631

3952632

8074399

8218

A_23_P143559

GE62763

GO:0000278

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005768

GO:0005770

GO:0005794

GO:0005802

GO:0005819

GO:0005829

GO:0005856

GO:0005886

GO:0005905

GO:0006886

GO:0006898

GO:0009653

GO:0012505

GO:0016020

GO:0016192

GO:0030130

GO:0030132

GO:0030135

GO:0030136

GO:0030659

GO:0031410

GO:0032051

GO:0042147

GO:0043226

GO:0045334

GO:0046326

GO:0046907

GO:0048856

GO:0055085

GO:0070062

GO:0071439

GO:0097443

HMNXSV003011237

HMNXSV003024346

HMNXSV003033948

ILMN_1694584

ILMN_1739734

PH_hs_0010879

TC22000487.hg

U41763_at

g9257201_3p_a_at

Participates

as a member of

Clathrin heavy chain [cytosol] (Homo sapiens)

Other forms of this molecule

CLTCL1 [lysosomal membrane]

CLTCL1 [plasma membrane]

Inferred To

Chc [cytosol] (Drosophila melanogaster)

CLTCL1 [cytosol] (Canis familiaris)

CLTCL1 [cytosol] (Danio rerio)

CLTCL1 [cytosol] (Gallus gallus)

chc-1 [cytosol] (Caenorhabditis elegans)

chc1 [cytosol] (Schizosaccharomyces pombe)

CHC1 [cytosol] (Saccharomyces cerevisiae)

chcA [cytosol] (Dictyostelium discoideum)

cltcl1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001826.3, NP_009029.3

OpenTargets

ENSG00000070371

GeneCards

P53675

HPA

ENSG00000070371-CLTCL1

Ensembl

ENST00000621271, ENSP00000441158, ENSG00000070371, ENST00000427926, ENSP00000485020

PRO

P53675

Pharos - Targets

P53675

Orphanet

23739

HMDB Protein

HMDBP07613

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