Reactome | XRCC6 [cytosol]

XRCC6 [cytosol]

Stable Identifier

R-HSA-3134813

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ATP-dependent DNA helicase II, 70 kDa subunit, KU70, Lupus Ku autoantigen protein p70, 70 kDa subunit of Ku antigen, Thyroid-lupus autoantigen, TLAA, CTC box binding factor 75 kDa subunit, CTCBF, CTC75

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P12956 XRCC6

Gene Names

XRCC6, G22P1

Chain

initiator methionine:1, chain:2-609

Reference Genes

BioGPS Gene:2547 XRCC6

COSMIC (genes):XRCC6 XRCC6

CTD Gene:2547 XRCC6

dbSNP Gene:2547 XRCC6

ENSEMBL:ENSG00000196419 XRCC6

HGNC:4055 XRCC6

KEGG Gene (Homo sapiens):2547 XRCC6

Monarch:2547 XRCC6

NCBI Gene:2547 XRCC6

OMIM:152690 XRCC6

UCSC:P12956 XRCC6

Reference Transcript

Other Identifiers

0001340164

11730714_s_at

11754932_x_at

16930678

200792_PM_at

200792_at

2547

32766_at

3300572

3946972

3946973

3946974

3946975

3946976

3946978

3946981

3946982

3946984

3946987

3946989

3946990

3946993

3946994

3946995

3946997

3946998

3946999

4025651

4025653

4025659

4025661

4025663

8073457

A_23_P120942

GE61354

GE81028

GO:0000166

GO:0000723

GO:0000725

GO:0000781

GO:0000783

GO:0000976

GO:0002218

GO:0002376

GO:0003674

GO:0003677

GO:0003678

GO:0003684

GO:0003690

GO:0003691

GO:0003723

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006259

GO:0006266

GO:0006281

GO:0006303

GO:0006310

GO:0006464

GO:0006950

GO:0006974

GO:0008022

GO:0008094

GO:0008150

GO:0008152

GO:0008283

GO:0009058

GO:0016020

GO:0016787

GO:0016829

GO:0030154

GO:0030332

GO:0031410

GO:0032508

GO:0032991

GO:0032993

GO:0034641

GO:0034774

GO:0042162

GO:0043167

GO:0043226

GO:0043564

GO:0044877

GO:0045027

GO:0045087

GO:0045621

GO:0045860

GO:0045892

GO:0045893

GO:0045944

GO:0048660

GO:0048856

GO:0051276

GO:0051575

GO:0070418

GO:0070419

GO:0071480

GO:0071481

GO:0097110

GO:0097680

GO:0140657

GO:1904813

HMNXSV003043756

ILMN_1743097

ILMN_2166506

J04611_at

PH_hs_0022800

TC22000339.hg

g4503840_3p_at

Participates

as a component of

Ku70:Ku80 heterodimer [cytosol] (Homo sapiens)

Other forms of this molecule

XRCC6 [secretory granule lumen]

XRCC6 [extracellular region]

XRCC6 [ficolin-1-rich granule lumen]

XRCC6 [nucleoplasm]

Cross References

RefSeq

NP_001275906.1, NP_001460.1, NP_001275905.1

OpenTargets

ENSG00000196419

GeneCards

P12956

HPA

ENSG00000196419-XRCC6

Ensembl

ENSP00000384257, ENST00000405878, ENSP00000384941, ENST00000359308, ENSG00000196419, ENST00000360079, ENSP00000352257, ENSP00000353192, ENST00000402580

PRO

P12956

Pharos - Targets

P12956

PDB

6ERH, 6ERG, 7K1N, 1JEQ, 7AXZ, 6ZHA, 7LSY, 6ZHE, 7LT3, 3RZX, 1JJR, 1JEY, 7K0Y, 7NFE, 7K1J, 7NFC, 7K1K, 6ERF, 5Y3R

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.864	9
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302)	0.86	7
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.757	7
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.703	21
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.667	7
UniProt:Q13426 XRCC4	2	monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892) XRCC4 [nucleoplasm] (R-HSA-75911)	0.656	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	9
UniProt:Q96P48 ARAP1	2	p-Y231-ARAP1 [cytosol] (R-HSA-8848869) ARAP1 [cytosol] (R-HSA-3211582)	0.508	2
UniProt:P22415 USF1	1	USF1 [nucleoplasm] (R-HSA-9023562)	0.462	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.462	3